公开(公告)号：US20120264949A1

公开(公告)日：2012-10-18

申请号：US13086254

申请日：2011-04-13

申请人： Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chieh Chen

发明人： Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chieh Chen

IPC分类号： C07D207/09

CPC分类号： C07D207/09

摘要： A method is provided to label dopamine D2 receptors at striatum and areas outside of striatum. A radiosynthesized ligand of iodine(I)-123-Epidepride is used. The I-123-Epidepride can be strongly bonded to the D2 receptor and has a rare characteristic of non-specificity. Hence, it is suitable for developing a tracer for areas outside of striatum, where D2 receptor densities are low. Besides, I-123-Epidepride can be passed through blood brain barrier and has a high affinity to an animal's brain, so it can be used to develop medicines for diagnosing schizophrenia.

摘要翻译： 提供了一种在纹状体和纹状体外区域标记多巴胺D2受体的方法。 使用放射合成碘（I）-123-依替西普的配位体。 I-123-表阿司亭可以与D2受体结合牢固，并且具有非特异性的罕见特征。 因此，适用于对D2受体密度低的纹状体以外的区域开发示踪剂。 此外，I-123-Epidepride可以通过血脑屏障，对动物的大脑具有高亲和力，因此可用于开发用于诊断精神分裂症的药物。

公开(公告)号：US20110288303A1

公开(公告)日：2011-11-24

申请号：US12783242

申请日：2010-05-19

申请人： Kang-Wei Chang ,  Shih-Ying Lee ,  Chia-Chieh Chen ,  Lie-Hang Shen

发明人： Kang-Wei Chang ,  Shih-Ying Lee ,  Chia-Chieh Chen ,  Lie-Hang Shen

IPC分类号： C07D263/54

CPC分类号： C07D263/57

摘要： A method is provided for fabricating I-123-IBOX. I-123-IBOX is used for SPECT of brain. During the fabrication, radioactivity of reaction vial and purification column can be detected. Thus, I-123-IBOX can be obtained in a short time through a simple process with reduced radioactive harms.

摘要翻译： 提供了制备I-123-IBOX的方法。 I-123-IBOX用于大脑SPECT。 在制造过程中，可以检测反应瓶和纯化塔的放射性。 因此，I-123-IBOX可以在短时间内通过具有减少的放射性危害的简单方法获得。

公开(公告)号：US20100331577A1

公开(公告)日：2010-12-30

申请号：US12081947

申请日：2008-04-23

申请人： Chia-Chieh Chen ,  Shih-Ying Lee ,  Hung-Chun Kao ,  Kang-Wei Chang ,  Li-Chung Hwang

发明人： Chia-Chieh Chen ,  Shih-Ying Lee ,  Hung-Chun Kao ,  Kang-Wei Chang ,  Li-Chung Hwang

IPC分类号： C07C211/29

CPC分类号： C07C319/20 ,  C07B2200/05 ,  C07C323/32

摘要： There is disclosed a method for using 123I to radiolabel SnADAM become an serotonin transporter radiotracer(123I -ADAM). At first, there is provided SnADAM solution via mixing SnADAM with ethanol. The SnADAM solution is shaken and further mixed with thin KI solution. The SnADAM solution is mixed with 123I-NH4I solution and H2O2 solution. The SnADAM-123I-NH4I—H2O2 mixture is kept still. Later, the SnADAM solution is mixed with NaHSO3 solution, and the mixture is shaken and further mixed with buffer solution of saturated Na2HPO4. The SnADAM solution is filled in an Accubond C8 column. The Accubond C8 column is washed with sterile water for injection to isolate non-reacting 123I ions. The Accubond C8 column is washed with ethanol, thus providing 123I-ADAM. The 123I-ADAM is blended in normal saline mixture. Millipore Millex GV is used to filter impurities and bacteria from the 123I-ADAM solution.

摘要翻译： 公开了使用123I放射性标记SnADAM成为血清素转运体放射性示踪剂（123I-ADAM）的方法。 首先，通过混合SnADAM和乙醇提供SnADAM溶液。 将SnADAM溶液摇动并进一步与薄KI溶液混合。 将SnADAM溶液与123I-NH4I溶液和H 2 O 2溶液混合。 SnADAM-123I-NH4I-H2O2混合物保持静止。 然后将SnADAM溶液与NaHSO 3溶液混合，将混合物摇动并进一步与饱和Na 2 HPO 4缓冲溶液混合。 SnADAM溶液填充在Accubond C8柱中。 Accubond C8柱用无菌注射用水洗涤，分离出非反应性123I离子。 Accubond C8柱用乙醇洗涤，从而提供123I-ADAM。 123I-ADAM以生理盐水混合物混合。 Millipore Millex GV用于从123I-ADAM溶液中过滤杂质和细菌。

公开(公告)号：US20110178325A1

公开(公告)日：2011-07-21

申请号：US12689198

申请日：2010-01-18

申请人： Kang-Wei Chang ,  Yen-Hung Tu ,  Shih-Ying Lee ,  Jenn-Tzong Chen ,  Chia-Chieh Chen ,  Wuu-Jyh Lin

发明人： Kang-Wei Chang ,  Yen-Hung Tu ,  Shih-Ying Lee ,  Jenn-Tzong Chen ,  Chia-Chieh Chen ,  Wuu-Jyh Lin

IPC分类号： C07C255/34

CPC分类号： C07C253/30 ,  C07B2200/05 ,  C07C255/42

摘要： Disclosed is an automatic process for synthesizing F-18-FDDNP. The automatic process includes a preparation subroutine and a synthesis subroutine. The automatic process is efficient and simple. That is, it can be used to produce a large amount of chemicals in a short period of time. Furthermore, it reduces the risk of human exposure to radiation.

摘要翻译： 公开了一种合成F-18-FDDNP的自动化方法。 自动处理包括准备子程序和合成子程序。 自动过程高效简单。 也就是说，它可以在短时间内用于生产大量的化学品。 此外，它降低了人体接触辐射的风险。

公开(公告)号：US20140017173A1

公开(公告)日：2014-01-16

申请号：US13545238

申请日：2012-07-10

申请人： Jun-Ming Shih ,  Yuan-Ruei Huang ,  Yu-Lung Wu ,  Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chien Chen

发明人： Jun-Ming Shih ,  Yuan-Ruei Huang ,  Yu-Lung Wu ,  Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chien Chen

IPC分类号： A61K49/00

CPC分类号： A61K49/0017 ,  A61B5/0071

摘要： A process of evaluating blood-brain barrier permeability of a stroke rat by using fluorescent substance is disclosed. This process uses an Evans blue dye having spontaneous fluorescence properties, in combination with the use of a new non-invasive in vivo imaging system (IVIS), to obtain fluorescent signals so as to assess the change in the blood-brain barrier permeability of rodents after a cerebral artery stroke model surgery. In operation, an Evans blue dye is injected into a stroke rat of middle cerebral artery occlusion model. A non-invasive in vivo imaging system is used to detect the fluorescence distribution of the whole brain, and obtain images combined by the fluorescence images and optical images for the whole brain tissue. Thereby, the change in the blood-brain barrier permeability of the stroke rat can be completely realized.

摘要翻译： 公开了一种通过使用荧光物质评价中风大鼠的血脑屏障通透性的方法。 该方法使用具有自发荧光性质的伊文思蓝染料，结合使用新的非侵入性体内成像系统（IVIS）获得荧光信号，以评估啮齿动物血脑屏障通透性的变化 大脑动脉中风模型手术后。 在运行中，将伊文思蓝染料注射到大脑中动脉闭塞模型的中风大鼠中。 使用非侵入性体内成像系统检测全脑的荧光分布，并获得由整个脑组织的荧光图像和光学图像组合的图像。 由此能够完全实现卒中大鼠的血脑屏障通透性的变化。

公开(公告)号：US09017646B2

公开(公告)日：2015-04-28

申请号：US13545238

申请日：2012-07-10

申请人： Jun-Ming Shih ,  Yuan-Ruei Huang ,  Yu-Lung Wu ,  Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chien Chen

发明人： Jun-Ming Shih ,  Yuan-Ruei Huang ,  Yu-Lung Wu ,  Shih-Ying Lee ,  Kang-Wei Chang ,  Chia-Chien Chen

IPC分类号： A61K49/00 ,  A61B5/00

CPC分类号： A61K49/0017 ,  A61B5/0071

摘要： A process of evaluating blood-brain barrier permeability of a stroke rat by using fluorescent substance is disclosed. This process uses an Evans blue dye having spontaneous fluorescence properties, in combination with the use of a new non-invasive in vivo imaging system (IVIS), to obtain fluorescent signals so as to assess the change in the blood-brain barrier permeability of rodents after a cerebral artery stroke model surgery. In operation, an Evans blue dye is injected into a stroke rat of middle cerebral artery occlusion model. A non-invasive in vivo imaging system is used to detect the fluorescence distribution of the whole brain, and obtain images combined by the fluorescence images and optical images for the whole brain tissue. Thereby, the change in the blood-brain barrier permeability of the stroke rat can be completely realized.

摘要翻译： 公开了一种通过使用荧光物质评价中风大鼠的血脑屏障通透性的方法。 该方法使用具有自发荧光性质的伊文思蓝染料，结合使用新的非侵入性体内成像系统（IVIS）获得荧光信号，以评估啮齿动物血脑屏障通透性的变化 大脑动脉中风模型手术后。 在运行中，将伊文思蓝染料注射到大脑中动脉闭塞模型的中风大鼠中。 使用非侵入性体内成像系统检测全脑的荧光分布，并获得由整个脑组织的荧光图像和光学图像组合的图像。 由此能够完全实现卒中大鼠的血脑屏障通透性的变化。

公开(公告)号：US06205861B1

公开(公告)日：2001-03-27

申请号：US09235705

申请日：1999-01-22

申请人： Shih-Ying Lee

发明人： Shih-Ying Lee

IPC分类号： G01L912

CPC分类号： G01L19/04 ,  G01L9/0072

摘要： A capacitive pressure transducer includes a conductive diaphragm positioned between pneumatically separated chambers defined by concave body members. The diaphragm is fixed and sealingly coupled at its periphery to the peripheral rim of the concave body members. The diaphragm can be supported in tension by the peripheral rim of the body members. An electrode assembly, supported by one body member, establishes a substantially planar conductive surface opposite to and spaced apart by a nominal gap from the conductive diaphragm. The capacitive pressure transducer further includes a thermal compensation element securely coupled to the inside surface or the outside surface of one of the concave body members and/or to the electrode. The thermal compensation element has a different coefficient of thermal expansion from that of the concave body member or electrode to which it is attached. The combination of the concave body member or electrode and thermal compensation element having different coefficients of thermal expansion results in a bimetallic action which produces a thermally dependent force that compensates or counter-acts the thermally induced changes in the characteristics of the transducer.

摘要翻译： 一个电容式压力传感器包括一个定位在由凹形体构件限定的气动分离的腔室之间的导电隔膜。 隔膜固定并在其周边密封地连接到凹体构件的周缘。 隔膜可以被身体构件的周边边缘张紧地支撑。 由一个主体构件支撑的电极组件建立了与导电隔膜相对并与其隔开的基本平坦的导电表面。 电容式压力传感器还包括热补偿元件，该热补偿元件牢固地联接到凹体构件之一和/或电极的内表面或外表面。 热补偿元件的热膨胀系数与其所附接的凹体部件或电极的热膨胀系数不同。 凹体部件或电极与具有不同热膨胀系数的热补偿元件的组合导致双金属作用，其产生热依赖力，其补偿或反作用于热诱导的换能器特性的变化。

公开(公告)号：US6014800A

公开(公告)日：2000-01-18

申请号：US237377

申请日：1999-01-26

申请人： Shih-Ying Lee

发明人： Shih-Ying Lee

IPC分类号： G01L9/00 ,  G01L13/00 ,  H01G7/00

CPC分类号： G01L13/00 ,  G01L9/0072 ,  Y10T29/43

摘要： A capacitive pressure transducer includes a conductive diaphragm positioned between pneumatically separated chambers. The diaphragm is fixed and sealingly coupled at its periphery to the peripheral rim of a concave body member. The diaphragm is supported in tension by the peripheral rim of the body member. An electrode assembly, supported by the body member establishes a substantially planar conductive surface opposite to and spaced apart by a nominal gap from the conductive diaphragm. The body member includes a yieldable portion that is adapted to radially expand its peripheral rim in response to forces applied to the body member. When the forces are applied, the body member becomes strained beyond its elastic limit and takes a permanent set whereby the peripheral rim is expanded and the diaphragm becomes tensioned. The tension in the diaphragm can be determined as a function of the geometry of the body member and deformation resulting from the forces applied. Additional forces can be applied at a later point in time in order to change or adjust the tension in the diaphragm.

摘要翻译： 电容式压力换能器包括位于气动分离室之间的导电隔膜。 隔膜固定并在其周边密封地联接到凹体构件的周缘。 隔膜由主体构件的外围边缘张紧地支撑。 由本体构件支撑的电极组件建立了与导电隔膜相对并与其隔开的基本平坦的导电表面。 主体构件包括可屈曲部分，其适于响应于施加到主体构件的力而径向地扩张其外围边缘。 当施加力时，主体构件变得超过其弹性极限，并且采用永久变形，由此外围边缘膨胀并且隔膜变得张紧。 隔膜中的张力可以根据身体构件的几何形状和施加的力产生的变形来确定。 可以在稍后的时间点施加额外的力，以便改变或调整隔膜中的张力。

公开(公告)号：US4899600A

公开(公告)日：1990-02-13

申请号：US25846

申请日：1987-03-16

申请人： Shih-Ying Lee

发明人： Shih-Ying Lee

IPC分类号： G01G7/06 ,  G01G21/24 ,  G01L1/14

CPC分类号： G01G21/24 ,  G01G7/06 ,  G01L1/142

摘要： A compact force transducer has at least one flexible beam mounted at one or both its ends to a force summing member or members. The force-to-be-measured is applied to the force summing member along a first axis generally transverse to the beams to deform the beam elastically, without overstressing, through a displacement d. A sensor member carries a conductive surface and is coupled to the beam member. In a parallelogram form, there are a parallel pair of beam members extending between two force summing members and a sensor member is secured to each beam member at or near its point of inflection. One sensor member includes multiple arms that sandwich the other sensor member to produce a linear, push-pull mode of operation. In a low cost cantilevered beam form, the sensor is coupled to the beam at the force summing member in a parallel, spaced relationship. In a hybrid push-pull form, the transducer uses a two beam parallelogram construction with cantilevered sensors (1) coupled rigidly to each beam adjacent one force summing member with a hinge coupling between the beam and this one force summing member, and (2) extending generally in a parallel spaced relationship with respect to an associated one of the beams.

摘要翻译： 紧凑力传感器具有至少一个柔性梁，其一端或两端安装到力求和构件上。 被测量的力被施加到沿着大致横向于梁的第一轴线的力求和构件，以通过位移d弹性地变形梁，而不会过度应力。 传感器构件承载导电表面并且联接到梁构件。 在平行四边形形式中，存在在两个力求和构件之间延伸的平行的一对梁构件，并且传感器构件在其拐点处或附近固定到每个梁构件。 一个传感器构件包括夹着另一个传感器构件以产生线性的推挽操作模式的多个臂。 在低成本的悬臂梁形式中，传感器以平行，间隔的关系在力求和构件处联接到梁。 在混合推挽形式中，换能器使用具有悬臂传感器（1）的双梁平行四边形结构，该悬臂传感器（1）刚性地连接到与一个力求和构件之间的铰链联接的一个力求和构件附近的每个梁，以及（2） 通常以相对于一个梁的平行间隔的关系延伸。

公开(公告)号：US4463614A

公开(公告)日：1984-08-07

申请号：US359619

申请日：1982-03-18

申请人： Shih-Ying Lee

发明人： Shih-Ying Lee

IPC分类号： G01L1/14

CPC分类号： G01L1/142

摘要： A force transducer includes a pair of rigid force summing members that each extend toward one another along a central axis and a pair of beam members that each extend along the central axis and couple the force summing members to form a parallelogram frame. More specifically, the beam members are mounted to the force summing members to provide a frame such that a force applied to one force summing member along a first reference axis and resisted on the opposite side of the other force summing member produces a flexing of the beam members. The force summing members each include sensing members that also extend along the central axis toward one another. The sensing members are spaced from one another in the direction of the first reference axis. Electrically conductive members mounted on the opposite faces of the sensor form a variable gap capacitor that is integral with the frame. The flexing of the frame produces a change in the gap that relates to the applied force. The force summing and beam members are formed of a dielectric material. In one form each beam member is integral with an associated force summing member, the beam member being defined by an open slot. The beam members are each tapered along the central axis and toward the variable gap. In one form of the construction the beam member portions associated with each force summing member are joined at a point of inflection (i.e. the zero bending moment point) of the beam as joined. In the preferred form, the beam members and the associated force summing members are integral, monolithic and each force summing member and associated beam and sensor portions is identical to the other.

摘要翻译： 力传感器包括一对刚性力求和构件，每个刚力力求和构件沿着中心轴线彼此相对延伸，并且一对梁构件各自沿中心轴线延伸并且联接力求和构件以形成平行四边形框架。 更具体地，梁构件安装到力求和构件以提供框架，使得沿着第一参考轴施加到一个力求和构件并抵抗在另一个力求和构件的相对侧上的力产生梁的弯曲 会员 力求和构件各自包括也沿着中心轴线彼此延伸的感测构件。 感测构件在第一参考轴线的方向上彼此间隔开。 安装在传感器的相对面上的导电构件形成与框架成一体的可变间隙电容器。 框架的弯曲产生与施加的力相关的间隙的变化。 力求和和梁构件由电介质材料形成。 在一种形式中，每个梁构件与相关联的力求和构件成一体，梁构件由开口槽限定。 梁构件各自沿着中心轴逐渐变细并朝向可变间隙。 在结构的一种形式中，与每个力求和构件相关联的梁构件部分在连接的梁的拐点（即零弯矩点）处接合。 在优选形式中，梁构件和相关联的力求和构件是整体的，单块的，并且每个力求和构件和相关联的梁和传感器部分彼此相同。