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1.发明授权Gene useful for diagnosis and treatment of aplasia of corpus callosum and aspermatogenesis and use thereof 失效用于诊断和治疗胼of体发育不全的基因和不典型生成及其用途公开(公告)号：US07081338B2
公开(公告)日：2006-07-25
申请号：US10314395
申请日：2002-12-06
摘要： Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a novel cell adhesion molecule (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof: (A) a protein comprising the amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2; (B) a protein comprising an amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2 including substitution, deletion, insertion or addition of one or several amino acids and having a function as a cell adhesion molecule.
摘要翻译： 通过使用PCR引物或用于杂交的探针研究BT-IgSF基因的存在或表达来诊断胼the体或异常生殖的发生，包括编码下述定义的新型细胞粘附分子（BT-IgSF）的DNA （A）或（B）或其部分序列：（A）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质; （B）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质，包括一个或几个氨基酸的取代，缺失，插入或添加并具有作为细胞粘附分子的功能。
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公开(公告)号：US07217524B2
公开(公告)日：2007-05-15
申请号：US11409216
申请日：2006-04-21
摘要： Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a novel cell adhesion molecule (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof: (A) a protein comprising the amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2; (B) a protein comprising an amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2 including substitution, deletion, insertion or addition of one or several amino acids and having a function as a cell adhesion molecule.
摘要翻译： 通过使用PCR引物或用于杂交的探针研究BT-IgSF基因的存在或表达来诊断胼the体或异常生殖的发生，包括编码下述定义的新型细胞粘附分子（BT-IgSF）的DNA （A）或（B）或其部分序列：（A）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质; （B）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质，包括一个或几个氨基酸的取代，缺失，插入或添加并具有作为细胞粘附分子的功能。
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公开(公告)号：US20060178337A1
公开(公告)日：2006-08-10
申请号：US11409216
申请日：2006-04-21
IPC分类号： A61K48/00 , C07K14/705 , C07H21/04 , C12P21/06
摘要： Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a novel cell adhesion molecule (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof: (A) a protein comprising the amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2; (B) a protein comprising an amino acid sequence of the amino acid numbers 1 to 409 of SEQ ID NO: 2 including substitution, deletion, insertion or addition of one or several amino acids and having a function as a cell adhesion molecule.
摘要翻译： 通过使用PCR引物或用于杂交的探针研究BT-IgSF基因的存在或表达来诊断胼the体或异常生殖的发生，包括编码下述定义的新型细胞粘附分子（BT-IgSF）的DNA （A）或（B）或其部分序列：（A）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质; （B）包含SEQ ID NO：2的氨基酸编号1至409的氨基酸序列的蛋白质，包括一个或几个氨基酸的取代，缺失，插入或添加并具有作为细胞粘附分子的功能。
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公开(公告)号：US5288487A
公开(公告)日：1994-02-22
申请号：US789431
申请日：1991-11-06
申请人： Takuji Kawashima , Nobuya Yanai , Muneo Yamada , Hajime Yokota , Kunio Ujiie , Katsuo Yoshida , Shinya Suzu , Fumimaro Takaku , Kazuo Motoyoshi , Nobuhiro Yamada
发明人： Takuji Kawashima , Nobuya Yanai , Muneo Yamada , Hajime Yokota , Kunio Ujiie , Katsuo Yoshida , Shinya Suzu , Fumimaro Takaku , Kazuo Motoyoshi , Nobuhiro Yamada
CPC分类号： A61K47/42 , A61K38/193 , A61K47/26
摘要： Human M-CSF preparations and recombinant human M-CSF preparations against myelodysplastic syndrome, malignant tumor and hyperlipemia and auxiliary therapeutic preparations to be dosed along with platinum-complex anticancer preparations.
摘要翻译： 人M-CSF制剂和针对骨髓增生异常综合征，恶性肿瘤和高脂血症的重组人M-CSF制剂和与铂复合物抗癌制剂一起给药的辅助治疗制剂。
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