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1.发明授权
公开(公告)号：US5929027A
公开(公告)日：1999-07-27
申请号：US815574
申请日：1997-03-12
申请人： Shigeyuki Takama , Yukiko Inamoto , Takahiko Wato , Akiya Yamada , Naoki Uchida , Misuzu Kadoriku
发明人： Shigeyuki Takama , Yukiko Inamoto , Takahiko Wato , Akiya Yamada , Naoki Uchida , Misuzu Kadoriku
CPC分类号： A61K38/23 , A61K38/24 , A61K38/35 , A61K47/12 , A61K47/26 , A61K9/006 , A61K9/2013 , A61K9/2018
摘要： A pharmaceutical composition comprising a physiologically active polypeptide, an absorption promoting agent consisting of a combination of an organic acid and a fatty acid sucrose ester in admixture with a pharmaceutically acceptable carrier or diluent, which is suitable for oral administration and for application to the oral cavity, by which the polypeptide can sufficiently be absorbed through the intestinal tract or the mucous membrane in the oral cavity and exhibit the physiological activities without being suffered from enzymolysis.
摘要翻译： 一种药物组合物，其包含生理活性多肽，由有机酸和脂肪酸蔗糖酯的组合与药学上可接受的载体或稀释剂的混合物组成的吸收促进剂，其适合于口服给药并用于口腔 通过其可以充分地通过口腔内的肠道或粘膜吸收多肽，并且在没有受到酶解的情况下表现出生理活性。
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公开(公告)号：US5468503A
公开(公告)日：1995-11-21
申请号：US78294
申请日：1993-06-25
申请人： Akiya Yamada , Takahiko Wato , Naoki Uchida , Misuzu Fujisawa , Shigeyuki Takama , Yukiko Inamoto
发明人： Akiya Yamada , Takahiko Wato , Naoki Uchida , Misuzu Fujisawa , Shigeyuki Takama , Yukiko Inamoto
CPC分类号： A61K9/4858 , A61K9/4816 , A61K9/4891
摘要： An oral pharmaceutical preparation of a type released at infragastrointestinal tract was successfully prepared, wherein a solid organic acid dissolvable, in the form of a solution, of chitosan and a solid pharmaceutical preparation including a principal agent are filled in a hard capsule composed of the base principally comprising chitosan and an enteric coating is formed on the surface of the hard capsule, characterized in that a desirable releasing time can be arranged, with no pH dependency, via water permeability derived from the porosity of chitosan of the capsule preparation.
摘要翻译： PCT No.PCT / JP92 / 01037 Sec。 371日期：1993年6月25日 102（e）1993年6月25日PCT于1992年8月13日提交PCT成功制备了在胃肠道释放的类型的口服药物制剂，其中固体有机酸以溶液的形式溶解于壳聚糖和 将包含主剂的固体药物制剂填充在由主要包含壳聚糖的基质组成的硬胶囊中，并且在硬胶囊的表面上形成肠溶衣，其特征在于可以布置理想的释放时间，没有pH依赖性 ，通过由胶囊制剂的壳聚糖的孔隙度导致的透水性。
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公开(公告)号：US08183232B2
公开(公告)日：2012-05-22
申请号：US10545910
申请日：2004-02-17
IPC分类号： A61K31/19
CPC分类号： A61K31/616 , A61K9/0031
摘要： An external preparation containing acetylsalicylic acid or its pharmaceutically acceptable salt as an active ingredient for treating anal diseases having therapeutic activity on hemorrhoids (internal hemorrhoid, external hemorrhoid), hemorrhoidal disease owing to anal fissure and other anal diseases together with activity on pain and pruritus.
摘要翻译： 含有乙酰水杨酸或其药学上可接受的盐作为有效成分的外用制剂，用于治疗对痔疮具有治疗活性的肛门疾病（内痔疮，外痔疮），由于肛裂引起的痔疮疾病及其他肛门疾病以及疼痛和瘙痒的活动。
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4.发明申请APPARATUS FOR SIMULATIVELY MEASURING ENVIRONMENT OF WOUND DRESSING ON SKIN AND MEASURING METHOD THEREFOR 有权用于模拟测量环境中的皮肤接触环境的装置及其测量方法公开(公告)号：US20100326217A1
公开(公告)日：2010-12-30
申请号：US12918367
申请日：2008-02-21
IPC分类号： G01N33/00
CPC分类号： G01N15/08 , A61B5/445 , A61F2013/00944 , A61F2013/00953 , G01N5/025 , G01N19/04
摘要： There are provided an apparatus and a method for simulatively measuring an environment in a microspace between a human skin and a wound dressing. The simulative environment-measuring apparatus comprises a constant temperature-and-humidity chamber 14 for controlling an external environment; a heat exchanger 12 disposed in the chamber 14; a constant temperature water bath 10 and a pump 11 for supplying warm water to the heat exchanger; and a container 1 which is set on the heat exchanger 12 and is easily detachable therefrom. The container 1 holds a water retentive member 2 therein, and is covered at its upper opening with a water vapor diffusion-controlling member 4. A microspace 6 formed between the water vapor diffusion-controlling member 4 and a wound dressing 5 placed on the member 4 is a simulatively reproduced space between a human skin and the wound dressing 5. A thin temperature-and-humidity sensor 7 is set in this microspace 6 to measure temperature and humidity with time. When plural containers 1 are used, environments of plural wound dressings 5 can be measured at once.
摘要翻译： 提供了一种用于模拟测量人皮肤和伤口敷料之间的微空间中的环境的装置和方法。 模拟环境测量装置包括用于控制外部环境的恒温恒湿室14; 设置在室14中的热交换器12; 恒温水浴10和用于向热交换器供给温水的泵11; 以及设置在热交换器12上并容易拆卸的容器1。 容器1在其中保持保水构件2，并在其上开口处用水蒸气扩散控制构件4覆盖。形成在水蒸气扩散控制构件4和放置在构件上的伤口敷料5之间的微空间6 图4是人皮肤和伤口敷料5之间的模拟再现空间。在该微空间6中设置薄温湿度传感器7，以随时间测量温度和湿度。 当使用多个容器1时，可以一次测量多个伤口敷料5的环境。
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公开(公告)号：US20130211309A1
公开(公告)日：2013-08-15
申请号：US13823220
申请日：2011-09-08
IPC分类号： A61F13/00
CPC分类号： A61F13/00017 , A61L15/26 , A61L15/46 , A61L15/60 , C08L75/04
摘要： Wound bed preparation in a skin wound area can be carried out by using a hydrogel sheet, wherein the hydrogel sheet is prepared by spreading a hydrogel containing a water-soluble polymer, glycerin, and water on a two-layered laminated film consisting of a polyurethane film and a hydrophobic fiber and the moisture permeability of the hydrogel sheet is 200-2000 (g/m2/24 h).
摘要翻译： 皮肤伤口部位的伤口床制剂可以通过使用水凝胶片进行，其中通过将含有水溶性聚合物，甘油和水的水凝胶铺展在由聚氨酯组成的双层叠膜上制备水凝胶片 膜和疏水性纤维，水凝胶片的透湿性为200〜2000（g / m 2 / 24h）。
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公开(公告)号：US5776886A
公开(公告)日：1998-07-07
申请号：US557104
申请日：1995-12-06
IPC分类号： A61K9/02 , A61K9/00 , A61K9/70 , A61K38/00 , A61K38/22 , A61K38/23 , A61K38/28 , A61K38/29 , A61K47/12 , A61K47/26 , A61K47/14
CPC分类号： A61K47/12 , A61K38/23 , A61K38/28 , A61K38/29 , A61K47/26 , A61K9/0034 , Y10S514/808 , Y10S514/967
摘要： The present invention relates to an improved intravaginal preparation containing a physiologically active peptide, which comprises a physiologically active peptide, a sucrose fatty acid ester and an organic acid with a pharmaceutically acceptable carrier or diluent, by which the physiologically active peptide can be absorbed safely and efficiently.
摘要翻译： PCT No.PCT / JP94 / 00894 Sec。 371 1995年12月6日第 102（e）日期1995年12月6日PCT提交1994年6月2日PCT公布。 WO94 / 28918 PCT公开号 日期1994年12月22日本发明涉及含有生理活性肽的改良的阴道内制剂，其包含生理活性肽，蔗糖脂肪酸酯和具有药学上可接受的载体或稀释剂的有机酸，通过其生理活性肽 可以安全有效地吸收。
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公开(公告)号：US08377476B2
公开(公告)日：2013-02-19
申请号：US12936815
申请日：2009-03-24
CPC分类号： A61K31/137 , A61K8/0208 , A61K8/345 , A61K8/37 , A61K8/41 , A61K8/411 , A61K9/7053 , A61K9/7061 , A61K47/10 , A61K47/14 , A61Q3/00 , A61Q17/005
摘要： Disclosed is a water-based adhesive skin patch which has excellent storage stability, can achieve excellent accumulation of butenafine hydrochloride contained therein on a patched area such as the skin and a nail, and has a high therapeutic effect. Specifically disclosed is a water-based adhesive skin patch containing butenafine hydrochloride, which is characterized by containing butenafine hydrochloride, glycol salicylate and propylene glycol in a water-containing gel ointment. Specifically, butenafine hydrochloride is dissolved in a mixed solution of glycol salicylate and propylene glycol, and the resulting solution is dispersed in a water-containing gel. Particularly, the mixing ratio of glycol salicylate to propylene glycol is 1:2 to 1:30.
摘要翻译： 公开了一种水性粘合性皮肤贴剂，其具有优异的储存稳定性，可以在皮肤和钉子等修补区域上实现含有其中所含的盐酸布他他芬的优异积累，并且具有高治疗效果。 具体公开了含有盐酸布替萘芬的水性粘合性皮肤贴剂，其特征在于在含水凝胶软膏中含有盐酸丁酸，二水杨酸乙酯和丙二醇。 具体地说，将盐酸丁丙
锭溶于水杨酸二乙酯和丙二醇的混合溶液中，将所得溶液分散在含水凝胶中。 特别地，二醇水杨酸酯与丙二醇的混合比为1:2〜1:30。-
公开(公告)号：US20110097407A1
公开(公告)日：2011-04-28
申请号：US12936815
申请日：2009-03-24
CPC分类号： A61K31/137 , A61K8/0208 , A61K8/345 , A61K8/37 , A61K8/41 , A61K8/411 , A61K9/7053 , A61K9/7061 , A61K47/10 , A61K47/14 , A61Q3/00 , A61Q17/005
摘要： Disclosed is a water-based adhesive skin patch which has excellent storage stability, can achieve excellent accumulation of butenafine hydrochloride contained therein on a patched area such as the skin and a nail, and has a high therapeutic effect. Specifically disclosed is a water-based adhesive skin patch containing butenafine hydrochloride, which is characterized by containing butenafine hydrochloride, glycol salicylate and propylene glycol in a water-containing gel ointment. Specifically, butenafine hydrochloride is dissolved in a mixed solution of glycol salicylate and propylene glycol, and the resulting solution is dispersed in a water-containing gel. Particularly, the mixing ratio of glycol salicylate to propylene glycol is 1:2 to 1:30.
摘要翻译： 公开了一种水性粘合性皮肤贴剂，其具有优异的储存稳定性，可以在皮肤和钉子等修补区域上实现含有其中所含的盐酸布他他芬的优异积累，并且具有高治疗效果。 具体公开了含有盐酸布替萘芬的水性粘合性皮肤贴剂，其特征在于在含水凝胶软膏中含有盐酸丁酸，二水杨酸乙酯和丙二醇。 具体地说，将盐酸丁丙
锭溶于水杨酸二乙酯和丙二醇的混合溶液中，将所得溶液分散在含水凝胶中。 特别地，二醇水杨酸酯与丙二醇的混合比为1:2〜1:30。-
公开(公告)号：US09877871B2
公开(公告)日：2018-01-30
申请号：US13823220
申请日：2011-09-08
CPC分类号： A61F13/00017 , A61L15/26 , A61L15/46 , A61L15/60 , C08L75/04
摘要： Wound bed preparation in a skin wound area can be carried out by using a hydrogel sheet, wherein the hydrogel sheet is prepared by spreading a hydrogel containing a water-soluble polymer, glycerin, and water on a two-layered laminated film consisting of a polyurethane film and a hydrophobic fiber and the moisture permeability of the hydrogel sheet is 200-2000 (g/m2/24 h).
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公开(公告)号：US08658625B2
公开(公告)日：2014-02-25
申请号：US10589462
申请日：2004-02-16
IPC分类号： A61K31/616
CPC分类号： A61K31/616
摘要： External preparations for treatment of painful skin wound having an analgesic activity which comprises acetylsalicylic acid or its pharmacologically acceptable salt as an active ingredient.
摘要翻译： 用于治疗具有止痛活性的疼痛皮肤伤口的外用制剂，其包含乙酰水杨酸或其药理学上可接受的盐作为活性成分。
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