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1.发明申请Plant Stress Tolerance Related Protein GmSIK1 and Encoding Gene and Use Thereof 审中-公开植物胁迫耐受相关蛋白GmSIK1和编码基因及其用途公开(公告)号：US20120266325A1
公开(公告)日：2012-10-18
申请号：US13503163
申请日：2010-10-15
申请人： Shouyi Chen , Jinsong Zhang , Peng Liu , Wanke Zhang , Sijie He , Qing Lin
发明人： Shouyi Chen , Jinsong Zhang , Peng Liu , Wanke Zhang , Sijie He , Qing Lin
CPC分类号： C07K14/415 , C12N15/8273
摘要： Provided are a plant stress tolerance related protein GmSIK1 and encoding gene and use thereof. The GmSIK1 protein has the amino acid sequence as shown in SEQ ID NO: 2. The transgenic plant with enhanced stress tolerance such as drought tolerance and/or salt tolerance can be obtained from introducing the encoding gene of GmSIK1 protein into plant cell.
摘要翻译： 提供植物胁迫耐受相关蛋白GmSIK1和编码基因及其用途。 GmSIK1蛋白具有如SEQ ID NO：2所示的氨基酸序列。通过将GmSIK1蛋白的编码基因导入植物细胞，可以获得具有增强的胁迫耐受性如耐旱性和/或耐盐性的转基因植物。
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公开(公告)号：US20130014289A1
公开(公告)日：2013-01-10
申请号：US13580935
申请日：2010-02-24
申请人： Jinsong Zhang , Shouyi Chen , Canfang Niu , Biao Ma , Wanke Zhang , Qing Lin , Sijie He
发明人： Jinsong Zhang , Shouyi Chen , Canfang Niu , Biao Ma , Wanke Zhang , Qing Lin , Sijie He
CPC分类号： C07K14/415 , C12N15/8271
摘要： Compositions and methods for imparting stress tolerance to plants using WRKY nucleic acid and polypeptides.
摘要翻译： 使用WRKY核酸和多肽赋予植物胁迫耐受性的组合物和方法。
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公开(公告)号：US20120272352A1
公开(公告)日：2012-10-25
申请号：US13504846
申请日：2010-10-12
申请人： Shouyi Chen , Jinsong Zhang , Shouqiang Ouyang , Sijie He , Wanke Zhang , Biao Ma , Qing Lin
发明人： Shouyi Chen , Jinsong Zhang , Shouqiang Ouyang , Sijie He , Wanke Zhang , Biao Ma , Qing Lin
CPC分类号： C12N15/8273 , C12N9/90
摘要： Compositions and methods for conferring drought and salt tolerance to plants using tocopherol cyclase (TC) genes, including polynucleotides, polypeptides, vectors, cells and plants.
摘要翻译： 使用生育酚环化酶（TC）基因（包括多核苷酸，多肽，载体，细胞和植物）赋予对植物的干旱和耐盐性的组合物和方法。
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公开(公告)号：US08685435B2
公开(公告)日：2014-04-01
申请号：US10837355
申请日：2004-04-30
申请人： Thierry Nivaggioli , Jane Guo Shiah , Qing Lin
发明人： Thierry Nivaggioli , Jane Guo Shiah , Qing Lin
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61K9/204 , A61K31/57 , A61K31/573 , A61K47/34
摘要： Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
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5.发明授权Peptide-peptidase-inhibitor conjugates and methods of making and using same 失效肽 - 肽酶 - 抑制剂缀合物及其制备和使用方法公开(公告)号：US08598314B2
公开(公告)日：2013-12-03
申请号：US12680539
申请日：2008-09-26
申请人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
发明人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
CPC分类号： A61K47/64 , A61K47/545 , A61K47/55
摘要： Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译： 公开了肽肽酶抑制剂缀合物分子及其制备方法。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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公开(公告)号：US08586707B2
公开(公告)日：2013-11-19
申请号：US12561107
申请日：2009-09-16
申请人： Qing Lin , Mike Madden
发明人： Qing Lin , Mike Madden
CPC分类号： C07K1/045 , C07K1/107 , C07K1/1136
摘要： A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.
摘要翻译： 一种制备缝合肽的方法。 根据光化学方法[3 + 2]环加成反应制备包装螺旋缝合肽的缝合肽。 螺旋缝合肽表现出增加的螺旋度，热稳定性和细胞渗透性。
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公开(公告)号：US20080138339A1
公开(公告)日：2008-06-12
申请号：US11895207
申请日：2007-08-22
申请人： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
发明人： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
CPC分类号： C07K16/2809 , C07K16/3069 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
摘要翻译： 本发明提供了抗卵巢癌双特异性抗体。 所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或 其Fab片段，单CDR抗体或scFv。 本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。
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8.发明申请PEPTIDE-PEPTIDASE-INHIBITOR CONJUGATES AND METHODS OF MAKING AND USING SAME 失效肽 - 肽抑制剂结合物及其制备方法和使用方法公开(公告)号：US20100286365A1
公开(公告)日：2010-11-11
申请号：US12680539
申请日：2008-09-26
申请人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
发明人： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC分类号： C07K1/10
CPC分类号： A61K47/64 , A61K47/545 , A61K47/55
摘要： Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
摘要翻译： 公开了肽肽酶抑制剂缀合物分子及其制备方法。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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公开(公告)号：US20080274952A1
公开(公告)日：2008-11-06
申请号：US10589054
申请日：2005-02-11
申请人： Christopher J Soares , Michael R. Hanley , Diana Yvonne Lewis , David Geoffrey Parkes , Carolyn Marie Jodka , Kathryn S. Prickett , Soumitra Ghosh , Christine Marie Mack , Qing Lin
发明人： Christopher J Soares , Michael R. Hanley , Diana Yvonne Lewis , David Geoffrey Parkes , Carolyn Marie Jodka , Kathryn S. Prickett , Soumitra Ghosh , Christine Marie Mack , Qing Lin
CPC分类号： C07K14/575
摘要： The present invention relates to obesity related polypeptides (ORPs), related nucleic acids, expression constructs, host cells, and processes production of the obesity related polypeptides. The ORPs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.
摘要翻译： 本发明涉及肥胖相关多肽（ORPs），相关核酸，表达构建体，宿主细胞，并且涉及肥胖相关多肽的产生。 本发明的ORP包括一个或多个氨基酸序列修饰。 此外，公开了治疗和预防代谢紊乱如肥胖，糖尿病和增加的心血管风险的方法和组合物。
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公开(公告)号：US20080089228A1
公开(公告)日：2008-04-17
申请号：US11680607
申请日：2007-02-28
申请人： Qing Lin , Bin Gan , Xiaoyun Jing
发明人： Qing Lin , Bin Gan , Xiaoyun Jing
IPC分类号： H04Q7/00
CPC分类号： H04L69/16 , H04L47/10 , H04L47/14 , H04L47/193 , H04L47/2441 , H04L47/2466 , H04L47/283 , H04L69/163 , H04W80/06
摘要： A method to improve TCP throughput by separating TCP acknowledgment flow from TCP normal data flow in a wireless communications environment. This method creates dedicated signaling air interface link and signaling A10 link for TCP acknowledgment flow and assigns a higher priority value to TOS field of IP packets encapsulating TCP acknowledgments than those encapsulating TCP normal data.
摘要翻译： 一种通过在无线通信环境中将TCP确认流与TCP正常数据流分离来提高TCP吞吐量的方法。 该方法创建用于TCP确认流的专用信令空中接口链路和信令A10链路，并且为封装TCP确认的IP分组的TOS字段的TOS字段分配比封装TCP普通数据的IP分组更高的优先级值。
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