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    ADHESIVE SYSTEMS CONTAINING POLYISOCYANATE PREPOLYMERS AND ASPARTATE-ESTER CURING AGENTS, PROCESSES FOR PREPARING THE SAME, MEDICAL USES THEREFOR AND DISPENSING SYSTEMS FOR THE SAME
    2.
    发明申请
    ADHESIVE SYSTEMS CONTAINING POLYISOCYANATE PREPOLYMERS AND ASPARTATE-ESTER CURING AGENTS, PROCESSES FOR PREPARING THE SAME, MEDICAL USES THEREFOR AND DISPENSING SYSTEMS FOR THE SAME 审中-公开
    含有聚异氰酸酯预处理剂和乳酸酯固化剂的粘合剂体系，其制备方法，用于其的医疗用途和分配体系

    公开(公告)号：US20090191145A1

    公开(公告)日：2009-07-30

    申请号：US12358346

    申请日：2009-01-23

    申请人： Heike Heckroth ,  Burkhardt Kohler ,  Sebastian Dorr

    发明人： Heike Heckroth ,  Burkhardt Kohler ,  Sebastian Dorr

    IPC分类号： A61K31/785 ,  C09J175/00

    CPC分类号： C08G18/4837 ,  A61L24/046 ,  C08G18/10 ,  C08G18/73 ,  C09J175/04 ,  C08G18/3821 ,  C08G18/48 ,  C08G18/6685

    摘要： Adhesive systems comprising: (A) an isocyanate group-containing prepolymer prepared by reacting: (A1) an aliphatic isocyante; and (A2) a polyol having a number average molecular weight of ≧400 g/mol and 2 to 6 OH groups; and (B) a curing component comprising: (B1) an amino group-containing aspartate ester of the general formula (I); wherein X represents an n-valent organic radical derived from a corresponding n-functional primary amine X(NH2)n, R1 and R2 each independently represent an organic radical having no Zerevitinov active hydrogens and n represents a whole number of at least 2; and (B2) an organic filler having a viscosity of 10 to 6000 mPas at 23° C. measured according to DIN 53019; their use in wound and tissue incision closure, adhesive films comprising the same and dispensing systems therefor.

    摘要翻译： 粘合剂体系包括：（A）含异氰酸酯基的预聚物，其通过使（A1）脂族异氰酸酯反应而制备; 和（A2）数均分子量为> 400g / mol和2-6个OH基的多元醇; 和（B）固化组分，其包含：（B1）通式（I）的含氨基的天冬氨酸酯; 其中X表示衍生自相应的正官能伯胺X（NH 2）n的n价有机基团，R 1和R 2各自独立地表示不具有齐维可诺夫活性氢的有机基团，n表示整数至少为2; 和（B2）根据DIN 53019测量的在23℃下粘度为10至6000mPa·s的有机填料; 它们在伤口和组织切口闭合中的应用，包括其的粘合剂膜和其分配系统。

    Medical adhesive for stemming bleeding
    10.
    发明授权
    Medical adhesive for stemming bleeding 有权
    用于止血的医用胶粘剂

    公开(公告)号：US09393345B2

    公开(公告)日：2016-07-19

    申请号：US14112368

    申请日：2012-04-17

    申请人： Heike Heckroth ,  Christoph Eggert

    发明人： Heike Heckroth ,  Christoph Eggert

    IPC分类号： C08G18/10 ,  C08G18/12 ,  C08G18/73 ,  A61L24/04 ,  A61L24/00

    CPC分类号： A61L24/046 ,  A61L24/0015 ,  C08G18/10 ,  C08G18/12 ,  C08G18/73 ,  C08G18/3821 ,  C08L75/02

    摘要： The present invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which in particular can have a number-average molecular weight of ≧400 g/mol and a mean OH functionality of from 2 to 6, as component B) an amino-functional compound of the general formula (I) in which X is an organic radical containing a secondary amino function, Y is an organic radical that contains a tertiary amino group and does not contain Zerewitinoff-active hydrogen, R1 is a CH2—COOR3 radical in which R3 is an organic radical that does not contain Zerewitinoff-active hydrogen, a linear or branched C1- to C4-alkyl radical, a cyclopentyl radical, a cyclohexyl radical or H, R2 is an organic radical that does not contain Zerewitinoff-active hydrogen, a is 1 or 2, b is 1 or 2, and a+b=2 or 3, for stemming the escape of blood, and to a metering system for the polyurea system according to the invention.

    摘要翻译： 本发明涉及一种聚脲系统，其包含作为组分A）的异氰酸酯官能的预聚物，其可通过脂族异氰酸酯A1）与多元醇A2）的反应获得，该多异氰酸酯官能的预聚物特别可以具有≥400g/ mol的数均分子量， 2〜6的OH官能团，作为组分B）通式（I）的氨基官能化合物，其中X是含有仲氨基官能团的有机基团，Y是含有叔氨基的有机基团，并且 不含有Zerewitinoff活性氢，R1是CH2-COOR3基团，其中R3是不含Zerewitinoff活性氢的有机基团，直链或支链C 1 -C 4烷基，环戊基，环己基或 H，R2是不含Zerewitinoff活性氢的有机基团，a是1或2，b为1或2，a + b = 2或3，用于阻止血液逸出，并且用于计量系统 根据本发明的聚脲系统。