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公开(公告)号：US20050080262A1
公开(公告)日：2005-04-14
申请号：US10502734
申请日：2003-01-28
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda , Takeshi Takahashi , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda , Takeshi Takahashi , Shinobu Suzuki
IPC分类号： C07C201/08 , C07C205/59 , C07C205/60 , C07C227/04 , C07C229/56 , C07C229/64 , C07D239/88 , C07D239/90 , C07D239/72
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92 , C07C201/08 , C07C205/59 , C07C205/60 , C07C227/04 , C07C229/56 , C07C229/64 , C07D239/90
摘要： A process for producing a quinazolin-4-one compound having the formula: [wherein R1, R2, R3 and R4 each represents a group not participating in the below-mentioned reaction, and R1, R2, R3 and R4 can be combined together to form a ring] which comprises reacting an anthranilic acid derivative having the formula: [wherein R5 is a hydrogen atom or a hydrocarbyl group] with a formic acid derivative in the presence of an ammonium carboxylate.
摘要翻译： 制备具有下式的喹唑啉-4-酮化合物的方法：其中R 1，R 2，R 3和R 4各自表示不参与下述反应的基团，和 R 1，R 2，R 3和R 4可以组合在一起形成环]，其包括使具有下式的邻氨基苯甲酸衍生物：其中R 5是氢原子或 烃基]与甲酸衍生物在羧酸铵存在下反应。
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2.发明授权Process for preparation of 6, 7-bis(2-methoxyethoxy) quinazolin-4-one 有权制备6,7-双（2-甲氧基乙氧基）喹唑啉-4-酮的方法公开(公告)号：US08133999B2
公开(公告)日：2012-03-13
申请号：US12484632
申请日：2009-06-15
IPC分类号： C07D239/72
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92
摘要： 6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate of formula (4) with an orthoformic acid in the presence of an ammonium acetate:
摘要翻译： 可用于合成抗癌药物的式（5）的6,7-双（2-甲氧基乙氧基）喹唑啉-4-酮可以通过2-氨基-4,5-双（2-甲氧基乙氧基 ）苯甲酸酯与原甲酸在乙酸铵存在下反应：
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3.发明申请Process for producing 6, 7-bis (2-methoxyethoxy)-quinazolin-4-one 审中-公开制备6,7-双（2-甲氧基乙氧基） - 喹唑啉-4-酮的方法公开(公告)号：US20060276647A1
公开(公告)日：2006-12-07
申请号：US10565981
申请日：2004-07-30
IPC分类号： C07D239/80
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92
摘要： A process comprising a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate with a formic acid compound in the presence of an ammonium carboxylate gives 6,7-bis(2-methoxyethoxy)quinazolin-4-one in a high yield.
摘要翻译： 在羧酸铵存在下，将2-氨基-4,5-双（2-甲氧基乙氧基）苯甲酸乙酯与甲酸化合物反应的方法得到6,7-双（2-甲氧基乙氧基）喹唑啉-4-酮 以高收益。
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4.发明申请公开(公告)号：US20070106083A1
公开(公告)日：2007-05-10
申请号：US10564709
申请日：2004-07-14
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
IPC分类号： C07D309/14
CPC分类号： C07D309/10 , C07D309/14
摘要： The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (1): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, noble metal catalyst and metal oxide, and a synthetic intermediate thereof and a process for preparing the same.
摘要翻译： 本发明涉及一种由式（2）表示的4-氨基四氢吡喃化合物及其酸式盐的制备方法：其中R表示氢原子或烃基，其包括使4-肼基四氢吡喃化合物或其酸式盐 由式（1）表示：其中R具有与上述相同的含义，在至少一种选自阮内镍，贵金属催化剂和金属氧化物的化合物及其合成中间体存在下进行分解反应，以及其制备方法 准备一样
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5.发明授权公开(公告)号：US07365215B2
公开(公告)日：2008-04-29
申请号：US10564709
申请日：2004-07-14
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
IPC分类号： C07D315/00
CPC分类号： C07D309/10 , C07D309/14
摘要： The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (1): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (2): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, a noble metal catalyst and a metal oxide, and a synthetic intermediate thereof and a process for preparing the same.
摘要翻译： 本发明涉及一种由式（1）表示的4-氨基四氢吡喃化合物及其酸式盐的制备方法：其中R表示氢原子或烃基，其包括使4-肼基四氢吡喃化合物或其酸式盐 由式（2）表示：其中R具有与上述相同的含义，在至少一种选自阮内镍，贵金属催化剂和金属氧化物的化合物及其合成中间体存在下进行分解反应，和 制备方法
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公开(公告)号：US08367824B2
公开(公告)日：2013-02-05
申请号：US10502734
申请日：2003-01-28
IPC分类号： C07D239/72
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92 , C07C201/08 , C07C205/59 , C07C205/60 , C07C227/04 , C07C229/56 , C07C229/64 , C07D239/90
摘要： A process for producing a quinazolin-4-one compound having the formula: [wherein R1, R2, R3 and R4 each represents a group not participating in the below-mentioned reaction, and R1, R2, R3 and R4 can be combined together to form a ring] which comprises reacting an anthranilic acid derivative having the formula: [wherein R5 is a hydrogen atom or a hydrocarbyl group] with a formic acid derivative in the presence of an ammonium carboxylate.
摘要翻译： 制备具有下式的喹唑啉-4-酮化合物的方法：其中R 1，R 2，R 3和R 4各自表示不参与下述反应的基团，R 1，R 2，R 3和R 4可以组合在一起至 形成环]，其包括在羧酸铵存在下使具有式[其中R5是氢原子或烃基]的邻氨基苯甲酸衍生物与甲酸衍生物反应。
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公开(公告)号：US20050130995A1
公开(公告)日：2005-06-16
申请号：US10503664
申请日：2003-02-06
IPC分类号： C07D239/88 , C07D239/94 , A61K31/517
CPC分类号： C07D239/88 , C07D239/94
摘要： A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.
摘要翻译： 4-氨基喹唑啉衍生物可以通过以下步骤获得：将喹唑啉-4-酮或其衍生物与氯化剂在有机碱存在下在第一有机溶剂中反应，然后使反应产物与由 式R 5 -NH-R 6（R 5和R 6各自表示氢或任选地 取代的烃基）在第二有机溶剂的存在下进行。
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8.发明授权Process for producing quinoline carboxyaldehyde derivative and intermediate thereof 失效制备喹啉羧醛衍生物及其中间体的方法公开(公告)号：US06841681B2
公开(公告)日：2005-01-11
申请号：US10468062
申请日：2002-02-14
申请人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Naoko Okada , Takashi Harada , Akira Nakamura , Hiroyuki Oda
发明人： Katsumasa Harada , Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Naoko Okada , Takashi Harada , Akira Nakamura , Hiroyuki Oda
IPC分类号： C07D215/14 , C07D215/54 , C07C225/22 , C07C255/17 , C07D215/12
CPC分类号： C07D215/14
摘要： 2-Cyclopropyl-4-(4′-fluorophenyl)quinoline-3-carboxyaldehyde useful as a material for pharmaceutical products, can be obtained by reacting 3-cyclopropyl-3-oxopropanenitrile with 2-amino-4′-fluorobenzophenone to obtain 2-cyclopropyl-4-(4′-fluorophenyl)quinoline-3-carbonitrile, and reducing it.
摘要翻译： 可用作药物物质的2-环丙基-4-（4'-氟苯基）喹啉-3-甲醛可以通过3-环丙基-3-氧代丙腈与2-氨基-4'-氟二苯甲酮反应得到2- 环丙基-4-（4'-氟苯基）喹啉-3-腈，并还原。
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公开(公告)号：US08318932B2
公开(公告)日：2012-11-27
申请号：US12400895
申请日：2009-03-10
IPC分类号： C07D239/72
CPC分类号： C07D239/88 , C07D239/94
摘要： A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.
摘要翻译： 4-氨基喹唑啉衍生物可以通过以下步骤获得：将喹唑啉-4-酮或其衍生物与氯化剂在有机碱存在下在第一有机溶剂中反应，然后使反应产物与由 在第二有机溶剂的存在下，式R5-NH-R6（R5和R6各自表示氢或任选取代的烃基）。
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公开(公告)号：US07232903B2
公开(公告)日：2007-06-19
申请号：US10499361
申请日：2002-12-19
IPC分类号： C07D239/88
CPC分类号： C07D239/88 , C07C229/56
摘要： A process for preparing quinazolin-4-one or its derivative by reacting anthranilic acid or its derivative with formic acid or its derivative in the presence of ammonia, or by reacting ammonium anthranilate or its derivative with formic acid or its derivative.
摘要翻译： 通过邻氨基苯甲酸或其衍生物与甲酸或其衍生物在氨的存在下反应制备喹唑啉-4-酮或其衍生物的方法，或通过使邻氨基苯甲酸铵或其衍生物与甲酸或其衍生物反应。
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