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1.
公开(公告)号:US5162317A
公开(公告)日:1992-11-10
申请号:US445664
申请日:1989-12-05
申请人: Shigeru Souda , Shuhei Miyazawa , Norihiro Ueda , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人: Shigeru Souda , Shuhei Miyazawa , Norihiro Ueda , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D513/14
CPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D513/14
摘要: A pyridinium salt useful as an antiulcer agent, defined by formula (I) is disclosed. It includes a sulphenamide compound and a pyridinium compound. J is benzimidazole, K is --S-- or --SSR-- and Z is hydroxy or alkoxy. ##STR1##
摘要翻译: PCT No.PCT / JP89 / 00482 Sec。 371日期1989年12月5日第 102(e)日期1989年12月5日PCT提交1989年5月11日PCT公布。 出版物WO89 / 10927 日本公报(公开)公开了用作抗溃疡剂的吡啶鎓盐。 它包括苯丙胺化合物和吡啶鎓化合物。 J为苯并咪唑,K为-S-或-SSR-,Z为羟基或烷氧基。 (一)
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公开(公告)号:US5045552A
公开(公告)日:1991-09-03
申请号:US462328
申请日:1989-12-28
申请人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/54 , A61P1/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are described.
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公开(公告)号:US5840910A
公开(公告)日:1998-11-24
申请号:US354726
申请日:1994-12-06
申请人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/54 , A61P1/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are disclosed.
摘要翻译: 公开了用于预防或治疗消化性溃疡的吡啶衍生物,药物制剂和治疗消化性溃疡的方法。
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公开(公告)号:US5239079A
公开(公告)日:1993-08-24
申请号:US928742
申请日:1992-08-13
申请人: Shigeru Souda , Shuhei Miyazawa , Norihiro Ueda , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人: Shigeru Souda , Shuhei Miyazawa , Norihiro Ueda , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D513/14
CPC分类号: C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D513/14
摘要: A pyridinium salt is useful as an antiulcer and is defined by the following formula. It includes a sulphenamide compound and a pyridinium compound. J is benzoimidazole, K is --S-- or --SSR, Z is hydroxy or oxyalkyl. ##STR1##
摘要翻译: 吡啶鎓盐可用作抗溃疡剂并由下式定义。 它包括苯丙胺化合物和吡啶鎓化合物。 J为苯并咪唑,K为-S-或-SSR,Z为羟基或烷氧基。
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公开(公告)号:US5998445A
公开(公告)日:1999-12-07
申请号:US679473
申请日:1996-07-09
申请人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号: A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/54 , A61P1/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are described.
摘要翻译: 描述了可用于预防或治疗消化性溃疡的吡啶衍生物,药物制剂和治疗消化性溃疡的方法。
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6.
公开(公告)号:US5708013A
公开(公告)日:1998-01-13
申请号:US524109
申请日:1995-08-21
申请人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人: Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号: C07D401/12 , A61K31/44
CPC分类号: C07D401/12
摘要: A pyridine compound having the formula is disclosed and useful to treat the peptic ulcer. ##STR1## wherein R.sup.1 and R.sup.2 which may be the same or different are each a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogenated lower alkyl group, or a halogen atom, R.sup.3 and R.sup.4 which may be the same or different are each a hydrogen atom or a lower alkyl group, X is a group represented by the formula --S--, a group represented by the formula ##STR2## or a group represented by the formula ##STR3## and n is an integer of 1 to 6, provided that R.sup.3 and R.sup.4 are not simultaneously hydrogen atoms when n is 1.
摘要翻译: 公开了具有下式的吡啶化合物,可用于治疗消化性溃疡。 其中可以相同或不同的R 1和R 2各自为氢原子,低级烷基,低级烷氧基,卤代低级烷基或卤素原子,可以相同的R 3和R 4, 不同的是氢原子或低级烷基,X是由式-S-表示的基团,即由式d表示的基团,当n为1时,R3和R4不同时为氢原子。
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公开(公告)号:US5298649A
公开(公告)日:1994-03-29
申请号:US774237
申请日:1991-10-10
申请人: Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人: Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号: C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68 , C07C69/157 , C07F7/18 , C07C69/76
CPC分类号: C07F7/1852 , C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/298 , C07C45/30 , C07C45/305 , C07C45/513 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68
摘要: A naphthalene derivative having the formula is new and useful for medicine. ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;R.sup.3 and R.sup.4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;R.sup.5 represents a group of the formula, --OR.sup.7, (wherein R.sup.7 represents a hydrogen atom or a lower alkyl group), or a group of the formula, ##STR2## (wherein R.sup.8 and R.sup.9 are the same or different and represent a hydrogen atom or a lower alkyl group.
摘要翻译: 具有该式的萘衍生物是新的并且可用于药物。 其中R 1表示氢原子,低级烷基或酰基; R2独立地表示氢原子,低级烷基,低级烷氧基,卤素原子,环烷基,环烷基烷基,羟基,可被取代的芳基,芳基可以被取代的芳基烷基 杂芳基或杂芳基烷基; R3和R4相同或不同,表示氢原子,低级烷基,低级烯基,可以具有取代基的芳基,芳基可以被取代的芳基烷基,芳基可以被取代的芳基烯基 烷氧基烷基,杂芳基,杂芳基烷基,羧基,羧基烷基,氨基烷基或氰基; R5表示式-OR7的基团(其中R7表示氢原子或低级烷基)或下式的基团,其中R8和R9相同或不同,表示氢原子 或低级烷基。
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公开(公告)号:US5134111A
公开(公告)日:1992-07-28
申请号:US451468
申请日:1989-12-15
申请人: Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人: Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号: C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68 , C07C69/157 , C07F7/18
CPC分类号: C07F7/1852 , C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/298 , C07C45/30 , C07C45/305 , C07C45/513 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68
摘要: A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;R.sup.3 and R.sup.4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxy group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;R.sup.5 represents a group of the formula, --OR.sup.7, (wherein R.sup.7 represents a hydrogen atom or a lower alkyl group), or a group of the formula ##STR2## (wherein R.sup.8 and R.sup.9 are the same or different and represent a hydrogen atom or a lower alkyl group, or R.sup.8 and R.sup.9 can form, along with the nitrogen atom bonded with R.sup.8 and R.sup.9, a ring which may contain an oxygen atom);R.sup.6 independently represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, an amino group, an arylalkyl group, or an aryl group; andm is 0 or an integer of from 1 to 2, and n is 0 or an integer of from 1 to 4.]
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公开(公告)号:US5527948A
公开(公告)日:1996-06-18
申请号:US402569
申请日:1995-03-13
申请人: Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人: Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号: C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68 , C07C69/157 , C07F7/18 , C07C69/76 , C07C49/115
CPC分类号: C07F7/1852 , C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/298 , C07C45/30 , C07C45/305 , C07C45/513 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68
摘要: Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.
摘要翻译: 下式的萘衍生物:其中R 1,表示氢原子,低级烷基或酰基; R2独立地表示氢原子,低级烷基,低级烷氧基,卤素原子,环烷基,环烷基烷基,羟基,可被取代的芳基,芳基可以被取代的芳基烷基 ,杂芳基或杂芳基烷基; R 3表示氢原子,低级烷基,低级烯基,可以具有取代基的芳基,可以被取代芳基的芳基烷基,可以被芳基取代的芳基烯基,环烷基, 烷氧基烷基,杂芳基,杂芳基烷基,羧基,羧基烷基,氨基烷基或氰基; R6是C1-6烷基; 并且公开了m为0或可用于治疗自身免疫性疾病的1〜2的整数。
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公开(公告)号:US5635519A
公开(公告)日:1997-06-03
申请号:US388813
申请日:1995-02-15
申请人: Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Naoki Kobayashi , Masanobu Shinoda , Tetsuya Kawahara , Manabu Murakami , Kiyoshi Oketani , Takashi Inoue , Takashi Yamanaka , Isao Yamatsu
发明人: Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Naoki Kobayashi , Masanobu Shinoda , Tetsuya Kawahara , Manabu Murakami , Kiyoshi Oketani , Takashi Inoue , Takashi Yamanaka , Isao Yamatsu
IPC分类号: C07D277/82 , C07D417/06 , C07D417/12 , C07D401/02 , A61K31/44
CPC分类号: C07D417/06 , C07D277/82 , C07D417/12 , Y02P20/55
摘要: A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##
摘要翻译: 可用作抑制白细胞三烯和血栓素生成功能的疾病有效的预防或治疗剂的权利要求中所定义的下式的苯并噻唑衍生物或其药理学上可接受的盐:
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