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1.发明申请公开(公告)号：US20160158307A1
公开(公告)日：2016-06-09
申请号：US15044043
申请日：2016-02-15
申请人： Shanghui Hu , Lucy Xiumin Zhao , Jinying Ning , Xufang Tian , Chao Li , Wei Hu , Xu Liu , Bonnie Y. Hu
发明人： Shanghui Hu , Lucy Xiumin Zhao , Jinying Ning , Xufang Tian , Chao Li , Wei Hu , Xu Liu , Bonnie Y. Hu
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K5/0205 , C07K16/2863 , C07K16/32
摘要： The present invention provides a family of novel cytotoxic pentapeptides, which show potent antitumor activities against several cancer lines. The antibody-drug conjugates prepared from those pentapeptides can efficiently kill cancer cells.
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2.发明申请Potent and Efficient Cytotoxic Peptides and Antibody-Drug Conjugates thereof and Their Synthesis 审中-公开有效和高效的细胞毒性肽及其抗体 - 药物结合物及其合成公开(公告)号：US20150284425A1
公开(公告)日：2015-10-08
申请号：US14515807
申请日：2014-10-16
申请人： Shanghui Hu , Lucy Xiumin Zhao , Jinying Ning , Xufang Tian
发明人： Shanghui Hu , Lucy Xiumin Zhao , Jinying Ning , Xufang Tian
CPC分类号： C07K5/0207 , A61K38/00 , A61K47/48438 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K5/0205 , C07K5/06052 , C07K7/02
摘要： The present invention provides a family of novel cytotoxic pentapeptides, which show potent antitumor activities against several cancer lines. The antibody-drug conjugates prepared from those pentapeptides can efficiently kill cancer cells.
摘要翻译： 本发明提供了一种新的细胞毒性五肽家族，其对几种癌细胞系显示出有效的抗肿瘤活性。 从这些五肽制备的抗体 - 药物偶联物可以有效地杀死癌细胞。
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3.发明授权Potent and efficient cytotoxic peptides and antibody-drug conjugates thereof and their synthesis 有权有效和高效的细胞毒性肽及其抗体 - 药物偶联物及其合成公开(公告)号：US09260478B2
公开(公告)日：2016-02-16
申请号：US14515807
申请日：2014-10-16
申请人： Shanghui Hu , Lucy Xiumin Zhao , Jinying Ning , Xufang Tian
发明人： Shanghui Hu , Lucy Xiumin Zhao , Jinying Ning , Xufang Tian
CPC分类号： C07K5/0207 , A61K38/00 , A61K47/48438 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K5/0205 , C07K5/06052 , C07K7/02
摘要： The present invention provides a family of novel cytotoxic pentapeptides, which show potent antitumor activities against several cancer lines. The antibody-drug conjugates prepared from those pentapeptides can efficiently kill cancer cells.
摘要翻译： 本发明提供了一种新的细胞毒性五肽家族，其对几种癌细胞系显示出有效的抗肿瘤活性。 从这些五肽制备的抗体 - 药物偶联物可以有效地杀死癌细胞。
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公开(公告)号：US08759345B2
公开(公告)日：2014-06-24
申请号：US12990104
申请日：2009-04-28
申请人： Frances Meredith Hocutt , Barry Eastman Leonard, Jr. , Hillary M Peltier , Victor K. Phuong , Michael H. Rabinowitz , Mark D Rosen , Kyle T. Tarantino , Hariharan Venkatesan , Lucy Xiumin Zhao
发明人： Frances Meredith Hocutt , Barry Eastman Leonard, Jr. , Hillary M Peltier , Victor K. Phuong , Michael H. Rabinowitz , Mark D Rosen , Kyle T. Tarantino , Hariharan Venkatesan , Lucy Xiumin Zhao
IPC分类号： C07D403/04 , C07D403/14 , C07D487/04 , C07D401/14 , C07D413/14 , C07D471/04 , C07D513/04 , C07D487/14 , A61K31/5377 , A61K31/454 , A61K31/437 , A61K31/429 , A61K31/496 , A61K31/4985 , A61K31/52 , A61P7/06
CPC分类号： C07D403/04 , C07D235/24 , C07D403/14 , C07D471/04 , C07D473/40 , C07D487/04 , C07D513/04
摘要： The present invention is directed to benzoimidazole compounds of the formula (1) and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity.
摘要翻译： 本发明涉及式（1）的苯并咪唑化合物及其对映体，非对映异构体，外消旋体及其药学上可接受的盐。 本发明的化合物可用于治疗由脯氨酰羟化酶活性调节的疾病状态，病症和状况的药物组合物和方法。
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公开(公告)号：US20110046132A1
公开(公告)日：2011-02-24
申请号：US12990104
申请日：2009-04-28
申请人： Frances Meredith Hocutt , Barry Eastman Leonard, JR. , Hillary M. Peltier , Victor K. Phuong , Michael H. Rabinowitz , Mark D. Rosen , Kyle T. Tarantino , Hariharan Venkatesan , Lucy Xiumin Zhao
发明人： Frances Meredith Hocutt , Barry Eastman Leonard, JR. , Hillary M. Peltier , Victor K. Phuong , Michael H. Rabinowitz , Mark D. Rosen , Kyle T. Tarantino , Hariharan Venkatesan , Lucy Xiumin Zhao
IPC分类号： A61K31/5377 , C07D403/04 , C07D403/14 , C07D401/14 , C07D413/14 , C07D471/04 , C07D513/04 , C07D487/14 , C07D487/04 , C07D473/40 , A61K31/4184 , A61K31/454 , A61K31/437 , A61K31/429 , A61K31/496 , A61K31/4985 , A61K31/52 , A61P7/06 , A61P9/10 , A61P9/00 , A61P3/10 , A61P3/04 , A61P29/00 , A61P17/02 , A61P19/08
CPC分类号： C07D403/04 , C07D235/24 , C07D403/14 , C07D471/04 , C07D473/40 , C07D487/04 , C07D513/04
摘要： The present invention is directed to benzoimidazole compounds of the formula (1) and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity.
摘要翻译： 本发明涉及式（1）的苯并咪唑化合物及其对映体，非对映异构体，外消旋体及其药学上可接受的盐。 本发明的化合物可用于治疗由脯氨酰羟化酶活性调节的疾病状态，病症和状况的药物组合物和方法。
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