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    Indazole compounds and methods of use thereof
    1.
    发明申请
    Indazole compounds and methods of use thereof 审中-公开
    吲唑化合物及其使用方法

    公开(公告)号：US20060004043A1

    公开(公告)日：2006-01-05

    申请号：US10993981

    申请日：2004-11-19

    申请人： Shripad Bhagwat ,  Yoshitaka Satoh ,  Steven Sakata ,  Chris Buhr ,  Ronald Albers ,  John Sapienza ,  Veronique Plantevin ,  Qi Chao ,  Kiran Sahasrabudhe ,  Rachel Stengone ,  Rama Narla

    发明人： Shripad Bhagwat ,  Yoshitaka Satoh ,  Steven Sakata ,  Chris Buhr ,  Ronald Albers ,  John Sapienza ,  Veronique Plantevin ,  Qi Chao ,  Kiran Sahasrabudhe ,  Rachel Stengone ,  Rama Narla

    IPC分类号： C07D215/12 ,  C07D43/14 ,  A61K31/4709 ,  A61K31/4196

    CPC分类号： C07D403/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

    摘要： This invention is directed to Indazole Compounds or pharmaceutically acceptable salts, solvates and hydrates thereof. The Indazole Compounds have utility in the treatment or prevention of a wide range of diseases and disorders that are responsive to the inhibition, modulation or regulation of kinases, such as inflammatory diseases, abnormal angiogenesis and diseases related thereto, cancer, atherosclerosis, a cardiovascular disease, a renal disease, an autoimmune condition, macular degeneration, disease-related wasting, an asbestos-related condition, pulmonary hypertension, diabetes, obesity, pain and others. Thus, methods of treating or preventing such diseases and disorders are also disclosed, as are pharmaceutical compositions comprising one or more of the Indazole Compounds. This invention is based, in part, upon the discovery of a novel class of 5-triazolyl substituted indazole molecules that have potent activity with respect to the modulation of protein kinases. Thus, the invention encompasses orally active molecules as well as parenterally active molecules which can be used at lower doses or serum concentrations for treating diseses or disorders associated with protein kinase signal transduction.

    摘要翻译： 本发明涉及吲唑化合物或其药学上可接受的盐，溶剂化物和水合物。 吲唑化合物可用于治疗或预防对抑制，调节或调节激酶（例如炎性疾病，异常血管生成和与之相关的疾病，癌症，动脉粥样硬化，心血管疾病）的各种疾病和病症 肾脏疾病，自身免疫性疾病，黄斑变性，疾病相关性消耗，石棉相关病症，肺动脉高压，糖尿病，肥胖，疼痛等。 因此，还公开了治疗或预防这些疾病和病症的方法，以及包含一种或多种吲唑化合物的药物组合物。 本发明部分基于发现关于蛋白激酶调节具有强力活性的新一类5-三唑基取代的吲唑分子。 因此，本发明包括口服活性分子以及肠胃外活性分子，其可以以较低剂量或血清浓度使用，用于治疗与蛋白激酶信号转导相关的疾病或障碍。

    INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF
    4.
    发明申请
    INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
    INDAZOLE化合物及其使用方法

    公开(公告)号：US20090099178A1

    公开(公告)日：2009-04-16

    申请号：US12340129

    申请日：2008-12-19

    申请人： Shripad S. Bhagwat ,  Yoshitaka Satoh ,  Steven T. Sakata ,  Chris A. Buhr ,  Ronald Albers ,  John Sapienza ,  Veronique Plantevin ,  Qi Chao ,  Kiran Sahasrabudhe ,  Rachel Stengone ,  Rama K. Narla

    发明人： Shripad S. Bhagwat ,  Yoshitaka Satoh ,  Steven T. Sakata ,  Chris A. Buhr ,  Ronald Albers ,  John Sapienza ,  Veronique Plantevin ,  Qi Chao ,  Kiran Sahasrabudhe ,  Rachel Stengone ,  Rama K. Narla

    IPC分类号： A61K31/5377 ,  C07D403/10 ,  C07D413/14 ,  A61P35/04 ,  A61P25/00 ,  C07D403/14 ,  A61K31/416

    CPC分类号： C07D403/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

    摘要： This invention is directed to Indazole Compounds or pharmaceutically acceptable salts, solvates and hydrates thereof. The Indazole Compounds have utility in the treatment or prevention of a wide range of diseases and disorders that are responsive to the inhibition, modulation or regulation of kinases, such as inflammatory diseases, abnormal angiogenesis and diseases related thereto, cancer, atherosclerosis, a cardiovascular disease, a renal disease, an autoimmune condition, macular degeneration, disease-related wasting, an asbestos-related condition, pulmonary hypertension, diabetes, obesity, pain and others. Thus, methods of treating or preventing such diseases and disorders are also disclosed, as are pharmaceutical compositions comprising one or more of the Indazole Compounds. This invention is based, in part, upon the discovery of a novel class of 5-triazolyl substituted indazole molecules that have potent activity with respect to the modulation of protein kinases. Thus, the invention encompasses orally active molecules as well as parenterally active molecules which can be used at lower doses or serum concentrations for treating diseases or disorders associated with protein kinase signal transduction.

    摘要翻译： 本发明涉及吲唑化合物或其药学上可接受的盐，溶剂化物和水合物。 吲唑化合物可用于治疗或预防对抑制，调节或调节激酶（例如炎性疾病，异常血管生成和与之相关的疾病，癌症，动脉粥样硬化，心血管疾病）的各种疾病和病症 肾脏疾病，自身免疫性疾病，黄斑变性，疾病相关性消耗，石棉相关病症，肺动脉高压，糖尿病，肥胖，疼痛等。 因此，还公开了治疗或预防这些疾病和病症的方法，以及包含一种或多种吲唑化合物的药物组合物。 本发明部分基于发现关于蛋白激酶调节具有强力活性的新一类5-三唑基取代的吲唑分子。 因此，本发明包括口服活性分子以及可以以较低剂量或血清浓度用于治疗与蛋白激酶信号转导相关的疾病或病症的肠胃外活性分子。

    COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER, COMPOSITIONS THEREOF AND METHODS THEREWITH
    9.
    发明申请
    COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER, COMPOSITIONS THEREOF AND METHODS THEREWITH 失效
    用于治疗癌症的组合物及其组合物及其方法

    公开(公告)号：US20060030617A1

    公开(公告)日：2006-02-09

    申请号：US10463009

    申请日：2003-06-16

    申请人： Jeffrey McKenna ,  Frank Mercurio ,  Veronique Plantevin ,  Weilin Xie

    发明人： Jeffrey McKenna ,  Frank Mercurio ,  Veronique Plantevin ,  Weilin Xie

    IPC分类号： A61K31/35 ,  A61K31/277 ,  A61K31/195 ,  A61K31/137

    CPC分类号： A61K31/351 ,  A61K31/135 ,  A61K31/4025

    摘要： The present invention generally relates to compounds and compositions useful for the modulation of ligase activity. The invention further relates to Compounds of the Invention, compositions thereof, and methods for treating or preventing cancer, a neoplastic disorder, acute or chronic renal failure, an inflammatory disorder, an immune disorder, a cardiovascular disease, an effect of aging or an infectious disease comprising administering an effective amount of a Compound of the Invention. The invention further relates to the use of a Compound of the Invention as a preservative of a cell, blood, tissue or an organ or as an agent to modulate stem cells.

    摘要翻译： 本发明一般涉及可用于调节连接酶活性的化合物和组合物。 本发明还涉及本发明的化合物，其组合物，以及用于治疗或预防癌症，肿瘤性疾病，急性或慢性肾功能衰竭，炎症性疾病，免疫疾病，心血管疾病，衰老或感染性的影响的方法 疾病，包括施用有效量的本发明化合物。 本发明还涉及本发明的化合物作为细胞，血液，组织或器官的防腐剂或作为调节干细胞的药剂的用途。