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1.发明授权Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor 有权萘酚，喹啉和异喹啉衍生的凡士林VR1受体的尿素调节剂公开(公告)号：US07183411B2
公开(公告)日：2007-02-27
申请号：US10616579
申请日：2003-07-10
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： C07D217/22 , A61K31/47
CPC分类号： C07C275/28 , C07C275/30 , C07C275/32 , C07D213/40 , C07D215/38 , C07D217/02 , C07D217/22 , C07D217/24 , C07D235/14 , C07D307/52 , C07D333/20 , C07D333/58 , C07D401/12 , C07D409/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to naphthol, quinoline and isoquinoline-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地说，本发明涉及作为VR1的有效拮抗剂或激动剂的萘酚，喹啉和异喹啉衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛状况。
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2.发明申请公开(公告)号：US20080300236A1
公开(公告)日：2008-12-04
申请号：US12174017
申请日：2008-07-16
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： A61K31/47 , C07D215/38 , A61K31/55 , A61P9/00 , A61P25/00 , C07D401/14
CPC分类号： C07D215/38 , C07D215/60 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/10
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的喹啉衍生的酰胺，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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公开(公告)号：US06984647B2
公开(公告)日：2006-01-10
申请号：US10438477
申请日：2003-05-15
IPC分类号： A61K31/47 , C07D211/06 , C07D217/22
CPC分类号： C07D213/40 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2601/02 , C07C2602/10 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/64 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
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公开(公告)号：US08569505B2
公开(公告)日：2013-10-29
申请号：US12692128
申请日：2010-01-22
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： C07D217/02 , C07C275/28
CPC分类号： C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2602/10 , C07D217/02 , C07D217/08
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
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公开(公告)号：US08394828B2
公开(公告)日：2013-03-12
申请号：US12174017
申请日：2008-07-16
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D215/38 , C07D215/60 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/10
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的喹啉衍生的酰胺，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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6.发明申请公开(公告)号：US20100125140A1
公开(公告)日：2010-05-20
申请号：US12692128
申请日：2010-01-22
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： C07D217/02 , C07C275/28 , C07C335/18
CPC分类号： C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2602/10 , C07D217/02 , C07D217/08
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的β-氨基四氢萘衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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公开(公告)号：US07678812B2
公开(公告)日：2010-03-16
申请号：US11877220
申请日：2007-10-23
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： A61K31/47 , C07D211/06 , C07D217/22
CPC分类号： C07D213/40 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2601/02 , C07C2602/10 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/64 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的β-氨基四氢萘衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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8.发明申请公开(公告)号：US20080097102A1
公开(公告)日：2008-04-24
申请号：US11877220
申请日：2007-10-23
申请人： Ellen Codd , Scott Dax , Michele Jetter , Mark McDonnell , James McNally , Mark Youngman
发明人： Ellen Codd , Scott Dax , Michele Jetter , Mark McDonnell , James McNally , Mark Youngman
IPC分类号： C07D217/22 , C07C275/06
CPC分类号： C07D213/40 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2601/02 , C07C2602/10 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/64 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的β-氨基四氢萘衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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公开(公告)号：US20050187291A1
公开(公告)日：2005-08-25
申请号：US11045956
申请日：2005-01-28
申请人： Ellen Codd , Scott Dax , Michele Jetter , Mark McDonnell , James McNally , Mark Youngman
发明人： Ellen Codd , Scott Dax , Michele Jetter , Mark McDonnell , James McNally , Mark Youngman
IPC分类号： C07D233/64 , A61K31/17 , A61K31/36 , A61K31/4164 , A61K31/47 , A61K31/472 , A61P1/00 , A61P1/04 , A61P11/00 , A61P11/06 , A61P13/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P29/00 , A61P35/00 , A61P39/02 , A61P43/00 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07D213/40 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/54 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , A61K31/277 , A61K31/195
CPC分类号： C07D213/40 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2601/02 , C07C2602/10 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/64 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的β-氨基四氢萘衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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10.发明申请Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators 有权用作缓激肽受体调节剂的新型杂芳基烷基酰胺衍生物公开(公告)号：US20050159443A1
公开(公告)日：2005-07-21
申请号：US11014471
申请日：2004-12-16
申请人： John Carson , Michele Jetter , Jung Lee , Mark Youngman
发明人： John Carson , Michele Jetter , Jung Lee , Mark Youngman
IPC分类号： A61K31/4375 , A61K31/4709 , A61K31/4745 , A61P1/04 , A61P1/18 , A61P11/06 , A61P17/02 , A61P19/02 , A61P25/04 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D471/04 , C07D471/02 , C07D43/02
CPC分类号： C07D401/12 , A61K31/4709 , A61K31/4745 , C07D401/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D471/04
摘要： This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.
摘要翻译： 本发明涉及作为缓激肽受体拮抗剂的新型烷基酰胺衍生物，其用于治疗缓激肽调节障碍如疼痛，炎症，哮喘和过敏。 此外，本发明涉及作为可用于治疗缓激肽调节障碍如高血压等的缓激肽受体激动剂的新型烷基酰胺衍生物。
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