公开(公告)号：US20070078489A1

公开(公告)日：2007-04-05

申请号：US11242240

申请日：2005-10-03

申请人： Scott Meyer ,  Yanting Dong ,  Kevin Stalsberg ,  Alok Sathaye

发明人： Scott Meyer ,  Yanting Dong ,  Kevin Stalsberg ,  Alok Sathaye

IPC分类号： A61N1/362

CPC分类号： A61N1/371 ,  A61B5/04525 ,  A61B5/7217 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3712

摘要： The waveform morphology of a propagated pacing response signal may be adjusted to achieve a waveform morphology that enhances cardiac pacing response determination. One or more pacing intervals may be adjusted to achieve at least one cardiac pacing response waveform morphology that enhances determination of the cardiac pacing response. The heart is paced using the one or more adjusted pacing intervals and the cardiac response to the pacing is determined. The one or more adjusted pacing intervals may include an atrioventricular pacing delay, an interatrial pacing delay, an interventricular pacing delay, or other inter-chamber or inter-site pacing delays. Adjusting the one or more pacing intervals may be used to increase a difference between a first waveform morphology associated with multi-chamber capture and a second waveform morphology associated with single chamber capture.

摘要翻译： 可以调节传播的起搏响应信号的波形形态，以实现增强心脏起搏响应确定的波形形态。 可以调整一个或多个起搏间隔以实现至少一个心脏起搏响应波形形态，其增强心脏起搏响应的确定。 心脏使用一个或多个调整的起搏间隔进行起搏，并且确定对起搏的心脏反应。 一个或多个经调整的起搏间隔可以包括房室起搏延迟，房间起搏延迟，室间起搏延迟或其他间室间或间部间起搏延迟。 可以使用调整一个或多个起搏间隔来增加与多室捕获相关联的第一波形形态与与单室捕获相关联的第二波形形态之间的差异。

公开(公告)号：US20060293717A1

公开(公告)日：2006-12-28

申请号：US11168276

申请日：2005-06-28

申请人： Alok Sathaye ,  Scott Meyer ,  Derek Bohn

发明人： Alok Sathaye ,  Scott Meyer ,  Derek Bohn

IPC分类号： A61N1/00

CPC分类号： A61N1/3712 ,  A61N1/3627

摘要： Methods and systems are directed to selecting from a variety of capture verification modes. A plurality of capture verification modes, including a beat by beat capture detection mode and a capture threshold testing mode without intervening beat by beat capture detection is provided. An efficacy of at least one of the capture verification modes is evaluated and, based on the evaluation, a capture verification mode is selected.

摘要翻译： 方法和系统旨在从各种捕获验证模式中进行选择。 提供了多个拍摄验证模式，包括拍拍拍摄检测模式和拍摄阈值测试模式，而不会通过拍摄捕获检测进行中间拍摄。 评估捕获验证模式中的至少一个的功效，并且基于评估，选择捕获验证模式。

公开(公告)号：US20070150011A1

公开(公告)日：2007-06-28

申请号：US11320173

申请日：2005-12-28

申请人： Scott Meyer ,  Alok Sathaye

发明人： Scott Meyer ,  Alok Sathaye

IPC分类号： A61N1/36

CPC分类号： A61N1/3702 ,  A61N1/36114 ,  A61N1/3624

摘要： A system for reducing proarrhythmic effects of neural stimulation is provided. One aspect of this disclosure relates to an implantable medical device (IMD) for reducing proarrhythmic effects of neural stimulation. The IMD includes a neural stimulator adapted to deliver an electrical signal through at least one electrode to provide vagal stimulation. The IMD also includes a controller adapted to receive atrial arrhythmia vulnerability data and to control a therapeutic stimulator to limit atrial proarrhythmia using the atrial arrhythmia vulnerability data. The controller is further adapted to receive atrial arrhythmic history data and to control a therapeutic stimulator to limit atrial proarrhythmia using the atrial arrhythmic history data, according to various embodiments. According to one embodiment, the therapeutic stimulator includes the neural stimulator. The therapeutic stimulator includes a cardiac stimulator adapted to provide cardiac rhythm management therapy, according to various embodiments. Other aspects and embodiments are provided herein.

摘要翻译： 提供了减少神经刺激的心律失常作用的系统。 本公开的一个方面涉及用于减少神经刺激的心律失常作用的可植入医疗装置（IMD）。 IMD包括适于通过至少一个电极传递电信号以提供迷走神经刺激的神经刺激器。 IMD还包括一个控制器，适用于接收心房心律失常的脆弱性数据，并使用房性心律失常漏洞数据来控制治疗性刺激器来限制心房心律失常。 根据各种实施例，控制器还适于接收心房心律失常历史数据并且使用心房心律不齐历史数据来控制治疗性刺激器来限制心房心律失常。 根据一个实施例，治疗刺激器包括神经刺激器。 根据各种实施例，治疗性刺激器包括适于提供心律控制治疗的心脏刺激器。 本文提供了其它方面和实施例。

公开(公告)号：US08886300B2

公开(公告)日：2014-11-11

申请号：US13608721

申请日：2012-09-10

申请人： Alok Sathaye ,  Scott A. Meyer ,  Derek D. Bohn

发明人： Alok Sathaye ,  Scott A. Meyer ,  Derek D. Bohn

IPC分类号： A61B5/05 ,  A61N1/37 ,  A61N1/362

CPC分类号： A61N1/3712 ,  A61N1/3627

摘要： Methods and systems are directed to selecting from a variety of capture verification modes. A plurality of capture verification modes, including a beat by beat capture detection mode and a capture threshold testing mode without intervening beat by beat capture detection is provided. An efficacy of at least one of the capture verification modes is evaluated, and based on the evaluation, a capture verification mode is selected.

摘要翻译： 方法和系统旨在从各种捕获验证模式中进行选择。 提供了多个拍摄验证模式，包括拍拍拍摄检测模式和拍摄阈值测试模式，而不会通过拍摄捕获检测进行中间拍摄。 评估捕获验证模式中的至少一个的功效，并且基于评估，选择捕获验证模式。

公开(公告)号：US20100131027A1

公开(公告)日：2010-05-27

申请号：US12697853

申请日：2010-02-01

申请人： Alok Sathaye ,  Scott A. Meyer ,  Derek D. Bohn

发明人： Alok Sathaye ,  Scott A. Meyer ,  Derek D. Bohn

IPC分类号： A61N1/08

CPC分类号： A61N1/3712 ,  A61N1/3627

摘要： Methods and systems are directed to selecting from a variety of capture verification modes. A plurality of capture verification modes, including a beat by beat capture detection mode and a capture threshold testing mode without intervening beat by beat capture detection is provided. An efficacy of at least one of the capture verification modes is evaluated and, based on the evaluation, a capture verification mode is selected.

摘要翻译： 方法和系统旨在从各种捕获验证模式中进行选择。 提供了多个拍摄验证模式，包括拍拍拍摄检测模式和拍摄阈值测试模式，而不会通过拍摄捕获检测进行中间拍摄。 评估捕获验证模式中的至少一个的功效，并且基于评估，选择捕获验证模式。

公开(公告)号：US20080071319A1

公开(公告)日：2008-03-20

申请号：US11520880

申请日：2006-09-14

申请人： Alok Sathaye ,  M. Jason Brooke

发明人： Alok Sathaye ,  M. Jason Brooke

IPC分类号： A61N1/362

CPC分类号： A61N1/371

摘要： Approaches for performing capture detection for a heart chamber with backup pacing in a contralateral heart chamber are described. A cardiac signal of the first heart chamber is sensed following delivery of a pacing pulse. The cardiac response of the first heart chamber to the pacing pulse is classified based on one or more features of the sensed cardiac signal. A backup pacing pulse is delivered to a second heart chamber contralateral to the first heart chamber. For example, the timing of the delivery of the backup pacing pulse may be based on the expected or detected timing of the features used to classify the cardiac pacing response. The backup pace may be delivered within a detection window used for sensing the features indicative of the cardiac pacing response.

摘要翻译： 描述了在对侧心室中进行具有后备起搏的心室的捕获检测的方法。 在递送起搏脉冲之后感测第一心室的心脏信号。 基于检测到的心脏信号的一个或多个特征对第一心室对起搏脉搏的心脏反应进行分类。 备用起搏脉冲被传送到与第一心室对侧的第二心室。 例如，备用起搏脉冲的递送的定时可以基于用于对心脏起搏响应进行分类的特征的预期或检测的定时。 备用速度可以在用于感测指示心脏起搏响应的特征的检测窗口内传送。

公开(公告)号：US20080071182A1

公开(公告)日：2008-03-20

申请号：US11643220

申请日：2006-12-21

申请人： Shelley Cazares ,  Aaron McCabe ,  Alok Sathaye ,  Dan Li

发明人： Shelley Cazares ,  Aaron McCabe ,  Alok Sathaye ,  Dan Li

IPC分类号： A61B5/0402

CPC分类号： A61B5/0464 ,  A61B5/726

摘要： Methods and systems for arranging and labeling cardiac episodes based on acquired cardiac episode data are described. Cardiac episodes are algorithmically arranged based on one or more discriminating features of the episode data. A user is presented with at least one episode selected from the arrangement of cardiac episodes. The user inputs a label that characterizes the selected episode. The label is algorithmically appended to the data of the selected episode and to other episodes of the arrangement of cardiac episodes based on the discriminating features.

摘要翻译： 描述了基于获得性心脏病发作数据来安排和标记心脏发作的方法和系统。 基于事件数据的一个或多个鉴别特征，算术地布置心脏事件。 向用户呈现从心脏发作的排列中选出的至少一个情节。 用户输入表征所选剧集的标签。 基于鉴别特征，标签被算法地附加到所选事件的数据和心脏发作的安排的其他发作。

公开(公告)号：US08280509B2

公开(公告)日：2012-10-02

申请号：US12847704

申请日：2010-07-30

申请人： Alok Sathaye

发明人： Alok Sathaye

IPC分类号： A61N1/00

CPC分类号： A61N1/3712

摘要： Systems and methods provide for selection of automatic capture verification modes. A number of capture verification modes are evaluated, wherein at least one of the capture verification modes has a distinct temporal relationship between delivery of a pacing pulse and detection of capture of heart tissue by the pacing pulse than the other capture verification modes. One or more capture verification modes are selected based on the evaluation. Capture verification is implemented using the selected one or more capture verification modes.

摘要翻译： 系统和方法提供选择自动捕获验证模式。 评估多个捕获验证模式，其中捕获验证模式中的至少一个在起搏脉冲的传送与通过起搏脉冲捕获心脏组织的检测之间具有明显的时间关系，而不是其他捕获验证模式。 基于评估选择一个或多个捕获验证模式。 捕获验证使用所选的一个或多个捕获验证模式来实现。

公开(公告)号：US08260421B2

公开(公告)日：2012-09-04

申请号：US12154411

申请日：2008-05-22

申请人： Alok Sathaye

发明人： Alok Sathaye

IPC分类号： A61N1/37

CPC分类号： A61N1/36521 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3712

摘要： Methods and devices for reducing phrenic nerve stimulation of cardiac pacing systems involve delivering a pacing pulse to a ventricle of a heart. A transthoracic impedance signal is sensed, and a deviation in the signal resulting from the pacing pulse may be used to determine phrenic nerve stimulation. Methods may further involve detecting the phrenic nerve stimulation from the pacing pulse by delivering two or more pacing pulse to the ventricle of the heart, and determining a temporal relationship. A pacing vector may be selected from the two or more vectors that effects cardiac capture and reduces the phrenic nerve stimulation. A pacing voltage and/or pulse width may be selected that provides cardiac capture and reduces the phrenic nerve stimulation. In other embodiments, a pacing pulse width and a pacing voltage may be selected from a patient's strength-duration curve that effects cardiac capture and reduces the phrenic nerve stimulation.

摘要翻译： 用于减少心脏起搏系统的膈神经刺激的方法和装置包括将起搏脉冲递送到心脏的心室。 感测经胸阻抗信号，并且可以使用由起搏脉冲产生的信号的偏差来确定膈神经刺激。 方法还可以包括通过将两个或多个起搏脉冲递送到心脏的心室来检测来自起搏脉冲的膈神经刺激，以及确定时间关系。 可以从影响心脏捕获的两个或更多个载体中选择起搏载体并减少膈神经刺激。 可以选择提供心脏捕获并减少膈神经刺激的起搏电压和/或脉冲宽度。 在其他实施例中，起搏脉冲宽度和起搏电压可以从患者的强度 - 持续时间曲线中选择，该曲线影响心脏捕获并减少膈神经刺激。

公开(公告)号：US20080065165A1

公开(公告)日：2008-03-13

申请号：US11643221

申请日：2006-12-21

申请人： Christopher Dale Johnson ,  Alok Sathaye ,  Shelley Cazares

发明人： Christopher Dale Johnson ,  Alok Sathaye ,  Shelley Cazares

IPC分类号： A61N1/37

CPC分类号： A61B5/7264 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/04 ,  A61B5/04525 ,  A61B5/0464 ,  A61B5/6846 ,  A61B5/726 ,  A61N1/37247 ,  G06F19/00 ,  G06F19/3481

摘要： An implantable cardiac device is configured to classify cardiac arrhythmias using a plurality of arrhythmia discrimination algorithms. Data is provided that is associated with a plurality of cardiac arrhythmic episodes for which a cardiac electrical therapy was delivered or withheld by the implantable medical device based on the plurality of arrhythmia discrimination algorithms. A metric for each of the arrhythmic episodes is computed. The metric defines a measure by which the implantable cardiac device properly classified the arrhythmia. Potentially misclassified arrhythmic episodes of the plurality of cardiac arrhythmic episodes for which cardiac electrical therapy was inappropriately delivered or withheld are algorithmically identified using the metric.

摘要翻译： 可植入心脏装置被配置为使用多个心律失常鉴别算法对心律失常进行分类。 提供了与多个心律失常发作相关联的数据，根据多种心律不齐判别算法，心脏电疗法由可植入医疗装置递送或保留。 计算每个心律失常发作的指标。 该度量定义了可植入心脏装置适当分类心律失常的措施。 使用度量来算法地识别心电图治疗被不适当地递送或禁止的多个心律失调发作的潜在的错误分类的心律失常发作。