公开(公告)号：US10076600B2

公开(公告)日：2018-09-18

申请号：US14978910

申请日：2015-12-22

申请人： Henry J. Smith ,  James R. Smith

发明人： Henry J. Smith ,  James R. Smith

IPC分类号： B01D15/38 ,  A61M1/36 ,  C07K16/46 ,  A61K39/39 ,  A61M1/34 ,  B01D15/00

CPC分类号： A61M1/362 ,  A61M1/3486 ,  A61M1/3679 ,  B01D15/00 ,  B01D15/3804 ,  B01D15/3809

摘要： This invention uses “Targeted Apheresis” to treat patients with Rheumatoid Arthritis and other autoimmune and inflammatory disorders. “Targeted Apheresis” is a process whereby only the pathogenic and pro-inflammatory elements associated with the disease symptoms are simultaneously and selectively removed from the blood by passing the blood through an extracorporeal affinity device containing selective binding agents. Removal of these pathogenic and pro-inflammatory elements will ameliorate the symptoms of autoimmune disease and may prolong the period of disease remission.

公开(公告)号：US20170281544A1

公开(公告)日：2017-10-05

申请号：US15493688

申请日：2017-04-21

申请人： John W. Woodmansee, JR. ,  Robert A. Woodmansee ,  James R. Smith

发明人： John W. Woodmansee, JR. ,  Robert A. Woodmansee ,  James R. Smith

IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K33/00

CPC分类号： A61K9/143 ,  A61K9/0026 ,  A61K9/1611 ,  A61K33/00 ,  A61K33/08 ,  A61K47/6949 ,  C01F7/02 ,  C01F7/023 ,  C01P2004/60

摘要： A composition of chlorine-free poly-oxygenated aluminum hydroxide that comprises a clathrate containing oxygen gas molecules, In one embodiment, the poly-oxygenated aluminum hydroxide has particles having a diameter of 212 microns or less. The composition may be homogeneous.

公开(公告)号：US20120165781A1

公开(公告)日：2012-06-28

申请号：US13409855

申请日：2012-03-01

申请人： HENRY J. SMITH ,  JAMES R. SMITH

发明人： HENRY J. SMITH ,  JAMES R. SMITH

IPC分类号： A61M1/34

CPC分类号： A61M1/3679 ,  A61M1/3693

摘要： This invention uses “targeted apheresis” to treat rheumatoid arthritis patients. “Targeted Apheresis” is a process whereby the RF and immune complexes responsible for causing the disease symptoms are selectively removed from the blood by passing the blood through a cartridge containing immobilized IgG. The RF and immune complexes are bound out and the cleaned blood is returned to the patient Removal of circulating RF and immune complexes will ameliorate the symptoms of rheumatoid arthritis.

摘要翻译： 本发明使用“靶向单采”来治疗类风湿关节炎患者。 “靶向单采”是一种通过将血液通过含有固定化IgG的药筒从血液中选择性地除去引起疾病症状的RF和免疫复合物的过程。 RF和免疫复合物被结合，清洁的血液返回到患者。除去循环的RF和免疫复合物将改善类风湿性关节炎的症状。

公开(公告)号：US07777006B2

公开(公告)日：2010-08-17

申请号：US10334303

申请日：2002-12-31

申请人： Scott M. Kee ,  Paul I. Cook ,  James R. Smith ,  Robert Kling ,  Scott A. Fowler ,  David Weber

发明人： Scott M. Kee ,  Paul I. Cook ,  James R. Smith ,  Robert Kling ,  Scott A. Fowler ,  David Weber

IPC分类号： A61K35/14

CPC分类号： A61K38/57 ,  A61K9/19 ,  B01D15/327 ,  B01D15/363 ,  C07K14/8125 ,  G01N30/461

摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

摘要翻译： 提供了从含有AAT的蛋白质混合物如Cohn馏分IV沉淀物中纯化α-1-抗胰蛋白酶（AAT）的流线型方法。 在本发明的方法中，污染蛋白质通过用不影响AAT的还原剂如二硫醇裂解二硫键而不稳定。 然后将不稳定的蛋白质优先吸附在固体蛋白质吸附材料上，而不加入作为沉淀剂的盐。 固体吸附剂与溶液的分离留下直接适用于色谱纯化的纯化AAT溶液，而不需像现有技术方法那样进行广泛的脱盐。 还描述了一种以商业规模提供高产量的药物级AAT的方法。

公开(公告)号：US20100098698A1

公开(公告)日：2010-04-22

申请号：US12652561

申请日：2010-01-05

申请人： HENRY J. SMITH ,  James R. Smith

发明人： HENRY J. SMITH ,  James R. Smith

IPC分类号： A61K39/395

CPC分类号： A61M1/3679 ,  A61M1/3693

摘要： This invention uses “targeted apheresis” to treat rheumatoid arthritis patients. “Targeted Apheresis” is a process whereby the RF and immune complexes responsible for causing the disease symptoms are selectively removed from the blood by passing the blood through a cartridge containing immobilized IgG. The RF and immune complexes are bound out and the cleaned blood is returned to the patient Removal of circulating RF and immune complexes will ameliorate the symptoms of rheumatoid arthritis.

摘要翻译： 本发明使用“靶向单采”来治疗类风湿关节炎患者。 “靶向单采”是一种通过将血液通过含有固定化IgG的药筒从血液中选择性地除去引起疾病症状的RF和免疫复合物的过程。 RF和免疫复合物被结合，清洁的血液返回到患者。除去循环的RF和免疫复合物将改善类风湿性关节炎的症状。

公开(公告)号：US06818215B2

公开(公告)日：2004-11-16

申请号：US10008960

申请日：2001-12-07

申请人： James R. Smith ,  Asao Noda ,  Guy Adami

发明人： James R. Smith ,  Asao Noda ,  Guy Adami

IPC分类号： A61K39395

CPC分类号： A61K31/70 ,  A61K9/1272 ,  A61K38/00 ,  C07H21/00 ,  C07K14/4703 ,  C07K16/18 ,  C07K2319/00 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/322

摘要： Polyclonal and monoclonal antibodies that specifically bind senescent cell derived inhibitor protein (SDI-1), cell lines that produce such monoclonal antibodies, and the use of such antibodies are disclosed.

摘要翻译： 公开了特异性结合衰老细胞衍生的抑制蛋白（SDI-1）的多克隆和单克隆抗体，产生这种单克隆抗体的细胞系和这种抗体的使用。

公开(公告)号：US06574748B1

公开(公告)日：2003-06-03

申请号：US09596539

申请日：2000-06-16

申请人： Sidney L. Andress ,  Curtis D. Andes ,  Gerald E. Rightnour ,  James R. Smith

发明人： Sidney L. Andress ,  Curtis D. Andes ,  Gerald E. Rightnour ,  James R. Smith

IPC分类号： H02H305

CPC分类号： G06F11/2043 ,  G06F11/2025 ,  G06F11/203 ,  G06F11/2041

摘要： In a data processing system with multiple processors, failing processors are replaced with spare processors. This allows the system to continue to operate without degradation. An intercept process is notified of a processor failure so that it can collect processor registers and states. If the registers and states are collected correctly, an indication is set that relief is possible. The intercept process notifies a service processor of the failure and then halts the failed processor. The service processor then notifies the operating system of the failure and that relief is possible. If fast relief is acceptable, a spare processor is initialized and resumes execution with the state and registers of the failed processor. A service processor modeling file controls the number of active and spare processors in a system. Spare processors sharing the same L2 cache with the failed processor are preferred as replacements.

摘要翻译： 在具有多个处理器的数据处理系统中，故障处理器被替换为备用处理器。 这允许系统继续运行而不降级。 通知拦截进程处理器故障，以便它可以收集处理器寄存器和状态。 如果寄存器和状态被正确收集，则设置可以进行缓解的指示。 拦截过程通知服务处理器故障，然后停止故障处理器。 然后，服务处理器通知操作系统故障，并且可以进行缓解。 如果快速释放是可接受的，则会对备用处理器进行初始化，并使用故障处理器的状态和寄存器恢复执行。 服务处理器建模文件控制系统中的主动和备用处理器的数量。 与故障处理器共享相同L2缓存的备用处理器是替代品。

公开(公告)号：US5960368A

公开(公告)日：1999-09-28

申请号：US861483

申请日：1997-05-22

申请人： Robert A. Pierce ,  James R. Smith ,  William G. Ramsey ,  Connie A. Cicero-Herman ,  Dennis F. Bickford

发明人： Robert A. Pierce ,  James R. Smith ,  William G. Ramsey ,  Connie A. Cicero-Herman ,  Dennis F. Bickford

IPC分类号： A62D3/00 ,  A62D3/33 ,  A62D3/38 ,  A62D101/20 ,  A62D101/22 ,  A62D101/24 ,  A62D101/26 ,  G21F9/06 ,  G21F9/30 ,  G21F9/00

CPC分类号： A62D3/38 ,  A62D3/33 ,  G21F9/06 ,  G21F9/302 ,  G21F9/305 ,  A62D2101/20 ,  A62D2101/22 ,  A62D2101/24 ,  A62D2101/26

摘要： The present invention is directed to a process for reducing the volume of low level radioactive and mixed waste to enable the waste to be more economically stored in a suitable repository, and for placing the waste into a form suitable for permanent disposal. The invention involves a process for preparing radioactive, hazardous, or mixed waste for storage by contacting the waste starting material containing at least one organic carbon-containing compound and at least one radioactive or hazardous waste component with nitric acid and phosphoric acid simultaneously at a contacting temperature in the range of about 140.degree. C. to about 210 .degree. C. for a period of time sufficient to oxidize at least a portion of the organic carbon-containing compound to gaseous products, thereby producing a residual concentrated waste product containing substantially all of said radioactive or inorganic hazardous waste component; and immobilizing the residual concentrated waste product in a solid phosphate-based ceramic or glass form.

摘要翻译： 本发明涉及一种减少低放射性和混合废物体积的方法，以使废物更经济地储存在合适的储存库中，并将废物置于适于永久处置的形式。 本发明涉及一种制备用于储存的放射性，危险或混合废物的方法，该方法是在接触时同时接触含有至少一种含有机碳化合物的废料和至少一种放射性或危险废物组分与硝酸和磷酸 温度在约140℃至约210℃的温度下持续足以将至少一部分含有机碳的化合物氧化成气态产物的时间，从而产生残留的浓缩废物，其含有基本上全部 表示放射性或无机危险废物成分; 并将残留的浓缩废弃物固定在固体磷酸盐基陶瓷或玻璃形式中。

公开(公告)号：US5538702A

公开(公告)日：1996-07-23

申请号：US194546

申请日：1994-02-08

申请人： James R. Smith ,  Peter L. Timms

发明人： James R. Smith ,  Peter L. Timms

IPC分类号： B01D53/34 ,  B01D53/00 ,  B01D53/46 ,  C01B25/00 ,  C01B25/06

CPC分类号： B01D53/46 ,  B01D53/002

摘要： A method for the treatment of a stream of exhaust gases including phosphine in which the stream is heated to a sufficiently high temperature to decompose the phosphine to phosphorus vapor and the stream is then passed into a reactor containing calcium oxide heated to above about 100.degree. C. An oxygen containing stream is also passed into the reactor.

摘要翻译： 一种用于处理包括磷化氢的废气流的方法，其中将物流加热至足够高的温度以将磷酸盐分解为磷蒸气，然后将该物流进入含有加热至高于约100℃的氧化钙的反应器 含氧流也被送入反应器。

公开(公告)号：US5009496A

公开(公告)日：1991-04-23

申请号：US324202

申请日：1989-03-15

申请人： Ramer B. Holtan, Jr. ,  Kevin L. Falk ,  James F. Bergman ,  James R. Smith ,  Kenneth E. Nelson

发明人： Ramer B. Holtan, Jr. ,  Kevin L. Falk ,  James F. Bergman ,  James R. Smith ,  Kenneth E. Nelson

IPC分类号： G02C3/02

CPC分类号： A42B1/247 ,  G02C3/02

摘要： An eyeglasses and headgear combination is disclosed. The eyeglasses may be worn alone or in combination with the headgear. The temple member of the eyeglasses is alternatively positionable behind the ear of the user or attached to the headgear. When the temple is attached to the headgear, the temple extends outward from the front of the eyeglasses at an angle different than when the temple is positioned behind the ear of the user. This provides maximum comfort for the user in both positions. The coupling to which the temple is attached may be pivoted to move the eyeglass lenses out of the user's field of vision and rest them on his head or headgear.

摘要翻译： 公开了一种眼镜和头饰组合。 眼镜可以单独佩戴或与头带组合使用。 眼镜的镜腿成员可替代地定位在使用者的耳朵后面或附接到头饰上。 当寺庙附着在头饰上时，镜子以与镜腿位于使用者耳朵后方不同的角度从眼镜前方延伸出来。 这为两个位置的用户提供了最大的舒适度。 可以将连接到镜腿的联接器枢转以将眼镜镜片移出用户的视野并将其放置在头部或头带上。