公开(公告)号：US20120264949A1

公开(公告)日：2012-10-18

申请号：US13086254

申请日：2011-04-13

申请人： Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chieh Chen

发明人： Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chieh Chen

IPC分类号： C07D207/09

CPC分类号： C07D207/09

摘要： A method is provided to label dopamine D2 receptors at striatum and areas outside of striatum. A radiosynthesized ligand of iodine(I)-123-Epidepride is used. The I-123-Epidepride can be strongly bonded to the D2 receptor and has a rare characteristic of non-specificity. Hence, it is suitable for developing a tracer for areas outside of striatum, where D2 receptor densities are low. Besides, I-123-Epidepride can be passed through blood brain barrier and has a high affinity to an animal's brain, so it can be used to develop medicines for diagnosing schizophrenia.

摘要翻译： 提供了一种在纹状体和纹状体外区域标记多巴胺D2受体的方法。 使用放射合成碘（I）-123-依替西普的配位体。 I-123-表阿司亭可以与D2受体结合牢固，并且具有非特异性的罕见特征。 因此，适用于对D2受体密度低的纹状体以外的区域开发示踪剂。 此外，I-123-Epidepride可以通过血脑屏障，对动物的大脑具有高亲和力，因此可用于开发用于诊断精神分裂症的药物。

公开(公告)号：US20110178325A1

公开(公告)日：2011-07-21

申请号：US12689198

申请日：2010-01-18

申请人： Kang-Wei Chang ,  Yen-Hung Tu ,  Shih-Ying Lee ,  Jenn-Tzong Chen ,  Chia-Chieh Chen ,  Wuu-Jyh Lin

发明人： Kang-Wei Chang ,  Yen-Hung Tu ,  Shih-Ying Lee ,  Jenn-Tzong Chen ,  Chia-Chieh Chen ,  Wuu-Jyh Lin

IPC分类号： C07C255/34

CPC分类号： C07C253/30 ,  C07B2200/05 ,  C07C255/42

摘要： Disclosed is an automatic process for synthesizing F-18-FDDNP. The automatic process includes a preparation subroutine and a synthesis subroutine. The automatic process is efficient and simple. That is, it can be used to produce a large amount of chemicals in a short period of time. Furthermore, it reduces the risk of human exposure to radiation.

摘要翻译： 公开了一种合成F-18-FDDNP的自动化方法。 自动处理包括准备子程序和合成子程序。 自动过程高效简单。 也就是说，它可以在短时间内用于生产大量的化学品。 此外，它降低了人体接触辐射的风险。

公开(公告)号：US20100331577A1

公开(公告)日：2010-12-30

申请号：US12081947

申请日：2008-04-23

申请人： Chia-Chieh Chen ,  Shih-Ying Lee ,  Hung-Chun Kao ,  Kang-Wei Chang ,  Li-Chung Hwang

发明人： Chia-Chieh Chen ,  Shih-Ying Lee ,  Hung-Chun Kao ,  Kang-Wei Chang ,  Li-Chung Hwang

IPC分类号： C07C211/29

CPC分类号： C07C319/20 ,  C07B2200/05 ,  C07C323/32

摘要： There is disclosed a method for using 123I to radiolabel SnADAM become an serotonin transporter radiotracer(123I -ADAM). At first, there is provided SnADAM solution via mixing SnADAM with ethanol. The SnADAM solution is shaken and further mixed with thin KI solution. The SnADAM solution is mixed with 123I-NH4I solution and H2O2 solution. The SnADAM-123I-NH4I—H2O2 mixture is kept still. Later, the SnADAM solution is mixed with NaHSO3 solution, and the mixture is shaken and further mixed with buffer solution of saturated Na2HPO4. The SnADAM solution is filled in an Accubond C8 column. The Accubond C8 column is washed with sterile water for injection to isolate non-reacting 123I ions. The Accubond C8 column is washed with ethanol, thus providing 123I-ADAM. The 123I-ADAM is blended in normal saline mixture. Millipore Millex GV is used to filter impurities and bacteria from the 123I-ADAM solution.

摘要翻译： 公开了使用123I放射性标记SnADAM成为血清素转运体放射性示踪剂（123I-ADAM）的方法。 首先，通过混合SnADAM和乙醇提供SnADAM溶液。 将SnADAM溶液摇动并进一步与薄KI溶液混合。 将SnADAM溶液与123I-NH4I溶液和H 2 O 2溶液混合。 SnADAM-123I-NH4I-H2O2混合物保持静止。 然后将SnADAM溶液与NaHSO 3溶液混合，将混合物摇动并进一步与饱和Na 2 HPO 4缓冲溶液混合。 SnADAM溶液填充在Accubond C8柱中。 Accubond C8柱用无菌注射用水洗涤，分离出非反应性123I离子。 Accubond C8柱用乙醇洗涤，从而提供123I-ADAM。 123I-ADAM以生理盐水混合物混合。 Millipore Millex GV用于从123I-ADAM溶液中过滤杂质和细菌。

公开(公告)号：US20110288303A1

公开(公告)日：2011-11-24

申请号：US12783242

申请日：2010-05-19

申请人： Kang-Wei Chang ,  Shih-Ying Lee ,  Chia-Chieh Chen ,  Lie-Hang Shen

发明人： Kang-Wei Chang ,  Shih-Ying Lee ,  Chia-Chieh Chen ,  Lie-Hang Shen

IPC分类号： C07D263/54

CPC分类号： C07D263/57

摘要： A method is provided for fabricating I-123-IBOX. I-123-IBOX is used for SPECT of brain. During the fabrication, radioactivity of reaction vial and purification column can be detected. Thus, I-123-IBOX can be obtained in a short time through a simple process with reduced radioactive harms.

摘要翻译： 提供了制备I-123-IBOX的方法。 I-123-IBOX用于大脑SPECT。 在制造过程中，可以检测反应瓶和纯化塔的放射性。 因此，I-123-IBOX可以在短时间内通过具有减少的放射性危害的简单方法获得。

公开(公告)号：US09017646B2

公开(公告)日：2015-04-28

申请号：US13545238

申请日：2012-07-10

申请人： Jun-Ming Shih ,  Yuan-Ruei Huang ,  Yu-Lung Wu ,  Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chien Chen

发明人： Jun-Ming Shih ,  Yuan-Ruei Huang ,  Yu-Lung Wu ,  Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chien Chen

IPC分类号： A61K49/00 ,  A61B5/00

CPC分类号： A61K49/0017 ,  A61B5/0071

摘要： A process of evaluating blood-brain barrier permeability of a stroke rat by using fluorescent substance is disclosed. This process uses an Evans blue dye having spontaneous fluorescence properties, in combination with the use of a new non-invasive in vivo imaging system (IVIS), to obtain fluorescent signals so as to assess the change in the blood-brain barrier permeability of rodents after a cerebral artery stroke model surgery. In operation, an Evans blue dye is injected into a stroke rat of middle cerebral artery occlusion model. A non-invasive in vivo imaging system is used to detect the fluorescence distribution of the whole brain, and obtain images combined by the fluorescence images and optical images for the whole brain tissue. Thereby, the change in the blood-brain barrier permeability of the stroke rat can be completely realized.

摘要翻译： 公开了一种通过使用荧光物质评价中风大鼠的血脑屏障通透性的方法。 该方法使用具有自发荧光性质的伊文思蓝染料，结合使用新的非侵入性体内成像系统（IVIS）获得荧光信号，以评估啮齿动物血脑屏障通透性的变化 大脑动脉中风模型手术后。 在运行中，将伊文思蓝染料注射到大脑中动脉闭塞模型的中风大鼠中。 使用非侵入性体内成像系统检测全脑的荧光分布，并获得由整个脑组织的荧光图像和光学图像组合的图像。 由此能够完全实现卒中大鼠的血脑屏障通透性的变化。

公开(公告)号：US20140017173A1

公开(公告)日：2014-01-16

申请号：US13545238

申请日：2012-07-10

申请人： Jun-Ming Shih ,  Yuan-Ruei Huang ,  Yu-Lung Wu ,  Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chien Chen

发明人： Jun-Ming Shih ,  Yuan-Ruei Huang ,  Yu-Lung Wu ,  Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chien Chen

IPC分类号： A61K49/00

CPC分类号： A61K49/0017 ,  A61B5/0071

摘要： A process of evaluating blood-brain barrier permeability of a stroke rat by using fluorescent substance is disclosed. This process uses an Evans blue dye having spontaneous fluorescence properties, in combination with the use of a new non-invasive in vivo imaging system (IVIS), to obtain fluorescent signals so as to assess the change in the blood-brain barrier permeability of rodents after a cerebral artery stroke model surgery. In operation, an Evans blue dye is injected into a stroke rat of middle cerebral artery occlusion model. A non-invasive in vivo imaging system is used to detect the fluorescence distribution of the whole brain, and obtain images combined by the fluorescence images and optical images for the whole brain tissue. Thereby, the change in the blood-brain barrier permeability of the stroke rat can be completely realized.

摘要翻译： 公开了一种通过使用荧光物质评价中风大鼠的血脑屏障通透性的方法。 该方法使用具有自发荧光性质的伊文思蓝染料，结合使用新的非侵入性体内成像系统（IVIS）获得荧光信号，以评估啮齿动物血脑屏障通透性的变化 大脑动脉中风模型手术后。 在运行中，将伊文思蓝染料注射到大脑中动脉闭塞模型的中风大鼠中。 使用非侵入性体内成像系统检测全脑的荧光分布，并获得由整个脑组织的荧光图像和光学图像组合的图像。 由此能够完全实现卒中大鼠的血脑屏障通透性的变化。

公开(公告)号：US5659707A

公开(公告)日：1997-08-19

申请号：US320520

申请日：1994-10-07

申请人： Shih-Chieh Wang ,  Kang-Wei Chang ,  Jiahn-Jung Chen

发明人： Shih-Chieh Wang ,  Kang-Wei Chang ,  Jiahn-Jung Chen

IPC分类号： G06F13/36 ,  G06F13/00

CPC分类号： G06F13/36

摘要： A labelling method and system are disclosed for correlating multiple outstanding requests to utilize a shared resource issued by a particular master of a computer system. The labelling system includes a memory for storing an assigned indication corresponding to each label assigned by each master of a computer system. The memory is also for indicating a label available for assignment which is unique over each outstanding, unsatisfied request to utilize the shared resource issued by each master of the computers system. The labelling system also includes a first circuit which is responsive to the unique label indicated by the memory. The first circuit is provided for assigning the unique label indicated by the memory to a request to utilize the shared resource issued by the particular master in which the labelling system is located.

摘要翻译： 公开了一种用于关联多个未完成请求以利用由计算机系统的特定主机发布的共享资源的标签方法和系统。 标签系统包括用于存储对应于由计算机系统的每个主机分配的每个标签的分配指示的存储器。 存储器还用于指示可用于分配的标签，其在每个未完成的不满足的请求中是唯一的，以利用由计算机系统的每个主机发布的共享资源。 标签系统还包括响应于由存储器指示的唯一标签的第一电路。 提供第一电路用于将由存储器指示的唯一标签分配给使用由标签系统所在的特定主机发出的共享资源的请求。