公开(公告)号：US20120122895A1

公开(公告)日：2012-05-17

申请号：US12922527

申请日：2010-08-20

申请人： Shan Jiang ,  Xinglong Xing ,  Qishan Wang ,  Ren Kong

发明人： Shan Jiang ,  Xinglong Xing ,  Qishan Wang ,  Ren Kong

IPC分类号： A61K31/437 ,  A61P35/00 ,  A61P29/00 ,  A61P37/06 ,  A61P13/12 ,  A61K31/52 ,  A61P17/06 ,  A61P27/02 ,  C07D487/04 ,  A61K31/519 ,  C07D473/00 ,  C07D471/04 ,  A61P3/10

CPC分类号： C07D471/04

摘要： The present invention provides 5,6-bicyclic heteroaryl-containing urea compounds of Formula I or II and use of the same for treating conditions mediated by protein kinase such as VEGFR2, c-Met, PDGFRβ c-Kit, CSF1R, or EphA2.

摘要翻译： 本发明提供了式I或II的5,6-双环杂芳基脲化合物及其用于治疗由蛋白激酶介导的病症如VEGFR2，c-Met，PDGFR＆bgr; c-Kit，CSF1R或EphA2。

公开(公告)号：US08648086B2

公开(公告)日：2014-02-11

申请号：US12922527

申请日：2010-08-20

申请人： Shan Jiang ,  Xinglong Xing ,  Qishan Wang ,  Ren Kong

发明人： Shan Jiang ,  Xinglong Xing ,  Qishan Wang ,  Ren Kong

IPC分类号： A61K31/52 ,  C07D513/02

CPC分类号： C07D471/04

摘要： The present invention provides 5,6-bicyclic heteroaryl-containing urea compounds of Formula I or II and use of the same for treating conditions mediated by protein kinase such as VEGFR2, c-Met, PDGFRβ c-Kit, CSF1R, or EphA2.

摘要翻译： 本发明提供式I或II的5,6-双环杂芳基脲化合物及其用于治疗由蛋白激酶（例如VEGFR2，c-Met，PDGFRβC-Kit，CSF1R或EphA2）介导的病症的用途。

公开(公告)号：US20130165475A1

公开(公告)日：2013-06-27

申请号：US13817505

申请日：2011-09-01

申请人： Shan Jiang ,  Qishan Wang ,  Xiaoyong Gao

发明人： Shan Jiang ,  Qishan Wang ,  Xiaoyong Gao

IPC分类号： C07D401/06 ,  C07D471/04

CPC分类号： C07D401/06 ,  C07D403/06 ,  C07D471/04

摘要： The present invention provides deuterium-enriched heteroaryl-containing urea compounds (I) and use of the same for treating conditions mediated by protein kinase such as

摘要翻译： 本发明提供了含氘富含杂芳基的脲化合物（I）及其用于治疗蛋白激酶介导的病症，例如

公开(公告)号：US10748754B2

公开(公告)日：2020-08-18

申请号：US16123207

申请日：2018-09-06

申请人： Shan Jiang

发明人： Shan Jiang ,  Genming Jin

IPC分类号： H01J49/38 ,  H01J49/02

摘要： An isotope mass spectrometer including: an electron cyclotron resonance ion source, a front-end analysis device, a back-end analysis device and an ion detector; where the electron cyclotron resonance ion source is connected with the front-end analysis device, and is used for generating ion beams of multivalent charge states; the front-end analysis device is connected with the back-end analysis device, selects and separates the ion beams, and receives ion beams of constant, microscale and trace levels; the back-end analysis device is connected with the ion detector, and is used for eliminating a background of an isotope to be measured at an ultratrace level; and the ion detector is used for receiving ion beams of the ultratrace level, and carrying out energy measurement and separation on the ion beams of the ultratrace level, so as to obtain the isotope to be measured at the ultratrace level.

公开(公告)号：US20160034576A1

公开(公告)日：2016-02-04

申请号：US14446171

申请日：2014-07-29

申请人： Shan Jiang

发明人： Shan Jiang

IPC分类号： G06F17/30

CPC分类号： G06F17/30893 ,  G06F17/3051 ,  G06F17/30864

摘要： Techniques are described for creating a context-aware landing page. A context-aware landing page is capable of dynamically updating its tiles to include content tiles which are related to a received triggering event. The triggering event can be received from a business context source. When the triggering event is received, a weighting table that contains a plurality of content tiles can be retrieved. The method can then select one or more content tiles to include in the context-aware landing page. The selection of the one or more content tiles can depend on the triggering event.

摘要翻译： 描述了创建上下文感知着陆页的技术。 上下文感知着陆页能够动态地更新其瓦片以包括与接收的触发事件相关的内容瓦片。 可以从业务上下文源接收触发事件。 当接收到触发事件时，可以检索包含多个内容瓦片的加权表。 该方法然后可以选择一个或多个内容瓦片以包括在上下文感知登陆页面中。 一个或多个内容瓦片的选择可以取决于触发事件。

公开(公告)号：US20080311105A1

公开(公告)日：2008-12-18

申请号：US12197617

申请日：2008-08-25

申请人： Thomas P. Zimmerman ,  Valery Novokhatny ,  Shan Jiang ,  James Colandene

发明人： Thomas P. Zimmerman ,  Valery Novokhatny ,  Shan Jiang ,  James Colandene

IPC分类号： A61K38/48

CPC分类号： C12N9/6435 ,  A61K38/4833 ,  A61K38/484 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  C12N9/96 ,  C12N9/99 ,  C12Y304/21007

摘要： The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.

摘要翻译： 本发明提供一种纤维蛋白溶解组合物，其可用作用于给予具有血栓闭塞的患者的治疗剂。 在本发明的一个方面，纤维蛋白溶解组合物包含基本上不含纤溶酶原激活剂的可逆失活的酸化丝氨酸蛋白酶，低缓冲能力的缓冲液和任选的稳定剂。 在本发明的另一方面，本发明的纤维蛋白溶解组合物包含基本上不含纤溶酶原激活剂，低缓冲能力缓冲液和任选的稳定剂的可逆灭活的酸化纤溶酶。

公开(公告)号：US20060180579A1

公开(公告)日：2006-08-17

申请号：US11056544

申请日：2005-02-11

申请人： Ross Popescu ,  Shan Jiang

发明人： Ross Popescu ,  Shan Jiang

IPC分类号： B23K15/00

CPC分类号： H01L21/67092 ,  B23K26/704 ,  B26F3/008

摘要： A single multidirectional chuck for use with a cutting beam such as a fluid jet is disclosed. The single multidirectional chuck includes a first set of cutting slots oriented in a first direction and a second set of cutting slots oriented in a second direction that is transverse to the first direction. One set of cutting slots extends entirely through the chuck so that the cutting beam may pass therethrough. The other set of cutting slots, which are transverse to the first set, only extend partially into the chuck. The partially extended cutting slots each provide a space that leads to a sacrificial member housed with a cavity in the single chuck. During a cutting operation, the cutting beam passes through the partially extended cutting slots and bombards the sacrificial member. The sacrificial member is configured to sacrifice itself in order to protect the structural components of the chuck. The sacrificial member is also configured to temper and redirect the flow of the fluid jet so that it can be exhausted out of the chuck as for example through the fully extended cutting slots.

摘要翻译： 公开了一种用于与诸如流体射流的切割梁一起使用的单个多向卡盘。 单个多向卡盘包括沿第一方向定向的第一组切割槽和在横向于第一方向的第二方向上定向的第二组切割槽。 一组切割槽完全延伸穿过卡盘，使得切割梁可以穿过其中。 与第一组横向的另一组切割槽仅部分地延伸到卡盘中。 部分延伸的切割槽各自提供通向在单个卡盘中容纳有空腔的牺牲部件的空间。 在切割操作期间，切割光束穿过部分延伸的切割槽并且轰击牺牲部件。 牺牲构件被配置为牺牲自身以保护卡盘的结构部件。 牺牲构件还构造成回弹和重定向流体射流的流动，使得其可以例如通过完全延伸的切割槽从卡盘中排出。

公开(公告)号：US20060140373A1

公开(公告)日：2006-06-29

申请号：US10539603

申请日：2003-06-30

申请人： Xiangdong Liu ,  Yujin Luo ,  Yuanyi Zhang ,  Jingnan Huang ,  Weifeng Zhuang ,  Dekui Zhang ,  Yanpin Ren ,  Ming Li ,  Chuang Meng ,  Shan Jiang

发明人： Xiangdong Liu ,  Yujin Luo ,  Yuanyi Zhang ,  Jingnan Huang ,  Weifeng Zhuang ,  Dekui Zhang ,  Yanpin Ren ,  Ming Li ,  Chuang Meng ,  Shan Jiang

IPC分类号： H04M3/42 ,  H04Q7/20

CPC分类号： H04L12/2809 ,  H04L12/2836 ,  H04L12/66

摘要： This invention discloses a method of calling service among devices in home network, comprising following steps: a service calling party obtains a service handle of the called service by using the characterized information of the service, sends a service calling request information to a called party by using the obtained called service handle; the protocol stack of the called party determines whether or not the called service exists based on the service handle of the called service contained in the request information and whether or not the called service has established a renting relationship with the service calling party after receiving the request information, if not, the flow will be ended; if it is, the called party sends service call response message containing service call result to the service calling party; after receiving the service call response message, the protocol stack of the service calling patty determines whether or not the service exist based on the service handle of the called service included in the response message, and whether or not the calling service has established a renting relationship with the called party, if it is, the service calling party and the called party start the actual interacting processing of the service call; otherwise, the flow is ended. This method allows each of devices in the home network to share resources and ensure the reliability of the service call.

摘要翻译： 本发明公开了一种在家庭网络中的设备之间呼叫业务的方法，包括以下步骤：业务主叫方通过使用业务的特征信息获取被叫业务的业务句柄，通过以下方式向被叫方发送业务呼叫请求信息 使用获得的被叫服务句柄; 被叫方的协议栈根据请求信息中包含的被叫业务的业务句柄确定被叫业务是否存在，被叫业务是否在收到请求后与业务主叫方建立租用关系 信息，如果没有，流程将会结束; 如果是，则被叫方向服务呼叫方发送包含服务呼叫结果的服务呼叫响应消息; 在接收到业务呼叫响应消息之后，业务呼叫业务的协议栈基于响应消息中包含的被叫业务的业务句柄确定业务是否存在，以及呼叫业务是否建立了租用关系 如果是被叫方，则业务呼叫方和被叫方开始业务呼叫的实际交互处理; 否则，流程结束。 该方法允许家庭网络中的每个设备共享资源并确保服务呼叫的可靠性。

公开(公告)号：US20060009171A1

公开(公告)日：2006-01-12

申请号：US10888842

申请日：2004-07-09

申请人： Zhiwei Xu ,  Shan Jiang ,  Charles Chien

发明人： Zhiwei Xu ,  Shan Jiang ,  Charles Chien

IPC分类号： H04B1/02 ,  H04B1/04

CPC分类号： H04B1/0475

摘要： A system or method for calibrating an RF transmitter includes inputting a test tone to the RF transmitter. LO leakage calibration is performed on an output of the RF transmitter with the test tone inputted thereto, in order to determine a minimum LO leakage. Thereafter, sideband image calibration is performed on the output of the RF transmitter with the test tone inputted thereto, in order to determine a minimum sideband image. Operational values for the RF transmitter are stored in memory based on the detected minimum LO leakage and the detected minimum sideband image, to be used during a normal operation mode of the RF transmitter.

摘要翻译： 用于校准RF发射机的系统或方法包括将测试音调输入到RF发射机。 在输入了测试音的RF发射机的输出上执行LO泄漏校准，以便确定最小的LO泄漏。 此后，对输入了测试音的RF发射机的输出执行边带图像校准，以便确定最小边带图像。 基于检测到的最小LO泄漏和检测到的最小边带图像将RF发射机的操作值存储在存储器中，以在RF发射机的正常操作模式期间使用。

公开(公告)号：US20050282147A1

公开(公告)日：2005-12-22

申请号：US11084085

申请日：2005-03-17

申请人： Andrew Feinberg ,  Liora Strichman-Almashanu ,  Shan Jiang

发明人： Andrew Feinberg ,  Liora Strichman-Almashanu ,  Shan Jiang

IPC分类号： A01K67/027 ,  A61P35/00 ,  C12N5/074 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  C12Q1/00 ,  C12N5/08

CPC分类号： C12N5/0611 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/235 ,  C12N2501/385 ,  C12N2502/13 ,  C12N2503/00 ,  C12N2503/02 ,  C12N2510/00 ,  C12N2517/00 ,  C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/154

摘要： Genomic imprinting is a parent of origin-dependent gene silencing that involves marking of alleles in the germline and differential expression in somatic cells of the offspring. Imprinted genes and abnormal imprinting have been implicated in development, human disease, and embryonic stem cell transplantation. We have established a model system for genomic imprinting using pluripotent 8.5 d.p.c. mouse embryonic germ (EG) cell lines derived from an interspecific cross. We find that allele-specific imprinted gene expression has been lost in these cells. However, partial restoration of allele-specific silencing can occur for some imprinted genes after in vitro differentiation of EG cells into somatic cell lineages, indicating the presence of a gametic memory that is separable from allele-specific gene silencing. We have also generated a library containing most methylated CpG islands. A subset of these clones was analyzed and revealed a subdivision of methylated CpG islands into 4 distinct subtypes: CpG islands belonging to high copy number repeat families; unique CpG islands methylated in all tissues; unique methylated CpG islands that are unmethylated in the paternal germline; and unique CpG islands methylated in tumors. This approach identifies a methylome of methylated CpG islands throughout the genome.

摘要翻译： 基因印记是起源依赖基因沉默的亲本，其涉及在种系中标记等位基因和在后代的体细胞中的差异表达。 印迹基因和异常印记涉及发育，人类疾病和胚胎干细胞移植。 我们已经建立了使用多能8.5 d.p.c的基因组印迹模型系统。 来自种间交叉的小鼠胚胎胚芽（EG）细胞系。 我们发现在这些细胞中已经丢失了等位基因特异性印记的基因表达。 然而，在将EG细胞体外分化成体细胞谱系后，一些印迹基因可能发生等位基因特异性沉默的部分恢复，表明存在可与等位基因特异性基因沉默分离的配子记忆。 我们还生成了一个包含大多数甲基化CpG岛的文库。 分析了这些克隆的一个子集，并揭示了甲基化CpG岛分为4个不同的亚型：属于高拷贝数重复家族的CpG岛; 所有组织中独特的CpG岛甲基化; 在父系种系中未甲基化的独特的甲基化CpG岛; 和独特的CpG岛在肿瘤中甲基化。 该方法鉴定了整个基因组中甲基化CpG岛的甲基化。