公开(公告)号：US20240132444A1

公开(公告)日：2024-04-25

申请号：US18257595

申请日：2021-12-14

Applicant: NOURYON CHEMICALS INTERNATIONAL B.V.

Inventor： Eike Nicolas KANTZER ,  Alexey Borisovich ZAITSEV ,  Tjerk Oedse BOONSTRA ,  Ina EHLERS ,  Rolf Krister EDVINSSON ,  Martin HEUS ,  Antoon Jacob Berend TEN KATE ,  Michiel Jozef Thomas RAAIJMAKERS

IPC: C07C253/30 ,  C07C253/12 ,  C07C253/34 ,  C07D233/02

CPC classification number: C07C253/30 ,  C07C253/12 ,  C07C253/34 ,  C07D233/02

Abstract: A process for manufacturing a nitrile compound through chain elongation of an alkylene amine compound containing three or more amine units in which at least two amine units are protected by a cyclic urea unit and at least one amine unit is not protected, includes reacting the at least one amine unit that is not protected with glycolonitrile or with the combination of formaldehyde and a cyanide compound selected from HCN and inorganic cyanide salts, to add at least one acetonitrile group to the at least one amine unit that is not protected.

公开(公告)号：US11952351B2

公开(公告)日：2024-04-09

申请号：US18059765

申请日：2022-11-29

Applicant: KABUSHIKI KAISHA TOSHIBA

Inventor： Mitsuko Ishihara ,  Eiichi Akahoshi ,  Katsuyuki Naito ,  Emi Nozaki ,  Saeko Saruwatari

IPC: C07D243/08 ,  A61K9/127 ,  C07C229/30 ,  C07D211/14 ,  C07D233/02 ,  C07D241/04 ,  A61K31/7088

CPC classification number: C07D243/08 ,  A61K9/1271 ,  C07C229/30 ,  C07D211/14 ,  C07D233/02 ,  C07D241/04 ,  A61K31/7088

Abstract: The present embodiment provides a compound represented by the formula (1):

Q-CHR2  (1)

(Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and R is an aliphatic group containing a biodegradable group). From the compound in combination with other lipids such as a lipid capable of reducing aggregation, lipid particles can be formed. Further, the compound can be used for a pharmaceutical composition to deliver an activator into cells.

公开(公告)号：US11765972B2

公开(公告)日：2023-09-19

申请号：US16971260

申请日：2019-02-20

Applicant: IDEMITSU KOSAN CO.,LTD.

Inventor： Yoshinao Shirasaki ,  Tetsuya Masuda ,  Takushi Shiomi ,  Masatoshi Saito ,  Kei Yoshida ,  Masato Nakamura

IPC: H10K85/60 ,  C09K11/06 ,  C07D405/04 ,  C07D409/04 ,  H10K50/15 ,  H10K50/16 ,  H10K101/00 ,  C07C15/27 ,  C07D233/02 ,  C07D251/04

CPC classification number: H10K85/654 ,  C07C15/27 ,  C07D233/02 ,  C07D251/04 ,  C07D405/04 ,  C07D409/04 ,  C09K11/06 ,  H10K85/653 ,  H10K85/657 ,  H10K85/6574 ,  H10K85/6576 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1018 ,  H10K50/15 ,  H10K50/16 ,  H10K50/166 ,  H10K2101/27

Abstract: A compound represented by the following formula (1), wherein X1 is O or S, and two or more of Y1, Y2 and Y3 are N, provided that the case where one or both of —Ar1-Ar2 and —Ar3-Ar4 is a p-terphenyl-3-yl group is excluded.

公开(公告)号：US11753392B2

公开(公告)日：2023-09-12

申请号：US17047380

申请日：2019-04-12

Applicant: HINOVA PHARMACEUTICALS INC.

Inventor： Wu Du ,  Kun Wen ,  Jinyun He ,  Haibo Li ,  Dekun Qin ,  Xinghai Li ,  Yuanwei Chen

IPC: C07D401/04 ,  C07C231/24 ,  C07D233/02 ,  C07D401/06

CPC classification number: C07D401/04 ,  C07C231/24 ,  C07D233/02 ,  C07D401/06 ,  C07C2601/14 ,  C07C2601/16

Abstract: A novel method for synthesizing deuterated amides and deuterated sulfonamides includes the following steps: (1) adding a compound M, DMAP, R3—X to a solvent to obtain a compound N after a reaction is complete; and (2) adding the compound N, R4—NH—R5, or a salt and base thereof to a solvent, and purifying after a reaction is complete to obtain a compound I.

公开(公告)号：US09944589B2

公开(公告)日：2018-04-17

申请号：US14650292

申请日：2013-12-03

Applicant: Istituto Europeo de Oncologia S.r.L.

Inventor： Mario Varasi ,  Paola Vianello ,  Florian Thaler ,  Paolo Trifiro′ ,  Ciro Mercurio ,  Giuseppe Meroni

IPC: C07C211/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/496 ,  C07D215/12 ,  C07D295/195 ,  C07D207/50 ,  C07D213/61 ,  C07D311/70 ,  C07D211/58 ,  C07D263/04 ,  C07D233/02 ,  C07D271/113 ,  C07C209/00 ,  C07C231/12 ,  C07C269/06 ,  C07C303/36 ,  C07D319/16 ,  C07D233/32 ,  C07D239/42 ,  C07D249/06 ,  C07D263/22 ,  C07D271/10 ,  C07D295/155 ,  C07D213/64 ,  C07D307/54 ,  C07C271/28 ,  C07C211/49 ,  C07C215/42 ,  C07C217/58 ,  C07C217/74 ,  C07C233/44 ,  C07C233/80 ,  C07C237/06 ,  C07C247/16 ,  C07C311/21

CPC classification number: C07C211/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4164 ,  A61K31/496 ,  C07C209/00 ,  C07C211/49 ,  C07C215/42 ,  C07C217/58 ,  C07C217/74 ,  C07C231/12 ,  C07C233/44 ,  C07C233/80 ,  C07C237/06 ,  C07C247/16 ,  C07C269/06 ,  C07C271/28 ,  C07C303/36 ,  C07C311/21 ,  C07C2601/02 ,  C07D207/50 ,  C07D211/58 ,  C07D213/61 ,  C07D213/64 ,  C07D215/12 ,  C07D233/02 ,  C07D233/32 ,  C07D239/42 ,  C07D249/06 ,  C07D263/04 ,  C07D263/22 ,  C07D271/10 ,  C07D271/113 ,  C07D295/155 ,  C07D295/195 ,  C07D307/54 ,  C07D311/70 ,  C07D319/16 ,  A61K2300/00

Abstract: The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.

公开(公告)号：US20170320897A1

公开(公告)日：2017-11-09

申请号：US15656766

申请日：2017-07-21

Applicant: Allergan, Inc.

Inventor： Richard L. Beard ,  John E. Donello ,  Veena Wiswanath

IPC: C07F9/40 ,  C07D405/06 ,  C07D403/14 ,  C07D401/14 ,  C07D401/06 ,  C07D261/12 ,  C07D257/04 ,  C07D235/02 ,  C07D233/02 ,  C07D223/10 ,  C07D217/24 ,  C07C275/42 ,  C07C235/82 ,  A61K31/662 ,  A61K31/42 ,  A61K31/4166 ,  A61K31/196 ,  A61K31/17 ,  A61K9/00 ,  C07D409/06

CPC classification number: C07F9/40 ,  A61K9/0019 ,  A61K9/0048 ,  A61K31/17 ,  A61K31/196 ,  A61K31/4166 ,  A61K31/42 ,  A61K31/662 ,  C07C235/82 ,  C07C275/42 ,  C07D217/24 ,  C07D223/10 ,  C07D233/02 ,  C07D235/02 ,  C07D257/04 ,  C07D261/12 ,  C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/06 ,  C07D409/06

Abstract: The present invention relates to a method for treating ocular inflammatory diseases in a subject in need of such treatment, which comprises administering a pharmaceutical composition comprising a therapeutically effective amount of at least one agonist of Formyl peptide receptor 2.

公开(公告)号：US20170246131A1

公开(公告)日：2017-08-31

申请号：US15400087

申请日：2017-01-06

Applicant: NeuroPro Therapeutics, Inc.

Inventor： John J. PARTRIDGE ,  Daryl W. HOCHMAN

IPC: A61K31/18

CPC classification number: A61K31/18 ,  A61K31/4355 ,  C07C311/39 ,  C07D211/44 ,  C07D231/04 ,  C07D233/02 ,  C07D237/02 ,  C07D239/04 ,  C07D241/04 ,  C07D261/02 ,  C07D263/04 ,  C07D265/30 ,  C07D275/02 ,  C07D277/04 ,  C07D279/12 ,  C07D295/084 ,  C07D307/52

Abstract: The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are believed useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl− co-transporter or GABAA receptor.

公开(公告)号：US20170226064A1

公开(公告)日：2017-08-10

申请号：US15385427

申请日：2017-05-03

Applicant: PhilEra New Zealand Limited

Inventor： Marco Jonas ,  Irene Vaulont ,  Antonio Soi ,  Gunther Schmidt

IPC: C07D233/02

CPC classification number: C07D233/02 ,  C07B2200/13 ,  C07C55/10 ,  C07C57/145 ,  C07C57/15 ,  C07C209/48 ,  C07C209/62 ,  C07C209/76 ,  C07C211/10 ,  C07C211/13 ,  C07C211/14 ,  C07C255/30 ,  C07D233/26

Abstract: Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.

公开(公告)号：US20150080350A1

公开(公告)日：2015-03-19

申请号：US14472181

申请日：2014-08-28

Applicant: NeuroPro Therapeutics, Inc.

Inventor： John J. PARTRIDGE ,  Daryl W. HOCHMAN

IPC: C07C311/39

CPC classification number: A61K31/18 ,  A61K31/4355 ,  C07C311/39 ,  C07D211/44 ,  C07D231/04 ,  C07D233/02 ,  C07D237/02 ,  C07D239/04 ,  C07D241/04 ,  C07D261/02 ,  C07D263/04 ,  C07D265/30 ,  C07D275/02 ,  C07D277/04 ,  C07D279/12 ,  C07D295/084 ,  C07D307/52

Abstract: The present invention provides bumetanide, analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide, analogs and methods for their use. These analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl− co-transporter or GABAA receptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, autism, bipolar disorder, cancer, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma. Huntington's Disease, insomnia, ischemia, migraine, migraine with aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, personality disorders, postherpetic neuralgia, psychosis, schizophrenia, seizure disorders, tinnitus, and withdrawal syndromes.

Abstract translation: 本发明提供了包含这种类似物的布美他尼，类似物和组合物。 本发明还提供含有这些布美他尼的药物组合物，其用途及其用途。 这些类似物对于治疗和/或预防涉及Na + K + Cl-共转运蛋白或GABA A受体的病症特别有用，包​​括但不限于成瘾性疾病，阿尔茨海默病，焦虑症，腹水，孤独症，双相性精神障碍， 癌症，抑郁症，内皮角膜营养不良，水肿，癫痫，青光眼。 亨廷顿病，失眠，局部缺血，偏头痛，偏头痛，神经性疼痛，伤害性神经痛，伤害性疼痛，眼部疾病，疼痛，帕金森病，人格障碍，带状疱疹后神经痛，精神病，精神分裂症，癫痫发作，耳鸣和戒断综合征。

公开(公告)号：US20140213623A1

公开(公告)日：2014-07-31

申请号：US14049950

申请日：2013-10-09

Applicant: GTx, Inc. ,  University of Tennessee Research Foundation

Inventor： Duane D. Miller ,  Li Wei ,  Jianjun Chen ,  James T. Dalton ,  Chien-Ming Li ,  Sunjoo Ahn

IPC: C07D403/04 ,  A61K31/4178

CPC classification number: C07D403/04 ,  A61K31/4178 ,  A61K45/06 ,  C07D233/02 ,  C07D233/22 ,  C07D233/54 ,  C07D263/06 ,  C07D263/14 ,  C07D263/32 ,  C07D277/04 ,  C07D277/24 ,  C07D277/28 ,  C07D277/56 ,  C07D401/04 ,  C07D401/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  A61K2300/00

Abstract: The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.

Abstract translation: 本发明涉及式XXII化合物和式17ya化合物，其在本说明书中的任何地方定义为包含该化合物的组合物，以及其用于治疗各种形式的癌症的方法。