利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

45 条记录 (耗时 0.025 秒)

    Vaccinium plant named ‘Winter Bell’
    4.
    植物专利
    Vaccinium plant named ‘Winter Bell’ 有权
    牛痘植物名为“冬眠”

    公开(公告)号：USPP27642P3

    公开(公告)日：2017-02-07

    申请号：US14121437

    申请日：2014-09-08

    申请人： David Weber

    发明人： David Weber

    IPC分类号： A01H5/08

    摘要： A new and distinct Vaccinium spp. cultivar named ‘WINTER BELL’ is disclosed, characterized by a semi-upright plant habit, vigorous growth and semi-deciduous habit in Florida. The new variety shows tolerance for wetter soil conditions. Fruit yield is exceptionally high, with fruit ripening early, with first harvest in mid to late March. Fruit is somewhat bell-shaped with good size and an attractive waxy coating. The new variety is a Vaccinium, and is normally used as an ornamental garden or landscape plant.

    摘要翻译： 一种新的和不同的牛痘属 披露了名为“冬季贝尔”的品种，其特征在于佛罗里达州的半直立植物习性，旺盛的生长和半脱落习惯。 新品种显示了对湿润土壤条件的耐受性。 果实产量异常高，果实成熟早熟，3月中下旬首次收获。 水果有点钟形，尺寸好，有吸引力的蜡质涂层。 新品种是牛痘，通常用作观赏花园或景观植物。

    Alpha-1-antitrypsin compositions and methods of use
    5.
    发明授权
    Alpha-1-antitrypsin compositions and methods of use 有权
    α-1-抗胰蛋白酶组合物和使用方法

    公开(公告)号：US08722624B2

    公开(公告)日：2014-05-13

    申请号：US13385642

    申请日：2012-02-28

    申请人： Scott M Kee ,  Paul I Cook ,  James R Smith ,  Robert Kling ,  Scott A Fowler ,  David Weber

    发明人： Scott M Kee ,  Paul I Cook ,  James R Smith ,  Robert Kling ,  Scott A Fowler ,  David Weber

    IPC分类号： A61K38/17

    CPC分类号： A61K38/57 ,  A61K9/19 ,  B01D15/327 ,  B01D15/363 ,  C07K14/8125 ,  G01N30/461

    摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

    摘要翻译： 提供了从含有AAT的蛋白质混合物如Cohn馏分IV沉淀物中纯化α-1-抗胰蛋白酶（AAT）的流线型方法。 在本发明的方法中，污染蛋白质通过用不影响AAT的还原剂如二硫醇裂解二硫键而不稳定。 然后将不稳定的蛋白质优先吸附在固体蛋白质吸附材料上，而不加入作为沉淀剂的盐。 固体吸附剂与溶液的分离留下直接适用于色谱纯化的纯化AAT溶液，而不需像现有技术方法那样进行广泛的脱盐。 还描述了一种以商业规模提供高产量的药物级AAT的方法。

    DISPOSABLE ELECTROTHERMAL CAUTERIZATION AND LIGATION TOOL
    6.
    发明申请
    DISPOSABLE ELECTROTHERMAL CAUTERIZATION AND LIGATION TOOL 审中-公开
    不可替代的电热焦化和配位工具

    公开(公告)号：US20140046325A1

    公开(公告)日：2014-02-13

    申请号：US13569667

    申请日：2012-08-08

    申请人： David Weber ,  Thomas P. Clement

    发明人： David Weber ,  Thomas P. Clement

    IPC分类号： A61B18/14

    CPC分类号： A61B18/1447 ,  A61B2018/00077 ,  A61B2018/00202 ,  A61B2018/00595 ,  A61B2018/1475

    摘要： A disposable device for tissue cauterization, including a generally electrically insulating housing assembly and a generally electrically conducting elongated assembly. The housing assembly includes a barrel having a cylindrical aperture formed therethrough, a grip extending from the barrel, a trigger slidingly connected to the barrel, a spring connected to the trigger, and an end plug positioned adjacent the proximal end of the barrel. The elongated assembly includes a hollow elongated outer cylinder disposed within the barrel and extending from the distal end, a generally hollow elongated inner cylinder slidably disposed within the elongated outer cylinder and extending to snugly engage the end plug, and bipolar forceps operationally connected to the distal end of the elongated inner cylinder and defining a leaf spring. Actuation of the trigger urges the inner cylinder to slide in a proximal direction relative to the outer cylinder, urging the bipolar forceps partially into the outer cylinder and closer together.

    摘要翻译： 一种用于组织烧灼的一次性装置，包括通常电绝缘的壳体组件和通常导电的细长组件。 壳体组件包括具有穿过其形成的圆柱形孔的筒，从筒延伸的手柄，滑动地连接到筒的触发器，连接到触发器的弹簧以及邻近筒的近端定位的端塞。 细长组件包括设置在筒内并且从远端延伸的中空细长外筒，大致中空的细长内筒，其可滑动地设置在细长外筒内并延伸以紧密地接合端塞，并且双极镊操作地连接到远端 伸长的内筒的端部并限定一个板簧。 触发器的致动促使内筒相对于外筒沿近端方向滑动，将双极钳部分地推入外筒并更靠近在一起。

    Bicycle-Mounted Golf Club Carrying System, Combination With a Bicycle Having Extra-Wide Tires and Method of Use Thereof
    9.
    发明申请
    Bicycle-Mounted Golf Club Carrying System, Combination With a Bicycle Having Extra-Wide Tires and Method of Use Thereof 失效
    自行车高尔夫俱乐部携带系统，结合具有超宽轮胎的自行车及其使用方法

    公开(公告)号：US20070123363A1

    公开(公告)日：2007-05-31

    申请号：US11564724

    申请日：2006-11-29

    申请人： David Weber

    发明人： David Weber

    IPC分类号： A63B69/36 ,  B62J39/00 ,  B62J11/00 ,  B62J7/06

    CPC分类号： A63B55/60 ,  A63B55/00 ,  B62H1/02 ,  B62J11/00 ,  B62K2005/002

    摘要： Embodiments of the present invention comprise a system for carrying golf clubs on the front end of a bicycle by dividing the clubs between two enclosures: one to the left of the bicycle's front fork and one to the right thereof. Another Embodiment comprises the aforementioned system in combination with a bicycle having tires with a diameter in excess of 3.0 inches. The bicycle in combination with the system can be rented to golfers in place of golf carts to transport the golfer around a course.

    摘要翻译： 本发明的实施例包括一种用于在自行车的前端承载高尔夫球杆的系统，该球杆在两个机壳之间分开：一个在自行车前叉的左侧和一个右侧。 另一个实施例包括与具有直径超过3.0英寸的轮胎的自行车组合的上述系统。 与系统相结合的自行车可以出租给高尔夫球手代替高尔夫球车，以便将高尔夫球手运送到球场周围。

    Liquid formulations for treatment of diseases or conditions
    10.
    发明申请
    Liquid formulations for treatment of diseases or conditions 审中-公开

    公开(公告)号：US20060258698A1

    公开(公告)日：2006-11-16

    申请号：US11351761

    申请日：2006-02-09

    申请人： Sreenivasu Mudumba ,  Philippe Dor ,  Thierry Nivaggioli ,  David Weber ,  Sidiq Farooq

    发明人： Sreenivasu Mudumba ,  Philippe Dor ,  Thierry Nivaggioli ,  David Weber ,  Sidiq Farooq

    IPC分类号： A61K31/4745

    CPC分类号： A61K9/0046 ,  A61K9/0019 ,  A61K9/0048 ,  A61K31/045 ,  A61K31/436 ,  A61K31/44 ,  A61K31/4745 ,  A61K47/10 ,  A61K47/12 ,  A61K47/44

    摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are liquid formulations which deliver a variety of therapeutic agents, including but not limited to rapamycin, to a subject for an extended period of time; liquid formulations which form a non-dispersed mass when placed in an aqueous medium of a subject; non-dispersed mass-forming liquid formulations which form a gel or gel-like substance in an aqueous medium; liquid formulations, comprising a therapeutic agent and a plurality of polymers; and methods for delivering therapeutic agents to a subject for an extended period of time using the liquid formulations. The liquid formulation may be placed in an aqueous medium of a subject, including but not limited to via intraocular or periocular administration, or placement proximate to a site of a disease or condition to be treated in a subject. A method may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, or age-related macular degeneration, or wet age-related macular degeneration in a subject. The liquid formulations may comprise rapamycin or other therapeutic agents.