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    INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF
    2.
    发明申请
    INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
    INDAZOLE化合物及其使用方法

    公开(公告)号：US20090099178A1

    公开(公告)日：2009-04-16

    申请号：US12340129

    申请日：2008-12-19

    申请人： Shripad S. Bhagwat ,  Yoshitaka Satoh ,  Steven T. Sakata ,  Chris A. Buhr ,  Ronald Albers ,  John Sapienza ,  Veronique Plantevin ,  Qi Chao ,  Kiran Sahasrabudhe ,  Rachel Stengone ,  Rama K. Narla

    发明人： Shripad S. Bhagwat ,  Yoshitaka Satoh ,  Steven T. Sakata ,  Chris A. Buhr ,  Ronald Albers ,  John Sapienza ,  Veronique Plantevin ,  Qi Chao ,  Kiran Sahasrabudhe ,  Rachel Stengone ,  Rama K. Narla

    IPC分类号： A61K31/5377 ,  C07D403/10 ,  C07D413/14 ,  A61P35/04 ,  A61P25/00 ,  C07D403/14 ,  A61K31/416

    CPC分类号： C07D403/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

    摘要： This invention is directed to Indazole Compounds or pharmaceutically acceptable salts, solvates and hydrates thereof. The Indazole Compounds have utility in the treatment or prevention of a wide range of diseases and disorders that are responsive to the inhibition, modulation or regulation of kinases, such as inflammatory diseases, abnormal angiogenesis and diseases related thereto, cancer, atherosclerosis, a cardiovascular disease, a renal disease, an autoimmune condition, macular degeneration, disease-related wasting, an asbestos-related condition, pulmonary hypertension, diabetes, obesity, pain and others. Thus, methods of treating or preventing such diseases and disorders are also disclosed, as are pharmaceutical compositions comprising one or more of the Indazole Compounds. This invention is based, in part, upon the discovery of a novel class of 5-triazolyl substituted indazole molecules that have potent activity with respect to the modulation of protein kinases. Thus, the invention encompasses orally active molecules as well as parenterally active molecules which can be used at lower doses or serum concentrations for treating diseases or disorders associated with protein kinase signal transduction.

    摘要翻译： 本发明涉及吲唑化合物或其药学上可接受的盐，溶剂化物和水合物。 吲唑化合物可用于治疗或预防对抑制，调节或调节激酶（例如炎性疾病，异常血管生成和与之相关的疾病，癌症，动脉粥样硬化，心血管疾病）的各种疾病和病症 肾脏疾病，自身免疫性疾病，黄斑变性，疾病相关性消耗，石棉相关病症，肺动脉高压，糖尿病，肥胖，疼痛等。 因此，还公开了治疗或预防这些疾病和病症的方法，以及包含一种或多种吲唑化合物的药物组合物。 本发明部分基于发现关于蛋白激酶调节具有强力活性的新一类5-三唑基取代的吲唑分子。 因此，本发明包括口服活性分子以及可以以较低剂量或血清浓度用于治疗与蛋白激酶信号转导相关的疾病或病症的肠胃外活性分子。

    Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof a JNK inhibitors and compositions and methods related thereto
    6.
    发明授权
    Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof a JNK inhibitors and compositions and methods related thereto 失效
    异噻唑烷酮，异恶唑酮，异吲哚酮及其衍生物，JNK抑制剂及其组合物和方法

    公开(公告)号：US07354947B2

    公开(公告)日：2008-04-08

    申请号：US11159592

    申请日：2005-06-22

    申请人： Steven T. Sakata ,  Heather K. Raymon

    发明人： Steven T. Sakata ,  Heather K. Raymon

    IPC分类号： A61K31/403 ,  C07D209/80

    CPC分类号： C07D275/04 ,  C07D417/12

    摘要： Isaothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein R0 is —CH2—, —SO—, —O—, —SO2—, or —S—; compositions comprising the iazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof; and methods for treating or preventing a disorder alleviated by inhibiting Jun N-terminal kinase (JNK) by administering the isaothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof are described herein.

    摘要翻译： 异噻唑鎓，异恶唑酮，异吲哚酮及其衍生物及其药学上可接受的盐，其中R 0为-CH 2 - ， - SO - ， - O- ，-SO 2 - ， - 或-S-; 包含重氮芳烃，异恶唑酮，异吲哚酮及其衍生物的组合物; 本文描述了通过给予异噻唑酮，异恶唑酮，异吲哚酮及其衍生物来抑制Jun N末端激酶（JNK）减轻的疾病的治疗或预防方法。

    Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related
    7.
    发明授权
    Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related 失效
    异噻唑烷酮，异恶唑酮，异吲哚酮及其衍生物作为JNK抑制剂及其组合物和方法相关

    公开(公告)号：US06987184B2

    公开(公告)日：2006-01-17

    申请号：US10071390

    申请日：2002-02-07

    申请人： Steven T. Sakata ,  Heather K. Raymon

    发明人： Steven T. Sakata ,  Heather K. Raymon

    IPC分类号： C07D417/00 ,  C07D275/04

    CPC分类号： C07D275/04 ,  C07D417/12

    摘要： Isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein R0 is —CH2—, —SO—, —O—, —SO2—, or —S—; compositions comprising the isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof; and methods for treating or preventing a disorder alleviated by inhibiting Jun N-terminal kinase (JNK) by administering the isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof are described herein.

    摘要翻译： 异噻唑烷酮，异恶唑酮，异吲哚酮及其衍生物及其药学上可接受的盐，其中R 0为-CH 2 - ， - SO - ， - O- ，-SO 2 - 或-S-; 包含异噻唑烷，异恶唑酮，异吲哚酮及其衍生物的组合物; 本文描述了通过施用异噻唑酮，异恶唑酮，异吲哚酮及其衍生物来抑制Jun N末端激酶（JNK）减轻的病症的治疗或预防方法。