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1.发明授权Blocking cell adhesion molecules and treating animals with ocular inflammation 失效阻断细胞粘附分子并用眼部炎症治疗动物
公开(公告)号：US5597567A
公开(公告)日：1997-01-28
申请号：US192198
申请日：1994-02-04
IPC分类号： A61K39/395 , A61K38/00 , A61K39/40 , A61K39/42 , A61K39/44 , A61P29/00 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2854 , C07K16/2821 , C07K16/2845 , A61K38/00
摘要： The present invention relates, in general, to a method of blocking of cell adhesion molecules. In particular, the present invention relates to a method of blocking cell adhesion molecules with monoclonal antibodies or synthesized substances.
摘要翻译： 本发明一般涉及细胞粘附分子的阻断方法。 特别地，本发明涉及用单克隆抗体或合成物质阻断细胞粘附分子的方法。
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公开(公告)号：US11078262B2
公开(公告)日：2021-08-03
申请号：US11742350
申请日：2007-04-30
摘要： Anti-angiogenesis compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes are provided. Such compositions include MAAC solutions or particles present in a therapeutically effective amount, a viscosity-inducing component, and an aqueous carrier component. The compositions have viscosities at about 25° C. of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity at 25° C. is in the range of from about 80,000 cps to about 300,000 cps.
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3.发明授权Methods and compositions for intraocular administration to treat ocular conditions 有权用于眼内给药以治疗眼部病症的方法和组合物公开(公告)号：US08642067B2
公开(公告)日：2014-02-04
申请号：US11695527
申请日：2007-04-02
IPC分类号： A61F2/00
CPC分类号： A61K31/404 , A61K9/0048 , A61K31/33 , A61K31/728 , A61K47/14 , A61K47/36 , A61K2300/00
摘要： Anti-angiogenesis compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes are provided. Such compositions can include TKI component solutions or particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities at about 25° C. of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity at 25° C. is in the range of from about 80,000 cps to about 300,000 cps.
摘要翻译： 提供了抗血管生成组合物，以及使用这些组合物的方法，其可用于注射到人眼玻璃体中。 这样的组合物可以包括TKI组分溶液或以治疗有效量存在的颗粒，粘度诱导组分和水性载体组分。 组合物在约25℃下的粘度为0.1 /秒的剪切速率为至少约10cps或约100cps。 在优选的实施方案中，25℃下的粘度在约80,000cps至约300,000cps的范围内。
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公开(公告)号：US20130071349A1
公开(公告)日：2013-03-21
申请号：US13516159
申请日：2011-03-01
IPC分类号： A61K31/765 , A61K47/34
CPC分类号： A61K31/765 , A61K9/0051 , A61K31/557
摘要： The present invention provides a method of treating glaucoma, the method comprising the step of placing a polymer in an eye of a patient, which biologically degrades over a period of time to release biodegradants, which are effective to lower the intraocular pressure of the patient, thereby treating glaucoma. Said polymer is preferably selected from the group consisting of polymers of lactic acid, glycolic acid and/or mixtures thereof. More preferably the polymer is a copolymer of lactic acid and glycolic acid, e.g. a copolymer comprising from 50 to 100% lactic acid and from 0 to 50% glycolic acid, by weight.
摘要翻译： 本发明提供了一种治疗青光眼的方法，所述方法包括将聚合物置于患者的眼睛中的步骤，所述聚合物在一段时间内生物降解以释放生物降解剂，其有效降低患者的眼内压， 从而治疗青光眼。 所述聚合物优选选自乳酸，乙醇酸和/或其混合物的聚合物。 更优选地，聚合物是乳酸和乙醇酸的共聚物，例如， 包含50-100％乳酸和0-50％乙醇酸的共聚物，按重量计。
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5.发明申请公开(公告)号：US20090196905A1
公开(公告)日：2009-08-06
申请号：US12026736
申请日：2008-02-06
申请人： Lon T. Spada , Wendy M. Blanda , Marianne M. Do , Scott M. Whitcup , Patrick M. Hughes , Michael R. Robinson
发明人： Lon T. Spada , Wendy M. Blanda , Marianne M. Do , Scott M. Whitcup , Patrick M. Hughes , Michael R. Robinson
CPC分类号： A61K38/13 , A61F9/0017 , A61F2210/0004
摘要： Methods of treating ocular diseases and conditions using biodegradable ocular implants containing cyclosporine to inhibit mitochondrial permeability transition pore formation are disclosed.
摘要翻译： 公开了使用含有环孢菌素的生物降解性眼部植入物治疗眼部疾病和病症以抑制线粒体通透性转换孔形成的方法。
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6.发明申请公开(公告)号：US20080268051A1
公开(公告)日：2008-10-30
申请号：US11742350
申请日：2007-04-30
IPC分类号： A61K9/00 , A61P27/02 , A61K38/00 , A61K31/711 , A61K39/395
CPC分类号： C07K16/22 , A61K9/0048 , A61K9/08 , A61K38/39 , A61K47/34 , A61K2039/505 , C07K2317/24 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/332 , C12N2320/32
摘要： Anti-angiogenesis compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes are provided. Such compositions include MAAC solutions or particles present in a therapeutically effective amount, a viscosity-inducing component, and an aqueous carrier component. The compositions have viscosities at about 25° C. of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity at 25° C. is in the range of from about 80,000 cps to about 300,000 cps.
摘要翻译： 提供了抗血管生成组合物，以及使用这些组合物的方法，其可用于注射到人眼玻璃体中。 这样的组合物包括以治疗有效量存在的MAAC溶液或颗粒，粘度诱导组分和水性载体组分。 组合物在约25℃下的粘度为0.1 /秒的剪切速率为至少约10cps或约100cps。 在优选的实施方案中，25℃下的粘度在约80,000cps至约300,000cps的范围内。
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7.发明申请METHOD FOR DETERMINING OPTIMUM INTRAOCULAR LOCATIONS FOR DRUG DELIVERY IMPLANT 失效用于确定药物递送植入物的最佳内部位置的方法公开(公告)号：US20080181929A1
公开(公告)日：2008-07-31
申请号：US11948411
申请日：2007-11-30
申请人： Michael R. Robinson , Joan-En Chang-Lin , Devin F. Welty , Scott M. Whitcup , Patrick M. Hughes
发明人： Michael R. Robinson , Joan-En Chang-Lin , Devin F. Welty , Scott M. Whitcup , Patrick M. Hughes
CPC分类号： A61K39/3955 , A61F9/0017 , A61K9/0048 , A61K31/573 , A61K31/58
摘要： A method for determining the optimum location for placement of an intraocular implant containing used to treat an ocular condition, particularly implants comprised of a biodegradable polymer and a therapeutic agent for the treatment of retinal tissue.
摘要翻译： 用于确定用于放置用于治疗眼部病症的眼内植入物的最佳位置的方法，特别是由可生物降解的聚合物和用于治疗视网膜组织的治疗剂组成的植入物。
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公开(公告)号：US20140302007A1
公开(公告)日：2014-10-09
申请号：US13466806
申请日：2012-05-08
申请人： Wendy M. Blanda , Rober K. Aoki , Terrence J. Hunt , Patrick M. Hughes , James N. Chang , Scott M. Whitcup , Michael R. Robinson
发明人： Wendy M. Blanda , Rober K. Aoki , Terrence J. Hunt , Patrick M. Hughes , James N. Chang , Scott M. Whitcup , Michael R. Robinson
CPC分类号： A61K38/4893 , A61K9/0019 , A61K9/0024 , A61K47/36 , C12Y304/24069
摘要： Botulinum neurotoxin formulated with a hyaluronic acid carrier with increased residency time of the botulinum toxin at a subdermal location and fewer botulinum toxin induced complications or side effects.
摘要翻译： 用透明质酸载体配制的肉毒杆菌神经毒素，肉毒杆菌毒素在皮下位置的驻留时间增加，肉毒杆菌毒素诱导的并发症或副作用较少。
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9.发明授权Method for determining optimum intraocular locations for drug delivery systems 失效用于确定药物递送系统的最佳眼内位置的方法公开(公告)号：US08571802B2
公开(公告)日：2013-10-29
申请号：US11948411
申请日：2007-11-30
申请人： Michael R. Robinson , Joan-En Chang-Lin , Devin F. Welty , Scott M. Whitcup , Patrick M. Hughes
发明人： Michael R. Robinson , Joan-En Chang-Lin , Devin F. Welty , Scott M. Whitcup , Patrick M. Hughes
IPC分类号： G01N33/50
CPC分类号： A61K39/3955 , A61F9/0017 , A61K9/0048 , A61K31/573 , A61K31/58
摘要： A method for determining the optimum location for placement of an intraocular implant containing used to treat an ocular condition, particularly implants comprised of a biodegradable polymer and a therapeutic agent for the treatment of retinal tissue.
摘要翻译： 用于确定用于放置用于治疗眼部病症的眼内植入物的最佳位置的方法，特别是由可生物降解的聚合物和用于治疗视网膜组织的治疗剂组成的植入物。
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公开(公告)号：US20110092443A1
公开(公告)日：2011-04-21
申请号：US12683811
申请日：2010-01-07
摘要： The present invention is directed to cyclosporine compositions and methods for stimulating the growth of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to increase nail growth and thicken, strengthen and smooth the nail. The composition is also effective in strengthening and growing nails, including fingernails and toenails.
摘要翻译： 本发明涉及环孢素组合物和刺激哺乳动物（包括人）中指甲和角质层生长的方法。 组合物可以局部施用于甲床，指甲基质和角质层，其量可有效增加指甲生长并增厚，加强和平滑指甲。 组合也有效地加强和增长指甲，包括指甲和脚趾甲。
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