公开(公告)号：US20200240966A1

公开(公告)日：2020-07-30

申请号：US16491282

申请日：2017-03-07

Applicant: SHIMADZU CORPORATION

Inventor： Soichiro TAMAOKI ,  Tsutomu OKOBA ,  Takayuki IRIKI ,  Shiori UEDA

IPC: G01N30/82 ,  G01N30/86

Abstract: A fraction collector control device includes a peak designation part that displays a chromatogram for setting and requires a user to select at least one peak in the chromatogram for setting, a parameter extraction part that extracts, as a parameter, a signal level and/or a slope at a start point and an end point of each peak designated by a user, and a threshold candidate generation part that generates, based on the parameter extracted by the parameter extraction part, a threshold candidate usable as a common threshold for detecting start points of all peaks designated by a user and a common threshold for detecting end points of all peaks designated by a user.

公开(公告)号：US20220082533A1

公开(公告)日：2022-03-17

申请号：US17535774

申请日：2021-11-26

Applicant: SHIMADZU CORPORATION

Inventor： Taichi TOMONO ,  Takayuki IRIKI ,  Tomohiro SHAGAWA ,  Satoru WATANABE

IPC: G01N30/24 ,  G01N35/10

Abstract: An online HPLC dissolution test system includes a dissolution tester and a liquid chromatograph. An autosampler of the liquid chromatograph includes at least one flow vial, a sampling needle and an injection port. the flow vial is connected to the dissolution tester via a pipe and is for storing a sample solution supplied from the dissolution tester therein. The sampling needle is for collecting the sample solution by sucking from the flow vial. The injection port is for injecting the sample solution from the sampling needle into the analysis channel. The controller of the liquid chromatograph includes an immediate analyzing execution part configured to cause the autosampler to execute immediate analyzing operation for sucking the sample solution in the flow vial with the sampling needle and directly injecting the sample solution into the injection port when the sample solution is supplied from the dissolution tester to the flow vial.

公开(公告)号：US20200150099A1

公开(公告)日：2020-05-14

申请号：US16631508

申请日：2017-08-25

Applicant: SHIMADZU CORPORATION

Inventor： Taichi TOMONO ,  Takayuki IRIKI ,  Tomohiro SHAGAWA ,  Satoru WATANABE

IPC: G01N30/34 ,  G01N1/20 ,  G01N30/18

Abstract: An online HPLC dissolution test system includes a dissolution tester and a liquid chromatograph. An autosampler of the liquid chromatograph includes at least one flow vial, a sampling needle and an injection port. The flow vial is connected to the dissolution tester via a pipe and is for storing a sample solution supplied from the dissolution tester therein. The sampling needle is for collecting the sample solution by sucking from the flow vial. The injection port is for injecting the sample solution from the sampling needle into the analysis channel. The controller of the liquid chromatograph includes an immediate analyzing execution part configured to cause the autosampler to execute immediate analyzing operation for sucking the sample solution in the flow vial with the sampling needle and directly injecting the sample solution into the injection port when the sample solution is supplied from the dissolution tester to the flow vial.

公开(公告)号：US20230251232A1

公开(公告)日：2023-08-10

申请号：US18097707

申请日：2023-01-17

Applicant: SHIMADZU CORPORATION

Inventor： Takayuki IRIKI

IPC: G01N30/86 ,  G01N30/14 ,  G01N30/16 ,  B01D15/14

CPC classification number: G01N30/8631 ,  G01N30/14 ,  G01N30/16 ,  B01D15/14 ,  G01N2030/027

Abstract: A fraction collector (14) that is provided downstream of a detector (10) and for separating an eluate eluted from a separation column (8) into a plurality of parts and collecting each of the parts into a plurality of containers respectively, and a controller (16) configured to execute fractionation operation for each sample injected at one time into the mobile phase are provided. In the fractionation operation, the controller detects components separated from each other in the separation column (8) as peaks individually based on a signal output from the detector (10), and controls operation of the fraction collector (14) such that the components detected as the peaks are collected in different containers. The controller (16) is configured to set a reference number of the number of components in a sample injected into the mobile phase, to count the number of components detected as the peaks for each sample injected into the mobile phase at a time by the injector (6), and to determine that the fractionation operation of the sample is completed when the number of components counted reaches the reference number and all components as many as the reference number are collected in the container.

公开(公告)号：US20200064315A1

公开(公告)日：2020-02-27

申请号：US16485974

申请日：2017-03-07

Applicant: Shimadzu Corporation

Inventor： Soichiro TAMAOKI ,  Tsutomu OKOBA ,  Takayuki IRIKI ,  Shiori UEDA

IPC: G01N30/82 ,  G01N30/88 ,  G01N30/86 ,  B01D15/24

Abstract: A fraction collector controller includes a threshold storing part, a peak detecting part, a number-of-points-of-data setting part, and a control part. The peak detecting part retrieves, at regular intervals, signals that are from a detector of a liquid chromatograph and are used as points of data, and detects a start point and an end point of a peak by comparing a signal strength and/or an inclination of each of the points of data with the threshold(s). The number-of-points-of-data setting part is configured to set a number of the points of data with which the peak detecting part compares the threshold(s) to detect a start point and an end point of a peak.

公开(公告)号：US20200033303A1

公开(公告)日：2020-01-30

申请号：US16499413

申请日：2017-04-05

Applicant: SHIMADZU CORPORATION

Inventor： Soichiro TAMAOKI ,  Tsutomu OKOBA ,  Takayuki IRIKI ,  Shiori UEDA

IPC: G01N30/24 ,  G01N30/86

Abstract: In a preparative liquid chromatograph, a control device for controlling at least operation of a sample injection part includes a holding part for holding a chromatogram-for-setting created in advance for a sample to be analyzed, and an injection program creating part configured to create an injection program that defines timings at which injection operations are executed based on the chromatogram-for-setting, so that, in the case where the number of injections in a multiple injection mode is set, a peak of a chromatogram of the sample to be analyzed injected in each injection operation does not overlap a peak of a chromatogram of the sample to be analyzed injected in another injection operation.

公开(公告)号：US20160290976A1

公开(公告)日：2016-10-06

申请号：US15088280

申请日：2016-04-01

Applicant: SHIMADZU CORPORATION

Inventor： Tsutomu OKOBA ,  Takayuki IRIKI

IPC: G01N30/80 ,  G01N30/86 ,  G01N30/74

Abstract: Provided is a preparative separation chromatograph including: a chromatograph 10 having a detector 15; a fraction collector 20; a controller 34 for commanding the fraction collector to initiate a component-collecting operation with reference to a point when the rate of change in an output signal from the detector 15 exceeds a positive reference value and to discontinue the operation with reference to a point when the absolute value of the rate of change becomes smaller than that of a negative reference value after the rate of change turns negative; a storage section 31 for storing sampling-rate information which relates the value of the output signal to the time interval at which the controller determines the rate of change; and a sampling rate determiner 33 for determining the time interval for calculating the rate of change based on the sampling-rate information and actual values of the output signal.

Abstract translation: 提供了一种制备型分离色谱仪，其包括：具有检测器15的色谱仪10; 馏分收集器20; 控制器34，用于指示分数收集器参照当来自检测器15的输出信号的变化率超过正参考值时的点来启动分量收集操作，并且当参考点 变化率变为负值后，变化率的绝对值变得小于负参考值的绝对值; 存储部分31，用于存储将输出信号的值与控制器确定变化率的时间间隔相关联的采样率信息; 以及采样率确定器33，用于基于采样率信息和输出信号的实际值来确定用于计算变化率的时间间隔。