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    Methods and compositions for detection of biological materials using microfluidic devices
    9.
    发明授权
    Methods and compositions for detection of biological materials using microfluidic devices 有权
    使用微流体装置检测生物材料的方法和组合物

    公开(公告)号：US08507208B2

    公开(公告)日：2013-08-13

    申请号：US12842526

    申请日：2010-07-23

    申请人： Robert C. Corcoran ,  Debashis Dutta

    发明人： Robert C. Corcoran ,  Debashis Dutta

    IPC分类号： G01N33/53 ,  G01N33/573 ,  G01N33/561

    CPC分类号： G01N33/54366 ,  B01L3/502753 ,  B01L3/502776 ,  G01N33/558

    摘要： Provided herein are microfluidic devices and methods useful for sensitive detection of analytes. The methods and devices described herein are also useful for detecting direct or indirect binding of enzymes or catalysts to a surface, for example a surface having analytes bound thereon. Methods disclosed herein include embodiments utilizing a pre-concentration scheme to improve signal levels of corresponding reporter moieties.

    摘要翻译： 本文提供了用于敏感检测分析物的微流体装置和方法。 本文所述的方法和装置也可用于检测酶或催化剂对表面的直接或间接结合，例如具有结合在其上的分析物的表面。 本文公开的方法包括利用预浓缩方案来改善对应的报道部分的信号水平的实施方案。

    Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
    10.
    发明授权
    Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers 有权
    处理具有受控孔隙率的开孔微孔聚合物泡沫的方法，用作血管移植物和支架盖

    公开(公告)号：US06702849B1

    公开(公告)日：2004-03-09

    申请号：US09460271

    申请日：1999-12-13

    申请人： Debashis Dutta ,  Chicheng Wang ,  Kondapavulur T. V. Rao

    发明人： Debashis Dutta ,  Chicheng Wang ,  Kondapavulur T. V. Rao

    IPC分类号： A61F206

    CPC分类号： A61L31/16 ,  A61F2002/072 ,  A61L27/40 ,  A61L27/54 ,  A61L27/56 ,  A61L31/10 ,  A61L31/146 ,  A61L2300/602 ,  A61L2300/606 ,  C08L67/04

    摘要： Porous vascular grafts and stent covers are formed of open-celled microcellular polymeric foams having a porosity that can be modified to be adapted for carrying and delivering different types of therapeutic drugs. A stent cover is formed of a tubular member including at least one layer of a porous, microcellular foam formed from a polymeric material capable of absorbing and releasing therapeutic drugs at predictable rates for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. A composite metal and polymer vascular graft is formed of an interior structural stent member, and an outer layer or coating of the porous, microcellular foam. The method of making the composite metal and polymer vascular graft involves providing an interior structural stent member with an outer layer or coating of the porous, microcellular foam, and can further comprise the step of loading a therapeutic drug into the outer layer of the porous, microcellular foam for delivery of the therapeutic drugs in localized drug therapy in a blood vessel.

    摘要翻译： 多孔血管移植物和支架覆盖物由具有孔隙率的开孔微孔聚合物泡沫形成，孔隙度可以被修饰以适于携带和递送不同类型的治疗药物。 支架盖由管状构件形成，该管状构件包括由能够以可预测的速率吸收和释放治疗药物的聚合材料形成的多孔微孔泡沫层，用于在血管中的局部药物治疗中递送治疗药物。 复合金属和聚合物血管移植物由内部结构支架构件和多孔微孔泡沫的外层或涂层形成。 制备复合金属和聚合物血管移植物的方法包括提供具有多孔，微孔泡沫体的外层或涂层的内部结构支架构件，并且还可以包括将治疗药物装载到多孔， 用于在血管中局部药物治疗中递送治疗药物的微孔泡沫。