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    Activator of peroxisome proliferator-activated receptor delta
    3.
    发明申请
    Activator of peroxisome proliferator-activated receptor delta 有权
    过氧化物酶体增殖物激活受体δ的活化剂

    公开(公告)号：US20080009525A1

    公开(公告)日：2008-01-10

    申请号：US11888493

    申请日：2007-07-31

    申请人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    发明人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    IPC分类号： A61K31/4439 ,  A61K31/422 ,  C07D263/02 ,  C07D403/00 ,  C07D417/00 ,  C07D413/00 ,  C07D277/04 ,  A61K31/427

    CPC分类号： C07D263/62 ,  C07D263/32 ,  C07D277/24

    摘要： A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

    摘要翻译： 由以下通式（I）表示的化合物：（其中R 1表示苯基等，其可以具有选自C 1-8烷基的取代基 具有卤素，卤素，羟基等的C 1-8烷基; R 2表示C 1-8烷基等; A 表示氧，硫等; X表示C 1-8亚烷基链等; Y表示C（-O），CH-CH等; R 3 O R 4，R 5和R 5各自表示氢，C 1-8烷基等; B表示CH或氮; Z表示 氧或硫; R 6和R 7各自表示氢，C 1-8烷基等;和R 8， / SUP>表示氢或C 1-8烷基，条件是R 3，R 4和R 4中的至少一个， 5不是氢）或化合物的盐; 和含有该化合物或盐作为活性成分的PPAR-δ活化剂。

    PPAR delta activators
    6.
    发明授权
    PPAR delta activators 有权
    PPARδ激活剂

    公开(公告)号：US06787552B2

    公开(公告)日：2004-09-07

    申请号：US10344496

    申请日：2003-02-11

    申请人： Shogo Sakuma ,  Tsuyoshi Endo ,  Atsushi Tendo ,  Toshihiro Takahashi ,  Shinichi Yoshida ,  Kunio Kobayashi ,  Nobutaka Mochizuki ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    发明人： Shogo Sakuma ,  Tsuyoshi Endo ,  Atsushi Tendo ,  Toshihiro Takahashi ,  Shinichi Yoshida ,  Kunio Kobayashi ,  Nobutaka Mochizuki ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    IPC分类号： A61K31421

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D277/24

    摘要： Compounds of the general formula (I) or salts thereof and activators of PPAR&dgr; (peroxisome proliferator activated receptor &dgr;) containing the compounds or the salts as the active ingredient: wherein R1 and R2 each are hydrogen, C1-8 alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X1 and X2 are each a free valency, oxygen, S(O)p (wherein p is an integer of 0 to 2), C(═O), C(═O)NH, NHC(═O), CH═CH, or the like; Y is optionally substituted C1-8 alkylene; Z is oxygen or sulfur; R3 and R4 are each optionally substituted C1-8 alkyl; and R8 is hydrogen or C1-8 alkyl, with the proviso that when X1 is a free valency, X2 is not O or S(O)p, while when X1 is C(═O)NH, X2 is not a free valency.

    摘要翻译： 通式（I）的化合物或其盐和含有化合物或其盐作为活性成分的PPARdta（过氧化物酶体增殖物活化受体δ）的活化剂：其中R 1和R 2各自为氢，C 1-8 烷基，可被取代的芳基或杂环基等; A是氧，硫等; X 1和X 2各自为自由价，氧，S（O）p（其中p为0至2的整数），C（= O），C（= O）NH，NHC（= O），CH = CH等; Y是任选取代的C 1-8亚烷基; Z是氧或硫; R 3和R 4各自为任选取代的C 1-8烷基; 并且R 8是氢或C 1-8烷基，条件是当X 1是自由价时，X 2不是O或S（O）p，而当X 1是C（O） = O）NH，X 2不是自由价。

    Activator of peroxisome proliferator-activated receptor δ
    7.
    发明授权
    Activator of peroxisome proliferator-activated receptor δ 有权
    过氧化物酶体增殖物激活受体δ的活化剂

    公开(公告)号：US07402597B2

    公开(公告)日：2008-07-22

    申请号：US11544505

    申请日：2006-10-06

    申请人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    发明人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    IPC分类号： A61K31/4178 ,  A61K31/423 ,  A61K31/427

    CPC分类号： C07D403/06 ,  A61K31/00 ,  A61K31/423 ,  A61K31/427 ,  A61K31/454 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

    摘要： A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B1 represents N, etc.; B2 represents O, etc.; each of X1 and X2 represents O, S, a bond, etc.; Y represents C1-8 alkylene chain; z represents O or S; R1 represents aryl, etc. which can have substituents; R2 represents C1-8 alkyl, etc.; R3 represents C1-8 alkyl, C2-8 alkenyl, etc.; each of R4 and R5 represents hydrogen, C1-8 alkyl, etc.; and R6 represents hydrogen, etc.; provided that each of Z and R3 is attached to the benzene ring, and X2 is not attached to the benzene ring).

    摘要翻译： 由式（I）表示的化合物或化合物的盐和含有该化合物或盐作为活性成分的PPAR-δ活化剂：（其中A表示O或S; B < 表示N等; B 2表示O等; X 1和X 2各自表示O，S，键， Y表示C 1-8亚烷基链; z表示O或S; R 1表示可具有取代基的芳基等; R 2， / SUP表示C 1-8烷基等; R 3表示C 1-8烷基，C 2-8 链烯基等; R 4和R 5各自代表氢，C 1-8烷基等;和 R 6表示氢等;条件是Z和R 3各自连接到苯环上，并且X 2不连接 到苯环）。

    Activator for peroxisome proliferator-activated receptor delta
    8.
    发明申请
    Activator for peroxisome proliferator-activated receptor delta 有权
    过氧化物酶体增殖物激活受体δ的活化剂

    公开(公告)号：US20080009631A1

    公开(公告)日：2008-01-10

    申请号：US11888492

    申请日：2007-07-31

    申请人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    发明人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    IPC分类号： C07D413/00 ,  C07D233/00 ,  C07D263/02 ,  C07D417/00 ,  C07D277/04 ,  C07D403/00

    CPC分类号： C07D263/62 ,  C07D263/32 ,  C07D277/24

    摘要： A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

    摘要翻译： 由以下通式（I）表示的化合物：（其中R 1表示苯基等，其可以具有选自C 1-8烷基的取代基 具有卤素，卤素，羟基等的C 1-8烷基; R 2表示C 1-8烷基等; A 表示氧，硫等; X表示C 1-8亚烷基链等; Y表示C（-O），CH-CH等; R 3 O R 4，R 5和R 5各自表示氢，C 1-8烷基等; B表示CH或氮; Z表示 氧或硫; R 6和R 7各自表示氢，C 1-8烷基等;和R 8， / SUP>表示氢或C 1-8烷基，条件是R 3，R 4和R 4中的至少一个， 5不是氢）或化合物的盐; 和含有该化合物或盐作为活性成分的PPAR-δ活化剂。

    Activator of peroxisome proliferator-activated receptor δ
    9.
    发明授权
    Activator of peroxisome proliferator-activated receptor δ 有权
    过氧化物酶体增殖物激活受体δ的活化剂

    公开(公告)号：US07652045B2

    公开(公告)日：2010-01-26

    申请号：US11888493

    申请日：2007-07-31

    申请人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    发明人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    IPC分类号： A61K31/421 ,  A61K31/426 ,  C07D263/30 ,  C07D277/20

    CPC分类号： C07D263/62 ,  C07D263/32 ,  C07D277/24

    摘要： A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

    摘要翻译： 由以下通式（I）表示的化合物：（其中R 1表示可以具有选自C 1-8烷基，具有卤素的C 1-8烷基，卤素，羟基等的取代基的苯基等; R 2 表示C1-8烷基等; A表示氧，硫等; X表示C1-8亚烷基链等; Y表示C（-O），CH-CH等; R3，R4和R5 各自表示氢，C 1-8烷基等; B表示CH或氮; Z表示氧或硫; R6和R7各自表示氢，C1-8烷基等; R8表示氢或C1-8烷基; R3，R4和R5中的至少一个不是氢）或化合物的盐; 和含有该化合物或盐作为活性成分的PPAR-δ活化剂。

    Activator for peroxisome proliferator-activated receptor δ
    10.
    发明授权
    Activator for peroxisome proliferator-activated receptor δ 有权
    过氧化物酶体增殖物激活受体δ的活化剂

    公开(公告)号：US07648999B2

    公开(公告)日：2010-01-19

    申请号：US11888492

    申请日：2007-07-31

    申请人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    发明人： Shogo Sakuma ,  Tomio Yamakawa ,  Takashi Kanda ,  Seiichiro Masui

    IPC分类号： A61K31/426 ,  A61K31/4436 ,  A61K31/4709 ,  C07D277/22 ,  C07D417/04

    CPC分类号： C07D263/62 ,  C07D263/32 ,  C07D277/24

    摘要： A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.

    摘要翻译： 由以下通式（I）表示的化合物：（其中R 1表示可以具有选自C 1-8烷基，具有卤素的C 1-8烷基，卤素，羟基等的取代基的苯基等; R 2 表示C1-8烷基等; A表示氧，硫等; X表示C1-8亚烷基链等; Y表示C（-O），CH-CH等; R3，R4和R5 各自表示氢，C 1-8烷基等; B表示CH或氮; Z表示氧或硫; R6和R7各自表示氢，C1-8烷基等; R8表示氢或C1-8烷基; R3，R4和R5中的至少一个不是氢）或化合物的盐; 和含有该化合物或盐作为活性成分的PPAR-δ活化剂。