公开(公告)号：US20220317101A1

公开(公告)日：2022-10-06

申请号：US17702849

申请日：2022-03-24

申请人： SHIMADZU CORPORATION

发明人： Shiori UEDA ,  Tomohiro SHAGAWA ,  Soichiro TAMAOKI

IPC分类号： G01N30/86 ,  G01N30/82 ,  G01N30/16

摘要： A separation column (6), an injector (4) that injects a sample into a mobile phase flowing through a flow path (16) leading to the separation column (6), at least one detector (8;10) that is fluidly connected downstream of the separation column (6), and generates a plurality of detector signals different from each other derived from a component in a sample separated by the separation column (6), a fraction collector (12) for fractionating and collecting a portion containing a component separated by the separation column (6) in an eluate from the separation column (6) into an individual collection container, and a controller (14) that detects a component peak in a plurality of chromatograms based on each of a plurality of the detector signals and controls operation of the fraction collector (12) based on a result of the detection are included. The controller (14) includes a fractionating collection part (26) configured to execute fractionating collection in which a portion detected as a component peak only in one chromatogram of a plurality of the chromatograms and a portion detected as a component peak in all of a plurality of the chromatograms are collected separately in collection containers different from each other.

公开(公告)号：US20220299488A1

公开(公告)日：2022-09-22

申请号：US17680383

申请日：2022-02-25

申请人： SHIMADZU CORPORATION

发明人： Soichiro TAMAOKI ,  Tomoyuki YAMAZAKI ,  Shohei SATO

IPC分类号： G01N30/86 ,  G01N30/80 ,  G01N30/16

摘要： A preparative liquid chromatograph including an analysis channel (2), an injector (6), a separation column (8), a detector (10), a plurality of fraction collectors (14-1 to 14-n), a switching valve (12) that switches fraction collectors (14-1 to 14-n) to be connected to the outlet of the detector (10) among the plurality of fraction collectors (14-1 to 14-n), and a controller (16) for controlling operations of the plurality of fraction collectors (14-1 to 14-n) and the switching valve (12). In a case where the number of remaining unused collection containers of the fraction collector in use, which is connected to the outlet of the detector, falls below the number of buffers which is an integer of two or more, the controller (16) is configured to switch the switching valve (12) while the fraction collector in use is not performing a peak collection operation.

公开(公告)号：US20220283132A1

公开(公告)日：2022-09-08

申请号：US17676164

申请日：2022-02-20

申请人： SHIMADZU CORPORATION

发明人： Shiori UEDA ,  Tomohiro SHAGAWA ,  Soichiro TAMAOKI ,  Tomoyuki YAMAZAKI ,  Shohei SATO

IPC分类号： G01N30/82 ,  G01N30/16 ,  G01N30/86 ,  G01N30/46

摘要： A preparative liquid chromatograph for separating and extracting components in a sample, the preparative liquid chromatograph including a separation channel (2) through which a mobile phase flows, an injector (6) that injects the sample into the mobile phase, a separation column (8) for separating components in the sample injected into the mobile phase, the separation column (8) being provided downstream of the injector (6) on the separation channel (2), a detector (10) for detecting peaks of the components separated by the separation column (8), a fraction collector (12) configured to collect an eluate from the separation column (8) into a plurality of collection containers (20:22) at a downstream of the detector (10) while fractionating the eluate, and a controller (14) for controlling operation of the fraction collector (12), wherein the fraction collector (12) is provided with peak collection containers (20) and waste liquid collection containers (22), each peak collection container (20) is used for collecting a peak portion including a collection target peak detected by the detector (10) in the eluate, and each waste liquid collection container (22) is used for collecting a waste liquid portion not including the collection target peak in the eluate, and the controller (14) is configured to collect the peak portion including the collection target peak detected by the detector (10) in the eluate in the peak collection container (20), and to collect at least a part of the waste liquid portion in the waste liquid collection container (22).

公开(公告)号：US20240151694A1

公开(公告)日：2024-05-09

申请号：US18279822

申请日：2021-11-08

申请人： SHIMADZU CORPORATION

发明人： Soichiro TAMAOKI ,  Tomoyuki YAMAZAKI ,  Shohei SATO

IPC分类号： G01N30/24 ,  G01N30/02 ,  G01N30/82

CPC分类号： G01N30/24 ,  G01N30/82 ,  G01N2030/027

摘要： A separation channel on which a liquid delivery pump, a separation column, and a detector are provided, the liquid delivering pump being for feeding a mobile phase, the separation column being for separating a component in a sample, and the detector being for detecting peaks of components separated from each other by the separation column, a plurality of liquid handlers each including an injecting part and a collecting part, wherein when one of the plurality of liquid handlers is introduced into the separation channel, the injecting part of the one of the plurality of liquid handlers functions as an injector that executes injection operation of a sample into a mobile phase flowing through the analysis channel upstream of the separation column in the analysis channel and the collecting part of the one the plurality of liquid handlers functions as a fraction collector that executes collection operation of peaks of components separated from each other in the separation column, a selector for selectively switching a liquid handler to be introduced into the separation channel among a plurality of the liquid handlers, and a controller for controlling operation of a plurality of the liquid handlers and the selector.

公开(公告)号：US20200240966A1

公开(公告)日：2020-07-30

申请号：US16491282

申请日：2017-03-07

申请人： SHIMADZU CORPORATION

发明人： Soichiro TAMAOKI ,  Tsutomu OKOBA ,  Takayuki IRIKI ,  Shiori UEDA

IPC分类号： G01N30/82 ,  G01N30/86

摘要： A fraction collector control device includes a peak designation part that displays a chromatogram for setting and requires a user to select at least one peak in the chromatogram for setting, a parameter extraction part that extracts, as a parameter, a signal level and/or a slope at a start point and an end point of each peak designated by a user, and a threshold candidate generation part that generates, based on the parameter extracted by the parameter extraction part, a threshold candidate usable as a common threshold for detecting start points of all peaks designated by a user and a common threshold for detecting end points of all peaks designated by a user.

公开(公告)号：US20240044847A1

公开(公告)日：2024-02-08

申请号：US18221621

申请日：2023-07-13

申请人： SHIMADZU CORPORATION

发明人： Soichiro TAMAOKI ,  Tomoyuki YAMAZAKI ,  Shohei SATO

IPC分类号： G01N30/16 ,  G01N30/74 ,  G01N30/72 ,  G01N30/80

CPC分类号： G01N30/16 ,  G01N30/74 ,  G01N30/72 ,  G01N30/80 ,  G01N2030/326

摘要： Provided is a preparative liquid chromatograph capable of coping with a case where actual second delay time changes after start of a fractionation sequence. When a specific component detected as a peak in both a first detector and a second detector is injected during execution of a fractionation sequence, a control device executes maintenance operation of time difference information stored in an information storage area. In the maintenance operation, the control device executes peak determination as to whether or not a difference between first retention time and second retention time falls within a predetermined allowable range. By the above, the control device checks whether or not the second delay time from when a component is detected by the second detector to when the component reaches a fraction collector changes from a previous state.

公开(公告)号：US20200064315A1

公开(公告)日：2020-02-27

申请号：US16485974

申请日：2017-03-07

申请人： Shimadzu Corporation

发明人： Soichiro TAMAOKI ,  Tsutomu OKOBA ,  Takayuki IRIKI ,  Shiori UEDA

IPC分类号： G01N30/82 ,  G01N30/88 ,  G01N30/86 ,  B01D15/24

摘要： A fraction collector controller includes a threshold storing part, a peak detecting part, a number-of-points-of-data setting part, and a control part. The peak detecting part retrieves, at regular intervals, signals that are from a detector of a liquid chromatograph and are used as points of data, and detects a start point and an end point of a peak by comparing a signal strength and/or an inclination of each of the points of data with the threshold(s). The number-of-points-of-data setting part is configured to set a number of the points of data with which the peak detecting part compares the threshold(s) to detect a start point and an end point of a peak.

公开(公告)号：US20200033303A1

公开(公告)日：2020-01-30

申请号：US16499413

申请日：2017-04-05

申请人： SHIMADZU CORPORATION

发明人： Soichiro TAMAOKI ,  Tsutomu OKOBA ,  Takayuki IRIKI ,  Shiori UEDA

IPC分类号： G01N30/24 ,  G01N30/86

摘要： In a preparative liquid chromatograph, a control device for controlling at least operation of a sample injection part includes a holding part for holding a chromatogram-for-setting created in advance for a sample to be analyzed, and an injection program creating part configured to create an injection program that defines timings at which injection operations are executed based on the chromatogram-for-setting, so that, in the case where the number of injections in a multiple injection mode is set, a peak of a chromatogram of the sample to be analyzed injected in each injection operation does not overlap a peak of a chromatogram of the sample to be analyzed injected in another injection operation.