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1.
公开(公告)号:US20120294945A1
公开(公告)日:2012-11-22
申请号:US13326477
申请日:2011-12-15
申请人: Sei Kwang HAHN , Choun-Ki Joo , Yoon Keun Kim , Seung Kew Yoon , Eun Ju Oh , Ki Su Kim , Hyemin Kim , Kitae Park , Jeong-A Yang , Jun-sub Choi , You Me Tae , Wonhee Hur
发明人: Sei Kwang HAHN , Choun-Ki Joo , Yoon Keun Kim , Seung Kew Yoon , Eun Ju Oh , Ki Su Kim , Hyemin Kim , Kitae Park , Jeong-A Yang , Jun-sub Choi , You Me Tae , Wonhee Hur
IPC分类号: A61K9/14 , A61K31/573 , A61K31/704 , A61P11/06 , A61P9/00 , B05D5/00 , A61K31/353 , A61P35/00 , B82Y5/00
CPC分类号: A61K9/107 , A61K31/352 , A61K31/573 , A61K31/704 , A61K47/61 , A61K47/62 , A61K47/6907 , Y10S977/795 , Y10S977/906
摘要: The present invention relates to a drug delivery composition comprising a hyaluronic acid-peptide conjugate micelle and a production method thereof. According to the drug delivery composition and the production method of the drug-loaded, hyaluronic acid-peptide conjugate micelle of the present invention, the reaction for encapsulating can proceed in a mixed solvent of an aqueous solvent and an organic solvent. Therefore, the present invention can be applied to various types of water-insoluble active components and the biocompatible and biodegradable derivative can encapsulate a drug to provide a drug-loaded micelle, which is safe to be applied for human bodies. Moreover, the micelle has a therapeutic effect from the peptide contained therein, which can act in combination with the drug as packing therein. Therefore, the drug delivery composition and its production method can be utilized in the field of producing a sustained release formulation with an extended duration of the medicinal effect.
摘要翻译: 本发明涉及包含透明质酸 - 肽缀合物胶束的药物递送组合物及其制备方法。 根据本发明的药物载体的透明质酸 - 肽缀合物胶束的药物递送组合物和制造方法,可以在水性溶剂和有机溶剂的混合溶剂中进行包封反应。 因此,本发明可以应用于各种类型的水不溶性活性成分,并且生物相容性和生物降解性衍生物可以包封药物以提供药物负载的胶束,其可安全地用于人体。 此外,胶束具有从其中所含的肽的治疗效果,其可以与药物组合起作为其中的包装的作用。 因此,药物输送组合物及其制备方法可用于生产具有延长药效期的持续释放制剂领域。
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2.
公开(公告)号:US08895069B2
公开(公告)日:2014-11-25
申请号:US13326477
申请日:2011-12-15
申请人: Sei Kwang Hahn , Choun-Ki Joo , Yoon Keun Kim , Seung Kew Yoon , Eun Ju Oh , Ki Su Kim , Hyemin Kim , Kitae Park , Jeong-A Yang , Jun-Sub Choi , You Me Tae , Wonhee Hur
发明人: Sei Kwang Hahn , Choun-Ki Joo , Yoon Keun Kim , Seung Kew Yoon , Eun Ju Oh , Ki Su Kim , Hyemin Kim , Kitae Park , Jeong-A Yang , Jun-Sub Choi , You Me Tae , Wonhee Hur
IPC分类号: A61K31/573 , A61K31/704 , A61P11/06 , A61P9/00 , A61K31/353 , A61K9/107 , A61K47/48 , A61K31/352
CPC分类号: A61K9/107 , A61K31/352 , A61K31/573 , A61K31/704 , A61K47/61 , A61K47/62 , A61K47/6907 , Y10S977/795 , Y10S977/906
摘要: The present invention relates to a drug delivery composition comprising a hyaluronic acid-peptide conjugate micelle and a production method thereof. According to the drug delivery composition and the production method of the drug-loaded, hyaluronic acid-peptide conjugate micelle of the present invention, the reaction for encapsulating can proceed in a mixed solvent of an aqueous solvent and an organic solvent. Therefore, the present invention can be applied to various types of water-insoluble active components and the biocompatible and biodegradable derivative can encapsulate a drug to provide a drug-loaded micelle, which is safe to be applied for human bodies. Moreover, the micelle has a therapeutic effect from the peptide contained therein, which can act in combination with the drug as packing therein. Therefore, the drug delivery composition and its production method can be utilized in the field of producing a sustained release formulation with an extended duration of the medicinal effect.
摘要翻译: 本发明涉及包含透明质酸 - 肽缀合物胶束的药物递送组合物及其制备方法。 根据本发明的药物载体的透明质酸 - 肽缀合物胶束的药物递送组合物和制造方法,可以在水性溶剂和有机溶剂的混合溶剂中进行包封反应。 因此,本发明可以应用于各种类型的水不溶性活性成分,并且生物相容性和生物降解性衍生物可以包封药物以提供药物负载的胶束,其可安全地用于人体。 此外,胶束具有从其中所含的肽的治疗效果,其可以与药物组合起作为其中的包装的作用。 因此,药物输送组合物及其制备方法可用于生产具有延长药效期的持续释放制剂领域。
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