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    Glycopegylated Erythropoietin Formulations
    1.
    发明申请
    Glycopegylated Erythropoietin Formulations 审中-公开
    糖基化促红细胞生成素制剂

    公开(公告)号：US20110003744A1

    公开(公告)日：2011-01-06

    申请号：US11914104

    申请日：2006-05-25

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf ,  Jichao Kang ,  Walter Scott Willett

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf ,  Jichao Kang ,  Walter Scott Willett

    IPC分类号： C07K14/505 ,  A61K38/18

    CPC分类号： A61K38/1816 ,  A61K9/0019 ,  A61K47/26 ,  C07K14/505

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    Glycopegylated erythropoietin formulations
    2.
    发明授权
    Glycopegylated erythropoietin formulations 有权
    糖基化促红细胞生成素制剂

    公开(公告)号：US07842661B2

    公开(公告)日：2010-11-30

    申请号：US11440839

    申请日：2006-05-25

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf ,  Jichao Kang ,  Walter Scott Willett

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf ,  Jichao Kang ,  Walter Scott Willett

    IPC分类号： C07K14/00 ,  C07K14/505 ,  A61K38/00 ,  A61K38/16

    CPC分类号： C07K14/505 ,  A61K38/1816 ,  A61K47/549 ,  A61K47/60

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    ONE POT DESIALYLATION AND GLYCOPEGYLATION OF THERAPEUTIC PEPTIDES
    3.
    发明申请
    ONE POT DESIALYLATION AND GLYCOPEGYLATION OF THERAPEUTIC PEPTIDES 有权
    治疗药物的一次脱蛋白和糖蛋白

    公开(公告)号：US20100330645A1

    公开(公告)日：2010-12-30

    申请号：US12784323

    申请日：2010-05-20

    申请人： Shawn DeFrees ,  David A. Zopf ,  Susann Taudte ,  Walter Scott Willett ,  Robert J. Bayer ,  Matthew Kalo

    发明人： Shawn DeFrees ,  David A. Zopf ,  Susann Taudte ,  Walter Scott Willett ,  Robert J. Bayer ,  Matthew Kalo

    IPC分类号： C12N9/96

    CPC分类号： C12P21/005 ,  A61K38/4846

    摘要： The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供肽和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。

    One pot desialylation and glycopegylation of therapeutic peptides
    4.
    发明授权
    One pot desialylation and glycopegylation of therapeutic peptides 有权
    治疗性肽的一罐去唾液酸化和糖基化

    公开(公告)号：US08911967B2

    公开(公告)日：2014-12-16

    申请号：US12784323

    申请日：2010-05-20

    申请人： Shawn DeFrees ,  David A. Zopf ,  Susann Taudte ,  Walter Scott Willett ,  Robert J. Bayer ,  Matthew Kalo

    发明人： Shawn DeFrees ,  David A. Zopf ,  Susann Taudte ,  Walter Scott Willett ,  Robert J. Bayer ,  Matthew Kalo

    IPC分类号： C12P19/18 ,  C07K9/00

    CPC分类号： C12P21/005 ,  A61K38/4846

    摘要： The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.

    摘要翻译： 本发明提供肽和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。

    Glycopegylated erythropoietin
    6.
    发明授权
    Glycopegylated erythropoietin 失效

    公开(公告)号：US08633157B2

    公开(公告)日：2014-01-21

    申请号：US11144223

    申请日：2005-06-02

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf

    IPC分类号： A61K38/18 ,  A61P7/06 ,  C07K14/505

    CPC分类号： A61K38/1816

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.