公开(公告)号：US20230390343A1

公开(公告)日：2023-12-07

申请号：US18232433

申请日：2023-08-10

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

Abstract: A method to reduce the likelihood of a dysbiosis of the vaginal microbiome in an individual employing a probiotic method and composition for maintaining a healthy vaginal microbiome, with particular embodiments including a bacterial formulation of at least two live bacteria selected from the group consisting of L. reuteri, L johnsonii and L. crispatus, and at least one prebiotic having glycogen as a component thereof. The bacterial formulation is administered to an individual's vagina in an amount sufficient for the bacterial formulation to generate an amount of tryptophan metabolites sufficient to act as aryl hydrocarbon receptor (AHR) agonists, thereby reducing inflammation in the individual's vagina. Certain embodiments include increasing the production of SCFAs in the individual's gut microbiome, while reducing the production of SCFAs in the individual's vagina and introducing ammonia oxidizing microorganisms to the individual's vagina.

公开(公告)号：US20230241129A1

公开(公告)日：2023-08-03

申请号：US18130946

申请日：2023-04-05

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/1758 ,  A61K38/1709 ,  A61K2035/11

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria, postbiotics, metabolites and other microbe components to foster the growth and maintenance of a healthy skin microbiome. One embodiment includes a topical application of Lactobacillus Crispatus to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, postbiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne, through the production of tryptophan metabolites that act as AHR agonists.

公开(公告)号：US20230165706A1

公开(公告)日：2023-06-01

申请号：US18103768

申请日：2023-01-31

Applicant: SEED HEALTH .INC.

Inventor： Tye Jensen ,  Joseph E Kovarik

IPC: A61F5/56

CPC classification number: A61F5/566

Abstract: A method to facilitate the growth of desired bacteria in a human's mouth to reduce the likelihood of dental caries and halitosis and other oral diseases, and for inhibiting oral biofilm formation, gingivitis, periodontitis and halitosis via the employment of one or more probiotic bacterial, bioactive flavonoid, and zinc compound compositions effective in providing prevention and treatment options.

公开(公告)号：US20240366687A1

公开(公告)日：2024-11-07

申请号：US18738464

申请日：2024-06-10

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/17 ,  C12N1/20

Abstract: A method to reduce the likelihood of a dysbiosis of the vaginal microbiome in an individual employing a probiotic method and composition for maintaining a healthy vaginal microbiome, with particular embodiments including a bacterial formulation of three distinct species of Lactobacillus crispatus bacteria. In certain embodiments, the bacterial formulation is administered to an individual's vagina in an amount sufficient for the bacterial formulation to generate an amount of tryptophan metabolites sufficient to act as aryl hydrocarbon receptor (AHR) agonists, thereby reducing inflammation in the individual's vagina.

公开(公告)号：US20240156878A1

公开(公告)日：2024-05-16

申请号：US18535722

申请日：2023-12-11

Applicant: Seed Health, Inc.

Inventor： Tye Jensen ,  Joseph E. Kovarik ,  Raja Dhir

IPC: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. Embodiments include methods for treating an individual suffering from acne valgaris by topically administering a composition that includes live bacteria selected from the group consisting of L reuteri, L johnsonii, L crispatus, C. acnes, and Nitrosomonas eutropha, that have been modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system to reduce the production of a virulence factor of the bacteria.

公开(公告)号：US11951140B2

公开(公告)日：2024-04-09

申请号：US18143399

申请日：2023-05-04

Applicant: Seed Health, Inc.

Inventor： Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

Abstract: Various embodiments of the present invention are directed to the field of treating and preventing osteoporosis, with particular embodiments directed to a method of ameliorating, treating, or preventing osteoporosis in a human subject employing tomatidine, xylitol, rapamycin, etc., as well as modifying an individual's microbiome to reduce the likelihood of osteoporosis.

公开(公告)号：US20240277780A1

公开(公告)日：2024-08-22

申请号：US18615672

申请日：2024-03-25

Applicant: Seed Health, Inc.

Inventor： Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/17 ,  C12N1/20

CPC classification number: A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/1709 ,  A61K38/1758 ,  C12N1/20 ,  A61K2035/11 ,  A61K2035/115

Abstract: Various embodiments of the present invention are directed to the field of treating and preventing osteoporosis, with particular embodiments directed to a method of ameliorating, treating, or preventing osteoporosis in a human subject employing tomatidine, xylitol, rapamycin, etc., as well as modifying an individual's microbiome to reduce the likelihood of osteoporosis.

公开(公告)号：US11998479B2

公开(公告)日：2024-06-04

申请号：US18234544

申请日：2023-08-16

Applicant: SEED HEALTH, INC.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61F5/56

CPC classification number: A61F5/566

Abstract: A method and system to address the adverse effects on an individual's oral microbiome with the objective of restoring gingival health caused by exposure to sodium lauryl sulfate. Certain embodiments of the present invention facilitate the growth of desired bacteria in a human's mouth to reduce the likelihood of dental caries, halitosis, canker sores, and other oral diseases. Probiotic bacterial, bioactive flavonoid, xylitol and zinc compound compositions, provide effective prevention and treatment options, especially while precluding the use of sodium lauryl sulfate so as to reduce adverse consequences it has on gingival health.

公开(公告)号：US11833177B2

公开(公告)日：2023-12-05

申请号：US18130946

申请日：2023-04-05

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17 ,  A61K35/00

CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria, postbiotics, metabolites and other microbe components to foster the growth and maintenance of a healthy skin microbiome. One embodiment includes a topical application of Lactobacillus Crispatus to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, postbiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne, through the production of tryptophan metabolites that act as AHR agonists.

公开(公告)号：US20240024378A1

公开(公告)日：2024-01-25

申请号：US18235686

申请日：2023-08-18

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17

CPC classification number: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/1758 ,  A61K38/1709 ,  A61K2035/11

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria, postbiotics, metabolites and other microbe components to foster the growth and maintenance of a healthy skin microbiome. One embodiment includes a topical application of Lactobacillus crispatus to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, postbiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne, through the production of tryptophan metabolites that act as AHR agonists.