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    DRUG AGAINST CENTRAL NERVOUS SYSTEM INFLAMMATION
    1.
    发明申请
    DRUG AGAINST CENTRAL NERVOUS SYSTEM INFLAMMATION 审中-公开
    药物对抗中枢神经系统炎症

    公开(公告)号：US20130172293A1

    公开(公告)日：2013-07-04

    申请号：US13821407

    申请日：2011-09-22

    申请人： Shirou Mawatari ,  Takehiko Fujino ,  Masataka Ifuku ,  Masaaki Sugiyama ,  Hidetaka Fuchu

    发明人： Shirou Mawatari ,  Takehiko Fujino ,  Masataka Ifuku ,  Masaaki Sugiyama ,  Hidetaka Fuchu

    IPC分类号： A61K31/661 ,  C07F9/22

    CPC分类号： A61K31/661 ,  A61K31/685 ,  A61K35/57 ,  C07F9/222

    摘要： An objective of the present invention is to provide a novel method with an effect of alleviating central nervous system inflammation. The present invention provides a drug against central nervous system inflammation containing a plasmalogen. More preferably, the present invention provides a drug against central nervous system inflammation containing a plasmalogen extracted from a biological tissue (preferably an avian tissue) that mainly contains an ethanolamine plasmalogen and a choline plasmalogen.

    摘要翻译： 本发明的目的是提供一种减轻中枢神经系统炎症的新方法。 本发明提供了一种抗中性神经系统炎症的药物，其含有浆细胞原子。 更优选地，本发明提供了一种针对中枢神经系统炎症的药物，其含有从主要含有乙醇胺血浆原原细胞和胆碱原纤维素原的生物组织（优选禽类组织）提取的浆果糖原。

    PROCESS FOR PRODUCING FUNCTIONAL MATERIAL, THE FUNCTIONAL MATERIAL AND CONTINUOUS HEATING APPARATUS FOR OBTAINING THE SAME
    4.
    发明申请
    PROCESS FOR PRODUCING FUNCTIONAL MATERIAL, THE FUNCTIONAL MATERIAL AND CONTINUOUS HEATING APPARATUS FOR OBTAINING THE SAME 审中-公开
    生产功能材料的方法，功能材料和连续加热装置

    公开(公告)号：US20100055277A1

    公开(公告)日：2010-03-04

    申请号：US12527264

    申请日：2008-02-20

    申请人： Yoshitaka Nadachi ,  Takehiko Fujino ,  Yukio Ogasawara

    发明人： Yoshitaka Nadachi ,  Takehiko Fujino ,  Yukio Ogasawara

    IPC分类号： A23L1/015 ,  A23B4/005

    CPC分类号： A23J7/00 ,  A23L33/115

    摘要： A process for preparing a functional material by heat-treating a skin portion of poultry to carry out deoiling and defatting and to concentrate and pasteurize human-type sphingomyelin and plasmalogen-type glycerophospholipid contained in said skin portion, said heat-treatment comprising the steps of (A) continuously injecting hot water heated to 100° C. or higher and/or steam into a heating chamber of a semi-sealed space having said temperature or higher, to generate water microdroplets and moist hot steam, (B) replacing air in said heating chamber with said water microdroplets and moist hot steam, to fill a gas component (gaseous water) that has a composition having a relative humidity of 95% or more and an oxygen concentration of 0.2% by volume or less and that is maintained in a temperature range of 100 to 115° C., (C) injecting steam in a 100% wet state to said gaseous water to stably form a composite heating medium composed of hot water, water microdroplets and steam, and (D) applying continuous amplitude heating including a temperature difference of at least 10° C. to the skin portion of poultry with said composite heating medium in an atmosphere having a temperature of 100 to 115° C. and an oxygen concentration of 0.2% by volume or less.

    摘要翻译： 一种通过热处理家禽皮肤部分进行除油和脱脂并将包含在所述皮肤部分中的人型鞘磷脂和血浆原型甘油磷脂浓缩并巴氏杀菌的制备功能材料的方法，所述热处理包括以下步骤： （A）将加热至100℃以上的热水和/或蒸汽连续地注入到具有所述温度或更高温度的半密封空间的加热室中，以产生水微滴和湿热蒸汽，（B） 所述加热室具有所述水微滴和湿热蒸汽，以填充具有相对湿度为95％或更高且氧浓度为0.2体积％或更小的组成的气体组分（气态水），并保持在 温度范围为100〜115℃，（C）以100％湿态将蒸汽注入所述气态水中，稳定地形成由热水，水微滴和蒸汽组成的复合加热介质，（D） 在温度为100〜115℃，氧浓度为0.2体积％以下的气氛中，使用所述复合加热介质，将包含至少10℃的温差与家禽皮肤部分的连续振幅加热 。

    Process for producing sphingomyelin and plasmalogen-form glycerophospholipid
    6.
    发明授权
    Process for producing sphingomyelin and plasmalogen-form glycerophospholipid 有权
    产生鞘磷脂和浆细胞原型形成甘油磷脂的方法

    公开(公告)号：US08236978B2

    公开(公告)日：2012-08-07

    申请号：US12523778

    申请日：2008-01-23

    申请人： Takehiko Fujino ,  Keita Yunoki ,  Shiro Mawatari ,  Yoshitaka Nadachi

    发明人： Takehiko Fujino ,  Keita Yunoki ,  Shiro Mawatari ,  Yoshitaka Nadachi

    IPC分类号： C11B1/00

    CPC分类号： C11B1/10

    摘要： Disclosed is a process for producing sphingomyelin and plasmalogen-form glycerophospholipid, which comprises the step (A) of extracting a total lipids from a chicken skin powder and drying the extract, the step (B) of subjecting the dried total lipids obtained in said step (A), to extraction treatment with a solvent mixture of an aliphatic hydrocarbon solvent and a water-soluble ketone solvent to separate an insoluble portion composed mainly of sphingomyelin and a soluble portion, the step (C) subjecting the insoluble portion composed mainly of sphingomyelin, obtained in said step (B), to extraction treatment with a solvent mixture of water and a water-soluble ketone solvent to remove a non-lipid component contained in the soluble portion, and the step (D) of drying the soluble portion obtained in said step (B), and subjecting the thus-obtained dried product to extraction treatment with a water-soluble ketone solvent to separate and recover an insoluble portion composed mainly of plasmalogen-form giycerophospholiuld.According to the above production process, high-purity sphingomyelin, in particular, human-form sphingomyelin and plasmalogen-form sphingomyelin can be produced from chicken skin at high yields with simple procedures.

    摘要翻译： 公开了一种生产鞘磷脂和浆原纤维形成甘油磷脂的方法，其包括从鸡皮粉中提取总脂质并干燥提取物的步骤（A），将所述步骤（B）中获得的干燥总脂质 （A），用脂族烃溶剂和水溶性酮溶剂的溶剂混合物进行萃取处理，分离出主要由鞘磷脂和可溶性部分组成的不溶部分，对主要由鞘磷脂组成的不溶部分进行步骤（C） 在步骤（B）中获得的，用水和水溶性酮溶剂的溶剂混合物进行萃取处理以除去可溶部分中所含的非脂质成分，和干燥所得可溶部分的步骤（D） 在所述工序（B）中，将由此得到的干燥物质用水溶性酮溶剂进行萃取处理，分离并回收主要由浆料组成的不溶部分 异基因型giycerophospholiuld。 根据上述制造方法，可以通过简单的步骤以高产率从鸡皮制备高纯度鞘磷脂，特别是人形态的鞘磷脂和浆细胞形成鞘磷脂。

    HAIR GROWTH AND HAIR RESTORATION MATERIAL
    7.
    发明申请
    HAIR GROWTH AND HAIR RESTORATION MATERIAL 审中-公开
    头发生长和头发恢复材料

    公开(公告)号：US20140316120A1

    公开(公告)日：2014-10-23

    申请号：US14123074

    申请日：2012-05-30

    申请人： Takehiko Fujino ,  Osami Nada ,  Yoshitaka Nadachi ,  Gunki Funatsu

    发明人： Takehiko Fujino ,  Osami Nada ,  Yoshitaka Nadachi ,  Gunki Funatsu

    IPC分类号： A61K8/63 ,  A61Q7/00

    CPC分类号： A61K8/63 ,  A61K8/602 ,  A61K31/7028 ,  A61K31/7032 ,  A61K31/7034 ,  A61K31/704 ,  A61K2800/40 ,  A61Q7/00

    摘要： Provided is a novel hair growth and hair restoration material having excellent efficacy in hair growth and hair restoration for both men and women, even when the components thereof are at ultra-dilute concentrations; the hair growth and hair restoration material being characterized in containing a steryl glucopyranoside, preferably a cholesteryl glucopyranoside, represented by general formula (I). (In the formula, Z represents a sterol residue from which the hydroxyl group attached to the 3-position of a cyclopentanohydrophenanthrene ring has been removed.)

    摘要翻译： 本发明提供了一种新颖的头发生长和头发修复材料，即使其成分为超稀释浓度，对于男性和女性的头发生长和毛发修复都具有优异的效果， 毛发生长和毛发修复材料的特征在于含有由通式（I）表示的甾族吡喃葡萄糖苷，优选胆固醇基吡喃葡萄糖苷。 （式中，Z表示与环戊氢菲环的3位相连的羟基被除去的固醇残基。）

    PROCESS FOR PRODUCING SPHINGOMYELIN AND PLASMALOGEN-FORM GLYCEROPHOSPHOLIPID
    8.
    发明申请
    PROCESS FOR PRODUCING SPHINGOMYELIN AND PLASMALOGEN-FORM GLYCEROPHOSPHOLIPID 有权
    生产丝氨酸和磷酸形成糖苷磷酸的方法

    公开(公告)号：US20100029966A1

    公开(公告)日：2010-02-04

    申请号：US12523778

    申请日：2008-01-23

    申请人： Takehiko Fujino ,  Keita Yunoki ,  Shiro Mawatari ,  Yoshitaka Nadachi

    发明人： Takehiko Fujino ,  Keita Yunoki ,  Shiro Mawatari ,  Yoshitaka Nadachi

    IPC分类号： C11B1/10

    CPC分类号： C11B1/10

    摘要： Disclosed is a process for producing sphingomyelin and plasmalogen-form glycerophospholipid, which comprises the step (A) of extracting a total lipids from a chicken skin powder and drying the extract, the step (B) of subjecting the dried total lipids obtained in said step (A), to extraction treatment with a solvent mixture of an aliphatic hydrocarbon solvent and a water-soluble ketone solvent to separate an insoluble portion composed mainly of sphingomyelin and a soluble portion, the step (C) subjecting the insoluble portion composed mainly of sphingomyelin, obtained in said step (B), to extraction treatment with a solvent mixture of water and a water-soluble ketone solvent to remove a non-lipid component contained in the soluble portion, and the step (D) of drying the soluble portion obtained in said step (B), and subjecting the thus-obtained dried product to extraction treatment with a water-soluble ketone solvent to separate and recover an insoluble portion composed mainly of plasmalogen-form giycerophospholiuld.According to the above production process, high-purity sphingomyelin, in particular, human-form sphingomyelin and plasmalogen-form sphingomyelin can be produced from chicken skin at high yields with simple procedures.

    摘要翻译： 公开了一种生产鞘磷脂和浆原纤维形成甘油磷脂的方法，其包括从鸡皮粉中提取总脂质并干燥提取物的步骤（A），将所述步骤（B）中获得的干燥总脂质 （A），用脂族烃溶剂和水溶性酮溶剂的溶剂混合物进行萃取处理，分离出主要由鞘磷脂和可溶性部分组成的不溶部分，对主要由鞘磷脂组成的不溶部分进行步骤（C） 在步骤（B）中获得的，用水和水溶性酮溶剂的溶剂混合物进行萃取处理以除去可溶部分中所含的非脂质成分，和干燥所得可溶部分的步骤（D） 在所述工序（B）中，将由此得到的干燥物质用水溶性酮溶剂进行萃取处理，分离并回收主要由浆料组成的不溶部分 异基因型giycerophospholiuld。 根据上述制造方法，可以通过简单的步骤以高产率从鸡皮制备高纯度鞘磷脂，特别是人形态的鞘磷脂和浆细胞形成鞘磷脂。