公开(公告)号：US07820165B2

公开(公告)日：2010-10-26

申请号：US12085155

申请日：2006-11-21

申请人： Sean D. McKenna ,  Robert K. Campbell ,  Xuliang Jiang ,  Giampiero De Luca ,  Meijia Yang ,  Christie Ann Kelton ,  Stephen J. Arkinstall ,  Chaomei He ,  Rene Lynn Schweickhardt

发明人： Sean D. McKenna ,  Robert K. Campbell ,  Xuliang Jiang ,  Giampiero De Luca ,  Meijia Yang ,  Christie Ann Kelton ,  Stephen J. Arkinstall ,  Chaomei He ,  Rene Lynn Schweickhardt

IPC分类号： C07K16/46 ,  C07K14/59 ,  C07K16/28

CPC分类号： C07K16/22 ,  C07K16/2863 ,  C07K2317/56 ,  C07K2318/10 ,  C07K2318/20 ,  C07K2319/00

摘要： This disclosure relates to hybrid antigen binding molecules including at least two polypeptide chains, with at least one polypeptide chain comprises an antigen binding moiety linked to an amino acid sequence of a subunit of a heterodimeric proteinaceous hormone. Also disclosed are methods of making and using such hybrid antigen binding molecules for diagnosis and/or therapy.

摘要翻译： 本公开涉及包括至少两条多肽链的杂合抗原结合分子，其中至少一条多肽链包含与异二聚体蛋白质激素亚基的氨基酸序列连接的抗原结合部分。 还公开了制备和使用这种杂合抗原结合分子用于诊断和/或治疗的方法。

公开(公告)号：US20090130712A1

公开(公告)日：2009-05-21

申请号：US12085155

申请日：2006-11-21

申请人： Sean D. McKenna ,  Robert K. Campbell ,  Xuliang Jiang ,  Giampiero De Luca ,  Meijia Yang ,  Christie Ann Kelton ,  Stephen J. Arkinstall ,  Chaomei He ,  Rene Lynn Schweickhardt

发明人： Sean D. McKenna ,  Robert K. Campbell ,  Xuliang Jiang ,  Giampiero De Luca ,  Meijia Yang ,  Christie Ann Kelton ,  Stephen J. Arkinstall ,  Chaomei He ,  Rene Lynn Schweickhardt

IPC分类号： C12P21/00 ,  C12N5/10

CPC分类号： C07K16/22 ,  C07K16/2863 ,  C07K2317/56 ,  C07K2318/10 ,  C07K2318/20 ,  C07K2319/00

摘要： This disclosure relates to hybrid antigen binding molecules including at least two polypeptide chains, with at least one polypeptide chain comprises an antigen binding moiety linked to an amino acid sequence of a subunit of a heterodimeric proteinaceous hormone. Also disclosed are methods of making and using such hybrid antigen binding molecules for diagnosis and/or therapy.

摘要翻译： 本公开涉及包括至少两条多肽链的杂合抗原结合分子，其中至少一条多肽链包含与异二聚体蛋白质激素亚基的氨基酸序列连接的抗原结合部分。 还公开了制备和使用这种杂合抗原结合分子用于诊断和/或治疗的方法。

公开(公告)号：US20050069914A1

公开(公告)日：2005-03-31

申请号：US10811081

申请日：2004-03-25

申请人： Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan ,  Nabil El Tayar

发明人： Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan ,  Nabil El Tayar

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/59 ,  C07K16/26 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C07K14/575 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/59 ,  C07K16/26 ,  C07K2317/34

摘要： The present invention provides novel isolated ARP/BRP polynucleotides and the membrane-associated or secreted polypeptides encoded by the ARP/BRP polynucleotides. Also provided are ARP and BRP protein multimers. Further provided are the antibodies that immunospecifically bind to a ARP/BRP polypeptide or any derivative, variant, mutant or fragment of the ARP/BRP polypeptide, a ARP/BRP multimer polynucleotide or antibody. The invention additionally provides methods in which the ARP/BRP polypeptide, multimer, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, e.g. reproductive disorder, as well as to other uses.

公开(公告)号：US20050095676A1

公开(公告)日：2005-05-05

申请号：US10913944

申请日：2004-08-06

申请人： Nabil El Tayar ,  Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan

发明人： Nabil El Tayar ,  Robert Campbell ,  Christie Kelton ,  Chaomei He ,  Susan Kiernan

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/59 ,  C07K16/26 ,  A61K38/22 ,  C07H21/04 ,  C07K14/565

CPC分类号： C07K14/575 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/59 ,  C07K16/26 ,  C07K2317/34

摘要： The present invention provides novel isolated ARP/BRP polynucleotides and the membrane-associated or secreted polypeptides encoded by the ARP/BRP polynucleotides. Also provided are ARP and BRP protein multimers. Further provided are the antibodies that immunospecifically bind to a ARP/BRP polypeptide or any derivative, variant, mutant or fragment of the ARP/BRP polypeptide, a ARP/BRP multimer polynucleotide or antibody. The invention additionally provides methods in which the ARP/BRP polypeptide, multimer, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, e.g. reproductive disorder, as well as to other uses.

摘要翻译： 本发明提供新的分离的ARP / BRP多核苷酸和由ARP / BRP多核苷酸编码的膜相关或分泌的多肽。 还提供了ARP和BRP蛋白多聚体。 还提供免疫特异性结合ARP / BRP多肽或ARP / BRP多肽的任何衍生物，变体，突变体或片段，ARP / BRP多聚体多核苷酸或抗体的抗体。 本发明还提供了其中使用ARP / BRP多肽，多聚体，多核苷酸和抗体来检测和治疗广泛的病理状态的方法，例如， 生殖障碍，以及其他用途。