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公开(公告)号：US08357543B2
公开(公告)日：2013-01-22
申请号：US12486215
申请日：2009-06-17
申请人： Scott G. Safar , Stephen L. Herchenbach , Chadwick M. Dunn , Charles M. Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
发明人： Scott G. Safar , Stephen L. Herchenbach , Chadwick M. Dunn , Charles M. Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
CPC分类号： G01N35/1004 , B01L3/50255 , B01L3/5082 , B01L99/00 , B01L2200/0668 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N35/0098 , G01N35/1065 , Y10T137/0391 , Y10T137/0396 , Y10T436/25375 , Y10T436/2575
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
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公开(公告)号：US07815866B2
公开(公告)日：2010-10-19
申请号：US12486074
申请日：2009-06-17
申请人： Scott G. Safar , Stephen L. Herchenbach , Chadwick M. Dunn , Charles M. Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
发明人： Scott G. Safar , Stephen L. Herchenbach , Chadwick M. Dunn , Charles M. Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
CPC分类号： G01N35/1004 , B01L3/50255 , B01L3/5082 , B01L99/00 , B01L2200/0668 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N35/0098 , G01N35/1065 , Y10T137/0391 , Y10T137/0396 , Y10T436/25375 , Y10T436/2575
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
摘要翻译： 具有底部排放开口的反应容器，其通过流体的表面张力支撑选定的未压缩流体的头部。 装置处理区域包括支撑隔离排列的反应容器，与其支撑的容器的排放开口连通的通道，以及用于选择性地通过排放开口排出流体的压力源。 通常，水平条形磁体被支撑用于在容器列之间选择的垂直运动。 分配头具有可选择性地定位在X选择的反应容器上的X个排出口。 计量泵机构选择性地将X选定量的流体计量为批量供应（其中X为至少四个），并且选择性地将计量的所选量通过排放开口泵送到选定的反应容器。 还包括使用压力源从容器中抽取流体并移动磁体以形成分析物颗粒的方法。
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公开(公告)号：US20090314802A1
公开(公告)日：2009-12-24
申请号：US12486215
申请日：2009-06-17
申请人： Scott Safar , Stephen L. Herchenbach , Chadwick M. Dunn , Charles Michael Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
发明人： Scott Safar , Stephen L. Herchenbach , Chadwick M. Dunn , Charles Michael Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
CPC分类号： G01N35/1004 , B01L3/50255 , B01L3/5082 , B01L99/00 , B01L2200/0668 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N35/0098 , G01N35/1065 , Y10T137/0391 , Y10T137/0396 , Y10T436/25375 , Y10T436/2575
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
摘要翻译： 具有底部排放开口的反应容器，其通过流体的表面张力支撑选定的未压缩流体的头部。 装置处理区域包括支撑隔离排列的反应容器，与其支撑的容器的排放开口连通的通道，以及用于选择性地通过排放开口排出流体的压力源。 通常，水平条形磁体被支撑用于在容器列之间选择的垂直运动。 分配头具有可选择性地定位在X选择的反应容器上的X个排出口。 计量泵机构选择性地测量选定量的流体的批量供应（其中X是至少四个），并且选择性地将经计量的所选量通过排放开口泵送到选定的反应容器。 还包括使用压力源从容器中抽取流体并移动磁体以形成分析物颗粒的方法。
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公开(公告)号：US20090252652A1
公开(公告)日：2009-10-08
申请号：US12486074
申请日：2009-06-17
申请人： Scott Safar , Stephen Herchenbach , Chadwick M. Dunn , Charles Michael Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
发明人： Scott Safar , Stephen Herchenbach , Chadwick M. Dunn , Charles Michael Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
IPC分类号： B01L3/00
CPC分类号： G01N35/1004 , B01L3/50255 , B01L3/5082 , B01L99/00 , B01L2200/0668 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N35/0098 , G01N35/1065 , Y10T137/0391 , Y10T137/0396 , Y10T436/25375 , Y10T436/2575
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
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公开(公告)号：US08409528B2
公开(公告)日：2013-04-02
申请号：US10865207
申请日：2004-06-10
申请人： Scott Safar , Stephen Herchenbach , Chadwick M. Dunn , Charles Michael Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
发明人： Scott Safar , Stephen Herchenbach , Chadwick M. Dunn , Charles Michael Galitz , Julius J. Toth , Ronald E. Kukla , Michael G. Lowery , Eric B. Shain
IPC分类号： B01L3/00
CPC分类号： G01N35/1004 , B01L3/50255 , B01L3/5082 , B01L99/00 , B01L2200/0668 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N35/0098 , G01N35/1065 , Y10T137/0391 , Y10T137/0396 , Y10T436/25375 , Y10T436/2575
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
摘要翻译： 具有底部排放开口的反应容器，其通过流体的表面张力支撑选定的未压缩流体的头部。 装置处理区域包括支撑隔离排列的反应容器，与其支撑的容器的排放开口连通的通道，以及用于选择性地通过排放开口排出流体的压力源。 通常，水平条形磁体被支撑用于在容器列之间选择的垂直运动。 分配头具有可选择性地定位在X选择的反应容器上的X个排出口。 计量泵机构选择性地将X选定量的流体计量为批量供应（其中X为至少四个），并且选择性地将计量的所选量通过排放开口泵送到选定的反应容器。 还包括使用压力源从容器中抽取流体并移动磁体以形成分析物颗粒的方法。
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公开(公告)号：US06562298B1
公开(公告)日：2003-05-13
申请号：US09298711
申请日：1999-04-23
申请人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
发明人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
IPC分类号： G01N3504
CPC分类号： G01N35/0092 , G01N35/025 , G01N35/04 , G01N2035/00534 , G01N2035/00752 , G01N2035/0465 , G01N2035/0467 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831
摘要： The embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path. The process path comprises a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided. A first prime mover is operatively connected with the process path for moving a container holding the sample along the process path. A first pipetting system is operatively associated with the process path for introducing the sample to the container. A second pipetting system is operatively associated with the process path for introducing a reagent to the container. A device is operatively connected with the process path and is selectively engagable with the container for mixing the sample and the reagent in the container. A second prime mover is operatively connected with the process path for selectively positioning the container in a selected one of the process step performance lane and the process step avoidance lane. A reader is operatively connected with the process path for determining the item of interest in the sample based upon a reaction between the sample and the reagent.
摘要翻译： 所公开的实施例涉及确定样品中的感兴趣物品。 一个实施例涉及包括处理路径的结构。 处理路径包括包括执行处理步骤的处理步骤执行通道的处理通道，以及避免处理步骤的处理步骤回避通道。 第一原动机与工艺路径可操作地连接，用于沿着处理路径移动容纳样品的容器。 第一移液系统与用于将样品引入容器的过程路径可操作地相关联。 第二移液系统与用于将试剂引入容器的过程路径可操作地相关联。 一种装置与工艺路径可操作地连接，并且与该容器选择性地接合，用于将样品和试剂混合在容器中。 第二原动机与工艺路径可操作地连接，用于将容器选择性地定位在所选择的一个工艺步骤性能车道和工艺步骤回避车道中。 读取器可操作地与处理路径连接，用于基于样品和试剂之间的反应来确定样品中的感兴趣物品。
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公开(公告)号：US5856194A
公开(公告)日：1999-01-05
申请号：US715780
申请日：1996-09-19
申请人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
发明人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
IPC分类号： G01N33/483 , G01N33/49 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/0092 , G01N35/04 , G01N2035/00534 , G01N2035/00752 , G01N2035/0465 , G01N2035/0467 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831
摘要： The embodiments disclosed relate to determination of an item of interest in a sample. In one method, a process path comprising a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided is provided. A container holding the sample is moved along the process path. The sample is introduced to the container. A reagent is introduced to the container. The sample and the reagent are mixed in the container. The container is selectively positioned in a selected one of the process step performance lane and the process step avoidance lane. The item of interest in the sample is determined based upon a reaction between the sample and the reagent.
摘要翻译： 所公开的实施例涉及确定样品中的感兴趣物品。 在一种方法中，提供了一种处理路径，其包括包括执行处理步骤的处理步骤执行通道的处理通道，以及避免处理步骤的处理步骤回避通道。 保持样品的容器沿着处理路径移动。 将样品引入容器。 将试剂引入容器。 样品和试剂在容器中混合。 容器选择性地定位在所选择的一个工艺步骤性能车道和工艺步骤回避车道中。 基于样品和试剂之间的反应确定样品中的目标物。
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