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公开(公告)号：US20110150893A1
公开(公告)日：2011-06-23
申请号：US12827321
申请日：2010-06-30
IPC分类号： A61K39/395 , C07K16/28 , C12N5/12 , A61P25/00 , A61P17/02 , A61P35/04 , A61P3/00 , A61P25/28 , G01N33/566 , C12N9/10
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/75 , C07K2317/92 , C07K2319/30
摘要： The present invention provides monoclonal antibodies for human TrkB. In certain embodiments the inventive antibodies bind and activate human TrkB. In certain embodiments the inventive antibodies are selective for human TrkB in that they do not bind (or activate) human TrkA or human TrkC. In some embodiments the inventive monoclonal antibodies cross-react with murine TrkB. Humanized or veneered versions of the inventive antibodies are also encompassed. Pharmaceutical compositions that comprise inventive antibodies are provided as are methods for preparing the inventive antibodies and methods of using these for treatment, detection or purification purposes.
摘要翻译： 本发明提供了人TrkB的单克隆抗体。 在某些实施方案中，本发明的抗体结合并激活人TrkB。 在某些实施方案中，本发明的抗体对人TrkB是选择性的，因为它们不结合（或激活）人TrkA或人TrkC。 在一些实施方案中，本发明的单克隆抗体与鼠TrkB交叉反应。 还包括本发明抗体的人源化或贴面版本。 提供包含本发明抗体的药物组合物以及用于制备本发明抗体的方法和使用它们用于治疗，检测或纯化目的的方法。
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公开(公告)号：US07750122B2
公开(公告)日：2010-07-06
申请号：US11446875
申请日：2006-06-05
IPC分类号： C07K16/00 , A61K39/395 , C12N5/12 , C07K1/14 , C07K16/40
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/75 , C07K2317/92 , C07K2319/30
摘要： The present invention provides monoclonal antibodies for human TrkB. In certain embodiments the inventive antibodies bind and activate human TrkB. In certain embodiments the inventive antibodies are selective for human TrkB in that they do not bind (or activate) human TrkA or human TrkC. In some embodiments the inventive monoclonal antibodies cross-react with murine TrkB. Humanized or veneered versions of the inventive antibodies are also encompassed. Pharmaceutical compositions that comprise inventive antibodies are provided as are methods for preparing the inventive antibodies and methods of using these for treatment, detection or purification purposes.
摘要翻译： 本发明提供了人TrkB的单克隆抗体。 在某些实施方案中，本发明的抗体结合并激活人TrkB。 在某些实施方案中，本发明的抗体对人TrkB是选择性的，因为它们不结合（或激活）人TrkA或人TrkC。 在一些实施方案中，本发明的单克隆抗体与鼠TrkB交叉反应。 还包括本发明抗体的人源化或贴面版本。 提供包含本发明抗体的药物组合物以及用于制备本发明抗体的方法以及将其用于治疗，检测或纯化目的的方法。
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公开(公告)号：US06989144B1
公开(公告)日：2006-01-24
申请号：US09610118
申请日：2000-06-30
申请人： Samatha J. Busfield , Jean-Luc Villeval , Martine Jandrot-Perrus , William Vainchencker , Davinder Singh Gill , Ming Diana Qian , Gillian Kingsbury
发明人： Samatha J. Busfield , Jean-Luc Villeval , Martine Jandrot-Perrus , William Vainchencker , Davinder Singh Gill , Ming Diana Qian , Gillian Kingsbury
IPC分类号： A61K39/395 , C07K16/28 , C12P21/08
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K16/2803 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein V1, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the exposure vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码糖蛋白V1的分离的核酸分子和多肽分子，血小板膜糖蛋白涉及血小板 - 胶原相互作用。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，其中引入了暴露载体的宿主细胞，以及其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US20080050380A1
公开(公告)日：2008-02-28
申请号：US11478074
申请日：2006-06-29
IPC分类号： A61K39/395 , A61P43/00 , C07K16/18
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K16/2803 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子和编码糖蛋白VI的多肽分子，其涉及血小板 - 胶原相互作用的血小板膜糖蛋白。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US07101549B2
公开(公告)日：2006-09-05
申请号：US10850034
申请日：2004-05-20
IPC分类号： A61K39/395 , A61K39/44 , C07K16/28 , C12P21/08 , G01N33/533
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K16/2803 , C07K2317/565 , C07K2317/622 , C07K2319/00
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
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公开(公告)号：US07597888B2
公开(公告)日：2009-10-06
申请号：US11478074
申请日：2006-06-29
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K16/2803 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子和编码糖蛋白VI的多肽分子，其涉及血小板 - 胶原相互作用的血小板膜糖蛋白。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。
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