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    GAS-CONTAINING LIPOSOMES
    1.
    发明申请
    GAS-CONTAINING LIPOSOMES 有权
    含气体脂质体

    公开(公告)号：US20080175893A1

    公开(公告)日：2008-07-24

    申请号：US11873256

    申请日：2007-10-16

    申请人： Shaoling Huang ,  Robert C. MacDonald ,  Patrick Kee ,  David McPherson

    发明人： Shaoling Huang ,  Robert C. MacDonald ,  Patrick Kee ,  David McPherson

    IPC分类号： A61K9/127 ,  A61P9/10

    CPC分类号： A61K9/127 ,  A61K9/0009 ,  A61K9/1277 ,  A61K9/19 ,  Y10S977/907

    摘要： The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).

    摘要翻译： 本发明提供含气体的脂质体。 特别地，本发明提供产生气体在压力下引入气体的含气体脂质体的方法，以及含有大量气体的含气体脂质体（例如，每5mg含气体的气体为10μl气体 脂质体）。 在某些实施方案中，含气体脂质体含有一氧化氮气体。 在一些实施方案中，这种含氧化氮的脂质体用于治疗可由一氧化氮气体治疗的医学病症（例如，内膜增生）。

    Gas-containing liposomes
    2.
    发明授权
    Gas-containing liposomes 有权
    含气体的脂质体

    公开(公告)号：US07976743B2

    公开(公告)日：2011-07-12

    申请号：US11873256

    申请日：2007-10-16

    申请人： Shaoling Huang ,  Patrick Kee ,  Robert C. MacDonald ,  David McPherson

    发明人： Shaoling Huang ,  Patrick Kee ,  Robert C. MacDonald ,  David McPherson

    IPC分类号： A61K9/127 ,  A61K51/00 ,  C12N15/88

    CPC分类号： A61K9/127 ,  A61K9/0009 ,  A61K9/1277 ,  A61K9/19 ,  Y10S977/907

    摘要： The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).

    摘要翻译： 本发明提供含气体的脂质体。 特别地，本发明提供产生气体在压力下引入气体的含气体脂质体的方法，以及含有大量气体的含气体脂质体（例如，每5mg含气体的气体为10μl气体 脂质体）。 在某些实施方案中，含气体脂质体含有一氧化氮气体。 在一些实施方案中，这种含氧化氮的脂质体用于治疗可由一氧化氮气体治疗的医学病症（例如，内膜增生）。

    Elevator system
    4.
    发明授权
    Elevator system 失效
    电梯系统

    公开(公告)号：US4511017A

    公开(公告)日：1985-04-16

    申请号：US534005

    申请日：1983-09-20

    申请人： Robert C. MacDonald

    发明人： Robert C. MacDonald

    IPC分类号： B66B1/18 ,  B66B5/02

    CPC分类号： B66B5/02

    摘要： An elevator system, and method of operating same, in which emergency back-up service is provided all floors of a building when normal service is degraded, such as due to a dispatcher malfunction, a communication failure between the elevator cars of a bank of cars and a group supervisory controller or dispatcher, failure of the hall call circuits, and the like. When the emergency service is provided, a different initial block of floors is assigned to each elevator car, and as each elevator car completes a round trip its block of assignments are revised in a rotational manner. Thus, all floors are guaranteed service as long as at least one elevator car is operational.

    摘要翻译： 一种电梯系统及其操作方法，其中当正常服务劣化时，建筑物的所有楼层都提供紧急备用服务，例如由于调度员故障，一排汽车的电梯轿厢之间的通信故障 以及组管理控制器或调度员，门厅呼叫电路的故障等。 当提供紧急服务时，向每个电梯轿厢分配不同的初始楼层，并且当每个电梯轿厢完成往返时，其轮转方式被修改。 因此，只要至少一台电梯轿厢正在运行，所有楼层都能得到保证。

    Combinations of transfection lipids exhibiting increased transfection efficiencies
    5.
    发明授权
    Combinations of transfection lipids exhibiting increased transfection efficiencies 有权
    具有提高转染效率的转染脂质的组合

    公开(公告)号：US07732420B2

    公开(公告)日：2010-06-08

    申请号：US10957977

    申请日：2004-10-04

    申请人： Robert C. MacDonald ,  Li Wang

    发明人： Robert C. MacDonald ,  Li Wang

    IPC分类号： A01N43/04 ,  A61K31/70 ,  C12N5/00 ,  C12N5/02 ,  G01N33/92

    CPC分类号： C12N15/88

    摘要： The present invention provides optimized transfection reagents comprising mixtures of cationiclipoids. In particular, the present invention provides DNA delivery vehicles based on identifying the optimal hydrophobicity of novel cationic phospholipid derivatives that, alone or in combination, form complexes with DNA (lipoplexes) and exhibit enhanced transfection activity.

    摘要翻译： 本发明提供包含阳离子脂质混合物的优化的转染试剂。 特别地，本发明提供了基于鉴定与DNA单独或组合形成复合物（lipoplexes）并显示增强的转染活性的新型阳离子磷脂衍生物的最佳疏水性的DNA递送载体。

    Coincident call optimization in an elevator dispatching system
    7.
    发明授权
    Coincident call optimization in an elevator dispatching system 失效
    电梯调度系统中的重合调用优化

    公开(公告)号：US4782921A

    公开(公告)日：1988-11-08

    申请号：US168791

    申请日：1988-03-16

    申请人： Robert C. MacDonald ,  Elsa Abrego

    发明人： Robert C. MacDonald ,  Elsa Abrego

    IPC分类号： B66B1/18 ,  B66B1/20 ,  B66B1/24

    CPC分类号： B66B1/2458 ,  B66B2201/102 ,  B66B2201/211 ,  B66B2201/233

    摘要： A method of optimizing the handling of coincident calls in an elevator system which employs ETA strategy in assigning hall calls to a plurality of elevator cars. The method dynamically biases the ETA value of a car having a car call for the floor of the hall call being assigned, with the bias being applied to favor assignment of the hall call to the car having the coincident car call. The amount of the bias is inversely proportional to the car travel distance between the advanced position (AVP floor) of the elevator car and the floor associated with the hall call (scan floor). The relative effect of the bias is predetermined for each floor by preselection of a constant K used in the bias calculation.

    摘要翻译： 一种在电梯系统中优化一致呼叫的处理方法，该电梯系统采用ETA策略来向多个电梯轿厢分配门厅呼叫。 该方法动态地偏置具有被分配的门厅呼叫的楼层的轿厢呼梯的汽车的ETA值，并且施加偏压以有利于将门厅呼叫分配给具有重合汽车呼叫的汽车。 偏置量与电梯轿厢的高级位置（AVP楼层）与门厅呼叫（扫描楼层）相关联的楼层之间的轿厢行驶距离成反比。 通过预先选择偏差计算中使用的常数K，预定每个层的偏置的相对影响。

    Cationic phospholipids for transfection
    8.
    发明授权
    Cationic phospholipids for transfection 有权
    用于转染的阳离子磷脂

    公开(公告)号：US06187760B1

    公开(公告)日：2001-02-13

    申请号：US09245541

    申请日：1999-02-05

    申请人： Gary W. Ashley ,  Robert C. MacDonald ,  Miho Shida

    发明人： Gary W. Ashley ,  Robert C. MacDonald ,  Miho Shida

    IPC分类号： A01N4304

    CPC分类号： C12N15/88 ,  A61K9/1272 ,  B82Y5/00 ,  C07F9/10 ,  C07F9/113 ,  C07F9/65324

    摘要： A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic acids. These novel phospholipids are particularly attractive because of they are not only effective in lipofection, but are extremely cheap and easy to male.

    摘要翻译： 公开了一类新型的阳离子磷脂及其合成方法。 磷脂类包括磷酸甘油酯和鞘脂的磷酸三酯衍生物。 意外地发现包含这些阳离子磷脂中的一种或多种的脂质体在核酸的脂质体转染中是有效的。 这些新型磷脂是特别有吸引力的，因为它们不仅在脂质转染中有效，而且对于男性来说是非常便宜和容易的。

    Elevator emergency control system
    10.
    发明授权
    Elevator emergency control system 失效
    电梯应急控制系统

    公开(公告)号：US4482032A

    公开(公告)日：1984-11-13

    申请号：US488340

    申请日：1983-04-25

    申请人： Emanuel E. Enriquez ,  Robert C. MacDonald

    发明人： Emanuel E. Enriquez ,  Robert C. MacDonald

    IPC分类号： B66B1/46 ,  B66B5/02 ,  B66B5/00

    CPC分类号： B66B1/468 ,  B66B5/021 ,  B66B2201/4646 ,  B66B2201/4661 ,  B66B2201/4676

    摘要： An emergency control system for use in an elevator system. When an emergency situation arises in an elevator car, an elevator passenger recites a code word. A microphone in the elevator car transforms the vocal signal to an electrical signal, and using a voice-recognition system, the spoken code word is compared with a code word stored in memory. If the spoken code word matches the stored code word, control of the elevator system is switched to an emergency mode. In this mode the elevator car is brought to a predetermined landing and an intercom system providing communication between the elevator car and the guard station is activated. At the predetermined landing, security personnel are available to render assistance to the elevator passenger when the elevator doors open.

    摘要翻译： 一种用于电梯系统的应急控制系统。 当电梯轿厢出现紧急情况时，电梯乘客背着码字。 电梯轿厢中的麦克风将声音信号转换为电信号，并且使用语音识别系统将口语码字与存储在存储器中的码字进行比较。 如果口语码字与存储的码字匹配，则电梯系统的控制被切换到紧急模式。 在这种模式中，电梯轿厢被带到预定的起落架，并且启动了提供电梯轿厢和保护站之间的通信的对讲系统。 在预定的着陆点，当电梯门打开时，保安人员可以向电梯乘客提供协助。