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    Method for Preparing Optically Active Compound
    1.
    发明申请
    Method for Preparing Optically Active Compound 失效
    光学活性化合物的制备方法

    公开(公告)号：US20070292925A1

    公开(公告)日：2007-12-20

    申请号：US11667688

    申请日：2005-10-31

    申请人： Shigeru Tanaka ,  Shinya Watanabe ,  Ken-ichi Yamamoto ,  Hiroyuki Matsuda

    发明人： Shigeru Tanaka ,  Shinya Watanabe ,  Ken-ichi Yamamoto ,  Hiroyuki Matsuda

    IPC分类号： C12P7/24 ,  C12P7/62

    CPC分类号： C12P7/26 ,  C12P41/003

    摘要： According to the present invention, there is provided a method for preparing an optically active compound, characterized in that said method comprises permitting a mixture of optical isomers relative to the carbon atom in the β-position in relation to the carbon atom bound to an esterified hydroxy group of an enol ester to hydrolyse either one optical isomer preferentially in the presence of an enzyme and allowing the carbonyl compound resulting from such hydrolysis to enrich the proportion of its isomer having either one configuration in the β-position in relation to the carbonyl group or allowing the enol ester left non-hydrolyzed to enrich the proportion of its isomer having either one configuration on the carbon atom in the β-position in relation to the carbon atom to which the esterified hydroxyl group bonds.

    摘要翻译： 根据本发明，提供了一种制备光学活性化合物的方法，其特征在于所述方法包括允许相对于与酯化的结合的碳原子相对于β-位置的碳原子的光学异构体的混合物 使烯醇酯的羟基在酶的存在下优先水解一种旋光异构体，并使得由这种水解产生的羰基化合物能够富集其相对于羰基在β-位上具有一个结构的异构体的比例 或使烯醇酯未水解以富集其相对于酯化羟基键合的碳原子在β-位上的碳原子上具有一种构型的异构体的比例。

    Method for preparing optically active compound
    2.
    发明授权
    Method for preparing optically active compound 失效
    光学活性化合物的制备方法

    公开(公告)号：US07846701B2

    公开(公告)日：2010-12-07

    申请号：US11667688

    申请日：2005-10-31

    申请人： Shigeru Tanaka ,  Shinya Watanabe ,  Ken-ichi Yamamoto ,  Hiroyuki Matsuda

    发明人： Shigeru Tanaka ,  Shinya Watanabe ,  Ken-ichi Yamamoto ,  Hiroyuki Matsuda

    IPC分类号： C12P7/26

    CPC分类号： C12P7/26 ,  C12P41/003

    摘要： According to the present invention, there is provided a method for preparing an optically active compound, characterized in that said method comprises permitting a mixture of optical isomers relative to the carbon atom in the β-position in relation to the carbon atom bound to an esterified hydroxy group of an enol ester to hydrolyse either one optical isomer preferentially in the presence of an enzyme and allowing the carbonyl compound resulting from such hydrolysis to enrich the proportion of its isomer having either one configuration in the β-position in relation to the carbonyl group or allowing the enol ester left non-hydrolyzed to enrich the proportion of its isomer having either one configuration on the carbon atom in the β-position in relation to the carbon atom to which the esterified hydroxyl group bonds.

    摘要翻译： 根据本发明，提供了一种制备光学活性化合物的方法，其特征在于所述方法包括允许相对于与一个碳原子结合的碳原子相对于碳原子的光学异构体的混合物 烯醇酯的酯化羟基在酶的存在下优先水解任一种旋光异构体，并使得由这种水解产生的羰基化合物能够富集其相对于化合物中的任何一种构型的其异构体的比例 使烯醇酯残留未水解以富集其相对于与酯化羟基键合的碳原子相关的碳原子上具有一个构型的异构体的比例。

    Method of Producing Macrocyclic Ketone, and Intermediate Thereof
    4.
    发明申请
    Method of Producing Macrocyclic Ketone, and Intermediate Thereof 有权
    生产大环酮及其中间体的方法

    公开(公告)号：US20070287870A1

    公开(公告)日：2007-12-13

    申请号：US11667476

    申请日：2004-11-11

    申请人： Hiroyuki Matsuda ,  Shigeru Tanaka

    发明人： Hiroyuki Matsuda ,  Shigeru Tanaka

    IPC分类号： C07C45/00

    CPC分类号： C07C45/513 ,  C07B2200/07 ,  C07C45/511 ,  C07C45/54 ,  C07C49/385 ,  C07C67/08 ,  C07C68/06 ,  C07C69/013 ,  C07C69/96 ,  C07C2601/18 ,  C07C69/24 ,  C07C69/145

    摘要： A process for producing muscone by methyl addition to the 1,4-conjugation of 2-cyclopentadecenone. By the process, muscone is produced in high yield not under reaction condition including an extremely low temperature and a low concentration but under practical condition. The process comprises subjecting 2-cyclopentadecenone to a 1,4-conjugation addition reaction with an organometallic methylation reagent in the presence of a copper or nickel catalyst and an enol anion scavenger to obtain a 3-methyl-1-cyclopentadecene derivative represented by General Formula (II) and then solvolyzing the enol moiety of the 3-methyl-1-cyclopentadecene derivative to obtain muscone.

    摘要翻译： 通过甲基添加到2-环戊烯酮的1,4-缀合物来生产肌肉的方法。 通过该方法，在非常低的温度和低浓度但在实际条件下的反应条件下，以高产率生产肌肉。 该方法包括在铜或镍催化剂和烯醇阴离子清除剂存在下，使有机金属甲基化试剂与2-环戊烯酮进行1,4-缀合加成反应，得到通式（1）表示的3-甲基-1-环戊烯衍生物 （II），然后溶剂化3-甲基-1-环十五碳烯衍生物的烯醇部分以获得肌肉酮。

    Method of producing macrocyclic ketone, and intermediate thereof
    5.
    发明授权
    Method of producing macrocyclic ketone, and intermediate thereof 有权
    制备大环酮的方法及其中间体

    公开(公告)号：US07479574B2

    公开(公告)日：2009-01-20

    申请号：US11667476

    申请日：2004-11-11

    申请人： Hiroyuki Matsuda ,  Shigeru Tanaka

    发明人： Hiroyuki Matsuda ,  Shigeru Tanaka

    IPC分类号： C07C45/00

    CPC分类号： C07C45/513 ,  C07B2200/07 ,  C07C45/511 ,  C07C45/54 ,  C07C49/385 ,  C07C67/08 ,  C07C68/06 ,  C07C69/013 ,  C07C69/96 ,  C07C2601/18 ,  C07C69/24 ,  C07C69/145

    摘要： A process for producing muscone by methyl addition to the 1,4-conjugation of 2-cyclopentadecenone. By the process, muscone is produced in high yield not under reaction condition including an extremely low temperature and a low concentration but under practical condition. The process comprises subjecting 2-cyclopentadecenone to a 1,4-conjugation addition reaction with an organometallic methylation reagent in the presence of a copper or nickel catalyst and an enol anion scavenger to obtain a 3-methyl-1-cyclopentadecene derivative represented by General Formula (II) and then solvolyzing the enol moiety of the 3-methyl-1-cyclopentadecene derivative to obtain muscone.

    摘要翻译： 通过甲基添加到2-环戊烯酮的1,4-缀合物来生产肌肉的方法。 通过该方法，在非常低的温度和低浓度但在实际条件下的反应条件下，以高产率生产肌肉。 该方法包括在铜或镍催化剂和烯醇阴离子清除剂存在下，使有机金属甲基化试剂与2-环戊烯酮进行1,4-缀合加成反应，得到通式（1）表示的3-甲基-1-环戊烯衍生物 （II），然后溶剂化3-甲基-1-环十五碳烯衍生物的烯醇部分以获得肌肉酮。

    Spinal stabilization devices, systems, and methods
    7.
    发明授权
    Spinal stabilization devices, systems, and methods 有权

    公开(公告)号：US10517650B2

    公开(公告)日：2019-12-31

    申请号：US12434515

    申请日：2009-05-01

    申请人： Michael L. Reo ,  Shigeru Tanaka

    发明人： Michael L. Reo ,  Shigeru Tanaka

    IPC分类号： A61B17/70

    摘要： This specification describes spinal stabilization devices that may be introduced into the spine via surgical procedures. In particular, this specification describes an inter-spinous process spacer having a core chosen, in one variation, to provide a kyphotic or lordotic angle to the device. The specification also describes systems including the described devices and methods of introducing the devices and systems into the spine to provide effective stabilization.

    LATERAL MASS FIXATION SYSTEM
    8.
    发明申请
    LATERAL MASS FIXATION SYSTEM 审中-公开
    侧向质量固定系统

    公开(公告)号：US20150342649A1

    公开(公告)日：2015-12-03

    申请号：US14723410

    申请日：2015-05-27

    申请人： Bruce M. McCormack ,  Edward Liou ,  Shigeru Tanaka ,  Christopher U. Phan

    发明人： Bruce M. McCormack ,  Edward Liou ,  Shigeru Tanaka ,  Christopher U. Phan

    IPC分类号： A61B17/70 ,  A61B17/17 ,  A61B17/16

    CPC分类号： A61B17/7082 ,  A61B17/1604 ,  A61B17/1671 ,  A61B17/1757 ,  A61B17/7011 ,  A61B17/7032 ,  A61B17/7064

    摘要： A device for accessing and guiding at least one fixation device to a spine may include a distal portion configured to fit in a facet of the spine and a proximal portion extending from the distal portion. The proximal portion may be detachable from the distal portion and may be hollow or solid. A system for accessing and guiding at least one fixation device to a spine may include a distal portion configured to fit in a facet of the spine, a proximal portion extending from the distal portion, and a slidable guide device for sliding over the facet guide device to guide at least one instrument to the spine.

    摘要翻译： 用于访问和引导至少一个固定装置到脊椎的装置可以包括构造成装配在脊的小平面中的远侧部分和从远端部分延伸的近端部分。 近端部分可以从远侧部分可拆卸并且可以是中空的或实心的。 用于访问和引导至少一个固定装置到脊椎的系统可以包括构造成装配在脊柱的小平面中的远端部分，从远侧部分延伸的近端部分和用于在小平面导向装置上滑动的可滑动的引导装置 将至少一个仪器引导到脊柱。