公开(公告)号：US06531295B1

公开(公告)日：2003-03-11

申请号：US08471970

申请日：1995-06-06

申请人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

发明人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

IPC分类号： C12P2100

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/4725 ,  C07K14/475 ,  C07K14/495 ,  C07K14/50 ,  C07K14/705 ,  C07K14/78 ,  C07K2319/00 ,  C08B37/0075 ,  C12N15/1138 ,  C12P19/26

摘要： A purified mammalian proteoglycan, and genetic information encoding such proteoglycans, having a core polypetide molecular weight of about 30 kD to about 35 kD, and comprising a hydrophilic amino terminal extracellular region, a hydrophilic carboxy terminal cytoplasmic region, a transmembrane hydrophobic region between said cytoplasmic and extracellular regions, a protease susceptible cleavage sequence extracellularly adjacent the transmembrane region of the peptide; and at least one glycosylation site for attachment of a heparan sulfate chain to said extracellular region, said glycosylation site comprising a heparan sulfate attachment sequence represented by a formula Xac-Z-Ser-Gly-Ser-Gly, where Xac represents an amino acid residue having an acidic sidechain, and Z represents from 1 to 10 amino acid residues. Additional peptides having this glycosylation site and genetic information useful for preparing a number of variations based on this glycosylation site are also provided.

摘要翻译： 纯化的哺乳动物蛋白聚糖和编码这种蛋白聚糖的遗传信息，其核心多肽分子量约为30kD至约35kD，并且包含亲水氨基末端胞外区，亲水性羧基末端胞质区，所述胞质之间的跨膜疏水区 和细胞外区域，在肽跨膜区附近胞外邻近的蛋白酶易裂解序列; 以及用于将硫酸乙酰肝素链连接到所述细胞外区域的至少一个糖基化位点，所述糖基化位点包含由式Xac-Z-Ser-Gly-Ser-Gly表示的硫酸乙酰肝素附着序列，其中Xac表示氨基酸残基 具有酸性侧链，Z表示1〜10个氨基酸残基。 还提供了具有这种糖基化位点的附加肽和用于制备基于该糖基化位点的多种变异的遗传信息。

公开(公告)号：US07183393B2

公开(公告)日：2007-02-27

申请号：US10776989

申请日：2004-02-11

申请人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

发明人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

IPC分类号： C07K14/00 ,  C07K19/00 ,  A61K38/00 ,  A61K38/03 ,  A61K38/16 ,  C12P21/00

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C07K14/4725 ,  C07K14/475 ,  C07K14/495 ,  C07K14/50 ,  C07K14/705 ,  C07K14/78 ,  C07K16/28 ,  C07K2319/00 ,  C08B37/0075 ,  C12P19/26 ,  Y02A50/411

摘要： A purified mammalian proteoglycan, and genetic information encoding such proteoglycans, having a core polypetide molecular weight of about 30 kD to about 35 kD, and comprising a hydrophilic amino terminal extracellular region, a hydrophilic carboxy terminal cytoplasmic region, a transmembrane hydrophobic region between said cytoplasmic and extracellular regions, a protease susceptible cleavage sequence extracellularly adjacent the transmembrane region of the peptide, and at least one glycosylation site for attachment of a heparan sulfate chain to said extracellular region, said glycosylation site comprising a heparan sulfate attachment sequence represented by a formula Xac-Z-Ser-Gly-Ser-Gly (SEQ ID NO: 44), where Xac represents an amino acid residue having an acidic sidechain, and Z represents from 1 to 10 amino acid residues. Additional peptides having this glycosylation site and genetic information useful for preparing a number of variations based on this glycosylation site are also provided.

摘要翻译： 纯化的哺乳动物蛋白聚糖和编码这种蛋白聚糖的遗传信息，其核心多肽分子量约为30kD至约35kD，并且包含亲水氨基末端胞外区，亲水性羧基末端胞质区，所述胞质之间的跨膜疏水区 和细胞外区域，在细胞外邻近肽的跨膜区域的蛋白酶敏感的切割序列，以及用于将硫酸乙酰肝素链连接到所述细胞外区域的至少一个糖基化位点，所述糖基化位点包含由式Xac表示的硫酸乙酰肝素连接序列 -Z-Ser-Gly-Ser-Gly（SEQ ID NO：44），其中Xac表示具有酸性侧链的氨基酸残基，Z表示1至10个氨基酸残基。 还提供了具有这种糖基化位点的附加肽和用于制备基于该糖基化位点的多种变异的遗传信息。

公开(公告)号：US5486599A

公开(公告)日：1996-01-23

申请号：US78683

申请日：1993-06-17

申请人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

发明人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/495 ,  C07K14/50 ,  C07K14/705 ,  C07K14/78 ,  C07K16/28 ,  C08B37/00 ,  C12N15/113 ,  C12N15/12 ,  C12P19/26 ,  C07K14/435 ,  C07K19/00 ,  C12N15/62

CPC分类号： C07K16/28 ,  C07K14/4725 ,  C07K14/475 ,  C07K14/495 ,  C07K14/50 ,  C07K14/705 ,  C07K14/78 ,  C08B37/0075 ,  C12N15/1138 ,  C12P19/26 ,  A61K38/00 ,  C07K2319/00

摘要： A purified mammalian proteoglycan, and genetic information encoding such proteoglycans, having a core polypetide molecular weight of about 30 kD to about 35 kD, and comprising a hydrophilic amino terminal extracellular region, a hydrophilic carboxy terminal cytoplasmic region, a transmembrane hydrophobic region between said cytoplasmic and extracellular regions, a protease susceptible cleavage sequence extracellularly adjacent the transmembrane region of the peptide, and at least one glycosylation site for attachment of a heparan sulfate chain to said extracellular region, said glycosylation site comprising a heparan sulfate attachment sequence represented by a formula Xac-Z-Ser-Gly-Ser-Gly, where Xac represents an amino acid residue having an acidic sidechain, and Z represents from 1 to 10 amino acid residues. Additional peptides having this glycosylation site and genetic information useful for preparing a number of variations based on this glycosylation site are also provided.

摘要翻译： 纯化的哺乳动物蛋白聚糖和编码这种蛋白聚糖的遗传信息，其核心多肽分子量约为30kD至约35kD，并且包含亲水氨基末端胞外区，亲水性羧基末端胞质区，所述胞质之间的跨膜疏水区 和细胞外区域，在细胞外邻近肽的跨膜区域的蛋白酶敏感的切割序列，以及用于将硫酸乙酰肝素链连接到所述细胞外区域的至少一个糖基化位点，所述糖基化位点包含由式Xac表示的硫酸乙酰肝素连接序列 -Z-Ser-Gly-Ser-Gly，其中Xac表示具有酸性侧链的氨基酸残基，Z表示1至10个氨基酸残基。 还提供了具有这种糖基化位点的附加肽和用于制备基于该糖基化位点的多种变异的遗传信息。

公开(公告)号：US20050075484A1

公开(公告)日：2005-04-07

申请号：US10776989

申请日：2004-02-11

申请人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

发明人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/495 ,  C07K14/50 ,  C07K14/705 ,  C07K14/78 ,  C07K16/28 ,  C08B37/00 ,  C12N15/113 ,  C12P19/26

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C07K14/4725 ,  C07K14/475 ,  C07K14/495 ,  C07K14/50 ,  C07K14/705 ,  C07K14/78 ,  C07K16/28 ,  C07K2319/00 ,  C08B37/0075 ,  C12P19/26 ,  Y02A50/411

摘要： A purified mammalian proteoglycan, and genetic information encoding such proteoglycans, having a core polypetide molecular weight of about 30 kD to about 35 kD, and comprising a hydrophilic amino terminal extracellular region, a hydrophilic carboxy terminal cytoplasmic region, a transmembrane hydrophobic region between said cytoplasmic and extracellular regions, a protease susceptible cleavage sequence extracellularly adjacent the transmembrane region of the peptide, and at least one glycosylation site for attachment of a heparan sulfate chain to said extracellular region, said glycosylation site comprising a heparan sulfate attachment sequence represented by a formula Xac-Z-Ser-Gly-Ser-Gly (SEQ ID NO: 44), where Xac represents an amino acid residue having an acidic sidechain, and Z represents from 1 to 10 amino acid residues. Additional peptides having this glycosylation site and genetic information useful for preparing a number of variations based on this glycosylation site are also provided.

摘要翻译： 纯化的哺乳动物蛋白聚糖和编码这种蛋白聚糖的遗传信息，其核心多肽分子量约为30kD至约35kD，并且包含亲水氨基末端胞外区，亲水性羧基末端胞质区，所述胞质之间的跨膜疏水区 和细胞外区域，在细胞外邻近肽的跨膜区域的蛋白酶敏感的切割序列，以及用于将硫酸乙酰肝素链连接到所述细胞外区域的至少一个糖基化位点，所述糖基化位点包含由式Xac表示的硫酸乙酰肝素连接序列 -Z-Ser-Gly-Ser-Gly（SEQ ID NO：44），其中Xac表示具有酸性侧链的氨基酸残基，Z表示1至10个氨基酸残基。 还提供了具有这种糖基化位点的附加肽和用于制备基于该糖基化位点的多种变异的遗传信息。

公开(公告)号：US06699968B1

公开(公告)日：2004-03-02

申请号：US09723677

申请日：2000-11-28

申请人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

发明人： Scott Saunders ,  Merton Bernfield ,  Masato Kato

IPC分类号： C07K100

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C07K14/4725 ,  C07K14/475 ,  C07K14/495 ,  C07K14/50 ,  C07K14/705 ,  C07K14/78 ,  C07K16/28 ,  C07K2319/00 ,  C08B37/0075 ,  C12P19/26 ,  Y02A50/411

摘要： A purified mammalian proteoglycan, and genetic information encoding such proteoglycans, having a core polypetide molecular weight of about 30 kD to about 35 kD, and comprising a hydrophilic amino terminal extracellular region, a hydrophilic carboxy terminal cytoplasmic region, a transmembrane hydrophobic region between said cytoplasmic and extracellular regions, a protease susceptible cleavage sequence extracellularly adjacent the transmembrane region of the peptide, and at least one glycosylation site for attachment of a heparan sulfate chain to said extracellular region, said glycosylation site comprising a heparan sulfate attachment sequence represented by a formula Xac-Z-Ser-Gly-Ser-Gly (SEQ ID NO: 44), where Xac represents an amino acid residue having an acidic sidechain, and Z represents from 1 to 10 amino acid residues. Additional peptides having this glycosylation site and genetic information useful for preparing a number of variations based on this glycosylation site are also provided.

摘要翻译： 纯化的哺乳动物蛋白聚糖和编码这种蛋白聚糖的遗传信息，其核心多肽分子量约为30kD至约35kD，并且包含亲水氨基末端胞外区，亲水性羧基末端胞质区，所述胞质之间的跨膜疏水区 和细胞外区域，在细胞外邻近肽的跨膜区域的蛋白酶敏感的切割序列，以及用于将硫酸乙酰肝素链连接到所述细胞外区域的至少一个糖基化位点，所述糖基化位点包含由式Xac表示的硫酸乙酰肝素连接序列 -Z-Ser-Gly-Ser-Gly（SEQ ID NO：44），其中Xac表示具有酸性侧链的氨基酸残基，Z表示1至10个氨基酸残基。 还提供了具有这种糖基化位点的附加肽和用于制备基于该糖基化位点的多种变异的遗传信息。

公开(公告)号：US20100043957A1

公开(公告)日：2010-02-25

申请号：US12356556

申请日：2009-01-21

申请人： Claude Baril ,  Kevin P. Steck ,  Scott Saunders ,  Michael Davison ,  Maurice Guitton ,  Mike Myra ,  Troy Brake

发明人： Claude Baril ,  Kevin P. Steck ,  Scott Saunders ,  Michael Davison ,  Maurice Guitton ,  Mike Myra ,  Troy Brake

IPC分类号： B29C63/44

CPC分类号： B29C37/0057 ,  B29C35/02 ,  B29C70/30 ,  Y10T156/1002 ,  Y10T156/1008 ,  Y10T156/1038 ,  Y10T156/1043

摘要： A wrinkle control process for manufacturing a closed cross-sectional, composite laminate structure on a male tool cured under temperature and pressure. The process includes the step of creating a plurality of filled or unfilled depressions at strategic locations in the laminate prior to curing. The depressions are created by depression forming elements that have a predetermined size designed to create a depression in under plies, alone or combined with intensification techniques. The depressions may be left unfilled or be partially or completely filled. Depression forming elements are removed after cure or remain part of the structure. The number of elements being determined by the following equation: N=(OPL−OPC)÷(Li−Lj), where OPL is the outside perimeter of the composite structure after lay-up and prior to curing, OPC is the outside perimeter of the composite structure after lay-up and after curing, Li is the linear length of the composite segment formed by a depression forming element and Lj is the theoretical linear length of the corresponding composite segment without a depression.

摘要翻译： 用于在温度和压力下固化的阳工具上制造封闭的横截面复合层压结构的皱纹控制方法。 该方法包括在固化之前在层压板的重要位置处产生多个填充或未填充的凹陷的步骤。 凹陷由凹陷形成元件产生，凹陷形成元件具有预定尺寸，其设计成单独地或与强化技术相组合地在层下形成凹陷。 凹陷可能未填充或部分或完全填充。 凹陷形成元件在固化之后被去除或保持结构的一部分。 元素的数量由以下等式确定：N =（OPL-OPC）÷（Li-Lj），其中OPL是复合结构在铺设之后并且在固化之前的外周，OPC是 堆叠后固化后的复合结构，Li是由凹陷形成元件形成的复合段的线性长度，Lj是没有凹陷的相应复合段的理论线性长度。

公开(公告)号：US20050264987A1

公开(公告)日：2005-12-01

申请号：US10852906

申请日：2004-05-25

申请人： Robert Krancher ,  Scott Saunders

发明人： Robert Krancher ,  Scott Saunders

IPC分类号： G06F1/16

CPC分类号： G06F1/1632

摘要： A docking station includes a port with a corresponding status indicator.

摘要翻译： 对接站包括具有相应状态指示灯的端口。

公开(公告)号：US08206526B2

公开(公告)日：2012-06-26

申请号：US12356556

申请日：2009-01-21

申请人： Claude Baril ,  Kevin P. Steck ,  Scott Saunders ,  Michael Davison ,  Maurice Guitton ,  Mike Myra ,  Troy Brake

发明人： Claude Baril ,  Kevin P. Steck ,  Scott Saunders ,  Michael Davison ,  Maurice Guitton ,  Mike Myra ,  Troy Brake

IPC分类号： B32B41/00

CPC分类号： B29C37/0057 ,  B29C35/02 ,  B29C70/30 ,  Y10T156/1002 ,  Y10T156/1008 ,  Y10T156/1038 ,  Y10T156/1043

摘要： A wrinkle control process for manufacturing a closed cross-sectional, composite laminate structure on a male tool cured under temperature and pressure. The process includes the step of creating a plurality of filled or unfilled depressions at strategic locations in the laminate prior to curing. The depressions are created by depression forming elements that have a predetermined size designed to create a depression in under plies, alone or combined with intensification techniques. The depressions may be left unfilled or be partially or completely filled. Depression forming elements are removed after cure or remain part of the structure. The number of elements being determined by the following equation: N=(OPL−OPC)÷(Li−Lj), where OPL is the outside perimeter of the composite structure after lay-up and prior to curing, OPC is the outside perimeter of the composite structure after lay-up and after curing, Li is the linear length of the composite segment formed by a depression forming element and Lj is the theoretical linear length of the corresponding composite segment without a depression.

摘要翻译： 用于在温度和压力下固化的阳工具上制造封闭的横截面复合层压结构的皱纹控制方法。 该方法包括在固化之前在层压板的重要位置处产生多个填充或未填充的凹陷的步骤。 凹陷由凹陷形成元件产生，凹陷形成元件具有预定尺寸，其设计成单独地或与强化技术相组合地在层下形成凹陷。 凹陷可能未填充或部分或完全填充。 凹陷形成元件在固化之后被去除或保持结构的一部分。 元素的数量由以下等式确定：N =（OPL-OPC）÷（Li-Lj），其中OPL是复合结构在铺设之后并且在固化之前的外周，OPC是 堆叠后固化后的复合结构，Li是由凹陷形成元件形成的复合段的线性长度，Lj是没有凹陷的相应复合段的理论线性长度。

公开(公告)号：US20070019557A1

公开(公告)日：2007-01-25

申请号：US11186215

申请日：2005-07-21

申请人： Bruce Catter ,  Scott Saunders ,  Ennis McCaffrey

发明人： Bruce Catter ,  Scott Saunders ,  Ennis McCaffrey

IPC分类号： H04J3/14 ,  H04L12/28

CPC分类号： H04L12/2801 ,  H04N7/17309 ,  H04N17/004 ,  H04N21/2402 ,  H04N21/6118 ,  H04N21/6168

摘要： A fault location system (FLS) for a hybrid fiber coax (HFC) cable network. The FLS comprises an interactive map, a datastore, an object generator, and a display server. The datastore receives identifying information and status information of customer premises equipment (CPE) units connected to the HFC cable network. The object generator associates the identifying information and the status of CPE units with an object and further associates graphical attributes with the object. The display server graphically displays the object on the interactive map at location coordinates indicative of the street address, and graphically displays the object according to its graphical attributes. When used with a processor, the FLS applies algorithms to non-responsive CPE units selected from the interactive map to identify possible common sources of a fault.

摘要翻译： 用于混合光纤同轴电缆（HFC）电缆网络的故障定位系统（FLS）。 FLS包括交互式地图，数据存储区，对象生成器和显示服务器。 数据存储区接收连接到HFC电缆网络的客户端设备（CPE）单元的识别信息和状态信息。 对象生成器将识别信息和CPE单元的状态与对象相关联，并进一步将图形属性与对象相关联。 显示服务器以指示街道地址的位置坐标图形地显示交互式地图上的对象，并且根据图形属性图形地显示该对象。 当与处理器一起使用时，FLS将算法应用于从交互式地图中选择的非响应CPE单元，以识别可能的常见故障源。