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5 条记录 (耗时 0.017 秒)

    4-Carboxy-2-acetamido thiazolidine derivatives
    1.
    发明授权
    4-Carboxy-2-acetamido thiazolidine derivatives 失效
    4-羧基-2-乙酰氨基噻唑烷衍生物

    公开(公告)号：US4398026A

    公开(公告)日：1983-08-09

    申请号：US383526

    申请日：1982-06-01

    申请人： Seiichi Takano ,  Susumu Otomo ,  Takehiro Amano

    发明人： Seiichi Takano ,  Susumu Otomo ,  Takehiro Amano

    IPC分类号： A61K31/425 ,  A61K31/426 ,  A61P37/04 ,  C07D277/06 ,  C07D417/06

    CPC分类号： C07D277/06

    摘要： A novel thiazolidine derivative having the following general formula ##STR1## wherein R.sup.1 and R.sup.2 are each lower alkyl having 1 to 3 carbon atoms, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a heterocyclic ring selected from the group consisting of morpholino, piperazino, piperidino and pyrrolidino, or said heterocyclic ring substituted with 1 or 2 methyl groups, and the pharmaceutically acceptable salts thereof are useful immunomodulators.

    摘要翻译： 一种具有以下通式的新型噻唑烷衍生物，其中R 1和R 2各自为具有1至3个碳原子的低级烷基，或者R 1和R 2与它们所连接的氮原子一起形成选自以下的杂环： 吗啉代，哌嗪子基，哌啶子基和吡咯烷子基，或被1或2个甲基取代的所述杂环，其药学上可接受的盐是有用的免疫调节剂。

    Fluorine-containing 2-nitroimidazole derivatives
    3.
    发明授权
    Fluorine-containing 2-nitroimidazole derivatives 失效
    含氟的2-硝基咪唑衍生物

    公开(公告)号：US4977273A

    公开(公告)日：1990-12-11

    申请号：US448909

    申请日：1989-12-12

    申请人： Tsutomu Kagiya ,  Mitsuyuki Abe ,  Seiichi Nishimoto ,  Yuta Shibamoto ,  Susumu Otomo ,  Tohru Tanami ,  Kazuhiro Shimokawa ,  Toru Yoshizawa ,  Yorisato Hisanaga

    发明人： Tsutomu Kagiya ,  Mitsuyuki Abe ,  Seiichi Nishimoto ,  Yuta Shibamoto ,  Susumu Otomo ,  Tohru Tanami ,  Kazuhiro Shimokawa ,  Toru Yoshizawa ,  Yorisato Hisanaga

    IPC分类号： C07D233/91

    CPC分类号： C07D233/91

    摘要： A 2-nitroimidazole derivative of the formula: ##STR1## wherein R.sub.f is a group of the following formula (II) or (III):--CH.sub.2 CFXCH.sub.2 OR.sub.1 (II)wherein X is a hydrogen atom or a halogen atom; R.sub.1 is a group of the formula: ##STR2## wherein R.sub.2 is a hydrogen atom, a hydroxyl group, a C.sub.1 -C.sub.3 alkyl group, a C.sub.2 -C.sub.4 acyl group, benzylidene or acetonide; R.sub.3 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; Z is a hydrogen atom, COOY, COOR.sub.3, CONHOY, CONR.sub.4 R.sub.5 (wherein R.sub.4 and R.sub.5 are hydroxyl group-containing C.sub.1 -C.sub.3 alkyl groups or hydrogen atoms; Y is a hydrogen atom or a monovalent metal atom), an amino group, a hydroxyl group or OR.sub.3 ; l is an integer of 1 to 3; o is an integer of 0 to 3; p is an integer of 0 to 2; q is an integer of 0 to 3; m and n are integers of 0 to 4; and 1.ltoreq.m+n.ltoreq.4 or ##STR3## wherein R.sub.3, X and p are the same as defined above; Z' is the same as Z or is OCOOCH.sub.3 ; r is an integer of 1 to 3; s is 0 or 1; t is an integer of 0 to 4 provided that when p=0, s.noteq.0 and at least one X is a fluorine atom; and a radiosensitizer comprising said nitroimidazole derivative.