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公开(公告)号：US08771676B2
公开(公告)日：2014-07-08
申请号：US11767095
申请日：2007-06-22
IPC分类号： A61K38/00
CPC分类号： A01N63/04 , A01N37/12 , A01N37/02 , A01N25/30 , A01N2300/00
摘要： The present invention provides an agrochemically active microbial formulation comprising a combination of an agrochemically active microbe with a specified ester compound and a surfactant, the formulation exhibiting a stable pest controlling effect with no harmful effect on a plant and having highly stable viability of the agrochemically active microbe.
摘要翻译： 本发明提供了农业化学活性微生物制剂，其包含农业化学活性微生物与特定的酯化合物和表面活性剂的组合，该制剂表现出对植物没有有害影响并且具有高度稳定的农业化学活性的可行性的稳定的害虫防治效果 微生物。
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公开(公告)号：US20090035280A1
公开(公告)日：2009-02-05
申请号：US11767095
申请日：2007-06-22
CPC分类号： A01N63/04 , A01N37/12 , A01N37/02 , A01N25/30 , A01N2300/00
摘要： The present invention provides an agrochemically active microbial formulation comprising a combination of an agrochemically active microbe with a specified ester compound and a surfactant, the formulation exhibiting a stable pest controlling effect with no harmful effect on a plant and having highly stable viability of the agrochemically active microbe
摘要翻译： 本发明提供了农业化学活性微生物制剂，其包含农业化学活性微生物与特定的酯化合物和表面活性剂的组合，该制剂表现出对植物没有有害影响并且具有高度稳定的农业化学活性的可行性的稳定的害虫防治效果 微生物
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3.发明申请Insecticidal oil-based formulations comprising an insecticidal filamentous fungus 审中-公开包含杀虫丝状真菌的杀虫油基制剂公开(公告)号：US20070141032A1
公开(公告)日：2007-06-21
申请号：US11362803
申请日：2006-02-28
IPC分类号： A01N63/04
摘要： The present invention provides an insecticidal oil-based formulation, which comprises a petroleum hydrocarbon oil, a nonionic surfactant suitable for emulsifying the petroleum hydrocarbon oil, a desiccating agent and an insecticidal filamentous fungus; and a method for controlling insect pests, which comprises applying said formulation to an insect pests, a habitat of the insect pest or a plant vulnerable to the insect pest; and the like.
摘要翻译： 本发明提供一种杀虫油性制剂，其包含石油烃油，适用于乳化石油烃油的非离子表面活性剂，干燥剂和杀虫丝状真菌; 以及一种防治害虫的方法，其中包括将所述制剂应用于害虫，昆虫害虫栖息地或易受虫害害虫害虫害的植物; 等等。
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4.发明授权Protein capable of catalyzing transamination stereoselectively, gene encoding said protein and use thereof 失效能够立体选择性地催化转氨酶的蛋白质，编码所述蛋白质的基因及其用途公开(公告)号：US06727083B2
公开(公告)日：2004-04-27
申请号：US10067291
申请日：2002-02-07
申请人： Yoshiki Takashima , Satoshi Mitsuda , Marco Wieser
发明人： Yoshiki Takashima , Satoshi Mitsuda , Marco Wieser
IPC分类号： C12N910
CPC分类号： C12N9/1096 , C12P41/009
摘要： DNA encoding a novel protein from Mycobacterium aurum SC-S423 capable of converting acetophenone to an optically active 1-phenylethlamine in the presence of a racemic mixture of sec-butylamine is provided, along with a vector and host cell comprising the same and a method of producing the same.
摘要翻译： 提供了编码来自能够在仲丁胺的外消旋混合物存在下将苯乙酮转化为光学活性的1-苯乙基胺的分枝杆菌SC-S423的新型蛋白质的DNA，以及包含其的载体和宿主细胞以及 生产相同。
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5.发明授权Protein capable of catalyzing transamination stereoselectively, gene encoding said protein and use thereof 失效能够立体选择性地催化转氨酶的蛋白质，编码所述蛋白质的基因及其用途公开(公告)号：US06413752B1
公开(公告)日：2002-07-02
申请号：US09527522
申请日：2000-03-16
申请人： Yoshiki Takashima , Satoshi Mitsuda , Marco Wieser
发明人： Yoshiki Takashima , Satoshi Mitsuda , Marco Wieser
IPC分类号： C12N910
CPC分类号： C12N9/1096 , C12P41/009
摘要： A novel protein from Mycobacterium aurum SC-D423 capable of converting acetophenone to an optically active 1-phenylethylamine in the presence of a racemic mixture of sec-butylamine is provided.
摘要翻译： 提供了在仲丁胺的外消旋混合物存在下能够将苯乙酮转化为光学活性1-苯基乙胺的来自分枝杆菌aurum SC-D423的新型蛋白质。
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6.发明授权Process for producing carboxylic acid isomer using Nocardia diaphanozonaria or Saccharopolyspora hirsuta 失效使用诺卡氏菌（Nocardia diaphanozonaria）或酿酒酵母（Saccharopolyspora hirsuta）生产羧酸异构体的方法公开(公告)号：US06365399B1
公开(公告)日：2002-04-02
申请号：US09625323
申请日：2000-07-25
申请人： Yoshiki Takashima , Yuko Kobayashi
发明人： Yoshiki Takashima , Yuko Kobayashi
IPC分类号： C12P4100
摘要： The present invention provides a process for producing a carboxylic acid isomer B represented by the general formula (2): (wherein, L is a C6 to C14 aryl group which may optionally been substituted, C4 to C12 heteroaryl group which may optionally been substituted, C6 to C14 aryloxy group which may optionally been substituted or C4 to C12 heteroaryloxy group which may optionally been substituted, and M is an C1 to C3 alkyl group.), which comprises: allowing a carboxylic acid isomer A represented by the general formula (1): (wherein, L and M have meanings as defined above.) to contact with a microbiological material having an ability to convert the carboxylic acid isomer A(1) into the carboxylic acid isomer B(2), and the like. According to the present invention, the carboxylic acid isomer B(2) useful as an intermediate of medicines, agricultural chemicals and like can be produced efficiently.
摘要翻译： 本发明提供一种由通式（2）表示的羧酸异构体B的制备方法：其中，L为任选被取代的C 6〜C 14芳基，可任选被取代的C 4〜C 12杂芳基， 可任选被取代的C 6至C 14芳氧基或可任选被取代的C 4至C 12杂芳氧基，M为C 1至C 3烷基），其包括：使由通式（1）表示的羧酸异构体A ）（其中，L和M具有如上定义的含义）与具有将羧酸异构体A（1）转化成羧酸异构体B（2）的能力的微生物材料接触等。 根据本发明，可有效地制备可用作药物，农药等的中间体的羧酸异构体B（2）。
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7.发明授权Process for producing optically active n-substituted azetidine-2 carboxylic acid compound 失效光学活性的n-取代的氮杂环丁烷-2-羧酸化合物的制备方法
公开(公告)号：US6143554A
公开(公告)日：2000-11-07
申请号：US352350
申请日：1999-07-13
申请人： Yoshiki Takashima , Junko Kudo , Ayumi Inoue , Motoo Hazama
发明人： Yoshiki Takashima , Junko Kudo , Ayumi Inoue , Motoo Hazama
CPC分类号： C07D205/04 , C12P41/005
摘要： There is provided a process for producing an optically active N-substituted azetidine-2-carboxylic acid compound represented by the formula (2): ##STR1## by contacting a corresponding N-substituted azetidine-2-carboxylic acid ester of formula (2) with an enzyme derived from a microorganism selected from Arthrobacter SC-6-98-28 strain, Arthrobacter sp. ATCC21908 strain, Chromobacterium SC-YM-1 strain, and a mutant thereof. A process is also provided for preparing an optically active azetidine-2-carboxylic acid by eliminating the N-substituent of a N-substituted azetidine-2-carboxylic acid ester of formula (2).
摘要翻译： 提供了制备由式（2）表示的光学活性的N-取代的氮杂环丁烷-2-羧酸化合物的方法：将式（2）的相应的N-取代的氮杂环丁烷-2-羧酸酯与酶 衍生自选自节杆菌SC-6-98-28菌株，节杆菌属（Arthrobacter sp。）的微生物 ATCC21908菌株，Chromobacterium SC-YM-1菌株及其突变体。 还提供了通过除去式（2）的N-取代的氮杂环丁烷-2-羧酸酯的N-取代基来制备光学活性氮杂环丁烷-2-羧酸的方法。
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公开(公告)号：US06828129B2
公开(公告)日：2004-12-07
申请号：US10114116
申请日：2002-05-07
申请人： Kae Kishimoto , Yuko Kobayashi , Yoshiki Takashima , Ayumu Inoue
发明人： Kae Kishimoto , Yuko Kobayashi , Yoshiki Takashima , Ayumu Inoue
IPC分类号： C12P1300
摘要： The present invention provides a novel gene encoding a protein having an excellent catalyst ability for producing (S)-N-substituted cyclic imino acid represented by the general formula (2) (=the (S)-cyclic imino acid (2)): and to provide a novel method for producing the (S)-cyclic imino acid (2) by an asymmetric hydrolization of the N-substituted cyclic imino acid ester represented by the general formula (1): in a manner of gene engineering technology utilizing the novel gene provided.
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公开(公告)号：US06812008B2
公开(公告)日：2004-11-02
申请号：US10114115
申请日：2002-04-03
申请人： Kae Kishimoto , Yuko Kobayashi , Yoshiki Takashima , Ayumu Inoue
发明人： Kae Kishimoto , Yuko Kobayashi , Yoshiki Takashima , Ayumu Inoue
IPC分类号： C12P1500
摘要： The present invention provides a novel gene encoding a protein having an excellent catalyst ability for producing (S)-N-substituted cyclic imino acid represented by the general formula (2) (=the (S)-cyclic imino acid (2)): and to provide a novel method for producing the (S)-cyclic imino acid (2) by an asymmetric hydrolization of the N-substituted cyclic imino acid ester represented by the general formula (1): in a manner of gene engineering technology utilizing the novel gene provided.
摘要翻译： 本发明提供了编码具有优异的催化能力的蛋白质的新型基因，该蛋白质具有优良的通式（2）表示的（S）-N-取代的环状亚氨基酸（=（S） - 环亚氨基酸（2））的催化能力： 并且提供通过由通式（1）表示的N-取代的环亚氨基酸酯的不对称水解制备（S） - 环亚氨基酸（2）的新方法：以基因工程技术利用 提供新基因。
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公开(公告)号：US5563053A
公开(公告)日：1996-10-08
申请号：US382152
申请日：1995-02-01
摘要： The present invention provides a process for production of amide compounds, which includes converting a nitrile compound into its corresponding amide compound by hydrating the nitrile compound in the presence of a cultured broth of bacterial cells, intact bacterial cells, disrupted bacterial cells or enzymes contained therein, or immobilized preparations obtainable by immobilizing intact bacterial cells, disrupted bacterial cells or enzymes contained therein, the bacterial cells being those of a biologically pure culture of a thermophilic microorganism having hydration activity to convert a nitrile compound into its corresponding amide compound, such as Bacillus smithii SC-J05-1 (FERM BP-4935).
摘要翻译： 本发明提供一种制备酰胺化合物的方法，其包括在培养的细菌细胞培养液，完整的细菌细胞，破坏的细菌细胞或其中含有的酶的存在下，使腈化合物水合，将腈化合物转化成其相应的酰胺化合物 或通过固定完整的细菌细胞，破坏的细菌细胞或其中所含的酶而获得的固定化制剂，细菌细胞是具有水合活性的嗜热微生物的生物学纯培养物的细菌细胞，其将腈化合物转化成其相应的酰胺化合物，例如芽孢杆菌 史密斯SC-J05-1（FERM BP-4935）。
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