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公开(公告)号：US09017712B2
公开(公告)日：2015-04-28
申请号：US13809432
申请日：2011-07-11
申请人： Il Hwan Cho , Eui Jin Hwang , Moo Seok Seo , Young Soo Park , Byung Su Kim , Sei Kwang Hahn , Jung Kyu Park , Jun Seok Yeom , Eun Ju Oh
发明人： Il Hwan Cho , Eui Jin Hwang , Moo Seok Seo , Young Soo Park , Byung Su Kim , Sei Kwang Hahn , Jung Kyu Park , Jun Seok Yeom , Eun Ju Oh
IPC分类号： A61K8/73 , A61Q19/08 , A61K31/167 , A61L27/20 , A61L27/52 , C08B37/08 , C08J3/075 , C08L5/08 , A61L27/54
CPC分类号： A61K8/735 , A61K31/167 , A61L27/20 , A61L27/52 , A61L27/54 , A61L2300/402 , A61L2400/06 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要： The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.
摘要翻译： 本发明涉及用于组织增强的填充剂组合物，包括透明质酸和亚烷基二胺交联的水凝胶。 填充剂组合物显示组织增强所需的正性物理性质，例如生物相容性和溶胀能力，以及有益效果，因为它们长时间保留在体内。
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公开(公告)号：US08247493B2
公开(公告)日：2012-08-21
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： A61K47/48
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译： 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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公开(公告)号：US20100210509A1
公开(公告)日：2010-08-19
申请号：US12680955
申请日：2008-10-09
申请人： Eun-Ju Oh , Jung-Wook Kim , Sung-Ho Ryu , Sei-Kwang Hahn
发明人： Eun-Ju Oh , Jung-Wook Kim , Sung-Ho Ryu , Sei-Kwang Hahn
摘要： The invention relates to a novel bioconjugation protocol for peptide suitable for in vivo applications. Bioconjugation of the peptide to HA derivative increases its half life in circulation contributing for a high efficacy. More over, conjugate of HA derivative and peptide which is treated with hyaluronidase shows increased bioactivity. And also, in contrast to PEGylation, HA derivative can be conjugated with many numbers of peptide molecules per single HA derivative chain, which enables multiple action of peptide drugs.
摘要翻译： 本发明涉及适用于体内应用的肽的新型生物缀合方案。 肽与HA衍生物的生物共轭增加其循环的半衰期有助于高效力。 更具体地，HA衍生物和用透明质酸酶处理的肽的缀合物显示增加的生物活性。 而且，与聚乙二醇化相反，HA衍生物可以与单个HA衍生物链中的许多肽分子缀合，这使得肽药物能够多次作用。
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公开(公告)号：US08183229B2
公开(公告)日：2012-05-22
申请号：US12438628
申请日：2007-08-27
申请人： Sei Kwang Hahn , Eun Ju Oh , Jung Kyu Park , Kwang Bum Park , Kyoung Ho Ryoo , Seok Kyu Choi , Dong Jun Yang , Hyun Wook An
发明人： Sei Kwang Hahn , Eun Ju Oh , Jung Kyu Park , Kwang Bum Park , Kyoung Ho Ryoo , Seok Kyu Choi , Dong Jun Yang , Hyun Wook An
CPC分类号： A61L27/46 , A61F2/28 , A61L2430/02 , C08L5/08
摘要： Provided is a bone filling complex and method of preparing the same. The bone filling complex includes a matrix including a hydrogel-type hyaluronic acid derivative; and a bone derivative filling the matrix For example, the bone filling complex can be used to regenerate an injured alveolar bone.
摘要翻译： 提供骨填充复合物及其制备方法。 骨填充复合物包括包含水凝胶型透明质酸衍生物的基质; 和填充基质的骨衍生物例如，骨填充复合物可用于再生受损的牙槽骨。
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公开(公告)号：US20100261245A1
公开(公告)日：2010-10-14
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： C12N9/00 , C07D207/40 , C07K14/00 , C07H21/00 , C07H1/00
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译： 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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6.发明授权公开(公告)号：US08895069B2
公开(公告)日：2014-11-25
申请号：US13326477
申请日：2011-12-15
申请人： Sei Kwang Hahn , Choun-Ki Joo , Yoon Keun Kim , Seung Kew Yoon , Eun Ju Oh , Ki Su Kim , Hyemin Kim , Kitae Park , Jeong-A Yang , Jun-Sub Choi , You Me Tae , Wonhee Hur
发明人： Sei Kwang Hahn , Choun-Ki Joo , Yoon Keun Kim , Seung Kew Yoon , Eun Ju Oh , Ki Su Kim , Hyemin Kim , Kitae Park , Jeong-A Yang , Jun-Sub Choi , You Me Tae , Wonhee Hur
IPC分类号： A61K31/573 , A61K31/704 , A61P11/06 , A61P9/00 , A61K31/353 , A61K9/107 , A61K47/48 , A61K31/352
CPC分类号： A61K9/107 , A61K31/352 , A61K31/573 , A61K31/704 , A61K47/61 , A61K47/62 , A61K47/6907 , Y10S977/795 , Y10S977/906
摘要： The present invention relates to a drug delivery composition comprising a hyaluronic acid-peptide conjugate micelle and a production method thereof. According to the drug delivery composition and the production method of the drug-loaded, hyaluronic acid-peptide conjugate micelle of the present invention, the reaction for encapsulating can proceed in a mixed solvent of an aqueous solvent and an organic solvent. Therefore, the present invention can be applied to various types of water-insoluble active components and the biocompatible and biodegradable derivative can encapsulate a drug to provide a drug-loaded micelle, which is safe to be applied for human bodies. Moreover, the micelle has a therapeutic effect from the peptide contained therein, which can act in combination with the drug as packing therein. Therefore, the drug delivery composition and its production method can be utilized in the field of producing a sustained release formulation with an extended duration of the medicinal effect.
摘要翻译： 本发明涉及包含透明质酸 - 肽缀合物胶束的药物递送组合物及其制备方法。 根据本发明的药物载体的透明质酸 - 肽缀合物胶束的药物递送组合物和制造方法，可以在水性溶剂和有机溶剂的混合溶剂中进行包封反应。 因此，本发明可以应用于各种类型的水不溶性活性成分，并且生物相容性和生物降解性衍生物可以包封药物以提供药物负载的胶束，其可安全地用于人体。 此外，胶束具有从其中所含的肽的治疗效果，其可以与药物组合起作为其中的包装的作用。 因此，药物输送组合物及其制备方法可用于生产具有延长药效期的持续释放制剂领域。
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公开(公告)号：US20100249059A1
公开(公告)日：2010-09-30
申请号：US12438628
申请日：2007-08-27
申请人： Sei Kwang Hahn , Eun Ju Oh , Jung Kyu Park , Kwang Bum Park , Kyoung Ho Ryoo , Seok Kyu Choi , Dong Jun Yang , Hyun Wook An
发明人： Sei Kwang Hahn , Eun Ju Oh , Jung Kyu Park , Kwang Bum Park , Kyoung Ho Ryoo , Seok Kyu Choi , Dong Jun Yang , Hyun Wook An
IPC分类号： A61K31/715 , A61P19/00
CPC分类号： A61L27/46 , A61F2/28 , A61L2430/02 , C08L5/08
摘要： Provided is a bone filling complex and a method of preparing the same. The bone filling complex includes a matrix including a hydrogel-type hyaluronic acid derivative; and a bone derivative filling the matrix, and thus adhesion can be prevented and excellent bone generation property can be obtained. For example, the bone filling complex can be used to an injured portion of alveolar bone to derive an regeneration of the alveolar bone.
摘要翻译： 提供骨填充复合物及其制备方法。 骨填充复合物包括包含水凝胶型透明质酸衍生物的基质; 和填充基质的骨衍生物，因此可以防止粘附，并且可以获得优异的骨产生性能。 例如，骨填充复合物可用于牙槽骨的受损部分以导致牙槽骨的再生。
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公开(公告)号：US20120294945A1
公开(公告)日：2012-11-22
申请号：US13326477
申请日：2011-12-15
申请人： Sei Kwang HAHN , Choun-Ki Joo , Yoon Keun Kim , Seung Kew Yoon , Eun Ju Oh , Ki Su Kim , Hyemin Kim , Kitae Park , Jeong-A Yang , Jun-sub Choi , You Me Tae , Wonhee Hur
发明人： Sei Kwang HAHN , Choun-Ki Joo , Yoon Keun Kim , Seung Kew Yoon , Eun Ju Oh , Ki Su Kim , Hyemin Kim , Kitae Park , Jeong-A Yang , Jun-sub Choi , You Me Tae , Wonhee Hur
IPC分类号： A61K9/14 , A61K31/573 , A61K31/704 , A61P11/06 , A61P9/00 , B05D5/00 , A61K31/353 , A61P35/00 , B82Y5/00
CPC分类号： A61K9/107 , A61K31/352 , A61K31/573 , A61K31/704 , A61K47/61 , A61K47/62 , A61K47/6907 , Y10S977/795 , Y10S977/906
摘要： The present invention relates to a drug delivery composition comprising a hyaluronic acid-peptide conjugate micelle and a production method thereof. According to the drug delivery composition and the production method of the drug-loaded, hyaluronic acid-peptide conjugate micelle of the present invention, the reaction for encapsulating can proceed in a mixed solvent of an aqueous solvent and an organic solvent. Therefore, the present invention can be applied to various types of water-insoluble active components and the biocompatible and biodegradable derivative can encapsulate a drug to provide a drug-loaded micelle, which is safe to be applied for human bodies. Moreover, the micelle has a therapeutic effect from the peptide contained therein, which can act in combination with the drug as packing therein. Therefore, the drug delivery composition and its production method can be utilized in the field of producing a sustained release formulation with an extended duration of the medicinal effect.
摘要翻译： 本发明涉及包含透明质酸 - 肽缀合物胶束的药物递送组合物及其制备方法。 根据本发明的药物载体的透明质酸 - 肽缀合物胶束的药物递送组合物和制造方法，可以在水性溶剂和有机溶剂的混合溶剂中进行包封反应。 因此，本发明可以应用于各种类型的水不溶性活性成分，并且生物相容性和生物降解性衍生物可以包封药物以提供药物负载的胶束，其可安全地用于人体。 此外，胶束具有从其中所含的肽的治疗效果，其可以与药物组合起作为其中的包装的作用。 因此，药物输送组合物及其制备方法可用于生产具有延长药效期的持续释放制剂领域。
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公开(公告)号：US20110111477A9
公开(公告)日：2011-05-12
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： C12N9/00 , C07D207/40 , C07K14/00 , C07H21/00 , C07H1/00
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译： 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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公开(公告)号：US20130203856A1
公开(公告)日：2013-08-08
申请号：US13809432
申请日：2011-07-11
申请人： Il Hwan Cho , Eui Jin Hwang , Moo Seok Seo , Young Soo Park , Byung Su Kim , Sei Kwang Hahn , Jung Kyu Park , Jun Seok Yeom , Eun Ju Oh
发明人： Il Hwan Cho , Eui Jin Hwang , Moo Seok Seo , Young Soo Park , Byung Su Kim , Sei Kwang Hahn , Jung Kyu Park , Jun Seok Yeom , Eun Ju Oh
IPC分类号： A61K8/73 , A61Q19/08 , A61K31/167
CPC分类号： A61K8/735 , A61K31/167 , A61L27/20 , A61L27/52 , A61L27/54 , A61L2300/402 , A61L2400/06 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要： The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.
摘要翻译： 本发明涉及用于组织增强的填充剂组合物，包括透明质酸和亚烷基二胺交联的水凝胶。 填充剂组合物显示组织增强所需的正性物理性质，例如生物相容性和溶胀能力，以及有益效果，因为它们长时间保留在体内。
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