公开(公告)号：US08063205B2

公开(公告)日：2011-11-22

申请号：US12065347

申请日：2006-08-30

申请人： Shoji Hara ,  Tsuyoshi Fukuhara ,  Toshio Hidaka

发明人： Shoji Hara ,  Tsuyoshi Fukuhara ,  Toshio Hidaka

IPC分类号： C07D263/12 ,  C07D263/16 ,  C07D263/56 ,  C07D265/08 ,  C07D277/10 ,  C07D279/06

CPC分类号： C07D263/12 ,  C07D263/16 ,  C07D263/56 ,  C07D265/08 ,  C07D277/10

摘要： The present invention is a method for producing a 2-oxazoline analogue or a 1,3-oxazine analogue represented by the following general formula (3) by reacting a 1,2-aminoalcohol compound or a 1,2-aminothiol compound with an α,α-dihaloamine compound.(In the formula, n represents 0 or 1, and R represents an oxygen atom or a sulfur atom. R1, R2 and R3 each represents an atom or a group shown in Group 1 to Group 3, and R0 represents an atom or a group shown in Group 2 or Group 3. Two or more of R1, R2 and R3 may be bonded to each other to form a ring.Group 1: a hydrogen atom, a halogen atom, a nitro group, a cyano group, a formyl group, a carboxyl group, a sulfonyl group, a sulfinoyl group or a sulfenyl group;Group 2: an alkyl group, which may have an arbitrary substituent, an aryl group or an aralkyl group; andGroup 3: an alkyl-substituted, aryl-substituted or aralkyl-substituted oxy group, a carbonyl group, an oxycarbonyl group, a carbonyloxy group, a thio group, a sulfonyl group, a sulfinoyl group or a sulfenyl group)

摘要翻译： 本发明是通过使1,2-氨基醇化合物或1,2-氨基硫醇化合物与α反应生成2-恶唑啉类似物或由以下通式（3）表示的1,3-恶嗪类似物的方法， ，α-二卤代胺化合物。 （式中，n表示0或1，R表示氧原子或硫原子，R1，R2和R3各自表示1〜3族所示的原子或基团，R0表示原子或基团） 第1组：氢原子，卤素原子，硝基，氰基，甲酰基等。另外，R 1，R 2，R 3可以相互结合形成环。 ，羧基，磺酰基，亚磺酰基或亚磺酰基;第2族：可以具有任意取代基的烷基，芳基或芳烷基;第3族：烷基取代的芳基 - 取代或芳烷基取代的氧基，羰基，氧羰基，羰氧基，硫基，磺酰基，亚磺酰基或亚磺酰基）

公开(公告)号：US08093429B2

公开(公告)日：2012-01-10

申请号：US12302362

申请日：2007-05-31

申请人： Toshio Hidaka ,  Takafumi Yoshimura ,  Shoji Hara ,  Tsuyoshi Fukuhara

发明人： Toshio Hidaka ,  Takafumi Yoshimura ,  Shoji Hara ,  Tsuyoshi Fukuhara

IPC分类号： C07C211/27

CPC分类号： C07C211/29 ,  C07C231/12 ,  Y02P20/582 ,  C07C233/65

摘要： Provided are a fluorous-tag-introduced fluoroamine of a general formula (I), its production method, a method of fluorination of a substrate having functional group containing oxygen with the fluoroamine serving as a fluorinating agent, and a method of recovering a fluorous-tag-introduced amide after the fluorination. The fluoroamine and its production method, as well as the fluorination method with the fluoroamine and the method of recovery of a fluorous-tag-introduced amide are ecological and advantageous in industrial use, as the load for separating and collecting the product after the fluorination with the fluoroamine serving as a fluorinating agent is small. (In the formula, R0 is an alkyl group or an aryl group having substituent(s) of Rf—(CH2)m—; Rf is a perfluoroalkyl group; m is from 0 to 2; R1 and R2 each are an alkyl group or an aryl group.)

摘要翻译： 提供了通式（I）的氟标记导入的氟胺，其制备方法，含氟氧基官能团的底物氟化作为氟化剂的方法，以及回收氟 - 标签引入酰胺后氟化。 氟胺及其制备方法以及氟胺的氟化方法和引入氟标签的酰胺的回收方法在工业上是生态和有利的，作为在氟化后分离和收集产物的负载 作为氟化剂的氟胺是小的。 （式中，R 0为具有Rf - （CH 2）m - 的取代基的烷基或芳基，Rf为全氟烷基，m为0〜2，R 1和R 2各自为烷基或 芳基）

公开(公告)号：US07829741B2

公开(公告)日：2010-11-09

申请号：US11718526

申请日：2005-10-20

申请人： Tsuyoshi Fukuhara ,  Shoji Hara ,  Toshio Hidaka

发明人： Tsuyoshi Fukuhara ,  Shoji Hara ,  Toshio Hidaka

IPC分类号： C07C209/68 ,  C07C209/74

CPC分类号： C07C209/74 ,  C07C213/08 ,  C07D233/02 ,  C07C211/29 ,  C07C217/58

摘要： A process for producing an α,α-difluoroamine which comprises using hydrogen fluoride and a Lewis base in specific amounts in the halogen-fluorine exchange reaction using an α,α-dihaloamine as the substrate. The process can be industrially applied, enables to obtain the object compound in a short time at a great yield and can be conducted easily with excellent productivity.

摘要翻译： 一种制备α，α-二氟胺的方法，其包括使用α，α-二卤代胺作为底物，在卤素 - 氟交换反应中使用氟化氢和路易斯碱。 该工艺可以在工业上应用，能够在短时间内以大的收率获得目标化合物，并且可以以优异的生产率容易地进行。

公开(公告)号：US20090281309A1

公开(公告)日：2009-11-12

申请号：US12065347

申请日：2006-08-30

申请人： Shoji Hara ,  Tsuyoshi Fukuhara ,  Toshio Hidaka

发明人： Shoji Hara ,  Tsuyoshi Fukuhara ,  Toshio Hidaka

IPC分类号： C07D263/12 ,  C07D265/08

CPC分类号： C07D263/12 ,  C07D263/16 ,  C07D263/56 ,  C07D265/08 ,  C07D277/10

摘要： The present invention is a method for producing a 2-oxazoline analogue or a 1,3-oxazine analogue represented by the following general formula (3) by reacting a 1,2-aminoalcohol compound or a 1,2-aminothiol compound with an α,α-dihaloamine compound.(In the formula, n represents 0 or 1, and R represents an oxygen atom or a sulfur atom. R1, R2 and R3 each represents an atom or a group shown in Group 1 to Group 3, and R0 represents an atom or a group shown in Group 2 or Group 3. Two or more of R1, R2 and R3 may be bonded to each other to form a ring.Group 1: a hydrogen atom, a halogen atom, a nitro group, a cyano group, a formyl group, a carboxyl group, a sulfonyl group, a sulfinoyl group or a sulfenyl group;Group 2: an alkyl group, which may have an arbitrary substituent, an aryl group or an aralkyl group; andGroup 3: an alkyl-substituted, aryl-substituted or aralkyl-substituted oxy group, a carbonyl group, an oxycarbonyl group, a carbonyloxy group, a thio group, a sulfonyl group, a sulfinoyl group or a sulfenyl group)

摘要翻译： 本发明是通过使1,2-氨基醇化合物或1,2-氨基硫醇化合物与α-羟基喹啉类化合物反应来制备由以下通式（3）表示的2-恶唑啉类似物或1,3-恶嗪类似物的方法， ，α-二卤代胺化合物。 （式中，n表示0或1，R表示氧原子或硫原子，R1，R2和R3各自表示1〜3族所示的原子或基团，R0表示原子或基团） 第1组：氢原子，卤素原子，硝基，氰基，甲酰基等。另外，R 1，R 2，R 3可以相互结合形成环。 ，羧基，磺酰基，亚磺酰基或亚磺酰基;第2族：可以具有任意取代基的烷基，芳基或芳烷基;第3族：烷基取代的芳基 - 取代或芳烷基取代的氧基，羰基，氧羰基，羰氧基，硫基，磺酰基，亚磺酰基或亚磺酰基）

公开(公告)号：US20090198086A1

公开(公告)日：2009-08-06

申请号：US12302362

申请日：2007-05-31

申请人： Toshio Hidaka ,  Takafumi Yoshimura ,  Shoji Hara ,  Tsuyoshi Fukuhara

发明人： Toshio Hidaka ,  Takafumi Yoshimura ,  Shoji Hara ,  Tsuyoshi Fukuhara

IPC分类号： C07C53/21 ,  C07C233/64 ,  C07C209/00 ,  C07C211/01 ,  C07C31/34

CPC分类号： C07C211/29 ,  C07C231/12 ,  Y02P20/582 ,  C07C233/65

摘要： Provided are a fluorous-tag-introduced fluoroamine of a general formula (I), its production method, a method of fluorination of a substrate having functional group containing oxygen with the fluoroamine serving as a fluorinating agent, and a method of recovering a fluorous-tag-introduced amide after the fluorination. The fluoroamine and its production method, as well as the fluorination method with the fluoroamine and the method of recovery of a fluorous-tag-introduced amide are ecological and advantageous in industrial use, as the load for separating and collecting the product after the fluorination with the fluoroamine serving as a fluorinating agent is small. (In the formula, R0 is an alkyl group or an aryl group having substituent(s) of Rf—(CH2)m—; Rf is a perfluoroalkyl group; m is from 0 to 2; R1 and R2 each are an alkyl group or an aryl group.)

摘要翻译： 提供了通式（I）的氟标记导入的氟胺，其制备方法，含氟氧基官能团的底物氟化作为氟化剂的方法，以及回收氟 - 标签引入酰胺后氟化。 氟胺及其制备方法以及氟胺的氟化方法和引入氟标签的酰胺的回收方法在工业上是生态和有利的，作为在氟化后分离和收集产物的负载 作为氟化剂的氟胺是小的。 （式中，R 0为具有Rf - （CH 2）m - 的取代基的烷基或芳基，Rf为全氟烷基，m为0〜2，R 1和R 2各自为烷基或 芳基）

公开(公告)号：US20090177012A1

公开(公告)日：2009-07-09

申请号：US11718526

申请日：2005-10-20

申请人： Tsuyoshi Fukuhara ,  Shoji Hara ,  Toshio Hidaka

发明人： Tsuyoshi Fukuhara ,  Shoji Hara ,  Toshio Hidaka

IPC分类号： C07C209/00

CPC分类号： C07C209/74 ,  C07C213/08 ,  C07D233/02 ,  C07C211/29 ,  C07C217/58

摘要： A process for producing an α,α-difluoroamine which comprises using hydrogen fluoride and a Lewis base in specific amounts in the halogen-fluorine exchange reaction using an α,α-dihaloamine as the substrate. The process can be industrially applied, enables to obtain the object compound in a short time at a great yield and can be conducted easily with excellent productivity.

摘要翻译： 一种制备α，α-二氟胺的方法，其包括使用α，α-二卤代胺作为底物，在卤素 - 氟交换反应中使用氟化氢和具有特定量的路易斯碱。 该工艺可以在工业上应用，能够在短时间内以大的收率获得目标化合物，并且可以以优异的生产率容易地进行。

公开(公告)号：US07615650B2

公开(公告)日：2009-11-10

申请号：US10587545

申请日：2005-01-28

申请人： Kazuo Tanaka ,  Youichi Kyuuko ,  Toshio Hidaka

发明人： Kazuo Tanaka ,  Youichi Kyuuko ,  Toshio Hidaka

IPC分类号： C07D311/66

CPC分类号： C07D311/66 ,  C07D311/62

摘要： The invention provides a process for producing a chroman compound represented by formula (1), characterized in that the process includes allowing a phenol, an unsaturated compound, and a formaldehyde to react in the absence of catalyst and in the presence of water in an amount by mole 1 to 10 times that of the phenol.According to the present invention, a high-purity chroman compound can be produced in the absence of catalyst and under mild conditions. In addition, the invention provides an industrial means for producing the compound, without using a large amount of an acid or a base serving as a reaction promoter or a catalyst, which would otherwise cause side reactions, apparatus corrosion, etc.

摘要翻译： 本发明提供一种制备由式（1）表示的苯并二氢吡喃化合物的方法，其特征在于该方法包括使苯酚，不饱和化合物和甲醛在不存在催化剂的情况下和在水存在下反应， 为摩尔比的1〜10倍。 根据本发明，可以在不存在催化剂的条件下，在温和的条件下生产高纯度色满化合物。 此外，本发明提供了一种用于生产化合物的工业方法，而不使用大量的酸或作为反应促进剂或催化剂的碱，否则会引起副反应，装置腐蚀等。

公开(公告)号：US07019173B2

公开(公告)日：2006-03-28

申请号：US10433412

申请日：2002-08-22

申请人： Toshio Hidaka ,  Norio Fushimi ,  Takafumi Yoshimura ,  Takeshi Kawai

发明人： Toshio Hidaka ,  Norio Fushimi ,  Takafumi Yoshimura ,  Takeshi Kawai

IPC分类号： C07C211/00

CPC分类号： C07F9/54 ,  C07B39/00 ,  C07C17/16 ,  C07C17/18 ,  C07C211/29 ,  C07C251/30 ,  C07C271/20 ,  C07F9/5004 ,  Y02P20/582

摘要： A fluorine compound represented by Formula (1) is provided. The above fluorine compound is effective for introducing a fluorine atom into a compound having an active group such as an oxygen-containing functional group, and it can be used for uses of surface treatment, cleaning and coating. Further, after the fluorination reaction, the above compound is recovered and can be reused as a starting material for producing the above fluorine compound, and it is useful for various fluorination processes. (wherein X represents a nitrogen or phosphorus atom; R0, R1, and R2 represent hydrogen, an alkyl group or aryl group which may have a substituent, and they each may be the same or different; and R0, R1, and R2 may be combined with each other to form a ring).

公开(公告)号：US06710009B2

公开(公告)日：2004-03-23

申请号：US10191963

申请日：2002-07-10

申请人： Toshio Hidaka ,  Katsumi Higuchi ,  Takeshi Kawai

发明人： Toshio Hidaka ,  Katsumi Higuchi ,  Takeshi Kawai

IPC分类号： B01J27182

CPC分类号： C07C209/16 ,  B01J29/85 ,  B01J35/023 ,  B01J2229/42 ,  C01B37/08 ,  C07C211/04

摘要： Catalysts useful for producing methylamines and having practical catalyst life and large selectivity for dimethylamine comprise crystalline silicoaluminophosphate molecular sieves which have a molar ratio of silicon atom to aluminum atom in the range of 0.01-0.30.

摘要翻译： 可用于生产甲胺并具有实用的催化剂寿命和对二甲胺的大选择性的催化剂包括硅原子与铝原子的摩尔比在0.01-0.30范围内的结晶硅铝磷酸盐分子筛。

公开(公告)号：US4274913A

公开(公告)日：1981-06-23

申请号：US41505

申请日：1979-05-22

申请人： Makoto Kikuiri ,  Yoshimi Nakashio ,  Yasue Arai ,  Toshio Hidaka

发明人： Makoto Kikuiri ,  Yoshimi Nakashio ,  Yasue Arai ,  Toshio Hidaka

IPC分类号： D21C3/02 ,  D21C3/24 ,  D21C3/26 ,  D21C7/08

CPC分类号： D21C7/08 ,  D21C3/263

摘要： A process for producing alkali pulp by using a single, cylindrical pressurized reaction vessel having therein a liquor-inpregnating zone, a cooking zone, a washing zone, and a diluting zone in that order, and having a motor-driven scraping or agitating device and a pulp discharging outlet in the end portion of the diluting zone. Alkaline aqueous medium containing dissolved oxygen therein is introduced into the diluting zone. A part of the introduced alkaline aqueous medium countercurrently contacts cooked cellulosic materials transferred from the washing zone to the diluting zone to proceed with oxygen-alkali delignification, and is finally discharged out of the vessel from the end portion of the cooking zone. The remainder of the introduced alkaline aqueous medium contacts the cooked cellulosic materials in the diluting zone in a scraping or agitating manner by means of the motor-driven scraping or agitating device to proceed with oxygen-alkali delignification, and finally serves as diluting liquor to be discharged out of the vessel accompanying the resulting pulp.

摘要翻译： 一种通过使用其中具有浸渍浸渍区，蒸煮区，洗涤区和稀释区的单个圆柱形加压反应容器来生产碱浆的方法，并且具有马达驱动的刮擦或搅拌装置和 在稀释区的端部的纸浆排出口。 将含有溶解氧的碱性水性介质引入稀释区。 引入的碱性水性介质的一部分与从洗涤区转移到稀释区的煮熟的纤维素材料逆流接触，进行氧碱脱木质素，最后从烹调区的端部排出容器。 引入的碱性水性介质的其余部分通过马达驱动的刮擦或搅拌装置以刮擦或搅拌方式与稀释区中的熟化纤维素材料接触，进行氧碱脱木质素，最后作为稀释液体 从伴随所产生的纸浆的容器中排出。