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42 条记录 (耗时 0.086 秒)

    Glycopegylated erythropoietin
    2.
    发明授权
    Glycopegylated erythropoietin 失效

    公开(公告)号：US08633157B2

    公开(公告)日：2014-01-21

    申请号：US11144223

    申请日：2005-06-02

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf

    IPC分类号： A61K38/18 ,  A61P7/06 ,  C07K14/505

    CPC分类号： A61K38/1816

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    Glycopegylated erythropoietin formulations
    7.
    发明授权
    Glycopegylated erythropoietin formulations 有权
    糖基化促红细胞生成素制剂

    公开(公告)号：US07842661B2

    公开(公告)日：2010-11-30

    申请号：US11440839

    申请日：2006-05-25

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf ,  Jichao Kang ,  Walter Scott Willett

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf ,  Jichao Kang ,  Walter Scott Willett

    IPC分类号： C07K14/00 ,  C07K14/505 ,  A61K38/00 ,  A61K38/16

    CPC分类号： C07K14/505 ,  A61K38/1816 ,  A61K47/549 ,  A61K47/60

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。

    Glycopegylated erythropoietin
    9.
    发明申请
    Glycopegylated erythropoietin 审中-公开
    糖基化促红细胞生成素

    公开(公告)号：US20080305992A1

    公开(公告)日：2008-12-11

    申请号：US11982273

    申请日：2007-10-31

    申请人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf

    发明人： Shawn DeFrees ,  Robert J. Bayer ,  David A. Zopf

    IPC分类号： C07K14/505 ,  A61K38/22 ,  C12P21/02 ,  A61P7/06 ,  A61P17/02

    CPC分类号： C12P21/005 ,  A61K38/00 ,  A61K38/22

    摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

    摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。