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    AZA-BRIDGED-RING COMPOUND
    6.
    发明申请
    AZA-BRIDGED-RING COMPOUND 有权
    AZA-BRIDGED-RING化合物

    公开(公告)号：US20100105658A1

    公开(公告)日：2010-04-29

    申请号：US12524758

    申请日：2008-02-07

    申请人： Shinya Nagashima ,  Toru Kontani ,  Hiroshi Nagata ,  Yuji Matsushima ,  Hisao Hamaguchi ,  Tadatsura Koshika

    发明人： Shinya Nagashima ,  Toru Kontani ,  Hiroshi Nagata ,  Yuji Matsushima ,  Hisao Hamaguchi ,  Tadatsura Koshika

    IPC分类号： A61K31/439 ,  C07D453/02 ,  C07D223/14 ,  A61K31/55 ,  A61P29/00

    CPC分类号： C07D453/02 ,  C07D471/18

    摘要： [Problems] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.[Means for Solving Problems] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M3 receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M3 receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M3 receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.

    摘要翻译： [问题]提供对毒蕈碱M3受体具有拮抗作用的化合物，并且可用作炎性疾病如慢性阻塞性肺病（COPD），哮喘的预防和/或治疗剂的活性成分 喜欢。 解决问题的手段本发明人研究了对毒蕈碱性M3受体的结合具有拮抗作用的化合物，并且已经发现，氮杂桥环化合物或其盐对其有拮抗作用 结合毒蕈碱M3受体，从而完成本发明。 本发明的氮杂桥环化合物对毒蕈碱性M3受体的结合具有拮抗作用，可用作炎性疾病如慢性阻塞性肺疾病（COPD）的预防和/或治疗剂， ，哮喘等。

    Aza-bridged-ring compound
    7.
    发明授权
    Aza-bridged-ring compound 有权
    氮杂桥环化合物

    公开(公告)号：US08367696B2

    公开(公告)日：2013-02-05

    申请号：US12524758

    申请日：2008-02-08

    申请人： Shinya Nagashima ,  Toru Kontani ,  Hiroshi Nagata ,  Yuji Matsushima ,  Hisao Hamaguchi ,  Tadatsura Koshika

    发明人： Shinya Nagashima ,  Toru Kontani ,  Hiroshi Nagata ,  Yuji Matsushima ,  Hisao Hamaguchi ,  Tadatsura Koshika

    IPC分类号： A61K31/439 ,  C07D221/00 ,  C07D221/02

    CPC分类号： C07D453/02 ,  C07D471/18

    摘要： [PROBLEMS] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.[MEANS For SOLVING PROBLEMS] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M3 receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M3 receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M3 receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.

    摘要翻译： [问题]提供对毒蕈碱M3受体具有拮抗作用并可用作炎性疾病如慢性阻塞性肺疾病（COPD），哮喘的预防和/或治疗剂的活性成分的化合物 喜欢。 解决问题的手段本发明人研究了对毒蕈碱性M3受体的结合具有拮抗作用的化合物，并且已经发现氮杂桥环化合物或其盐对其具有拮抗作用 结合毒蕈碱M3受体，从而完成本发明。 本发明的氮杂桥环化合物对毒蕈碱性M3受体的结合具有拮抗作用，可用作炎性疾病如慢性阻塞性肺疾病（COPD）的预防和/或治疗剂， ，哮喘等。

    2,4-DIAMINOPYRIMIDINE COMPOUND
    8.
    发明申请
    2,4-DIAMINOPYRIMIDINE COMPOUND 审中-公开
    2,4-二氨基吡啶化合物

    公开(公告)号：US20110159019A1

    公开(公告)日：2011-06-30

    申请号：US13061311

    申请日：2009-08-31

    申请人： Akira Tanaka ,  Koichiro Mukoyoshi ,  Shigeki Kunikawa ,  Yuji Takasuna ,  Jun Maeda ,  Noboru Chida ,  Shinya Nagashima

    发明人： Akira Tanaka ,  Koichiro Mukoyoshi ,  Shigeki Kunikawa ,  Yuji Takasuna ,  Jun Maeda ,  Noboru Chida ,  Shinya Nagashima

    IPC分类号： A61K31/551 ,  C07D403/12 ,  C07D401/12 ,  C07D239/48 ,  C07D413/12 ,  C07D405/12 ,  C07D409/12 ,  C07D405/14 ,  C07D413/14 ,  A61K31/506 ,  A61K31/505 ,  A61K31/5377 ,  A61P37/06

    CPC分类号： C07D239/48

    摘要： Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKCθ inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. The present inventors have conducted extensive studies on a compound having a PKCθ inhibition activity, and as a result, they have found that a compound having a structure such as aralkyl and the like on an amino group at the 2-position and also having a structure such as an adamantylalkyl group and the like on an amino group at the 4-position of 2,4-diaminopyrimidine, or a salt thereof has an excellent PKCθ inhibition activity, thereby completing the present invention. The 2,4-diaminopyrimidine compound of the present invention can be used as a PKCθ inhibitor or an inhibitor of acute rejection occurring in transplantation.

    摘要翻译： 提供可用作具有PKC和药物的药物的活性成分的化合物; 特别是用于抑制移植中发生急性排斥反应的药物组合物。 本发明人对具有PKC的化合物进行了广泛的研究; 抑制活性，结果发现，在2-位的氨基上具有芳烷基等结构的化合物，还具有金刚烷基烷基等的结构，氨基上的氨基上 2,4-二氨基嘧啶的4位或其盐具有优异的PKC和重量; 从而完成了本发明。 本发明的2,4-二氨基嘧啶化合物可以用作PKC＆amp; 抑制剂或移植中发生的急性排斥抑制剂。

    Optical wavelength meter with an up-down counter which measures the amounts of the overshoot and the back-shift of the moving mirror
    9.
    发明授权
    Optical wavelength meter with an up-down counter which measures the amounts of the overshoot and the back-shift of the moving mirror 失效
    具有上下计数器的光学波长计，用于测量移动镜的过冲量和反向移动量

    公开(公告)号：US5486918A

    公开(公告)日：1996-01-23

    申请号：US389397

    申请日：1995-02-16

    申请人： Shinya Nagashima

    发明人： Shinya Nagashima

    IPC分类号： G01J9/02 ,  G01B9/02

    CPC分类号： G01J9/0246

    摘要： The purpose of the present invention is to provide a highly accurate optical wavelength meter in which the accurate starting and stop points of the measurement are detected. In accordance with the present invention, a detector which detects the back-shift of the moving mirror due to elastic force of the belt and an up-down counter which measures the amounts of the overshoot and the back-shift of the moving mirror so as to cancel the overshoot and the back-shift are provided, by which the accurate starting and stop points of the measurement can be detected.

    摘要翻译： 本发明的目的是提供一种高精度的光波长计，其中检测出测量的准确起点和停止点。 根据本发明，检测器由于皮带的弹力检测移动镜的反向移动，以及检测移动镜的过冲量和反向移动量的上下计数器，以便 为了消除过冲，提供了可以检测出测量的准确起点和停止点的反向移位。

    Optical wavemeter employing a length measuring machine with a white light source for achieving maximum interfering efficiency
    10.
    发明授权
    Optical wavemeter employing a length measuring machine with a white light source for achieving maximum interfering efficiency 失效
    光学波长计使用具有白光源的长度测量机，以实现最大的干扰效率

    公开(公告)号：US5523838A

    公开(公告)日：1996-06-04

    申请号：US401165

    申请日：1995-03-09

    申请人： Shinya Nagashima

    发明人： Shinya Nagashima

    IPC分类号： G01J9/02 ,  G01B9/02 ,  G01J1/02 ,  G01J1/04

    CPC分类号： G01J9/0246 ,  G01B9/02029 ,  G01B9/0209

    摘要： Each of beams originated from a light source to be measured and a white light source is branched by a beam splitter into two beams, which are reflected by a fixed and a movable mirrors respectively to meet each other again so as to generate interfering light, the white light being maximum in interfering efficiency when the optical path reaching the movable mirror is equal in length to that reaching the fixed mirror. The interfering light originated from the light source is converted into an electric signal by a first light receiver and further into pulses by a first converter. A length measuring machine outputs a pulse signal corresponding to the moving length of the movable mirror. A second light receiver converts the interfering light originated from the white light source into an electric signal. When it exceeds a set value, a second converter supplies an origin signal to the interfering light counting portion and the distance counting portion so that they start counting pulses and the position detecting portion outputs a position detecting signal when the movable mirror is moved for an arbitrary distance. A calculator calculates the wavelength of the light to be measured based on the counted values to display the result on a display. As a result, it is possible to provide an optical wavemeter which is increased in effective length of scale by permitting light originated from a white light source to be incident to an interferometer to find the position of the movable mirror where interfering efficiency is maximum and performing calibration as far as an arbitrary moving distance relative thereto.

    摘要翻译： 每个光束源自待测光源，白光源通过分束器分支成两束，分别由固定镜和可移动镜反射，以再次相遇以产生干涉光， 当到达可移动镜的光路的长度与到达固定镜的长度相等时，白光在干扰效率上最大。 源自光源的干扰光由第一光接收器转换为电信号，并由第一转换器进一步转换为脉冲。 长度测量机输出与可移动镜的移动长度对应的脉冲信号。 第二光接收器将来自白光源的干涉光转换为电信号。 当超过设定值时，第二转换器向干涉光计数部分和距离计数部分提供原点信号，使得它们开始计数脉冲，并且当可移动反射镜移动任意时，位置检测部分输出位置检测信号 距离。 计算器根据计数值计算要测量的光的波长，以在显示器上显示结果。 结果，可以通过允许源自白光源的光入射到干涉仪来提供有效的刻度长度的光波计，以找到干涉效率最大的可移动反射镜的位置，并执行 校准至相对于其任意移动距离。