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102 条记录 (耗时 0.023 秒)

    Differentiation-suppressive polypeptide serrate-2
    2.
    发明授权
    Differentiation-suppressive polypeptide serrate-2 失效
    分化抑制多肽锯齿-2

    公开(公告)号：US06638741B2

    公开(公告)日：2003-10-28

    申请号：US09855722

    申请日：2001-05-16

    申请人： Seiji Sakano ,  Akira Itoh

    发明人： Seiji Sakano ,  Akira Itoh

    IPC分类号： C12P2102

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： An isolated polypeptide comprising a first amino acid sequence selected from the group consisting of SEQ ID NOs. 1 to 3, and a second amino acid sequence selected from the group consisting of SEQ ID NO. 22 and Fc sequence below hinge region of human IgG, wherein said second amino acid sequence is linked to the C-terminal of said first amino acid sequence.

    摘要翻译： 一种分离的多肽，其包含选自SEQ ID NO的第一氨基酸序列。 1至3，以及选自SEQ ID NO：1的第二个氨基酸序列。 22和Fc序列在人IgG的铰链区之下，其中所述第二氨基酸序列连接到所述第一氨基酸序列的C末端。

    Differentiation-suppressive polypeptide
    3.
    发明授权
    Differentiation-suppressive polypeptide 失效
    分化抑制性多肽

    公开(公告)号：US06337387B1

    公开(公告)日：2002-01-08

    申请号：US09068740

    申请日：1998-06-18

    申请人： Seiji Sakano ,  Akira Itoh

    发明人： Seiji Sakano ,  Akira Itoh

    IPC分类号： C07K100

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  Y02A50/473

    摘要： A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the supression of the proliferation and defferentiation of undifferentiated blood cells. this polypeptide is expected to be usable in medicines and medical supplies.

    摘要翻译： 含有序列表中序列号1所记载的氨基酸序列的多肽，由序列表中源自人的基因编码。 因为作为抑制未分化血细胞增殖和分化的化学物质。 该多肽预计可用于药物和医疗用品。

    Nucleic acid encoding a human serrate-1 polypeptide
    5.
    发明授权
    Nucleic acid encoding a human serrate-1 polypeptide 失效
    编码人血清-1多肽的核酸

    公开(公告)号：US07198918B2

    公开(公告)日：2007-04-03

    申请号：US11051631

    申请日：2005-01-27

    申请人： Seiji Sakano ,  Akira Itoh

    发明人： Seiji Sakano ,  Akira Itoh

    IPC分类号： C12N5/10 ,  C12N15/19 ,  C12N15/63

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  Y02A50/473

    摘要： A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to be usable in medicines and medical supplies.

    摘要翻译： 含有序列表中序列号1所记载的氨基酸序列的多肽，由序列表中源自人的基因编码。 由于作为有效抑制未分化血细胞增殖和分化的化学物质，预期该多肽可用于药物和医疗用品。

    Method of suppressing differentiation by administering a human serrate-1 polypeptide
    6.
    发明授权
    Method of suppressing differentiation by administering a human serrate-1 polypeptide 失效
    通过施用人血清-1多肽抑制分化的方法

    公开(公告)号：US07179622B2

    公开(公告)日：2007-02-20

    申请号：US11043357

    申请日：2005-01-27

    申请人： Seiji Sakano ,  Akira Itoh

    发明人： Seiji Sakano ,  Akira Itoh

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  C07K14/475

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  Y02A50/473

    摘要： A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to be usable in medicines and medical supplies.

    摘要翻译： 含有序列表中序列号1所记载的氨基酸序列的多肽，由序列表中源自人的基因编码。 由于作为有效抑制未分化血细胞增殖和分化的化学物质，预期该多肽可用于药物和医疗用品。

    Differentiation-suppressive polypeptide serrate-2 and methods of use
    10.
    发明授权
    Differentiation-suppressive polypeptide serrate-2 and methods of use 失效
    分化抑制多肽serrate-2和使用方法

    公开(公告)号：US07138276B2

    公开(公告)日：2006-11-21

    申请号：US10219248

    申请日：2002-08-16

    申请人： Seiji Sakano ,  Akira Itoh

    发明人： Seiji Sakano ,  Akira Itoh

    IPC分类号： C12N5/08 ,  A61K38/18

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： A novel human serrate-2 polypeptide consisting of a polypeptide containing the amino acid sequence described in SEQ ID NO:1 in the Sequence Listing and having the effect of regulating the differentiation of undifferentiated cells involving stem cells; its gene; a process for producing the same; and an antibody specifically recognizing the polypeptide.

    摘要翻译： 一种由包含序列表中SEQ ID NO：1所述的氨基酸序列的多肽组成并且具有调节涉及干细胞的未分化细胞分化的作用的新型人锯状细胞-2多肽; 其基因; 其制造方法; 和特异性识别多肽的抗体。