公开(公告)号：US20110213335A1

公开(公告)日：2011-09-01

申请号：US13128066

申请日：2009-11-17

申请人： Scott A. Burton ,  Franklyn L. Frederickson ,  Kristen J. Hansen ,  Ryan P. Simmers ,  Percy T. Fenn ,  Craig S. Moeckly

发明人： Scott A. Burton ,  Franklyn L. Frederickson ,  Kristen J. Hansen ,  Ryan P. Simmers ,  Percy T. Fenn ,  Craig S. Moeckly

IPC分类号： A61M5/00

CPC分类号： A61M37/0015 ,  A61B5/150022 ,  A61B5/150106 ,  A61B5/150396 ,  A61B5/150969 ,  A61B5/150984 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0061

摘要： Rapid, high-volume, intradermal infusion with minimal pain, is achived by applying an array of 10 to 30 hollow microneedles having a length of greater than 100 um to less than 1 mm into the skin of a patient, with a microneedle spacing of no less than 1.5 mm on average between adjacent microneedles, and pumping greater than 200 uL of fluid through the hollow microneedles at a rate of greater than 20 uL/min.

摘要翻译： 通过将长度大于100um至小于1mm的长度大于100um至小于1mm的10至30个空心微针阵列应用于患者皮肤，以微针间距为无，可以快速，大容量，具有最小疼痛的皮内输注 在相邻的微针之间平均小于1.5mm，并且以大于20uL / min的速率通过中空微针泵送大于200uL的流体。

公开(公告)号：USD733290S1

公开(公告)日：2015-06-30

申请号：US29411954

申请日：2012-01-27

申请人： Scott A. Burton ,  Kristen J. Hansen ,  Catherine G. Kriske ,  Craig S. Moeckly ,  Ryan Patrick Simmers ,  Kieron H. Tse

设计人： Scott A. Burton ,  Kristen J. Hansen ,  Catherine G. Kriske ,  Craig S. Moeckly ,  Ryan Patrick Simmers ,  Kieron H. Tse

公开(公告)号：US20140066842A1

公开(公告)日：2014-03-06

申请号：US14003663

申请日：2012-03-06

申请人： Ying Zhang ,  Kristen J. Hansen ,  Amy S. Determan

发明人： Ying Zhang ,  Kristen J. Hansen ,  Amy S. Determan

IPC分类号： A61K9/00 ,  A61M37/00

CPC分类号： A61K9/0021 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

摘要翻译： 一种医疗装置，包括：微针阵列和设置在所述微针上的涂层，其中所述涂层包括：局部麻醉剂，其选自利多卡因，丙戊酸及其组合; 以及选自α1肾上腺素能激动剂，α2肾上腺素能激动剂及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂以基于所述涂层中固体总重量的至少1重量％的量存在，并且其中所述剂量延伸组分/局部麻醉剂重量比至少为0.0001; 包括可溶性微针阵列的医疗装置，所述微针包括：可溶性基质材料; 至少1重量％的选自利多卡因，丙戊酸及其组合的局部麻醉剂; 以及选自α1肾上腺素能激动剂，α2肾上腺素能激动剂及其组合的局部麻醉剂剂量延伸组分; 其中所述剂量延伸组分/局部麻醉重量比为至少0.0001，并且其中wt％基于含有所述局部麻醉剂的可溶性微针的所有部分中固体的总重量; 使用所述装置延长哺乳动物组织中局部递送的局部麻醉剂剂量的方法; 并提供制造设备的方法。

公开(公告)号：US09693950B2

公开(公告)日：2017-07-04

申请号：US13699805

申请日：2011-05-26

申请人： Amy S. Determan ,  Peter R. Johnson ,  Joan T. Moseman ,  Ryan T. Woldt ,  Kristen J. Hansen

发明人： Amy S. Determan ,  Peter R. Johnson ,  Joan T. Moseman ,  Ryan T. Woldt ,  Kristen J. Hansen

IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61M37/00 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

CPC分类号： A61K9/0021 ,  A61K47/10 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61M37/0015

摘要： Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 s−1 and a temperature of 25° C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.

公开(公告)号：US20140066843A1

公开(公告)日：2014-03-06

申请号：US14003693

申请日：2012-03-06

申请人： Ying Zhang ,  Kristen J. Hansen ,  Amy S. Determan

发明人： Ying Zhang ,  Kristen J. Hansen ,  Amy S. Determan

IPC分类号： A61K9/00 ,  A61M37/00

CPC分类号： A61K9/0021 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

摘要翻译： 一种医疗装置，包括：微针阵列和设置在所述微针上的涂层，其中所述涂层包括：选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂以基于所述涂层中固体总重量的至少1重量％的量存在，并且其中所述局部麻醉剂和剂量延伸组分为非共晶重量比; 包括可溶性微针阵列的医疗装置，所述微针包括：可溶性基质材料; 至少1重量％的选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂和剂量延伸组分处于非共晶重量比，并且其中wt％基于含有所述局部麻醉剂的可溶性微针的所有部分中固体的总重量; 使用所述装置延长哺乳动物组织中局部递送的局部麻醉剂剂量的方法; 并提供制造设备的方法。

公开(公告)号：US20130123707A1

公开(公告)日：2013-05-16

申请号：US13699805

申请日：2011-05-26

申请人： Amy S. Determan ,  Peter R. Johnson ,  Joan T. Moseman ,  Ryan T. Woldt ,  Kristen J. Hansen

发明人： Amy S. Determan ,  Peter R. Johnson ,  Joan T. Moseman ,  Ryan T. Woldt ,  Kristen J. Hansen

IPC分类号： A61K9/00 ,  A61M37/00

CPC分类号： A61K9/0021 ,  A61K47/10 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61M37/0015

摘要： Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 s−1 and a temperature of 25° C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.

摘要翻译： 包含至少一种活性药物成分的水性制剂; 和至少一种赋形剂，其中当在100s -1的剪切速率和25℃的温度下测量时，所述水性制剂具有500至30,000厘泊的粘度。 当在环境条件下测量时，表面张力不大于60达因/厘米; 或在环境条件下测量时，医疗级聚合物材料的接触角为50°或更大。 本文还公开了使用水性制剂的包衣和包衣微针阵列的方法。