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公开(公告)号：US11066661B2
公开(公告)日：2021-07-20
申请号：US16856947
申请日：2020-04-23
发明人： Tim Rausch , Walter R Eppler , Gemma Mendonsa
摘要： A system for DNA gene assembly that utilizes a DNA symbol library and a DNA linker library. The symbol library has a number of DNA symbols each having a first overhanging end and a second overhanging end different than and non-complimentary to the first end, the first and second ends being the same nucleotides for each DNA symbol. The linker library has pairs of DNA linkers, a first linker of a pair having a first overhanging end and a second overhanging end and a second linker of the pair having a first overhanging end and a second overhanging end, the first end of the first linker being the same nucleotides for each first linker and the second end of the second linker being the same nucleotides for each second linker, wherein the second end of the first linker and the first end of the second linker have complementary nucleotides. The first linker joins to the first end of a DNA symbol and the second linker joins to the second end of another DNA symbol.
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公开(公告)号：US11643647B2
公开(公告)日：2023-05-09
申请号：US17348642
申请日：2021-06-15
发明人： Tim Rausch , Walter R Eppler , Gemma Mendonsa
CPC分类号： C12N15/1031 , B01L3/5027 , C12N15/1065 , C12N15/1093 , C40B60/14 , G06F12/02 , G11C13/02 , G16B50/30
摘要： A system for DNA gene assembly that utilizes a DNA symbol library and a DNA linker library. The symbol library has a number of DNA symbols each having a first overhanging end and a second overhanging end different than and non-complimentary to the first end, the first and second ends being the same nucleotides for each DNA symbol. The linker library has pairs of DNA linkers, a first linker of a pair having a first end and a second end and a second linker of the pair having a first end and a second end, the first end of the first linker being the same nucleotides for each first linker and the second end of the second linker being the same nucleotides for each second linker, wherein the second end of the first linker and the first end of the second linker have complementary nucleotides. The first linker joins to the first end of a DNA symbol and the second linker joins to the second end of another DNA symbol.
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公开(公告)号：US11939570B2
公开(公告)日：2024-03-26
申请号：US16857006
申请日：2020-04-23
发明人： Tim Rausch , Walter R Eppler , Gemma Mendonsa
CPC分类号： C12N15/1031 , B01L3/5027 , C12N15/1065 , C12N15/1093 , C40B60/14 , G06F12/02 , G11C13/02 , G16B50/30
摘要： A microfluidic lab-on-a-chip system for DNA gene assembly that utilizes a DNA symbol library and a DNA linker library. The lab-on-a-chip has a fluidic platform with a plurality of arrays operably connected to a voltage source and a controller for the voltage source, a set of first inlets operably connected to the fluidic platform, each first inlet for one DNA symbol from a DNA symbol library, a set of second inlets operably connected to the fluidic platform, each second inlet for one DNA linker from a DNA linker library, and a mixing area operably connected to the fluidic platform and to the plurality of first inlets and the plurality of second inlets.
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公开(公告)号：US10410661B1
公开(公告)日：2019-09-10
申请号：US16172141
申请日：2018-10-26
发明人： Riyan Alex Mendonsa , Walter R Eppler , Puskal P Pokharel , Gary Ernest Hillukka , Stephanie Hernandez
摘要： A hard disc drive includes a slider including a first reader and a second reader. The hard disc drive also includes a magnetic recording medium and a controller. The controller is configured to determine a distance between the slider and the magnetic recording medium based at least in part on amplitudes of read signals from both the first reader and the second reader.
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