公开(公告)号：US20050226867A1

公开(公告)日：2005-10-13

申请号：US10959326

申请日：2004-10-07

申请人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara ,  Masamichi Koike

发明人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara ,  Masamichi Koike

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2866 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732

摘要： The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human interleukin-5 receptor α chain and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

摘要翻译： 本发明提供一种抗体组合物，其包含特异性结合人白细胞介素-5受体α链并在Fc区具有复合型N-糖苷连接的糖链的抗体分子，其中复合型N-糖苷连接的糖链具有 岩藻糖在糖链的还原端不与N-乙酰氨基葡萄糖结合的结构; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

公开(公告)号：US20080095765A1

公开(公告)日：2008-04-24

申请号：US11730992

申请日：2007-04-05

申请人： Shigeru Ilda ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara ,  Masamichi Koike

发明人： Shigeru Ilda ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara ,  Masamichi Koike

IPC分类号： A61K39/395 ,  A61P37/08 ,  C07K16/00 ,  C12N1/21 ,  C12P21/00

CPC分类号： C07K16/2866 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732

摘要： The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human interleukin-5 receptor α chain and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

摘要翻译： 本发明提供一种抗体组合物，其包含特异性结合人白细胞介素-5受体α链并在Fc区具有复合型N-糖苷连接的糖链的抗体分子，其中复合型N-糖苷连接的糖链具有 岩藻糖在糖链的还原端不与N-乙酰氨基葡萄糖结合的结构; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

公开(公告)号：US20050287138A1

公开(公告)日：2005-12-29

申请号：US10959310

申请日：2004-10-07

申请人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

发明人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2866 ,  C07K2317/41 ,  C07K2317/732

摘要： The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human CC chemokine receptor 4 (CCR4) and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

摘要翻译： 本发明提供一种抗体组合物，其包含特异性结合人类CC趋化因子受体4（CCR4）的抗体分子，并且在Fc区具有复合型N-糖苷连接的糖链，其中复合型N-糖苷连接的糖链 在糖链的还原端具有岩藻糖不与N-乙酰葡糖胺结合的结构; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

公开(公告)号：US20080213266A1

公开(公告)日：2008-09-04

申请号：US11969555

申请日：2008-01-04

申请人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

发明人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

IPC分类号： A61K39/395 ,  A61P43/00

CPC分类号： C07K16/2866 ,  C07K2317/41 ,  C07K2317/732

摘要： The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human CC chemokine receptor 4 (CCR4) and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

摘要翻译： 本发明提供一种抗体组合物，其包含特异性结合人类CC趋化因子受体4（CCR4）的抗体分子，并且在Fc区具有复合型N-糖苷连接的糖链，其中复合型N-糖苷连接的糖链 在糖链的还原端具有岩藻糖不与N-乙酰葡糖胺结合的结构; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

公开(公告)号：US20090028877A1

公开(公告)日：2009-01-29

申请号：US10575114

申请日：2004-10-08

申请人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Takabe ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

发明人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Takabe ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/06 ,  A61P31/00 ,  C12P21/04

CPC分类号： C07K16/3084 ,  A61K2039/505 ,  C07K2317/52 ,  C07K2317/732

摘要： An anti-ganglioside GM2 antibody composition having enhanced effector function which is useful as a medicament has been desired. The present invention provides an antibody composition comprising an antibody molecule which specifically binds to ganglioside GM2 and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

摘要翻译： 已经需要可用作药物的具有增强的效应子功能的抗神经节苷脂GM2抗体组合物。 本发明提供一种抗体组合物，其包含特异性结合神经节苷脂GM2并且在Fc区中具有复合型N-糖苷连接的糖链的抗体分子，其中复合型N-糖苷连接的糖链具有其中岩藻糖 在糖链的还原末端不与N-乙酰氨基葡萄糖结合; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

公开(公告)号：US20080241884A1

公开(公告)日：2008-10-02

申请号：US10575261

申请日：2004-10-08

申请人： Kenya Shitara ,  Emi Hosaka ,  Akito Natsume ,  Masako Wakitani ,  Kazuhisa Uchida ,  Mitsuo Satoh ,  Naoko Ohnuki ,  Kazuyasu Nakamura

发明人： Kenya Shitara ,  Emi Hosaka ,  Akito Natsume ,  Masako Wakitani ,  Kazuhisa Uchida ,  Mitsuo Satoh ,  Naoko Ohnuki ,  Kazuyasu Nakamura

IPC分类号： C07H21/04 ,  C12P21/04 ,  C12N9/90 ,  C12N5/06

CPC分类号： C07K16/30 ,  A61K38/00 ,  C07K14/70528 ,  C07K14/7151 ,  C07K16/00 ,  C07K16/3092 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/32 ,  C12N9/1051 ,  C12N9/88 ,  C12N9/90

摘要： A fusion protein composition of an antibody Fc region which is useful as a medicament in which effector function is improved is desired.The present invention provides a fusion protein composition comprising a fusion protein molecule of an antibody Fc region having complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant producing the fusion protein composition; a process for producing the fusion protein composition; and a medicament comprising the fusion protein composition.

摘要翻译： 需要可用作改善效应子功能的药物的抗体Fc区的融合蛋白组合物。 本发明提供了融合蛋白组合物，其包含Fc区中具有复合型N-糖苷连接的糖链的抗体Fc区的融合蛋白分子，其中复合型N-糖苷连接的糖链具有其中岩藻糖 在糖链的还原末端不与N-乙酰氨基葡萄糖结合; 产生融合蛋白组合物的转化体; 制备融合蛋白组合物的方法; 和包含该融合蛋白组合物的药物。

公开(公告)号：US07064191B2

公开(公告)日：2006-06-20

申请号：US09970154

申请日：2001-10-04

申请人： Toyohide Shinkawa ,  Kazuhisa Uchida ,  Motoo Yamasaki ,  Emi Hosaka ,  Kenya Shitara

发明人： Toyohide Shinkawa ,  Kazuhisa Uchida ,  Motoo Yamasaki ,  Emi Hosaka ,  Kenya Shitara

IPC分类号： C07K1/22 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K16/065 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/732 ,  Y10S436/824 ,  Y10S436/827

摘要： The present invention relates to a process for purifying an antibody having a desired property, which comprises using a substance having an affinity to a carbohydrate binding to the antibody; a medicament comprising, as an active ingredient, the antibody purified by the process; and a method for diagnosing or preventing various diseases, which comprises using a substance having an affinity to a carbohydrate binding to an antibody.

公开(公告)号：US20060078990A1

公开(公告)日：2006-04-13

申请号：US11287324

申请日：2005-11-28

申请人： Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

发明人： Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

IPC分类号： C12N5/06

CPC分类号： C12P21/005 ,  C07K16/1063 ,  C07K16/18 ,  C07K16/241 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/3084 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2319/30 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/90 ,  C12N15/8245 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12Y204/01068

摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

公开(公告)号：US20060063254A1

公开(公告)日：2006-03-23

申请号：US11218473

申请日：2005-09-06

申请人： Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

发明人： Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

IPC分类号： A61K39/395 ,  C12N5/06 ,  C07K16/44

CPC分类号： C12P21/005 ,  C07K16/1063 ,  C07K16/18 ,  C07K16/241 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/3084 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2319/30 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/90 ,  C12N15/8245 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12Y204/01068

摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

公开(公告)号：US08158760B2

公开(公告)日：2012-04-17

申请号：US12351695

申请日：2009-01-09

申请人： Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

发明人： Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

IPC分类号： C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/00

CPC分类号： C12P21/005 ,  C07K16/1063 ,  C07K16/18 ,  C07K16/241 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/3084 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2319/30 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/90 ,  C12N15/8245 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12Y204/01068

摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

摘要翻译： 本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。