摘要:
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要:
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要:
The various implementations of the present invention are provided as a network computer system configured to allow for the tracking and reporting of user-specified events, including but not limited to, performance metrics and attendance data. This network computer system provides a user interface that allows a user to create metrics to be monitored, view and update event-related information, and to configure and review various pre-programmed and ad hoc reports so the users can monitor and evaluate performance metrics over time. Further, a wide variety of user and system generated alerts and messages or message events can be configured, allowing for automated and manual messaging related to the attendance or performance metrics that are being monitored. Alerts can be provided via email, non-electronic mail, telephone, SMS, facsimile, social networking sites and services (such as “tweets”), etc. In at least one implementation of the present invention, a computer-implemented method of tracking and reporting student performance and attendance-related events for an educational environment is provided.
摘要:
The invention provides a method of reducing ocular inflammation in an individual susceptible to ocular inflammation. The method involves administering to the individual an effective amount of a neutralizing agent specific for CXCL10. Also provided is a method for reducing spread of viral infection within ocular tissues of an individual susceptible to ocular viral infection, which involves administering to the individual an effective amount of a neutralizing agent specific for CXCL10. Further provided is a method of extending corneal graft survival following corneal transplantation in an individual, which involves administering to said individual an effective amount of a neutralizing agent specific for CXCL10. Additionally, the invention provides a method for identifying a compound for reducing ocular inflammation in an animal.