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14 条记录 (耗时 0.043 秒)

    Dihydrobenzofuran derivatives, process for the preparing thereof and agents
    2.
    发明授权
    Dihydrobenzofuran derivatives, process for the preparing thereof and agents 失效
    二氢苯并呋喃衍生物，其制备方法和试剂

    公开(公告)号：US07008940B1

    公开(公告)日：2006-03-07

    申请号：US10069314

    申请日：2000-08-18

    申请人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Tetsuya Tsukamoto

    发明人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Tetsuya Tsukamoto

    IPC分类号： A61P9/00 ,  A61P25/00 ,  A61K31/407 ,  A61K31/55 ,  C07D491/48

    CPC分类号： C07D491/04

    摘要： A compound represented by the formula (I): or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production, wherein ring A denotes a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, B ring denotes a benzene ring which may be further substituted, C ring denotes a dihydrofuran ring which may be further substituted, and R denotes hydrogen atom or an acyl group.

    摘要翻译： 由式（I）表示的化合物或其盐表现出优异的脂质过氧化抑制活性，可用作抑制脂肪过氧化物产生的试剂，其中环A表示非芳香族5至7元含氮杂环 环可以进一步被取代，B环表示可以被进一步取代的苯环，C环表示可以被进一步取代的二氢呋喃环，R表示氢原子或酰基。

    Cyclic ether compounds as sodium channel modulators
    3.
    发明授权
    Cyclic ether compounds as sodium channel modulators 失效
    环状醚化合物作为钠通道调节剂

    公开(公告)号：US06172085B2

    公开(公告)日：2001-01-09

    申请号：US09242067

    申请日：1999-02-08

    申请人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Kohji Fukatsu

    发明人： Shigenori Ohkawa ,  Tadatoshi Hashimoto ,  Kohji Fukatsu

    IPC分类号： C07D40506

    CPC分类号： C07D405/06 ,  C07D307/81 ,  C07D407/12

    摘要： A compound of the formula: wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R4 and R5 taken together represent a 5- or 6-membered carbocyclic group; R6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5- to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lower alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH2, COCH2, OCH2, SCH2, NHCH2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.

    摘要翻译： 下式的化合物：其中R1和R2各自表示氢，可被取代的或低级烷基的酰基; R 3，R 4和R 5各自表示可以被取代的低级烷基或可被取代的低级烷氧基，或者R 4和R 5一起代表5-或6-元碳环基; R6代表低级烷基; Ar表示可以被取代的芳基; 环A表示可以被取代的5至8元含氮杂环; X表示可以被取代的低级亚烷基; Y表示碳或氮; Za表示CH2，COCH2，OCH2，SCH2，NHCH2等; Zb表示可以被取代并可以含有O，N或S的键或二价脂族烃基; m表示1〜3的整数，或其盐可用于调制钠通道的药物组合物。

    Piperidine derivative, process for producing the same, and use
    5.
    发明授权
    Piperidine derivative, process for producing the same, and use 失效
    哌啶衍生物，其制备方法和用途

    公开(公告)号：US07622487B2

    公开(公告)日：2009-11-24

    申请号：US10516252

    申请日：2003-05-29

    申请人： Yoshinori Ikeura ,  Tadatoshi Hashimoto ,  Naoki Tarui ,  Junya Shirai

    发明人： Yoshinori Ikeura ,  Tadatoshi Hashimoto ,  Naoki Tarui ,  Junya Shirai

    IPC分类号： A61K31/445 ,  C07D403/12

    CPC分类号： C07D405/14 ,  C07D211/46 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/10 ,  C07D409/06 ,  C07D409/10 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14

    摘要： The present invention provides a compound represented by the formula: wherein Ar is an aryl group, an aralkyl group or an aromatic heterocyclic group, each of which may be substituted, R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group, X is an oxygen atom or an optionally substituted imino group, Z is an optionally substituted methylene group, Ring A is an optionally further substituted piperidine ring, and Ring B is an optionally substituted aromatic ring, provided that when Z is a methylene group substituted with an oxo group, R1 is not a methyl group, and when Z is a methylene group substituted with a methyl group, Ring B is a substituted aromatic ring, or a salt thereof, which is a novel piperidine derivative having excellent antagonistic action for a tachykinin receptor and useful as a medicament, particularly an agent for preventing and/or treating urinary frequency and/or urinary incontinence.

    摘要翻译： 本发明提供由下式表示的化合物：其中Ar是芳基，芳烷基或芳族杂环基，其各自可以被取代，R 1是氢原子，任选取代的烃基，酰基或 任选取代的杂环基，X是氧原子或任选取代的亚氨基，Z是任选取代的亚甲基，环A是任选进一步取代的哌啶环，环B是任选取代的芳环，条件是当Z 是被氧基取代的亚甲基，R1不是甲基，当Z是被甲基取代的亚甲基时，环B是取代的芳香环或其盐，它是具有 用于速激肽受体的优异拮抗作用，可用作药物，特别是用于预防和/或治疗尿频和/或尿失禁的药剂。

    Piperidine derivative, process for producing the same, and use
    10.
    发明申请
    Piperidine derivative, process for producing the same, and use 失效
    哌啶衍生物，其制备方法和用途

    公开(公告)号：US20060167052A1

    公开(公告)日：2006-07-27

    申请号：US10516252

    申请日：2003-05-29

    申请人： Yoshinori Ikeura ,  Tadatoshi Hashimoto ,  Naoki Tarui ,  Junya Shirai ,  Masayuki Yamashita

    发明人： Yoshinori Ikeura ,  Tadatoshi Hashimoto ,  Naoki Tarui ,  Junya Shirai ,  Masayuki Yamashita

    IPC分类号： A61K31/454 ,  C07D403/02

    CPC分类号： C07D405/14 ,  C07D211/46 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/10 ,  C07D409/06 ,  C07D409/10 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14

    摘要： The present invention provides a compound represented by the formula: wherein Ar is an aryl group, an aralkyl group or an aromatic heterocyclic group, each of which may be substituted, R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group, X is an oxygen atom or an optionally lo substituted imino group, Z is an optionally substituted methylene group, Ring A is an optionally further substituted piperidine ring, and Ring B is an optionally substituted aromatic ring, provided that when Z is a methylene group substituted with an oxo group, R1 is not a methyl group, and 15 when Z is a methylene group substituted with a methyl group, Ring B is a substituted aromatic ring, or a salt thereof, which is a novel piperidine derivative having excellent antagonistic action for a tachykinin receptor and useful as a medicament, particularly an agent for preventing and/or treating urinary frequency and/or urinary incontinence.

    摘要翻译： 本发明提供由下式表示的化合物：其中Ar是芳基，芳烷基或芳族杂环基，其各自可以被取代，R 1是氢原子，任选地 取代烃基，酰基或任选取代的杂环基，X是氧原子或任选取代的亚氨基，Z是任选取代的亚甲基，环A是任选进一步取代的哌啶环，环B是 任选取代的芳环，条件是当Z是被氧代基取代的亚甲基时，R 1不是甲基，而当Z是被甲基取代的亚甲基时，R 1是环B 是取代的芳香环或其盐，其是对速激肽受体具有优异拮抗作用的新型哌啶衍生物，并且可用作药物，特别是用于预防和/或治疗尿频和/或 尿失禁