Process for producing 4-aminoquinazoline compound
    5.
    发明授权
    Process for producing 4-aminoquinazoline compound 失效
    4-氨基喹唑啉化合物的制备方法

    公开(公告)号:US08318932B2

    公开(公告)日:2012-11-27

    申请号:US12400895

    申请日:2009-03-10

    IPC分类号: C07D239/72

    CPC分类号: C07D239/88 C07D239/94

    摘要: A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.

    摘要翻译: 4-氨基喹唑啉衍生物可以通过以下步骤获得:将喹唑啉-4-酮或其衍生物与氯化剂在有机碱存在下在第一有机溶剂中反应,然后使反应产物与由 在第二有机溶剂的存在下,式R5-NH-R6(R5和R6各自表示氢或任选取代的烃基)。

    Processes for preparing alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound and 4-acyltetrahydropyrane
    10.
    发明授权
    Processes for preparing alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound and 4-acyltetrahydropyrane 失效
    制备3-(4-四氢吡喃基)-3-氧代丙酸烷基酯化合物和4-酰基四氢吡喃的方法

    公开(公告)号:US07741497B2

    公开(公告)日:2010-06-22

    申请号:US10583473

    申请日:2004-12-17

    IPC分类号: C07D309/06

    CPC分类号: C07D309/06

    摘要: The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.

    摘要翻译: 本发明提供一种制备式(1)表示的3-(4-四氢吡喃基)-3-氧代丙酸烷基酯化合物的方法:其中R 1和R 2可以相同或不同,并且表示基团 其不参与反应,并且R 1和R 2可以键合形成环,并且该环可以含有杂原子,并且R 3表示烃基,其包括使由式(Ⅳ)表示的4-酰基四氢吡喃与 2):其中R1和R2具有与上述相同的含义,和由式(3)表示的碳酸二酯:其中R 3具有与上述相同的含义,并且两个R 3可以彼此键合形成 在碱的存在下,以及制备4-酰基四氢吡喃的方法。