公开(公告)号：US4977179A

公开(公告)日：1990-12-11

申请号：US341234

申请日：1989-04-19

申请人： Shizuo Nakamura ,  Masatoshi Inai ,  Makoto Inoue ,  Kazushi Nagao ,  Yoshiaki Tsuda

发明人： Shizuo Nakamura ,  Masatoshi Inai ,  Makoto Inoue ,  Kazushi Nagao ,  Yoshiaki Tsuda

IPC分类号： C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  C07K5/02 ,  C07K5/06

CPC分类号： C07K5/0222 ,  A61K38/00

摘要： Disclosed is a proline derivative of the formula ##STR1## or a pharmaceutically acceptable salt thereof. These derivatives have useful utilities such as activity of inhibiting angiotensin converting enzyme.

摘要翻译： 公开了式（1）的脯氨酸衍生物或其药学上可接受的盐。 这些衍生物具有有用的用途，例如抑制血管紧张素转化酶的活性。

公开(公告)号：US4886813A

公开(公告)日：1989-12-12

申请号：US856901

申请日：1986-04-28

申请人： Shizuo Nakamura ,  Makoto Inoue ,  Masatoshi Inai ,  Yoshiaki Tsuda

发明人： Shizuo Nakamura ,  Makoto Inoue ,  Masatoshi Inai ,  Yoshiaki Tsuda

IPC分类号： A61K38/00 ,  C07K5/062

CPC分类号： C07K5/06026 ,  A61K38/00

摘要： Disclosed is a proline derivative of the formula ##STR1## or a pharmaceutically acceptable salt thereof. These derivatives have useful utilities such as activity of inhibiting angiotensin converting enzyme.

摘要翻译： 公开了式（1）的脯氨酸衍生物或其药学上可接受的盐。 这些衍生物具有有用的用途，例如抑制血管紧张素转化酶的活性。

公开(公告)号：US4642355A

公开(公告)日：1987-02-10

申请号：US703365

申请日：1985-02-20

申请人： Shizuo Nakamura ,  Makoto Inoue ,  Yoshiaki Tsuda

发明人： Shizuo Nakamura ,  Makoto Inoue ,  Yoshiaki Tsuda

IPC分类号： A61K38/00 ,  C07K5/02 ,  C07D207/00 ,  A61K37/64 ,  C07K5/06

CPC分类号： C07K5/0222 ,  A61K38/00

摘要： This invention provides a proline derivative represented by the formula ##STR1## wherein: R.sub.1 is C.sub.5 -C.sub.14 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.6 alkyl or a group ##STR2## (wherein R.sub.5 is hydrogen, C.sub.1 -C.sub.14 alkyl or phenyl and R.sub.6 is hydrogen or C.sub.1 -C.sub.6 alkyl);R.sub.2 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.3 is C.sub.1 -C.sub.6 alkyl;R.sub.4 is hydrogen, C.sub.1 -C.sub.6 alkyl or phenyl-C.sub.1 -C.sub.6 alkyl; andn is 0, 1 or 2,and a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供由式（1）表示的脯氨酸衍生物，其中：R 1是C 5 -C 14烷基，C 2 -C 6烯基，C 3 -C 8环烷基-C 1 -C 6烷基或基团（其中R 5是氢 ，C 1 -C 14烷基或苯基，R 6是氢或C 1 -C 6烷基）; R2是氢或C1-C6烷基; R3是C1-C6烷基; R 4是氢，C 1 -C 6烷基或苯基-C 1 -C 6烷基; 和n为0,1或2及其药学上可接受的盐。

公开(公告)号：US5204326A

公开(公告)日：1993-04-20

申请号：US493359

申请日：1990-03-14

申请人： Setsuro Fujii, deceased ,  by Keiko Fujii, successor ,  by Shinichiro Fujii, successor ,  by Kaoruko Takada, successor ,  Yoshihito Yamamoto ,  Fumio Shimizu ,  Masatoshi Inai ,  Naosumi Kinoshita ,  Shizuo Nakamura ,  Mitsuru Hirohashi ,  Takashi Sakamoto ,  Kazuhiko Tsutsumi ,  Tetsuhiko Shirasaka

发明人： Setsuro Fujii, deceased ,  by Keiko Fujii, successor ,  by Shinichiro Fujii, successor ,  by Kaoruko Takada, successor ,  Yoshihito Yamamoto ,  Fumio Shimizu ,  Masatoshi Inai ,  Naosumi Kinoshita ,  Shizuo Nakamura ,  Mitsuru Hirohashi ,  Takashi Sakamoto ,  Kazuhiko Tsutsumi ,  Tetsuhiko Shirasaka

IPC分类号： A61K38/00 ,  C07K14/585

CPC分类号： C07K14/585 ,  A61K38/00

摘要： Novel polypeptide derivatives, acid-addition salts thereof and complexes thereof, having the activities for inhibiting bone calcium absorption, for lowering the blood level of calcium, as analgesics, for inhibiting secretion of the gastric juice.Pharmaceutical composition can be prepared by formulating, at least one of the novel polypeptide derivatives, acid-addition salts thereof and complexes thereof, together with a proteolytic enzyme inhibitors and/or pharmaceutically acceptable acids.The pharmaceutical composition are quite effective as agents for curing hypercalcemia, for curing Peget's disease, for curing osteoporosis, analgetic agent, anti-ulcerative agent and the like.

公开(公告)号：US06753964B2

公开(公告)日：2004-06-22

申请号：US10002000

申请日：2001-12-05

申请人： Kai Chen ,  Fumihiko Omura ,  Akihito Minamitsu ,  Shizuo Nakamura

发明人： Kai Chen ,  Fumihiko Omura ,  Akihito Minamitsu ,  Shizuo Nakamura

IPC分类号： G01B1100

CPC分类号： H01L21/681

摘要： A film-thickness measurement apparatus of the present invention includes a lifter, a support mount, a light-emitting device, and a light-receiving device. With the center of a wafer staying in alignment with that of the support mount, the lifter places the wafer onto the surface of the support mount to determine the center of the wafer. While the wafer is being rotated about the center of the wafer, the light-emitting device irradiates the circumferential portion of the wafer with a laser beam, thereby allowing the position of a notch to be detected depending on whether or not the laser beam passes through the notch. This makes it possible to detect the positions of the notch and the center of the wafer to determine the center axis line of the surface of the wafer, thereby allowing the coordinates of a given position on the surface of the wafer to be defined in accordance with the center axis line and the center of the wafer. The thickness of the thin film on the surface of the wafer at the predetermined positions can then be determined.

摘要翻译： 本发明的薄膜厚度测量装置包括升降机，支撑架，发光装置和光接收装置。 随着晶片的中心保持与支撑安装座的中心对准，升降器将晶片放置在支撑座的表面上以确定晶片的中心。 当晶片围绕晶片的中心旋转时，发光器件用激光束照射晶片的圆周部分，从而根据激光束是否通过来检测凹口的位置 缺口 这使得可以检测晶片的凹口和中心的位置以确定晶片的表面的中心轴线，从而允许根据晶片的表面限定晶片表面上的给定位置的坐标 中心轴线和晶圆的中心。 然后可以确定晶片在预定位置的表面上的薄膜的厚度。

公开(公告)号：US20100095995A1

公开(公告)日：2010-04-22

申请号：US12253607

申请日：2008-10-17

申请人： Takeshi Toyoda ,  Shizuo Nakamura ,  Mikio Takimoto ,  Naoki Kidani ,  Hiroshi Kamei ,  Hiroharu Mizukoshi ,  Megumi Masui

发明人： Takeshi Toyoda ,  Shizuo Nakamura ,  Mikio Takimoto ,  Naoki Kidani ,  Hiroshi Kamei ,  Hiroharu Mizukoshi ,  Megumi Masui

IPC分类号： H01L35/00

CPC分类号： H01L35/34 ,  H01L35/22 ,  H01L35/32

摘要： The present invention provides a thermoelectric conversion module, comprising plural first electrode films (11, 12, 13) formed apart from each other on the top surface of an insulating body (10), plural p- and n-type thermoelectric semiconductor element films (16, 19) and (17, 18) formed thereon, which are arranged apart from each other so that p- and n-type thermoelectric semiconductor element films alternate with each other, and second electrode films (20) connecting p-type thermoelectric semiconductor element film (19) and n-type thermoelectric semiconductor element film (18) over the gaps between the first electrode films; and a terminal electrode is connected to each of the p-and n-type thermoelectric semiconductor element film (16, 17) at the end; and a production method thereof. The thermoelectric conversion module of the present invention, which can be produced at a low cost using thermoelectric conversion elements having a thin-film structure, is excellent in thermal stability and chemical durability and enables to secure high thermoelectric conversion efficiency.

摘要翻译： 本发明提供了一种热电转换模块，其包括在绝缘体（10）的顶表面上彼此分开形成的多个第一电极膜（11,12,13），多个p型和n型热电半导体元件膜 16和19）和（17,18），它们彼此分开布置，使得p型和n型热电半导体元件膜彼此交替;以及第二电极膜（20），连接p型热电半导体 元件膜（19）和n型热电半导体元件膜（18），位于第一电极膜之间的间隙上。 并且端子电极在端部连接到p型和n型热电半导体元件膜（16,17）中的每一个; 及其制造方法。 可以使用具有薄膜结构的热电转换元件以低成本制造的本发明的热电转换模块具有优异的热稳定性和化学耐久性，并且能够确保高的热电转换效率。

公开(公告)号：US5155129A

公开(公告)日：1992-10-13

申请号：US662105

申请日：1991-02-28

申请人： Toshio Tatsuoka ,  Kayoko Nomura ,  Yuzo Nakagawa ,  Shizuo Nakamura

发明人： Toshio Tatsuoka ,  Kayoko Nomura ,  Yuzo Nakagawa ,  Shizuo Nakamura

IPC分类号： A61K31/35 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P25/28 ,  C07D311/94 ,  C07D315/00

CPC分类号： A61K31/35 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  C07D311/94

摘要： A therapeutic agent for alleviating disorders caused by nerve cell degeneration in the brain which contains a cyclopropachromen derivative represented by the following general formula (I): ##STR1## wherein n is an integer of from 2 to 5;the carbon atom in the --(CH.sub.2).sub.n -- moiety may be optionally substituted with a methyl group or a hydroxyl group;R.sup.1 and R.sup.2 independently represent a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms; or alternatively R.sup.1 and R.sup.2 form together with the nitrogen atom to which they are attached, a morpholino group, a thiomorpholino group, a pyrrolidinyl group, a piperidinyl group, a homopiperidinyl group, a piperazinyl group, a homopiperazinyl group, an N-alkylpiperazinyl group, N-alkylhomopiperazinyl group, an N-hydroxyalkylpiperazinyl group or a pyrrolidonyl group or alternatively R.sup.1 and R.sup.2 form together with the nitrogen atom to which they are attached, and further a carbon atom to which said nitrogen atom is bound, a pyrrolitidinyl group;A.sup.1 and A.sup.2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an optionally substituted alkoxy group, an acyloxy group, a carbamyloxy group or an optionally substituted carboxyl group;and B.sup.1 and B.sup.2 independently represents a hydrogen atom, a halogen atom, a nitro group, a cyano group, an optionally halogenated alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an optionally substituted carboxyl group;or a pharmaceutically acceptable salt thereof as an active ingredient, together with a pharmaceutical carrier or adjuvant.

公开(公告)号：US06700370B2

公开(公告)日：2004-03-02

申请号：US09985526

申请日：2001-11-05

申请人： Kai Chen ,  Shizuo Nakamura ,  Akihito Minamitsu

发明人： Kai Chen ,  Shizuo Nakamura ,  Akihito Minamitsu

IPC分类号： G01B706

CPC分类号： G01B7/085 ,  G01B7/105 ,  G01B21/08

摘要： The thickness of a conductive film formed on a substrate can be measured efficiently at low cost with a film thickness measuring apparatus of the invention, which includes an eddy current coil sensor, disposable at a predetermined position near a conductive film, for generating a predetermined eddy current in the conductive film and for detecting a magnetic field caused by the eddy current. The apparatus also includes a displacement sensor for measuring a displacement between the eddy current coil sensor and the conductive film. The thickness of the conductive film is measured in accordance with a variation in inductance of the eddy current coil sensor and the amount of displacement measured by the displacement sensor.

摘要翻译： 可以通过本发明的膜厚测量装置以低成本有效地测量形成在基板上的导电膜的厚度，其包括涡流线圈传感器，在导电膜附近的预定位置处一次性地用于产生预定的涡流 导电膜中的电流和用于检测由涡流引起的磁场。 该装置还包括用于测量涡流线圈传感器和导电膜之间的位移的位移传感器。 导电膜的厚度根据涡电流线圈传感器的电感变化和位移传感器测量的位移量来测量。

公开(公告)号：US4875065A

公开(公告)日：1989-10-17

申请号：US155316

申请日：1988-02-12

申请人： Takayuki Kubodera ,  Shizuo Nakamura ,  Masanori Onizawa ,  Hirotaka Shiroshita ,  Eiichi Mochizuki ,  Masao Tsujimura ,  Toshikatsu Atsuta ,  Takayoshi Morooka

发明人： Takayuki Kubodera ,  Shizuo Nakamura ,  Masanori Onizawa ,  Hirotaka Shiroshita ,  Eiichi Mochizuki ,  Masao Tsujimura ,  Toshikatsu Atsuta ,  Takayoshi Morooka

IPC分类号： G03B17/02 ,  G03B19/12

CPC分类号： G03B17/02 ,  G03B19/12

摘要： In a camera whose camera body is extended along the optical axis, the camera body has a camera body gripping recess at a position where the index, middle, ring and little fingers ae placed when the operator holds the camera with the hand from below so that the operator can hold the camera stable with the hand for a long period of time.

摘要翻译： 在相机体沿着光轴延伸的相机中，当操作者用手从下方握住相机时，照相机主体具有在索引，中间，环和小手指放置的位置处的照相机主体夹持凹部，使得 操作者可以长时间用手握住相机的稳定性。

公开(公告)号：US4637808A

公开(公告)日：1987-01-20

申请号：US701874

申请日：1985-02-15

申请人： Shizuo Nakamura

发明人： Shizuo Nakamura

IPC分类号： B62M9/1242 ,  B62M9/126 ,  B62M9/127 ,  B62M9/16 ,  F16H9/24

CPC分类号： B62M9/16

摘要： A bicycle rear derailleur including a tensioner frame which rotatably support a guide pulley and a tension pulley, a shifter for shifting the tensioner frame in directions substantially parallel to an axis of a rear wheel hub, the tensioner frame including a tension pulley support arm which is resiliently urged to pivotally move rearwardly of the bicycle, and a compensating mechanism for compensating a sagging in an endless drive chain, which is arranged to stretch out the drive chain rearwardly of the bicycle so that a distance between a geometrical vertical line passing through a center of the tension pulley and a vertical tangential line at a rearmost point of a rearwardly stretched portion of the drive chain is larger than a radius of the guide pulley when the tension pulley support arm takes its rearmost position.

摘要翻译： 一种自行车后拨链器，包括可旋转地支撑引导滑轮和张力滑轮的张紧器框架，用于使张紧器框架沿大致平行于后轮毂的轴线的方向移动的换档器，张紧器框架包括张力皮带轮支撑臂， 弹性地推动以自行车向后枢转运动，以及用于补偿环形驱动链中的下垂的补偿机构，其被布置成将自行车后方的驱动链拉伸，使得穿过中心的几何垂直线之间的距离 并且当张紧皮带轮支撑臂处于其最后位置时，在驱动链的向后延伸部分的最后部点处的垂直切向线大于引导滑轮的半径。