公开(公告)号：US09309199B2

公开(公告)日：2016-04-12

申请号：US13582555

申请日：2011-02-28

申请人： Scott Wolkenberg ,  James C. Barrow ,  Scott T. Harrison ,  B. Wesley Trotter ,  Kausik K. Nanda ,  Peter J. Manley ,  Zhijian Zhao

发明人： Scott Wolkenberg ,  James C. Barrow ,  Scott T. Harrison ,  B. Wesley Trotter ,  Kausik K. Nanda ,  Peter J. Manley ,  Zhijian Zhao

IPC分类号： C07D211/86 ,  C07D213/69 ,  C07D213/84 ,  C07D213/85 ,  C07D401/04 ,  C07D413/10 ,  C07D417/04

CPC分类号： C07D213/69 ,  C07D211/86 ,  C07D213/84 ,  C07D213/85 ,  C07D401/04 ,  C07D413/10 ,  C07D417/04

摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.

公开(公告)号：US20130005744A1

公开(公告)日：2013-01-03

申请号：US13582555

申请日：2011-02-28

申请人： Scott Wolkenberg ,  James C. Barrow ,  Scott T. Harrison ,  B. Wesley Trotter ,  Kausik K. Nanda ,  Peter J. Manley ,  Zhijian Zhao

发明人： Scott Wolkenberg ,  James C. Barrow ,  Scott T. Harrison ,  B. Wesley Trotter ,  Kausik K. Nanda ,  Peter J. Manley ,  Zhijian Zhao

IPC分类号： A61K31/4418 ,  A61P25/00 ,  A61P25/18 ,  A61K31/506 ,  A61P25/34 ,  A61P25/36 ,  C07D401/04 ,  A61K31/4439 ,  C07D213/69 ,  A61P25/30

CPC分类号： C07D213/69 ,  C07D211/86 ,  C07D213/84 ,  C07D213/85 ,  C07D401/04 ,  C07D413/10 ,  C07D417/04

摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.

公开(公告)号：US09024032B2

公开(公告)日：2015-05-05

申请号：US13582601

申请日：2011-02-28

申请人： Scott Wolkenberg ,  James C. Barrow ,  Michael S. Poslusney ,  Scott T. Harrison ,  B. Wesley Trotter ,  James Mulhearn ,  Kausik K. Nanda ,  Peter J. Manley ,  Zhijian Zhao ,  Jeffrey W. Schubert ,  Nathan Kett ,  Amy Zartman

发明人： Scott Wolkenberg ,  James C. Barrow ,  Michael S. Poslusney ,  Scott T. Harrison ,  B. Wesley Trotter ,  James Mulhearn ,  Kausik K. Nanda ,  Peter J. Manley ,  Zhijian Zhao ,  Jeffrey W. Schubert ,  Nathan Kett ,  Amy Zartman

IPC分类号： A61K31/44 ,  C07D211/90 ,  C07D213/69 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/69 ,  A61K45/06 ,  C07D213/73 ,  C07D213/74 ,  C07D401/10 ,  C07D401/14 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04 ,  C07F5/02 ,  C07D401/04 ,  C07D401/06

CPC分类号： C07F5/025 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/69 ,  A61K45/06 ,  C07D213/69 ,  C07D213/73 ,  C07D213/74 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04

摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.

摘要翻译： 本发明涉及作为儿茶酚O-甲基转移酶（COMT）的抑制剂的4-吡啶酮化合物，可用于治疗和预防涉及COMT酶的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及COMT的疾病中的用途。

公开(公告)号：US20130084346A1

公开(公告)日：2013-04-04

申请号：US13582601

申请日：2011-02-28

申请人： Scott Wolkenberg ,  James C. Barrow ,  Michael S. Poslusney ,  Scott T. Harrison ,  B. Wesley Trotter ,  James Mulhearn ,  Kausik K. Nanda ,  Peter J. Manley ,  Zhijian Zhao ,  Jeffrey W. Schubert ,  Nathan Kett ,  Amy Zartman

发明人： Scott Wolkenberg ,  James C. Barrow ,  Michael S. Poslusney ,  Scott T. Harrison ,  B. Wesley Trotter ,  James Mulhearn ,  Kausik K. Nanda ,  Peter J. Manley ,  Zhijian Zhao ,  Jeffrey W. Schubert ,  Nathan Kett ,  Amy Zartman

IPC分类号： C07D213/69 ,  C07D401/10 ,  A61K31/4439 ,  C07D213/73 ,  C07D213/74 ,  C07F5/02 ,  A61K31/69 ,  A61K31/444 ,  C07D401/14 ,  C07D471/04 ,  A61K31/4725 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/10 ,  A61K31/5377 ,  A61K31/4545 ,  C07D417/10 ,  A61K31/541 ,  C07D413/12 ,  A61K31/4418

CPC分类号： C07F5/025 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/69 ,  A61K45/06 ,  C07D213/69 ,  C07D213/73 ,  C07D213/74 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04

摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.

公开(公告)号：US08969364B2

公开(公告)日：2015-03-03

申请号：US13582637

申请日：2011-02-28

申请人： Scott Wolkenberg ,  Scott T. Harrison ,  James C. Barrow ,  Zhijian Zhao ,  Jeffrey Melamed ,  Nathan R. Kett ,  Amy Zartman

发明人： Scott Wolkenberg ,  Scott T. Harrison ,  James C. Barrow ,  Zhijian Zhao ,  Jeffrey Melamed ,  Nathan R. Kett ,  Amy Zartman

IPC分类号： A01N43/54 ,  A61K31/505 ,  C07D401/14 ,  A61K31/519 ,  C07D239/54 ,  C07D239/553 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D498/04 ,  A61K31/513 ,  A61K45/06

CPC分类号： C07D401/14 ,  A61K31/505 ,  A61K31/513 ,  A61K31/519 ,  A61K45/06 ,  C07D239/54 ,  C07D239/553 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D498/04

摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.

摘要翻译： 本发明涉及作为儿茶酚O-甲基转移酶（COMT）的抑制剂的4-嘧啶酮化合物，可用于治疗和预防涉及COMT酶的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及COMT的疾病中的用途。

公开(公告)号：US20130196002A1

公开(公告)日：2013-08-01

申请号：US13582637

申请日：2011-02-28

申请人： Scott Wolkenberg ,  Scott T. Harrison ,  James C. Barrow ,  Zhijian Zhao ,  Jeffrey Melamed ,  Nathan R. Kett ,  Amy Zartman

发明人： Scott Wolkenberg ,  Scott T. Harrison ,  James C. Barrow ,  Zhijian Zhao ,  Jeffrey Melamed ,  Nathan R. Kett ,  Amy Zartman

IPC分类号： C07D401/14 ,  A61K45/06 ,  C07D401/10 ,  C07D239/54 ,  A61K31/513

CPC分类号： C07D401/14 ,  A61K31/505 ,  A61K31/513 ,  A61K31/519 ,  A61K45/06 ,  C07D239/54 ,  C07D239/553 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D498/04

摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.

摘要翻译： 本发明涉及作为儿茶酚O-甲基转移酶（COMT）的抑制剂的4-嘧啶酮化合物，可用于治疗和预防涉及COMT酶的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及COMT的疾病中的用途。