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公开(公告)号:US07811790B2
公开(公告)日:2010-10-12
申请号:US12096789
申请日:2006-11-08
申请人: Seung-Hwan Park , Jihyun F. Kim , ChoongHwan Lee , Soo-Keun Choi , Heayoung Jeong , Seong-Bin Kim , Yon Kyoung Park , Rumi Kim , Choong-Min Ryu , Soo-Young Park
发明人: Seung-Hwan Park , Jihyun F. Kim , ChoongHwan Lee , Soo-Keun Choi , Heayoung Jeong , Seong-Bin Kim , Yon Kyoung Park , Rumi Kim , Choong-Min Ryu , Soo-Young Park
CPC分类号: C12N15/52
摘要: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin synthetase of the present invention can be effectively used for the increase of productivity of polymyxin and the development of a novel antibiotic.
摘要翻译: 本发明涉及从革兰氏阳性Paenibacillus sp。分离的多粘菌素合成酶。 和编码该基因簇的基因簇,更确切地说,是从多粘类芽孢杆菌E681分离的多粘菌素合成酶,其编码基因簇和使用该基因簇的多粘菌素或其衍生物的制备方法。 本发明的多粘菌素合成酶可有效地用于提高多粘菌素的生产力和开发新的抗生素。
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公开(公告)号:US08329430B2
公开(公告)日:2012-12-11
申请号:US12728039
申请日:2010-03-19
申请人: Seung-Hwan Park , Jihyun F Kim , ChoongHwan Lee , Soo-Keun Choi , Heayoung Jeong , Seong-Bin Kim , Yon Kyoung Park , Rumi Kim , Choong-Min Ryu , Soo-Young Park
发明人: Seung-Hwan Park , Jihyun F Kim , ChoongHwan Lee , Soo-Keun Choi , Heayoung Jeong , Seong-Bin Kim , Yon Kyoung Park , Rumi Kim , Choong-Min Ryu , Soo-Young Park
摘要: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, ATCC21830 and F4 strains, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin synthetase of the present invention can be effectively used for the increase of productivity of polymyxin and the development of a novel antibiotic.
摘要翻译: 本发明涉及从革兰氏阳性Paenibacillus sp。分离的多粘菌素合成酶。 和编码其的基因簇,更确切地说,分离自多形性粘虫芽孢杆菌E681,ATCC21830和F4菌株的多粘菌素合成酶,其编码的基因簇和使用该基因簇的多粘菌素或其衍生物的制备方法。 本发明的多粘菌素合成酶可有效地用于提高多粘菌素的生产力和开发新的抗生素。
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公开(公告)号:US20100279347A1
公开(公告)日:2010-11-04
申请号:US12728039
申请日:2010-03-19
申请人: Seung-Hwan Park , Jihyun F. Kim , ChoongHwan Lee , Soo-Keun Choi , Heayoung Jeong , Seong-Bin Kim , Yon Kyoung Park , Rumi Kim , Choong-Min Ryu , Soo-Young Park
发明人: Seung-Hwan Park , Jihyun F. Kim , ChoongHwan Lee , Soo-Keun Choi , Heayoung Jeong , Seong-Bin Kim , Yon Kyoung Park , Rumi Kim , Choong-Min Ryu , Soo-Young Park
摘要: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, ATCC21830 and F4 strains, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin synthetase of the present invention can be effectively used for the increase of productivity of polymyxin and the development of a novel antibiotic.
摘要翻译: 本发明涉及从革兰氏阳性Paenibacillus sp。分离的多粘菌素合成酶。 和编码其的基因簇,更确切地说,分离自多形性粘虫芽孢杆菌E681,ATCC21830和F4菌株的多粘菌素合成酶,其编码的基因簇和使用该基因簇的多粘菌素或其衍生物的制备方法。 本发明的多粘菌素合成酶可有效地用于提高多粘菌素的生产力和开发新的抗生素。
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公开(公告)号:US20090226964A1
公开(公告)日:2009-09-10
申请号:US12096789
申请日:2006-11-08
申请人: Seung-Hwan Park , Jihyun F. Kim , ChoongHwan Lee , Soo-Keun Choi , Heayoung Jeong , Seong-Bin Kim , Yon Kyoung Park , Rumi Kim , Choong-Min Ryu , Soo-Young Park
发明人: Seung-Hwan Park , Jihyun F. Kim , ChoongHwan Lee , Soo-Keun Choi , Heayoung Jeong , Seong-Bin Kim , Yon Kyoung Park , Rumi Kim , Choong-Min Ryu , Soo-Young Park
CPC分类号: C12N15/52
摘要: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin synthetase of the present invention can be effectively used for the increase of productivity of polymyxin and the development of a novel antibiotic.
摘要翻译: 本发明涉及从革兰氏阳性Paenibacillus sp。分离的多粘菌素合成酶。 和编码该基因簇的基因簇,更确切地说,是从多粘类芽孢杆菌E681分离的多粘菌素合成酶,其编码基因簇和使用该基因簇的多粘菌素或其衍生物的制备方法。 本发明的多粘菌素合成酶可有效地用于提高多粘菌素的生产力和开发新的抗生素。
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