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1.发明授权Process for preparing ethyl-alpha-amino-gamma-oxo-gamma-phenybutyrate derivatives 失效制备乙基-γ-氨基-γ-氧代-γ-苯基丁酸酯衍生物的方法
公开(公告)号：US4925969A
公开(公告)日：1990-05-15
申请号：US324497
申请日：1989-03-16
申请人： Satomi Takahashi , Yasuyoshi Ueda , Kazuhiko Yamada , Yukio Yamada , Takehiko Yamane , Yoshifumi Yanagita , Yoshio Shimada , Kiyoshi Watanabe , Michio Nomura , Takehisa Ohashi , Kenji Inoue
发明人： Satomi Takahashi , Yasuyoshi Ueda , Kazuhiko Yamada , Yukio Yamada , Takehiko Yamane , Yoshifumi Yanagita , Yoshio Shimada , Kiyoshi Watanabe , Michio Nomura , Takehisa Ohashi , Kenji Inoue
IPC分类号： C07C227/08 , C07C233/46 , C07C271/06
CPC分类号： C07C233/46 , C07C227/08 , C07C271/06
摘要： Ethyl-.beta.-benzoyacrylate is reacted with an alkali metal salt of (S)-alanine or an alkali metal salt of N.sup.6 -trifluoroacetyl-L-lysine to form the corresponding Michael addition product, and not less than an equivalent amount of acid is added after completion of the Michael addition to prevent conversion of the (S,S) form of the product to the (R,S) form.
摘要翻译： 乙基-β-苯甲酸酯与（S） - 丙氨酸的碱金属盐或N6-三氟乙酰基-L-赖氨酸的碱金属盐反应形成相应的迈克尔加成产物，加入不少于等量的酸 完成迈克尔加成以防止（S，S）形式的产物转化为（R，S）形式。
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2.发明授权Method of collecting highly pure polyhydroxyalkanoate from microbial cells 有权从微生物细胞中收集高纯度聚羟基链烷酸酯的方法公开(公告)号：US07393668B2
公开(公告)日：2008-07-01
申请号：US10541389
申请日：2004-01-20
CPC分类号： C12P7/625
摘要： The present invention has an object to provide a method for separating and purifying a PHA without causing a serious decrease of the molecular weight to obtain a highly pure PHA in a high yield, which comprises efficiently removing cell components other than PHA particles from a cultured PHA-containing microbial cell. Another object of the present invention is to provide a method for obtaining an agglomerate of PHA particles.The method for recovering a PHA according to the present invention is a method which comprises efficiently disrupting a cell to recover the PHA by carrying out a physical disruption treatment and an alkali addition at low temperature for an aqueous suspension of the PHA-containing microbial cell, and then treating the PHA with an enzyme and/or a surfactant. Moreover, the particle diameter of the PHA may be enlarged by suspending the PHA in a hydrophilic solvent and/or water, and stirring at a temperature equal to or below the boiling point of said suspension, to agglomerate said PHA.
摘要翻译： 本发明的目的是提供一种分离纯化PHA的方法，而不会导致分子量的严重降低以获得高产率的高纯度PHA，其包括从培养的PHA有效除去PHA颗粒以外的细胞成分 含微生物细胞。 本发明的另一个目的是提供一种获得PHA颗粒附聚物的方法。 根据本发明的回收PHA的方法是通过对含PHA的微生物细胞的水性悬浮液进行物理破坏处理和低温碱添加来有效地破坏细胞以回收PHA的方法， 然后用酶和/或表面活性剂处理PHA。 此外，通过将PHA悬浮在亲水溶剂和/或水中并在等于或低于所述悬浮液沸点的温度下搅拌以使所述PHA聚集，可以扩大PHA的粒径。
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3.发明申请Method of collecting highly pure polyhydroxyalkanoate from microbial cells 有权从微生物细胞中收集高纯度聚羟基链烷酸酯的方法公开(公告)号：US20060084161A1
公开(公告)日：2006-04-20
申请号：US10541389
申请日：2004-01-20
IPC分类号： C12N9/00
CPC分类号： C12P7/625
摘要： The present invention has an object to provide a method for separating and purifying a PHA without causing a serious decrease of the molecular weight to obtain a highly pure PHA in a high yield, which comprises efficiently removing cell components other than PHA particles from a cultured PHA-containing microbial cell. Another object of the present invention is to provide a method for obtaining an agglomerate of PHA particles. The method for recovering a PHA according to the present invention is a method which comprises efficiently disrupting a cell to recover the PHA by carrying out a physical disruption treatment and an alkali addition at low temperature for an aqueous suspension of the PHA-containing microbial cell, and then treating the PHA with an enzyme and/or a surfactant. Moreover, the particle diameter of the PHA may be enlarged by suspending the PHA in a hydrophilic solvent and/or water, and stirring at a temperature equal to or below the boiling point of said suspension, to agglomerate said PHA.
摘要翻译： 本发明的目的是提供一种分离纯化PHA的方法，而不会导致分子量的严重降低以获得高产率的高纯度PHA，其包括从培养的PHA有效除去PHA颗粒以外的细胞成分 含微生物细胞。 本发明的另一个目的是提供一种获得PHA颗粒附聚物的方法。 根据本发明的回收PHA的方法是通过对含PHA的微生物细胞的水性悬浮液进行物理破坏处理和低温碱添加来有效地破坏细胞以回收PHA的方法， 然后用酶和/或表面活性剂处理PHA。 此外，通过将PHA悬浮在亲水溶剂和/或水中并在等于或低于所述悬浮液沸点的温度下搅拌以使所述PHA聚集，可以扩大PHA的粒径。
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4.发明授权公开(公告)号：US09249258B2
公开(公告)日：2016-02-02
申请号：US13133610
申请日：2009-12-02
申请人： Masaki Takita , Yoshifumi Yanagita
发明人： Masaki Takita , Yoshifumi Yanagita
CPC分类号： C12P7/625 , C08G63/06 , C08G63/88 , C08G63/90 , C08J3/14 , C08J2367/04 , Y10T428/2982
摘要： When industrially separating and purifying poly-3-hydroxyalkanoic acid produced by a microorganism, to obtain poly-3-hydroxyalkanoic acid agglomerates having an arbitrary volume mean particle diameter with favorable productivity and with decreased amount of an organic solvent used is enabled while decreasing contaminants derived from constitutive components of cellular bodies. According to the present invention, agglomerates of poly-3-hydroxyalkanoic acid are obtained by adjusting the pH of an aqueous poly-3-hydroxyalkanoic acid suspension to fall within an acidic region.
摘要翻译： 当工业上分离和纯化由微生物产生的聚-3-羟基链烷酸时，得到具有任意体积平均粒径的聚-3-羟基链烷酸聚集体，其具有良好的生产率和减少所用有机溶剂的量，同时减少污染物 从细胞体的组成成分。 根据本发明，聚-3-羟基链烷酸的聚集体通过调节聚-3-羟基链烷酸水溶液的pH在酸性区域内而得到。
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5.发明申请公开(公告)号：US20110293938A1
公开(公告)日：2011-12-01
申请号：US13133610
申请日：2009-12-02
申请人： Masaki Takita , Yoshifumi Yanagita
发明人： Masaki Takita , Yoshifumi Yanagita
CPC分类号： C12P7/625 , C08G63/06 , C08G63/88 , C08G63/90 , C08J3/14 , C08J2367/04 , Y10T428/2982
摘要： When industrially separating and purifying poly-3-hydroxyalkanoic acid produced by a microorganism, to obtain poly-3-hydroxyalkanoic acid agglomerates having an arbitrary volume mean particle diameter with favorable productivity and with decreased amount of an organic solvent used is enabled while decreasing contaminants derived from constitutive components of cellular bodies. According to the present invention, agglomerates of poly-3-hydroxyalkanoic acid are obtained by adjusting the pH of an aqueous poly-3-hydroxyalkanoic acid suspension to fall within an acidic region.
摘要翻译： 当工业上分离和纯化由微生物产生的聚-3-羟基链烷酸时，得到具有任意体积平均粒径的聚-3-羟基链烷酸聚集体，其具有良好的生产率和减少所用有机溶剂的量，同时减少污染物 从细胞体的组成成分。 根据本发明，聚-3-羟基链烷酸的聚集体通过调节聚-3-羟基链烷酸水溶液的pH在酸性区域内而得到。
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