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8 条记录 (耗时 0.029 秒)

    Indole derivatives
    3.
    发明授权
    Indole derivatives 失效
    吲哚衍生物

    公开(公告)号：US5496844A

    公开(公告)日：1996-03-05

    申请号：US335833

    申请日：1994-11-08

    申请人： Masatoshi Inai ,  Tadanao Shibutani ,  Jun Kanaya ,  Masako Moritake ,  Akie Tanaka

    发明人： Masatoshi Inai ,  Tadanao Shibutani ,  Jun Kanaya ,  Masako Moritake ,  Akie Tanaka

    IPC分类号： C07D209/10 ,  C07D401/12 ,  A61K31/40 ,  C07D209/04

    CPC分类号： C07D401/12 ,  C07D209/10

    摘要： The present invention provides indole derivatives of the general formula: ##STR1## The indole derivatives of the invention have potent antiestrogen activity and are useful as drugs for the treatment of estrogen-dependent diseases, such as anovulatory infertility, prostatic hypertrophy, osteoporosis, breast cancer, endometrial cancer and melanoma.

    摘要翻译： PCT No.PCT / JP93 / 00560 Sec。 371日期：1994年11月8日 102（e）1994年11月8日PCT PCT 1993年4月28日PCT公布。 公开号WO93 / 23374 日本公开日：1993年11月25日。本发明提供以下通式的吲哚衍生物：本发明的吲哚衍生物具有有效的抗雌激素活性，可用作治疗雌激素依赖性疾病的药物，例如排卵不孕， 前列腺肥大，骨质疏松症，乳腺癌，子宫内膜癌和黑素瘤。

    Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor
    4.
    发明授权
    Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor 失效

    公开(公告)号：US5420128A

    公开(公告)日：1995-05-30

    申请号：US854619

    申请日：1992-06-09

    申请人： Hiroshi Kiyokawa ,  Satoshi Yamada ,  Keisuke Miyajima ,  Kinji Hashimoto ,  Masatoshi Inai ,  Makoto Inoue ,  Kunihiko Tatsumi ,  Takeshi Yamauchi ,  Kazunobu Kurisu ,  Yoshifumi Chone

    发明人： Hiroshi Kiyokawa ,  Satoshi Yamada ,  Keisuke Miyajima ,  Kinji Hashimoto ,  Masatoshi Inai ,  Makoto Inoue ,  Kunihiko Tatsumi ,  Takeshi Yamauchi ,  Kazunobu Kurisu ,  Yoshifumi Chone

    IPC分类号： C07D487/04 ,  A61K31/53 ,  A61K31/505 ,  C07D231/38

    CPC分类号： C07D487/04

    摘要： The invention discloses a pyrimidien derivative expressed in Formula [I]: ##STR1## where R.sup.1 denotes a hydrogen atom or hydroxyl group, R.sup.2 denotes a hydrogen atom, lower alkoxycarbonyl group, lower alkoxy group, halogen atom, lower alkyl group, cycloalkyl group with 3 to 8 carbon atoms, lower alkoxycarbonyl lower alkyl group, carboxyl group, carboxy lower alkyl group, group: --CONHR.sup.6 (R.sup.6 represents a hydrogen atom, a phenyl group, which may possess halogen atom, or lower alkyl group), cyano group, phenyl group which may possess a group selected from the group consisting of hydroxyl group, halogen atom, lower alkyl group, lower alkoxy group and phenylthio group as a substituent, phenyl lower alkyl group which may possess a group selected from the group consisting of hydroxyl group and lower alkoxy group as a substituent on a phenyl ring, lower alkanoyloxy lower alkyl group, benzoyl group, lower alkanoyl group which may possess a halogen atom, or hydroxy lower alkyl group which may possess a group selected from the group consisting of phenyl group and halogen atom as a substituent, R.sup.3 denotes a hydrogen atom, hydroxyl group, lower alkyl group, cycloalkyl group with 3 to 8 carbon atoms, halogen lower alkyl group, or phenyl group, R.sup.4 denotes a hydrogen atom, lower alkyl group, or lower alkoxy group, and R.sup.5 denotes a hydrogen atom, lower alkyl group, lower alkoxy lower alkyl group, or halogen lower alkyl group; provided that R.sup.2 and R.sup.3 may be bonded to each other to form a lower alkylene group with 3 to 5 carbon atoms, or its pharmaceutically available salt. This derivative is excellent in therapeutic effects of benign prostatic hypertrophy, prostatic carcinoma, female hairiness, male baldness or pimple as an androgen inhibitor.

    Package for container of liquid medicine containing bicarbonate and pH indicator
    6.
    发明授权
    Package for container of liquid medicine containing bicarbonate and pH indicator 失效
    含有碳酸氢盐和pH指示剂的药液容器包装

    公开(公告)号：US06232128B1

    公开(公告)日：2001-05-15

    申请号：US09202497

    申请日：1998-12-16

    申请人： Seiichiro Iguchi ,  Shino Shinomiya ,  Rika Hamamoto ,  Akiyo Abe ,  Masatoshi Inai ,  Keiichi Kawakami

    发明人： Seiichiro Iguchi ,  Shino Shinomiya ,  Rika Hamamoto ,  Akiyo Abe ,  Masatoshi Inai ,  Keiichi Kawakami

    IPC分类号： G01N2177

    CPC分类号： A61J1/05 ,  A61J1/1462 ,  A61J1/16 ,  B65D79/02

    摘要： The invention relates to a bicarbonate-containing medical solution package. The package comprises a gas-permeable plastic container holding a bicarbonate-containing medical solution and a gas-impermeable plastic packaging member containing the gas-permeable plastic container. A carbon-dioxide atmosphere is established in the space between the container and packaging member. In addition, a pH indicating device is contained within the space between the container and packaging member. The pH indicating device is a gas-permeable plastic packet containing a bicarbonate-containing fluid (similar to the medical solution) and a pH indicator. The pH indicator undergoes a change in color in response to a change in pH of the fluid. Use of this package allows the easy monitoring of a change in pH and consequent aging of the medical solution due to prolonged storage or damage to the outer packaging member.

    摘要翻译： 本发明涉及含碳酸氢盐的药液包装。 该包装包括容纳含碳酸氢盐的医用溶液的透气性塑料容器和包含透气性塑料容器的不透气塑料包装构件。 在容器和包装部件之间的空间内建立二氧化碳气氛。 此外，pH指示装置容纳在容器和包装构件之间的空间内。 pH指示装置是含有含碳酸氢盐的流体（类似于药物溶液）和pH指示剂的透气塑料包装。 pH指示剂随着流体pH的变化而发生颜色变化。 使用该包装允许容易地监测由于长时间储存​​或损坏外包装构件而引起的pH变化和随之而来的医用溶液老化。